JP7326276B2 - 新規化合物及び疾患の治療のためのその医薬組成物 - Google Patents

新規化合物及び疾患の治療のためのその医薬組成物 Download PDF

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JP7326276B2
JP7326276B2 JP2020529717A JP2020529717A JP7326276B2 JP 7326276 B2 JP7326276 B2 JP 7326276B2 JP 2020529717 A JP2020529717 A JP 2020529717A JP 2020529717 A JP2020529717 A JP 2020529717A JP 7326276 B2 JP7326276 B2 JP 7326276B2
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dimethoxy
benzamide
substituted
alkoxy
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JP2021505553A (ja
JP2021505553A5 (https=
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ジョナサン アルベイ ルーク
モーリス アンノオト デニス
マリー‐エミリー ボンナテルレ フロレンス
ブシェル デニス
デュティオン ベランゲル
マリー ジャリー ヘレン
ペイショット クリストフェ
テマル‐ライブ タオウエス
チレラ アミナタ
デスロイ ニコラス
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Galapagos NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2020529717A 2017-12-02 2018-11-26 新規化合物及び疾患の治療のためのその医薬組成物 Active JP7326276B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1720101.3A GB201720101D0 (en) 2017-12-02 2017-12-02 Novel compounds and pharmaceutical compositions thereof for the treatment of diseases
GB1720101.3 2017-12-02
GB1817343.5 2018-10-25
GBGB1817343.5A GB201817343D0 (en) 2018-10-25 2018-10-25 Novel compounds and pharmaceutical compositions thereof for the treatment of diseases
PCT/EP2018/082537 WO2019105886A1 (en) 2017-12-02 2018-11-26 Novel compounds and pharmaceutical compositions thereof for the treatment of diseases

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JP2021505553A JP2021505553A (ja) 2021-02-18
JP2021505553A5 JP2021505553A5 (https=) 2022-01-06
JP7326276B2 true JP7326276B2 (ja) 2023-08-15

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EP (1) EP3717471B1 (https=)
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KR (1) KR102720958B1 (https=)
CN (1) CN111433200B (https=)
AU (1) AU2018374456B2 (https=)
BR (1) BR112020010364A2 (https=)
CA (1) CA3084090A1 (https=)
CO (1) CO2020008066A2 (https=)
CY (1) CY1125044T1 (https=)
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JP2022534578A (ja) * 2019-05-29 2022-08-02 ガラパゴス・ナムローゼ・フェンノートシャップ 新規化合物及び疾患の治療のためのその医薬組成物
JP2022534576A (ja) * 2019-05-29 2022-08-02 ガラパゴス・ナムローゼ・フェンノートシャップ 疾患の治療のための新規化合物及びその医薬組成物

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EA035095B1 (ru) 2013-04-19 2020-04-27 Инсайт Холдингс Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
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AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
SG11202004925QA (en) * 2017-12-02 2020-06-29 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of diseases
MA52493A (fr) 2018-05-04 2021-03-10 Incyte Corp Sels d'un inhibiteur de fgfr
CR20200590A (es) 2018-05-04 2021-04-26 Incyte Corp Formas sólidas de un inhibidor de fgfr y procesos para prepararlas
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CN116813608B (zh) * 2023-06-08 2024-03-22 英矽智能科技(上海)有限公司 噻唑类化合物及其应用
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Publication number Priority date Publication date Assignee Title
JP2022534578A (ja) * 2019-05-29 2022-08-02 ガラパゴス・ナムローゼ・フェンノートシャップ 新規化合物及び疾患の治療のためのその医薬組成物
JP2022534576A (ja) * 2019-05-29 2022-08-02 ガラパゴス・ナムローゼ・フェンノートシャップ 疾患の治療のための新規化合物及びその医薬組成物
JP7550174B2 (ja) 2019-05-29 2024-09-12 ガラパゴス・ナムローゼ・フェンノートシャップ 新規化合物及び疾患の治療のためのその医薬組成物
JP7621277B2 (ja) 2019-05-29 2025-01-24 ガラパゴス・ナムローゼ・フェンノートシャップ 疾患の治療のための新規化合物及びその医薬組成物

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PL3717471T3 (pl) 2022-03-21
CY1125044T1 (el) 2023-03-24
MY201849A (en) 2024-03-20
NZ765783A (en) 2024-12-20
WO2019105886A1 (en) 2019-06-06
AU2018374456A1 (en) 2020-07-16
PT3717471T (pt) 2022-03-08
DK3717471T3 (da) 2022-01-31
HUE057581T2 (hu) 2022-05-28
IL274938B2 (en) 2023-05-01
TW201930301A (zh) 2019-08-01
ES2908283T3 (es) 2022-04-28
US12065443B2 (en) 2024-08-20
US11339166B2 (en) 2022-05-24
ZA202004025B (en) 2021-09-29
PH12020550725A1 (en) 2021-02-15
US20220340581A1 (en) 2022-10-27
BR112020010364A2 (pt) 2021-01-26
EP3717471A1 (en) 2020-10-07
CA3084090A1 (en) 2019-06-06
IL274938A (en) 2020-07-30
IL274938B1 (en) 2023-01-01
RU2020121645A3 (https=) 2022-03-01
US20210101903A1 (en) 2021-04-08
CN111433200B (zh) 2024-03-22
EP3717471B1 (en) 2022-01-05
MA51200A (fr) 2020-10-07
SG11202004925QA (en) 2020-06-29
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AU2018374456B2 (en) 2022-07-07
MX2020005423A (es) 2020-08-27
RU2020121645A (ru) 2022-01-04
CO2020008066A2 (es) 2020-08-31
KR102720958B1 (ko) 2024-10-24
CN111433200A (zh) 2020-07-17

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