JP7426941B2 - 腎傷害を治療するための組成物および方法 - Google Patents
腎傷害を治療するための組成物および方法 Download PDFInfo
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- JP7426941B2 JP7426941B2 JP2020553610A JP2020553610A JP7426941B2 JP 7426941 B2 JP7426941 B2 JP 7426941B2 JP 2020553610 A JP2020553610 A JP 2020553610A JP 2020553610 A JP2020553610 A JP 2020553610A JP 7426941 B2 JP7426941 B2 JP 7426941B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| PCT/US2019/025812 WO2019195565A1 (en) | 2018-04-04 | 2019-04-04 | Compositions and methods for treating renal injury |
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| JP2021519797A JP2021519797A (ja) | 2021-08-12 |
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| JP7595413B2 (ja) | 2016-11-30 | 2024-12-06 | ケース ウエスタン リザーブ ユニバーシティ | １５－ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用 |
| WO2018145080A1 (en) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| CN120463721A (zh) | 2018-11-21 | 2025-08-12 | 卡斯西部储备大学 | 调节短链脱氢酶活性的组合物和方法 |
| KR20230011910A (ko) * | 2020-02-21 | 2023-01-25 | 케이스 웨스턴 리저브 유니버시티 | 신장 손상을 치료하기 위한 조성물 및 방법 |
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| WO2016168472A1 (en) | 2015-04-14 | 2016-10-20 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| JP2016537328A (ja) | 2013-10-15 | 2016-12-01 | ケース ウエスタン リザーブ ユニバーシティ | 短鎖デヒドロゲナーゼ活性を調節する組成物および方法 |
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| US20050187221A1 (en) * | 2003-09-08 | 2005-08-25 | Japan Tobacco Inc. | Method of treating ischemia reperfusion injury |
| DK2838533T3 (da) * | 2012-04-16 | 2017-11-27 | Univ Case Western Reserve | Sammensætninger og fremgangsmåder til at modulere 15-pgdh-aktivitet |
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| JP2016537328A (ja) | 2013-10-15 | 2016-12-01 | ケース ウエスタン リザーブ ユニバーシティ | 短鎖デヒドロゲナーゼ活性を調節する組成物および方法 |
| WO2016168472A1 (en) | 2015-04-14 | 2016-10-20 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
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| JP2021519797A (ja) | 2021-08-12 |
| EP3781154A4 (en) | 2022-02-23 |
| AU2025201403A1 (en) | 2025-03-20 |
| US20240024297A1 (en) | 2024-01-25 |
| US20210100779A1 (en) | 2021-04-08 |
| CA3095308A1 (en) | 2019-10-10 |
| EP3781154A1 (en) | 2021-02-24 |
| CN112739344A (zh) | 2021-04-30 |
| US20250325524A1 (en) | 2025-10-23 |
| AU2019247838A1 (en) | 2020-10-15 |
| WO2019195565A1 (en) | 2019-10-10 |
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