CN112135641A - 在辐射灭菌过程中保护生物活性分子 - Google Patents

在辐射灭菌过程中保护生物活性分子 Download PDF

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Publication number
CN112135641A
CN112135641A CN201980033117.0A CN201980033117A CN112135641A CN 112135641 A CN112135641 A CN 112135641A CN 201980033117 A CN201980033117 A CN 201980033117A CN 112135641 A CN112135641 A CN 112135641A
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CN
China
Prior art keywords
radiation
mixture
radioprotective
biologically active
biological activity
Prior art date
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Pending
Application number
CN201980033117.0A
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English (en)
Chinese (zh)
Inventor
P·Q·胡
N·P·艾伦
J·L·霍华德
J·鲍伊尔
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Kaijie Technology Co ltd
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Kaijie Technology Co ltd
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Publication date
Application filed by Kaijie Technology Co ltd filed Critical Kaijie Technology Co ltd
Publication of CN112135641A publication Critical patent/CN112135641A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/087—Particle radiation, e.g. electron-beam, alpha or beta radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201980033117.0A 2018-05-18 2019-05-17 在辐射灭菌过程中保护生物活性分子 Pending CN112135641A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862673671P 2018-05-18 2018-05-18
US62/673,671 2018-05-18
PCT/US2019/032885 WO2019222638A1 (en) 2018-05-18 2019-05-17 Protection of biologically active molecules during radiation sterilization

Publications (1)

Publication Number Publication Date
CN112135641A true CN112135641A (zh) 2020-12-25

Family

ID=66770587

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980033117.0A Pending CN112135641A (zh) 2018-05-18 2019-05-17 在辐射灭菌过程中保护生物活性分子

Country Status (9)

Country Link
US (1) US20210260225A1 (https=)
EP (1) EP3793621A1 (https=)
JP (2) JP7487184B2 (https=)
KR (2) KR102774917B1 (https=)
CN (1) CN112135641A (https=)
AU (2) AU2019269671B2 (https=)
MX (1) MX2020012237A (https=)
SG (1) SG11202009795PA (https=)
WO (1) WO2019222638A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114621467A (zh) * 2022-05-17 2022-06-14 天新福（北京）医疗器材股份有限公司 一种无菌自固化胶原蛋白修复凝胶及其制备方法
CN115611978A (zh) * 2022-11-21 2023-01-17 成都奇璞生物科技有限公司 一种辐照保护剂在制备胶原蛋白产品中的用途

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730933A (en) * 1996-04-16 1998-03-24 Depuy Orthopaedics, Inc. Radiation sterilization of biologically active compounds
US20030012687A1 (en) * 2000-03-23 2003-01-16 Macphee Martin J. Methods of sterilizing biological materials
CN1427729A (zh) * 2000-03-23 2003-07-02 科利昂特有限公司 生物材料消毒方法
US20030161753A1 (en) * 2001-03-23 2003-08-28 Macphee Martin Methods for sterilizing biological materials by multiple rates
EP1415669A1 (en) * 2002-09-19 2004-05-06 Aventis Behring GmbH Process for sterilization of protein containing biological compositions
CN1606457A (zh) * 2001-08-31 2005-04-13 克里兰特公司 将含有白蛋白的制剂灭菌的方法
WO2008081166A1 (en) * 2006-12-29 2008-07-10 Arecor Limited Protein sterilisation by radiation and addition of a stabilising composition
WO2016196662A1 (en) * 2015-06-02 2016-12-08 Medtronic Minimed, Inc. Protective agents against e-beam irradiation for proteins in optical sensing chemistry

