JP7325928B2 - 改善された免疫グロブリン可変ドメイン - Google Patents

改善された免疫グロブリン可変ドメイン Download PDF

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JP7325928B2
JP7325928B2 JP2017512424A JP2017512424A JP7325928B2 JP 7325928 B2 JP7325928 B2 JP 7325928B2 JP 2017512424 A JP2017512424 A JP 2017512424A JP 2017512424 A JP2017512424 A JP 2017512424A JP 7325928 B2 JP7325928 B2 JP 7325928B2
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amino acid
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JP2017518072A (ja
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バイセ,マリー-アンジュ
ブトン,カルロ
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アブリンクス エン.ヴェー.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
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    • C40B40/00Libraries per se, e.g. arrays, mixtures
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07K2317/567Framework region [FR]
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07K2319/00Fusion polypeptide
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    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2017512424A 2014-05-16 2015-05-13 改善された免疫グロブリン可変ドメイン Active JP7325928B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021087053A JP7454525B2 (ja) 2014-05-16 2021-05-24 改善された免疫グロブリン可変ドメイン
JP2024037026A JP2024069377A (ja) 2014-05-16 2024-03-11 改善された免疫グロブリン可変ドメイン

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Application Number Priority Date Filing Date Title
US201461994552P 2014-05-16 2014-05-16
US61/994,552 2014-05-16
US201462014015P 2014-06-18 2014-06-18
US201461014015P 2014-06-18 2014-06-18
US62/014,015 2014-06-18
US201462040167P 2014-08-21 2014-08-21
US62/040,167 2014-08-21
US201462047560P 2014-09-08 2014-09-08
US62/047,560 2014-09-08
US201562133600P 2015-03-16 2015-03-16
US62/133,600 2015-03-16
PCT/EP2015/060643 WO2015173325A2 (en) 2014-05-16 2015-05-13 Improved immunoglobulin variable domains

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JP2018122878A Division JP7098439B2 (ja) 2014-05-16 2018-06-28 改善された免疫グロブリン可変ドメイン
JP2021087053A Division JP7454525B2 (ja) 2014-05-16 2021-05-24 改善された免疫グロブリン可変ドメイン

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JP2017518072A JP2017518072A (ja) 2017-07-06
JP2017518072A5 JP2017518072A5 (enExample) 2018-06-21
JP7325928B2 true JP7325928B2 (ja) 2023-08-15

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JP2017512424A Active JP7325928B2 (ja) 2014-05-16 2015-05-13 改善された免疫グロブリン可変ドメイン
JP2018122878A Active JP7098439B2 (ja) 2014-05-16 2018-06-28 改善された免疫グロブリン可変ドメイン
JP2020167247A Active JP7471987B2 (ja) 2014-05-16 2020-10-01 改善された免疫グロブリン可変ドメイン
JP2021087053A Active JP7454525B2 (ja) 2014-05-16 2021-05-24 改善された免疫グロブリン可変ドメイン
JP2024004779A Pending JP2024041939A (ja) 2014-05-16 2024-01-16 改善された免疫グロブリン可変ドメイン
JP2024037026A Pending JP2024069377A (ja) 2014-05-16 2024-03-11 改善された免疫グロブリン可変ドメイン

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JP2018122878A Active JP7098439B2 (ja) 2014-05-16 2018-06-28 改善された免疫グロブリン可変ドメイン
JP2020167247A Active JP7471987B2 (ja) 2014-05-16 2020-10-01 改善された免疫グロブリン可変ドメイン
JP2021087053A Active JP7454525B2 (ja) 2014-05-16 2021-05-24 改善された免疫グロブリン可変ドメイン
JP2024004779A Pending JP2024041939A (ja) 2014-05-16 2024-01-16 改善された免疫グロブリン可変ドメイン
JP2024037026A Pending JP2024069377A (ja) 2014-05-16 2024-03-11 改善された免疫グロブリン可変ドメイン

