JP7442196B2 - イオン性自己組織化ペプチド - Google Patents

イオン性自己組織化ペプチド Download PDF

Info

Publication number
JP7442196B2
JP7442196B2 JP2020573255A JP2020573255A JP7442196B2 JP 7442196 B2 JP7442196 B2 JP 7442196B2 JP 2020573255 A JP2020573255 A JP 2020573255A JP 2020573255 A JP2020573255 A JP 2020573255A JP 7442196 B2 JP7442196 B2 JP 7442196B2
Authority
JP
Japan
Prior art keywords
composition
self
seq
pharmaceutical composition
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020573255A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021531248A (ja
JP2021531248A5 (https=
Inventor
ユン ソク ギル，
エルトン アレクシ，
直毅 山本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3D Matrix Ltd
Original Assignee
3D Matrix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3D Matrix Ltd filed Critical 3D Matrix Ltd
Publication of JP2021531248A publication Critical patent/JP2021531248A/ja
Publication of JP2021531248A5 publication Critical patent/JP2021531248A5/ja
Priority to JP2024019494A priority Critical patent/JP7835455B2/ja
Application granted granted Critical
Publication of JP7442196B2 publication Critical patent/JP7442196B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
JP2020573255A 2018-07-03 2019-07-03 イオン性自己組織化ペプチド Active JP7442196B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024019494A JP7835455B2 (ja) 2018-07-03 2024-02-13 イオン性自己組織化ペプチド

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862693877P 2018-07-03 2018-07-03
US62/693,877 2018-07-03
PCT/IB2019/055661 WO2020008377A2 (en) 2018-07-03 2019-07-03 Ionic self-assembling peptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024019494A Division JP7835455B2 (ja) 2018-07-03 2024-02-13 イオン性自己組織化ペプチド

Publications (3)

Publication Number Publication Date
JP2021531248A JP2021531248A (ja) 2021-11-18
JP2021531248A5 JP2021531248A5 (https=) 2022-06-23
JP7442196B2 true JP7442196B2 (ja) 2024-03-04

Family

ID=67667887

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020573255A Active JP7442196B2 (ja) 2018-07-03 2019-07-03 イオン性自己組織化ペプチド
JP2024019494A Active JP7835455B2 (ja) 2018-07-03 2024-02-13 イオン性自己組織化ペプチド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024019494A Active JP7835455B2 (ja) 2018-07-03 2024-02-13 イオン性自己組織化ペプチド

Country Status (5)

