JP7382431B2 - 加圧気体を動力とする薬剤の輸送と再懸濁の装置および方法 - Google Patents
加圧気体を動力とする薬剤の輸送と再懸濁の装置および方法 Download PDFInfo
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Description
図1~12は、2014年12月24日にPCT公開番号WO2014204894として公開された、バイアル輸送と注射器具と方法と題するPCT国際出願番号PCT/US2014/042627からの例示的な図であり、背景技術と一般的な開示の目的のために含まれている。
図13~24に示される本主題に従えば、移送および/または混合と再懸濁は、予め充填された圧力シリンダまたはカートリッジの形態であり得る圧力容器のような加圧気体源によって推進される。これは、上述の移動可能なばね付勢のピストンを有する可変体積の圧力室またはシリンダの除去を許容し、移送と混合/再懸濁器具の費用と大きさの潜在的な低減を与える。
以上と添付の請求項を制限することなく、この記載の主題の一般的な、そしてより具体的な局面と変形が以下に示される。
Claims (20)
- 液体を含むバイアルから注射装置への液体の移送方法であって、
液体を含むバイアルを、気体ルーメンと液体ルーメンとを含むバイアル受容ステーションに挿入することと、
挿入された前記バイアルを第1の位置から第2の位置に動かすこととを含み、
前記気体ルーメンと前記液体ルーメンは、挿入された前記バイアルが前記第2の位置に動かされたときに挿入された前記バイアルの内部と流体連通になり、
挿入された前記バイアルは、前記第2の位置に動かされたときにアクチュエータの部材と連動するよう係合され、それによって貫通ピンおよび/または予め充填された加圧容器が貫通位置に動かされ、前記貫通位置は、気体が前記気体ルーメンを通って流れるように、前記貫通ピンが加圧気体の供給源の封止を貫通する位置であり、
加圧された気体を、前記気体ルーメンを通して、挿入され動かされた前記バイアルに導入することと;
液体を挿入され動かされた前記バイアルから前記加圧気体からの圧力下で流すことと;
前記液体を、前記液体ルーメンを通して、挿入され動かされた前記バイアルから注射装置に前記加圧された気体の力の下で流すことを含む、方法。 - 前記液体を前記バイアルから流す後であって前記液体を前記注射装置の中に流す前に薬剤を前記液体と組み合わせる工程を含む、請求項1に記載の方法。
- 前記組み合わせる工程は、前記液体を前記バイアルから前記気体の圧力下で薬剤を含む第2のバイアルに流すことを含み、前記液体を前記注射装置の中に流すことは組み合わされた前記液体と前記薬剤を前記第2のバイアルから前記加圧された気体の力の下で前記注射装置の中に流すことを含む、請求項2に記載の方法。
- 前記液体は希釈剤である、請求項3に記載の方法。
- 前記液体は第1の液体薬剤であり、前記第2のバイアル中の前記薬剤は第2の液体薬剤である、請求項3に記載の方法。
- 前記第2のバイアル中の前記薬剤は凍結乾燥されており、前記希釈剤は前記薬剤を再構成する、請求項4に記載の方法。
- 前記注射装置は拡張可能な貯留部を含み、前記液体は前記加圧された気体の圧力下で拡張可能な貯留部の中に流される、請求項1から請求項6までのいずれか1項に記載の方法。
- 拡張可能な前記貯留部は弾性の袋を備える、請求項7に記載の方法。
- 前記貯留部は、前記液体または組み合わされた希釈剤と薬剤を排出するように偏向されている、請求項7に記載の方法。
- 前記加圧された気体は予め充填された圧力容器から流れる、請求項1から請求項9までのいずれか1項に記載の方法。
- 前記圧力容器は貫通可能な封止部を含み、方法は前記封止部を貫通することを含む、請求項10に記載の方法。
- 前記加圧された気体は実質的に病原体を含まない、請求項1から請求項11までのいずれか1項に記載の方法。
- 前記気体がバイアルに入る前に前記気体をろ過することを含む、請求項1から請求項12までのいずれか1項に記載の方法。
- 前記圧力容器は10ml以下の容積を有する、気体が充填されたカートリッジである、請求項10に記載の方法。
- 前記カートリッジは約1ml以下の容積を有する請求項14に記載の方法。
- 前記圧力容器は当初、気体を約500psig以上の圧力で含む、請求項10に記載の方法。
- 前記加圧された気体は不活性気体である、請求項1から請求項16までのいずれか1項に記載の方法。
- 前記気体は窒素、ヘリウム、ネオン、アルゴン、クリプトン、および、キセノンからなる群から選択される、請求項1から請求項17までのいずれか1項に気体の方法。
- 巻きこまれた気体が拡張可能な前記貯留部に入る前に前記液体から除去することを含む、請求項7に記載の方法。
- 前記加圧された気体は、約1ml以下の容積を有し、約900psig以上の圧力を有するプレフィルドカートリッジから流される、請求項1から請求項19までのいずれか1項に記載の方法。
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