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JP2649224B2 (ja) * 1987-02-25 1997-09-03 旭メディカル 株式会社 体液処理装置の滅菌方法および滅菌された体液処理装置
US6551794B1 (en) * 1995-11-09 2003-04-22 E. R. Squibb & Sons, Inc. Stable biotinylated biomolecule composition
DE69723243T2 (de) * 1996-02-05 2004-04-22 Asahi Medical Co. Ltd. Sterilisationsschutzmittel und verfahren zur sterilisation
US20040086420A1 (en) 2000-03-23 2004-05-06 Macphee Martin J. Methods for sterilizing serum or plasma
US6696060B2 (en) * 2001-06-14 2004-02-24 Clearant, Inc. Methods for sterilizing preparations of monoclonal immunoglobulins
US6946098B2 (en) 2001-08-10 2005-09-20 Clearant, Inc. Methods for sterilizing biological materials
US20030031584A1 (en) 2001-08-10 2003-02-13 Wilson Burgess Methods for sterilizing biological materials using dipeptide stabilizers
US6749851B2 (en) * 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes
US20050069453A1 (en) 2003-09-29 2005-03-31 Ren-Yo Forng Methods for sterilizing preparations of urokinase
US20050175630A1 (en) * 2003-12-23 2005-08-11 Eyal Raz Immunogenic compositions and methods of use thereof
US8304439B1 (en) * 2007-10-12 2012-11-06 Politechnika Lodzka Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage
EP2236520A1 (en) * 2009-03-31 2010-10-06 Leukocare Ag Stabilizing composition for immobilized biomolecules
EP2236617A1 (en) * 2009-03-31 2010-10-06 Leukocare Ag Methods of terminal sterilization of biofunctional compositions
US8999720B2 (en) * 2011-11-17 2015-04-07 Medtronic Minimed, Inc. Aqueous radiation protecting formulations and methods for making and using them
US20180055958A1 (en) * 2015-03-12 2018-03-01 Sanyo Chemical Industries, Ltd. Method for producing protein composition, and protein composition
US20180055822A1 (en) * 2015-03-13 2018-03-01 Repoceuticals Aps Melatonin for Preventing and Treating Radiation Cystitis
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WO2019166003A1 (zh) * 2018-03-02 2019-09-06 郑州大学 14-脱氧-11,12-脱氢-8,12-环氧或7,8-烯-穿心莲内酯及其15位取代衍生物和用途

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730933A (en) * 1996-04-16 1998-03-24 Depuy Orthopaedics, Inc. Radiation sterilization of biologically active compounds
US20030012687A1 (en) * 2000-03-23 2003-01-16 Macphee Martin J. Methods of sterilizing biological materials
CN1427729A (zh) * 2000-03-23 2003-07-02 科利昂特有限公司 生物材料消毒方法
US20030161753A1 (en) * 2001-03-23 2003-08-28 Macphee Martin Methods for sterilizing biological materials by multiple rates
CN1606457A (zh) * 2001-08-31 2005-04-13 克里兰特公司 将含有白蛋白的制剂灭菌的方法
EP1415669A1 (en) * 2002-09-19 2004-05-06 Aventis Behring GmbH Process for sterilization of protein containing biological compositions
WO2008081166A1 (en) * 2006-12-29 2008-07-10 Arecor Limited Protein sterilisation by radiation and addition of a stabilising composition
WO2016196662A1 (en) * 2015-06-02 2016-12-08 Medtronic Minimed, Inc. Protective agents against e-beam irradiation for proteins in optical sensing chemistry

Non-Patent Citations (1)

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ZBIKOWSKA等: "The role of ascorbate and histidine in fibrinogen protection against changes following exposure to a sterilizing dose of γ-irradiation", 《BLOOD COAGULATION & FIBRINOLYSIS》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114621467A (zh) * 2022-05-17 2022-06-14 天新福（北京）医疗器材股份有限公司 一种无菌自固化胶原蛋白修复凝胶及其制备方法
CN114621467B (zh) * 2022-05-17 2022-07-29 天新福（北京）医疗器材股份有限公司 一种无菌自固化胶原蛋白修复凝胶及其制备方法
CN115611978A (zh) * 2022-11-21 2023-01-17 成都奇璞生物科技有限公司 一种辐照保护剂在制备胶原蛋白产品中的用途
CN115611978B (zh) * 2022-11-21 2023-03-07 成都奇璞生物科技有限公司 一种辐照保护剂在制备胶原蛋白产品中的用途

Also Published As

Publication number Publication date
SG11202009795PA (en) 2020-12-30
AU2019269671A1 (en) 2020-10-22
JP7487184B2 (ja) 2024-05-20
MX2020012237A (es) 2021-03-25
KR20250030028A (ko) 2025-03-05
WO2019222638A1 (en) 2019-11-21
EP3793621A1 (en) 2021-03-24
US20210260225A1 (en) 2021-08-26
AU2025202786A1 (en) 2025-05-08
CA3096717A1 (en) 2019-11-21
KR20210013553A (ko) 2021-02-04
AU2019269671B2 (en) 2025-01-30
JP2024073470A (ja) 2024-05-29
KR102774917B1 (ko) 2025-03-04
BR112020021358A2 (pt) 2021-01-19
JP2021524362A (ja) 2021-09-13

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