Country Link
US (3) US11617778B2 (https=)
EP (1) EP3818071A2 (https=)
JP (2) JP7442196B2 (https=)
CN (1) CN112368295B (https=)
WO (1) WO2020008377A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3818071A2 (en) 2018-07-03 2021-05-12 3-D Matrix, Ltd. Ionic self-assembling peptides
US12383700B2 (en) 2019-06-13 2025-08-12 Hollister Incorporated Reusable urinary catheter products
EP4628107A3 (en) 2019-06-25 2025-12-17 Hollister Incorporated Reusable urinary catheter products
US20210106506A1 (en) * 2019-10-11 2021-04-15 Elc Management Llc Methods for cosmetic skin remodeling
US12390552B2 (en) * 2020-01-13 2025-08-19 Arch Biosurgery, Inc. Self-assembling peptide gel formulation and methods of use
CN111249469B (zh) * 2020-03-20 2022-03-08 临沂大学 一种能够溶酶体逃逸的肽纳米颗粒及其制备方法和应用
CN114377202B (zh) * 2021-12-16 2023-01-24 方向前 适用于软骨再生的功能化自组装miRNA/多肽复合水凝胶及其制备方法
WO2025106582A1 (en) * 2023-11-13 2025-05-22 University Of Florida Research Foundation, Incorporated Polymer assemblies for cargo delivery
WO2025240422A1 (en) * 2024-05-14 2025-11-20 University Of Florida Research Foundation, Incorporated Use of rada16 to reduce mucosal inflammation
CN119954905B (zh) * 2025-01-23 2025-11-14 遵义医科大学 纳米自组装短肽kld12-krh在药物、细胞载体和生物医学的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009072556A1 (ja) 2007-12-05 2009-06-11 3-D Matrix, Ltd. 創傷治癒・皮膚再建材
JP2010512393A (ja) 2006-12-11 2010-04-22 スリーディー マトリックス， インコーポレイテッド 心組織の保護および再生のための組成物および方法
JP2013525329A (ja) 2010-04-19 2013-06-20 ウニヴェルシタ デグリ ステュディ ディ ミラノ‐ビコッカ 新規自己集合ペプチド、およびヒドロゲル形成におけるその使用
JP2016514108A (ja) 2013-03-06 2016-05-19 株式会社スリー・ディー・マトリックス 精製された両親媒性ペプチド組成物を用いた、外科的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7846891B2 (en) 2003-10-17 2010-12-07 Massachusetts Institute Of Technology Self-assembling peptides for regeneration and repair of neural tissue
RU2011118341A (ru) 2008-10-06 2012-11-20 3-Д Матрикс, Лтд. (Jp) Агент для окклюзии тканей
SG174857A1 (en) * 2009-03-09 2011-11-28 Menicon Co Ltd Self-assembling peptide and peptide gel with high strength
US20110081398A1 (en) * 2009-10-01 2011-04-07 Tyco Healthcare Group Lp Multi-mechanism surgical compositions
JP6034868B2 (ja) 2011-09-02 2016-11-30 株式会社スリー・ディー・マトリックス 胸部の空気漏れ閉塞のための両親媒性ペプチド
US20150105336A1 (en) 2012-03-09 2015-04-16 3-D Matrix, Ltd. Mucosa-elevating agent
US9724448B2 (en) 2013-03-14 2017-08-08 3-D Matrix, Ltd. Materials for gastrointestinal obstruction prevention
EP3116522B1 (en) 2014-03-10 2019-05-08 3-D Matrix Ltd. Autoassembling peptides for the treatment of pulmonary leakage
US10245299B2 (en) 2014-03-10 2019-04-02 3-D Matrix, Ltd. Autoassembling peptides for the treatment of pulmonary bulla
RU2016139369A (ru) 2014-03-10 2018-04-10 3-Д Матрикс, Лтд. Композиции самоорганизующихся пептидов
JP6554121B2 (ja) * 2014-03-10 2019-07-31 株式会社スリー・ディー・マトリックス 気管支閉鎖剤としての自己組織化ペプチド
CA2952777A1 (en) 2014-06-20 2015-12-23 3-D Matrix, Ltd. Materials and methods for filling bone voids
US20170128172A1 (en) 2014-06-20 2017-05-11 3-D Matrix, Ltd. Materials and methods for filling dental bone voids
JP6042038B2 (ja) 2014-06-30 2016-12-14 国立大学法人名古屋大学 骨形成促進材
JP6962815B2 (ja) * 2014-12-12 2021-11-05 株式会社スリー・ディー・マトリックス 非イオン性極性アミノ酸を含む自己組織化ペプチド
CN118271422A (zh) * 2015-08-28 2024-07-02 分子传递有限公司 转染络合物和其使用方法
HK1258374A1 (zh) 2015-12-18 2019-11-08 立美基股份有限公司 止血组合物和使用止血组合物的止血方法
US10814038B2 (en) 2016-01-06 2020-10-27 3-D Matrix, Ltd. Combination compositions
BR112018068941A2 (pt) 2016-03-18 2019-04-16 3-D Matrix, Ltd. prevenção de adesão de tecidos biológicos
EP3463496A1 (en) 2016-06-01 2019-04-10 3-D Matrix Ltd. Hemostatic powders with self-assembling peptide hydrogels
EP3463495A1 (en) * 2016-06-01 2019-04-10 3-D Matrix Ltd. Hemostatic dressings with self-assembling peptide hydrogels
EP3818071A2 (en) 2018-07-03 2021-05-12 3-D Matrix, Ltd. Ionic self-assembling peptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010512393A (ja) 2006-12-11 2010-04-22 スリーディー マトリックス， インコーポレイテッド 心組織の保護および再生のための組成物および方法
WO2009072556A1 (ja) 2007-12-05 2009-06-11 3-D Matrix, Ltd. 創傷治癒・皮膚再建材
JP2014139201A (ja) 2007-12-05 2014-07-31 Three D Matrix:Kk 創傷治癒・皮膚再建材
JP2013525329A (ja) 2010-04-19 2013-06-20 ウニヴェルシタ デグリ ステュディ ディ ミラノ‐ビコッカ 新規自己集合ペプチド、およびヒドロゲル形成におけるその使用
JP2016514108A (ja) 2013-03-06 2016-05-19 株式会社スリー・ディー・マトリックス 精製された両親媒性ペプチド組成物を用いた、外科的方法

