JP7385284B2 - 癌処置のためのｂｃｌ－２タンパク質分解剤 - Google Patents

癌処置のためのｂｃｌ－２タンパク質分解剤 Download PDF

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JP7385284B2
JP7385284B2 JP2020540426A JP2020540426A JP7385284B2 JP 7385284 B2 JP7385284 B2 JP 7385284B2 JP 2020540426 A JP2020540426 A JP 2020540426A JP 2020540426 A JP2020540426 A JP 2020540426A JP 7385284 B2 JP7385284 B2 JP 7385284B2
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bcl
formula
cancer
compounds
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JP2021511342A5 (enExample
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グアンロン・ジェン
ダオホン・ジョウ
シュアン・ジャン
サジィド・カーン
ヨンハン・ホァ
ペイー・ジャン
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JP2020540426A 2018-01-22 2019-01-22 癌処置のためのｂｃｌ－２タンパク質分解剤 Active JP7385284B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862620219P 2018-01-22 2018-01-22
US62/620,219 2018-01-22
PCT/US2019/014545 WO2019144117A1 (en) 2018-01-22 2019-01-22 Bcl-2 proteins degraders for cancer treatment

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JP2021511342A JP2021511342A (ja) 2021-05-06
JP2021511342A5 JP2021511342A5 (enExample) 2022-01-31
JP7385284B2 true JP7385284B2 (ja) 2023-11-22

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US (1) US12118414B2 (enExample)
EP (1) EP3743069B1 (enExample)
JP (1) JP7385284B2 (enExample)
CN (1) CN112105360B (enExample)
CA (1) CA3088253A1 (enExample)
ES (1) ES3041854T3 (enExample)
WO (1) WO2019144117A1 (enExample)

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KR20190084063A (ko) 2016-10-28 2019-07-15 이칸 스쿨 오브 메디슨 엣 마운트 시나이 Ｅｚｈ２-매개성 암 치료용 조성물 및 방법
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US20260092057A1 (en) * 2022-05-12 2026-04-02 Kymera Therapeutics, Inc. Bcl-xl/bcl-2 degraders and uses thereof
CN117247374B (zh) * 2022-06-10 2026-03-17 四川科伦博泰生物医药股份有限公司 一种bcl-xl抑制剂及其制药用途
TW202402272A (zh) * 2022-07-12 2024-01-16 中國商正大天晴藥業集團股份有限公司 含有三氟甲基基團的化合物
TW202430522A (zh) * 2022-09-30 2024-08-01 大陸商江蘇恆瑞醫藥股份有限公司 一種用於ｂｃｌ－２蛋白靶向降解的嵌合體化合物、其製備方法及其在醫藥上的應用
CN120659777A (zh) * 2022-10-03 2025-09-16 佛罗里达大学研究基金公司 募集Cereblon的Bcl-xL/Bcl-2双重降解剂
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TW202527930A (zh) 2023-11-07 2025-07-16 美商樹線生物科學公司 四氫異喹啉異雙功能ｂｃｌ－ｘｌ降解劑
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