JP7487184B2 - 放射線滅菌中の生物学的活性分子の防護 - Google Patents

放射線滅菌中の生物学的活性分子の防護 Download PDF

Info

Publication number
JP7487184B2
JP7487184B2 JP2021514951A JP2021514951A JP7487184B2 JP 7487184 B2 JP7487184 B2 JP 7487184B2 JP 2021514951 A JP2021514951 A JP 2021514951A JP 2021514951 A JP2021514951 A JP 2021514951A JP 7487184 B2 JP7487184 B2 JP 7487184B2
Authority
JP
Japan
Prior art keywords
radiation
biologically active
activity
mixture
dried
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021514951A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021524362A (ja
Inventor
ポール キュー フ
ナディア パトリス アレン
ジェニー ルイーズ ハワード
ジェフ ボイル
Original Assignee
キアゲン サイエンシーズ リミテッド ライアビリティ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by キアゲン サイエンシーズ リミテッド ライアビリティ カンパニー filed Critical キアゲン サイエンシーズ リミテッド ライアビリティ カンパニー
Publication of JP2021524362A publication Critical patent/JP2021524362A/ja
Priority to JP2024026729A priority Critical patent/JP2024073470A/ja
Application granted granted Critical
Publication of JP7487184B2 publication Critical patent/JP7487184B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/087—Particle radiation, e.g. electron-beam, alpha or beta radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2021514951A 2018-05-18 2019-05-17 放射線滅菌中の生物学的活性分子の防護 Active JP7487184B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024026729A JP2024073470A (ja) 2018-05-18 2024-02-26 放射線滅菌中の生物学的活性分子の防護

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862673671P 2018-05-18 2018-05-18
US62/673,671 2018-05-18
PCT/US2019/032885 WO2019222638A1 (en) 2018-05-18 2019-05-17 Protection of biologically active molecules during radiation sterilization

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024026729A Division JP2024073470A (ja) 2018-05-18 2024-02-26 放射線滅菌中の生物学的活性分子の防護

Publications (2)

Publication Number Publication Date
JP2021524362A JP2021524362A (ja) 2021-09-13
JP7487184B2 true JP7487184B2 (ja) 2024-05-20

Family

ID=66770587

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021514951A Active JP7487184B2 (ja) 2018-05-18 2019-05-17 放射線滅菌中の生物学的活性分子の防護
JP2024026729A Pending JP2024073470A (ja) 2018-05-18 2024-02-26 放射線滅菌中の生物学的活性分子の防護

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024026729A Pending JP2024073470A (ja) 2018-05-18 2024-02-26 放射線滅菌中の生物学的活性分子の防護

Country Status (9)

Country Link
US (1) US20210260225A1 (https=)
EP (1) EP3793621A1 (https=)
JP (2) JP7487184B2 (https=)
KR (2) KR102774917B1 (https=)
CN (1) CN112135641A (https=)
AU (2) AU2019269671B2 (https=)
MX (1) MX2020012237A (https=)
SG (1) SG11202009795PA (https=)
WO (1) WO2019222638A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114621467B (zh) * 2022-05-17 2022-07-29 天新福（北京）医疗器材股份有限公司 一种无菌自固化胶原蛋白修复凝胶及其制备方法
CN115611978B (zh) * 2022-11-21 2023-03-07 成都奇璞生物科技有限公司 一种辐照保护剂在制备胶原蛋白产品中的用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005505324A (ja) 2001-08-31 2005-02-24 クリアラント・インコーポレイテッド 消化酵素製剤を殺菌する方法
JP2005517631A (ja) 2001-06-14 2005-06-16 クリアラント・インコーポレイテッド モノクローナル免疫グロブリン製剤を殺菌する方法
JP2010514747A (ja) 2006-12-29 2010-05-06 アレコー・リミテッド 放射線および安定化組成物の添加によるタンパク質の滅菌
JP2012522236A (ja) 2009-03-31 2012-09-20 ロイコケア・アクチェンゲゼルシャフト 固定化生体分子のための組成物の安定化
JP2015500687A (ja) 2011-11-17 2015-01-08 メドトロニック ミニメド インコーポレイテッド 放射線防護組成物と、その製造および使用法
WO2016143828A1 (ja) 2015-03-12 2016-09-15 三洋化成工業株式会社 タンパク質組成物の製造方法及びタンパク質組成物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2649224B2 (ja) * 1987-02-25 1997-09-03 旭メディカル 株式会社 体液処理装置の滅菌方法および滅菌された体液処理装置
US6551794B1 (en) * 1995-11-09 2003-04-22 E. R. Squibb & Sons, Inc. Stable biotinylated biomolecule composition
DE69723243T2 (de) * 1996-02-05 2004-04-22 Asahi Medical Co. Ltd. Sterilisationsschutzmittel und verfahren zur sterilisation
US5730933A (en) * 1996-04-16 1998-03-24 Depuy Orthopaedics, Inc. Radiation sterilization of biologically active compounds
US20030012687A1 (en) * 2000-03-23 2003-01-16 Macphee Martin J. Methods of sterilizing biological materials
US20040086420A1 (en) 2000-03-23 2004-05-06 Macphee Martin J. Methods for sterilizing serum or plasma
EP1299131A4 (en) * 2000-03-23 2003-06-18 Clearant Inc METHODS FOR STERILIZING BIOLOGICAL MATERIALS
US6682695B2 (en) * 2001-03-23 2004-01-27 Clearant, Inc. Methods for sterilizing biological materials by multiple rates
US6946098B2 (en) 2001-08-10 2005-09-20 Clearant, Inc. Methods for sterilizing biological materials
US20030031584A1 (en) 2001-08-10 2003-02-13 Wilson Burgess Methods for sterilizing biological materials using dipeptide stabilizers
US7252799B2 (en) * 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
EP1415669A1 (en) * 2002-09-19 2004-05-06 Aventis Behring GmbH Process for sterilization of protein containing biological compositions
US20050069453A1 (en) 2003-09-29 2005-03-31 Ren-Yo Forng Methods for sterilizing preparations of urokinase
US20050175630A1 (en) * 2003-12-23 2005-08-11 Eyal Raz Immunogenic compositions and methods of use thereof
US8304439B1 (en) * 2007-10-12 2012-11-06 Politechnika Lodzka Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage
EP2236617A1 (en) * 2009-03-31 2010-10-06 Leukocare Ag Methods of terminal sterilization of biofunctional compositions
US20180055822A1 (en) * 2015-03-13 2018-03-01 Repoceuticals Aps Melatonin for Preventing and Treating Radiation Cystitis
US20160354500A1 (en) * 2015-06-02 2016-12-08 Medtronic Minimed, Inc. Protective agents against e-beam irradiation for proteins in optical sensing chemistry
EP3478283A4 (en) * 2016-06-29 2020-07-22 Menlo Therapeutics Inc. USE OF NEUROKININ-1 ANTAGONISTS IN THE TREATMENT OF A VARIETY OF PRURITIUS CONDITIONS
WO2019166003A1 (zh) * 2018-03-02 2019-09-06 郑州大学 14-脱氧-11,12-脱氢-8,12-环氧或7,8-烯-穿心莲内酯及其15位取代衍生物和用途

