JP7465819B2 - 新規ベンゾジアゼピン誘導体及びそれらの使用 - Google Patents

新規ベンゾジアゼピン誘導体及びそれらの使用 Download PDF

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JP7465819B2
JP7465819B2 JP2020566662A JP2020566662A JP7465819B2 JP 7465819 B2 JP7465819 B2 JP 7465819B2 JP 2020566662 A JP2020566662 A JP 2020566662A JP 2020566662 A JP2020566662 A JP 2020566662A JP 7465819 B2 JP7465819 B2 JP 7465819B2
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JP2021525730A (ja
JP2021525730A5 (enExample
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パーク,デギョ
ウ,スン,ホ
キム,スンヨン
パーク,スホ
チョ,ジョンウン
ジュン,トゥファン
ソ,ドンフン
リ,ジェホ
リ,サングァン
ユン,サンヒョン
リ,ヒャン,ソク
パーク,オック
ソ,ボムソク
キム,セナ
ソル,ミナ
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イントゥーセル,インコーポレーティッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020566662A 2018-05-29 2019-05-29 新規ベンゾジアゼピン誘導体及びそれらの使用 Active JP7465819B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862677498P 2018-05-29 2018-05-29
US62/677,498 2018-05-29
PCT/IB2019/000691 WO2019229536A2 (en) 2018-05-29 2019-05-29 Novel benzodiazepine derivatives and uses thereof

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JP2021525730A JP2021525730A (ja) 2021-09-27
JP2021525730A5 JP2021525730A5 (enExample) 2022-06-07
JP7465819B2 true JP7465819B2 (ja) 2024-04-11

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US (2) US11084801B2 (enExample)
EP (1) EP3802546A4 (enExample)
JP (1) JP7465819B2 (enExample)
KR (1) KR102946423B1 (enExample)
CN (2) CN113444111A (enExample)
AU (2) AU2019276833A1 (enExample)
BR (1) BR112020023623A2 (enExample)
CA (1) CA3100141A1 (enExample)
EA (1) EA202092909A1 (enExample)
IL (1) IL278973B2 (enExample)
MX (1) MX2020012718A (enExample)
WO (1) WO2019229536A2 (enExample)

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CN120682290A (zh) 2017-07-04 2025-09-23 尹图赛利有限公司 包含可裂解接头的化合物及其用途
MX2020012718A (es) 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
CN112930350A (zh) 2018-10-31 2021-06-08 尹图赛利有限公司 稠合杂环苯并二氮杂䓬衍生物及其用途
WO2020141459A1 (en) * 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
KR20210099658A (ko) 2019-01-03 2021-08-12 주식회사 인투셀 절단가능 링커를 포함하는 화합물 및 이의 용도
KR20220108783A (ko) * 2019-12-02 2022-08-03 주식회사 인투셀 분자 접합과 관련된 조성물 및 방법
BR112022026401A2 (pt) * 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3
CN114805432A (zh) * 2022-03-03 2022-07-29 西北工业大学 新型可光催化剪切的羧酸保护基及其氨基酸衍生物的制备方法
CN119424671A (zh) 2023-08-01 2025-02-14 上海新理念生物医药科技有限公司 含糖基吡啶型连接子的抗体药物偶联物
WO2025262641A1 (en) * 2024-06-19 2025-12-26 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof

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JP7174757B2 (ja) 2017-07-04 2022-11-17 イントゥーセル,インコーポレーティッド 切断可能なリンカーを含む化合物及びその使用

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JP2012516896A (ja) 2009-02-05 2012-07-26 イミュノジェン・インコーポレーテッド 新規ベンゾジアゼピン誘導体
JP2014534200A (ja) 2011-10-14 2014-12-18 シアトル ジェネティクス,インコーポレーテッド ピロロベンゾジアゼピンおよび標的コンジュゲート
JP2018502131A (ja) 2015-01-14 2018-01-25 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
JP2018503639A (ja) 2015-01-14 2018-02-08 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company ベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
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WO2017201442A1 (en) 2016-05-20 2017-11-23 Abbvie Stemcentrx Llc Anti-dll3 drug conjugates for treating tumors at risk of neuroendocrine transition
JP7174757B2 (ja) 2017-07-04 2022-11-17 イントゥーセル,インコーポレーティッド 切断可能なリンカーを含む化合物及びその使用

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US20220162190A1 (en) 2022-05-26
BR112020023623A2 (pt) 2021-02-17
IL278973B2 (en) 2025-07-01
US20190367488A1 (en) 2019-12-05
IL278973B1 (en) 2025-03-01
KR20210003938A (ko) 2021-01-12
WO2019229536A3 (en) 2020-03-05
CN112166115A (zh) 2021-01-01
KR102946423B1 (ko) 2026-04-01
US11807628B2 (en) 2023-11-07
US11084801B2 (en) 2021-08-10
IL278973A (en) 2021-01-31
AU2023203485A1 (en) 2023-07-06
JP2021525730A (ja) 2021-09-27
EP3802546A4 (en) 2021-12-29
MX2020012718A (es) 2021-02-16
AU2023203485B2 (en) 2024-09-19
EA202092909A1 (ru) 2021-04-07
CN113444111A (zh) 2021-09-28
CA3100141A1 (en) 2019-12-05
EP3802546A2 (en) 2021-04-14
WO2019229536A2 (en) 2019-12-05
AU2019276833A1 (en) 2020-11-26

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