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US (10) US12180268B2 (enExample)
EP (4) EP3248986B1 (enExample)
JP (6) JP7325928B2 (enExample)
KR (5) KR20230145503A (enExample)
CN (3) CN106661100A (enExample)
AU (6) AU2015261536B2 (enExample)
BR (2) BR112016026773A2 (enExample)
CA (2) CA2948076A1 (enExample)
DK (2) DK3248986T3 (enExample)
ES (2) ES2815572T3 (enExample)
HR (2) HRP20220400T1 (enExample)
HU (2) HUE058008T2 (enExample)
IL (6) IL299282B2 (enExample)
LT (2) LT3248986T (enExample)
MX (4) MX383560B (enExample)
PH (1) PH12016502282B1 (enExample)
PL (2) PL3143042T3 (enExample)
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RU (1) RU2746738C2 (enExample)
SG (3) SG10201805288QA (enExample)
SI (2) SI3248986T1 (enExample)
WO (1) WO2015173325A2 (enExample)
ZA (5) ZA201607587B (enExample)

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WO2020221888A1 (en) 2019-04-30 2020-11-05 Vib Vzw Cystic fibrosis transmembrane conductance regulator stabilizing agents
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CN114981300B (zh) 2019-12-06 2025-10-31 艾伯霖克斯公司 包含靶向TNFα和IL-23的免疫球蛋白单个可变结构域的多肽
JP7641968B2 (ja) 2019-12-09 2025-03-07 アブリンクス エン.ヴェー. Il-13およびtslpを標的化する免疫グロブリン単一可変ドメインを含むポリペプチド
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US20220119512A1 (en) 2022-04-21
KR20230054503A (ko) 2023-04-24
IL248636A0 (en) 2017-01-31
US20220332806A1 (en) 2022-10-20
WO2015173325A3 (en) 2016-02-18
IL259972B (en) 2021-04-29
IL295534B1 (en) 2024-11-01
EP3248986A3 (en) 2017-12-20
US11485778B2 (en) 2022-11-01
US11708404B2 (en) 2023-07-25
EP3693386A1 (en) 2020-08-12
JP2024041939A (ja) 2024-03-27
US11312764B2 (en) 2022-04-26
PH12016502282B1 (en) 2024-05-22
PH12016502282A1 (en) 2017-02-13
MX2021007020A (es) 2021-08-05
LT3248986T (lt) 2022-03-25
IL281755A (en) 2021-05-31
NZ726448A (en) 2023-02-24
IL295534B2 (en) 2025-03-01
LT3143042T (lt) 2020-07-27
JP2018162297A (ja) 2018-10-18
DK3143042T3 (da) 2020-08-31
AU2022279374B2 (en) 2026-01-15
EP3143042A2 (en) 2017-03-22
IL299282B1 (en) 2024-05-01
IL299282A (en) 2023-02-01
US12180268B2 (en) 2024-12-31
RU2016149463A (ru) 2018-06-19
SG10201805288QA (en) 2018-07-30
KR20170002645A (ko) 2017-01-06
WO2015173325A8 (en) 2016-12-29
IL248636B2 (en) 2023-04-01
ZA202100742B (en) 2022-09-28
IL295534A (en) 2022-10-01
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IL311293B2 (en) 2025-07-01
IL311293B1 (en) 2025-03-01
HRP20200966T1 (hr) 2020-10-16
US11485777B2 (en) 2022-11-01
KR20230053002A (ko) 2023-04-20
CN106661100A (zh) 2017-05-10
MX2023010731A (es) 2023-09-20
MX2018007581A (es) 2020-11-12
EP3143042B1 (en) 2020-06-10
US20210269514A1 (en) 2021-09-02
KR20230145503A (ko) 2023-10-17
ZA202004759B (en) 2022-08-31
RU2016149463A3 (enExample) 2018-07-04
AU2015261536B2 (en) 2020-05-07
AU2022279373A1 (en) 2023-01-19
US20220332807A1 (en) 2022-10-20
WO2015173325A2 (en) 2015-11-19
PT3248986T (pt) 2022-04-05
IL299282B2 (en) 2024-09-01
RU2018120744A3 (enExample) 2022-01-28
KR20180091115A (ko) 2018-08-14
DK3248986T3 (da) 2022-04-04
ZA202004757B (en) 2022-08-31
AU2015261536A1 (en) 2016-11-17

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