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005517631A (ja) 2001-06-14 2005-06-16 クリアラント・インコーポレイテッド モノクローナル免疫グロブリン製剤を殺菌する方法
JP2005505324A (ja) 2001-08-31 2005-02-24 クリアラント・インコーポレイテッド 消化酵素製剤を殺菌する方法
JP2010514747A (ja) 2006-12-29 2010-05-06 アレコー・リミテッド 放射線および安定化組成物の添加によるタンパク質の滅菌
JP2012522236A (ja) 2009-03-31 2012-09-20 ロイコケア・アクチェンゲゼルシャフト 固定化生体分子のための組成物の安定化
JP2015500687A (ja) 2011-11-17 2015-01-08 メドトロニック ミニメド インコーポレイテッド 放射線防護組成物と、その製造および使用法
WO2016143828A1 (ja) 2015-03-12 2016-09-15 三洋化成工業株式会社 タンパク質組成物の製造方法及びタンパク質組成物

Also Published As

Publication number Publication date
SG11202009795PA (en) 2020-12-30
CN112135641A (zh) 2020-12-25
AU2019269671A1 (en) 2020-10-22
MX2020012237A (es) 2021-03-25
KR20250030028A (ko) 2025-03-05
WO2019222638A1 (en) 2019-11-21
EP3793621A1 (en) 2021-03-24
US20210260225A1 (en) 2021-08-26
AU2025202786A1 (en) 2025-05-08
CA3096717A1 (en) 2019-11-21
KR20210013553A (ko) 2021-02-04
AU2019269671B2 (en) 2025-01-30
JP2024073470A (ja) 2024-05-29
KR102774917B1 (ko) 2025-03-04
BR112020021358A2 (pt) 2021-01-19
JP2021524362A (ja) 2021-09-13

Similar Documents

Publication Publication Date Title
JP2024073470A (ja) 放射線滅菌中の生物学的活性分子の防護
JP5680055B2 (ja) 固定化生体分子のための組成物の安定化
JP6412477B2 (ja) 生物機能性組成物の滅菌の手段および方法
ES2386457T3 (es) Composición de estabilizador químicamente definida
JP6838958B2 (ja) （ポリ）ペプチドのアンフォールディングを防止し、および／または（ポリ）ペプチドの（リ）フォールディングを誘導するための方法
EP3060247A1 (en) A novel method for the production of stabile vaccines
Nomura et al. A biological study establishing the endotoxin limit for in vitro proliferation of human mesenchymal stem cells
Dogan et al. Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-term storage
Anamur et al. Stability of collapse lyophilized influenza vaccine formulations
EP0619824A1 (en) Trophoblast interferons and their use
CA3096717C (en) Protection of biologically active molecules during radiation sterilization
BR112020021358B1 (pt) Método de proteção da atividade biológica de uma proteína biologicamente ativa ou outra molécula biologicamente ativa contra danos de radiação durante a esterilização por radiação
US6787520B2 (en) Inactivating process for lipid envelopped virus, and new antivirus lipopeptides
US20180008722A1 (en) Use of pll for improving the stability of molecules in solution
CN114931557B (zh) 一种冻干保护剂、疫苗冻干制剂及其制备方法
US20240382541A1 (en) Formulations to stabilize virus-based therapeutics
RU2326944C2 (ru) Способ получения и препарат аналога рекомбинантного интерферона гамма человека
CN121226500A (zh) 一种抗原稳定剂、制备方法和应用
RU2245154C1 (ru) Способ повышения качества сохранения активности сырья для изготовления реактива тромбопластина полного растворимого до и во время сублимации
Hashem et al. The antioxidant effect of Humulus iupulus L on the oxidation of hepatocytes

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220422

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230215

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230511

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230620

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230815

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20231023

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240226

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20240325

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240418

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240508

R150 Certificate of patent or registration of utility model

Ref document number: 7487184

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150