KR102946423B1 - 신규한 벤조다이아제핀 유도체 및 그 용도 - Google Patents

신규한 벤조다이아제핀 유도체 및 그 용도

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Publication number
KR102946423B1
KR102946423B1 KR1020207037031A KR20207037031A KR102946423B1 KR 102946423 B1 KR102946423 B1 KR 102946423B1 KR 1020207037031 A KR1020207037031 A KR 1020207037031A KR 20207037031 A KR20207037031 A KR 20207037031A KR 102946423 B1 KR102946423 B1 KR 102946423B1
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alkyl
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preparation
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Korean (ko)
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KR20210003938A (ko
Inventor
박태교
우성호
김선영
박수호
조종운
정두환
서동훈
이재호
이상광
윤상현
이향숙
박옥구
서범석
김세나
설미나
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주식회사 인투셀
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020207037031A 2018-05-29 2019-05-29 신규한 벤조다이아제핀 유도체 및 그 용도 Active KR102946423B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862677498P 2018-05-29 2018-05-29
US62/677,498 2018-05-29
PCT/IB2019/000691 WO2019229536A2 (en) 2018-05-29 2019-05-29 Novel benzodiazepine derivatives and uses thereof

Publications (2)

Publication Number Publication Date
KR20210003938A KR20210003938A (ko) 2021-01-12
KR102946423B1 true KR102946423B1 (ko) 2026-04-01

Family

ID=68692822

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207037031A Active KR102946423B1 (ko) 2018-05-29 2019-05-29 신규한 벤조다이아제핀 유도체 및 그 용도

Country Status (12)

Country Link
US (2) US11084801B2 (enExample)
EP (1) EP3802546A4 (enExample)
JP (1) JP7465819B2 (enExample)
KR (1) KR102946423B1 (enExample)
CN (2) CN113444111A (enExample)
AU (2) AU2019276833A1 (enExample)
BR (1) BR112020023623A2 (enExample)
CA (1) CA3100141A1 (enExample)
EA (1) EA202092909A1 (enExample)
IL (1) IL278973B2 (enExample)
MX (1) MX2020012718A (enExample)
WO (1) WO2019229536A2 (enExample)

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CN120682290A (zh) 2017-07-04 2025-09-23 尹图赛利有限公司 包含可裂解接头的化合物及其用途
MX2020012718A (es) 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
CN112930350A (zh) 2018-10-31 2021-06-08 尹图赛利有限公司 稠合杂环苯并二氮杂䓬衍生物及其用途
WO2020141459A1 (en) * 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
KR20210099658A (ko) 2019-01-03 2021-08-12 주식회사 인투셀 절단가능 링커를 포함하는 화합물 및 이의 용도
KR20220108783A (ko) * 2019-12-02 2022-08-03 주식회사 인투셀 분자 접합과 관련된 조성물 및 방법
BR112022026401A2 (pt) * 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3
CN114805432A (zh) * 2022-03-03 2022-07-29 西北工业大学 新型可光催化剪切的羧酸保护基及其氨基酸衍生物的制备方法
CN119424671A (zh) 2023-08-01 2025-02-14 上海新理念生物医药科技有限公司 含糖基吡啶型连接子的抗体药物偶联物
WO2025262641A1 (en) * 2024-06-19 2025-12-26 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof

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EP2751111B1 (en) * 2011-10-14 2017-04-26 MedImmune Limited Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases
HK1211208A1 (zh) 2012-08-22 2016-05-20 Immunogen, Inc. 細胞毒性苯並二氮呯衍生物
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BR112022026401A2 (pt) 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3

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Also Published As

Publication number Publication date
US20220162190A1 (en) 2022-05-26
BR112020023623A2 (pt) 2021-02-17
IL278973B2 (en) 2025-07-01
US20190367488A1 (en) 2019-12-05
IL278973B1 (en) 2025-03-01
KR20210003938A (ko) 2021-01-12
WO2019229536A3 (en) 2020-03-05
CN112166115A (zh) 2021-01-01
JP7465819B2 (ja) 2024-04-11
US11807628B2 (en) 2023-11-07
US11084801B2 (en) 2021-08-10
IL278973A (en) 2021-01-31
AU2023203485A1 (en) 2023-07-06
JP2021525730A (ja) 2021-09-27
EP3802546A4 (en) 2021-12-29
MX2020012718A (es) 2021-02-16
AU2023203485B2 (en) 2024-09-19
EA202092909A1 (ru) 2021-04-07
CN113444111A (zh) 2021-09-28
CA3100141A1 (en) 2019-12-05
EP3802546A2 (en) 2021-04-14
WO2019229536A2 (en) 2019-12-05
AU2019276833A1 (en) 2020-11-26

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