Also Published As

Publication number Publication date
EP3818071A2 (en) 2021-05-12
US12611439B2 (en) 2026-04-28
CN112368295A (zh) 2021-02-12
US11617778B2 (en) 2023-04-04
US20200009214A1 (en) 2020-01-09
CN112368295B (zh) 2025-03-21
JP2021531248A (ja) 2021-11-18
JP2024045511A (ja) 2024-04-02
JP7835455B2 (ja) 2026-03-25
WO2020008377A2 (en) 2020-01-09
US20230226142A1 (en) 2023-07-20
US20230241157A1 (en) 2023-08-03
WO2020008377A3 (en) 2020-04-09

Similar Documents

Publication Publication Date Title
JP7835455B2 (ja) イオン性自己組織化ペプチド
He et al. Hyaluronic acid-based shape-memory cryogel scaffolds for focal cartilage defect repair
Yang et al. An immunomodulatory polypeptide hydrogel for osteochondral defect repair
Li et al. Kartogenin-incorporated thermogel supports stem cells for significant cartilage regeneration
CN102762715B (zh) 由聚合物-蛋白质结合物形成的支架，产生该支架的方法及其用途
CN105189532B (zh) 用于伤口愈合、皮肤护理和化妆品应用的自组装超短肽水凝胶
US20220031913A1 (en) Modified alginates for anti-fibrotic materials and applications
Wei et al. Biomimetic joint paint for efficient cartilage repair by simultaneously regulating cartilage degeneration and regeneration in pigs
Ju et al. A photo-crosslinked proteinogenic hydrogel enabling self-recruitment of endogenous TGF-β1 for cartilage regeneration
CN103237885B (zh) 用于细胞归巢和脂肪形成的组合物和方法
JP6851377B2 (ja) 骨再生のための生物活性重合体
JP2004504354A (ja) 非タンパク質分解的活性化トロンビンレセプターのアゴニストによる軟骨成長の刺激
US20240050586A1 (en) Compositions and methods for making and using double network hydrogels
Zhang et al. Tissue-adhesive paint of silk microparticles for articular surface cartilage regeneration
CA2938796C (en) Implant comprising fgf-18
WO2022035778A1 (en) Delivery of cells and tissues with self-assembling peptide hydrogel materials
JP2023508917A (ja) 生体適合性材料
JP5704344B2 (ja) 人工コラーゲンを用いた軟骨培養用基材及び該基材を用いた軟骨再生治療方法
CN109069661A (zh) 利用聚合蛋白共轭物的治疗
US20110287068A1 (en) Fibrin and fibrinogen matrices and uses of same
Kim et al. Regeneration of paralyzed vocal fold by the injection of plasmid DNA complex-loaded hydrogel bulking agent
Wang et al. Injectable visible light cross-linking aldehyde-based methacrylated hyaluronic acid hydrogels enhance cartilage repair via improved BMSC homing and chondrogenic differentiation
Silva et al. Drug delivery systems and cartilage tissue engineering scaffolding using marine-derived products
Alheib Tissue Engineering Strategies to Advance the Treatment of Skeletal Muscle Injuries
ES2705602T3 (es) Composiciones de péptidos anfifílicos purificadas y usos de las mismas

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220615

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220615

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230628

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230731

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231019

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240112

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240213

R150 Certificate of patent or registration of utility model

Ref document number: 7442196

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150