JP7312929B2 - 超明色二量体またはポリマー色素およびその調製のための方法 - Google Patents
超明色二量体またはポリマー色素およびその調製のための方法 Download PDFInfo
- Publication number
- JP7312929B2 JP7312929B2 JP2019526198A JP2019526198A JP7312929B2 JP 7312929 B2 JP7312929 B2 JP 7312929B2 JP 2019526198 A JP2019526198 A JP 2019526198A JP 2019526198 A JP2019526198 A JP 2019526198A JP 7312929 B2 JP7312929 B2 JP 7312929B2
- Authority
- JP
- Japan
- Prior art keywords
- independently
- occurrence
- linker
- moiety
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/109—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing other specific dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/106—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an azo dye
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N2001/302—Stain compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023024246A JP2023101477A (ja) | 2016-07-29 | 2023-02-20 | 超明色二量体またはポリマー色素およびその調製のための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662368819P | 2016-07-29 | 2016-07-29 | |
| US62/368,819 | 2016-07-29 | ||
| PCT/US2017/044233 WO2018022925A1 (en) | 2016-07-29 | 2017-07-27 | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023024246A Division JP2023101477A (ja) | 2016-07-29 | 2023-02-20 | 超明色二量体またはポリマー色素およびその調製のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527289A JP2019527289A (ja) | 2019-09-26 |
| JP2019527289A5 JP2019527289A5 (enExample) | 2020-12-24 |
| JP7312929B2 true JP7312929B2 (ja) | 2023-07-24 |
Family
ID=59702800
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019526198A Active JP7312929B2 (ja) | 2016-07-29 | 2017-07-27 | 超明色二量体またはポリマー色素およびその調製のための方法 |
| JP2023024246A Pending JP2023101477A (ja) | 2016-07-29 | 2023-02-20 | 超明色二量体またはポリマー色素およびその調製のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023024246A Pending JP2023101477A (ja) | 2016-07-29 | 2023-02-20 | 超明色二量体またはポリマー色素およびその調製のための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US12018159B2 (enExample) |
| EP (1) | EP3491071A1 (enExample) |
| JP (2) | JP7312929B2 (enExample) |
| WO (1) | WO2018022925A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3019559A4 (en) | 2013-08-22 | 2017-04-05 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| KR102676814B1 (ko) | 2015-02-26 | 2024-06-21 | 소니그룹주식회사 | 접합 그룹을 포함하는 수용성 형광 또는 착색 염료 |
| WO2016138457A1 (en) | 2015-02-26 | 2016-09-01 | Sony Corporation | Phenylethynylnaphthalene dyes and methods for their use |
| JP6849599B2 (ja) | 2015-05-11 | 2021-03-24 | ソニー株式会社 | 超明色ダイマーまたはポリマー染料 |
| KR102530707B1 (ko) | 2016-04-01 | 2023-05-11 | 소니그룹주식회사 | 초휘도 이량체성 또는 중합체성 염료 |
| US11434377B2 (en) | 2016-04-01 | 2022-09-06 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| KR20180133890A (ko) | 2016-04-06 | 2018-12-17 | 소니 주식회사 | 스페이싱 링커 그룹을 포함하는 초고명도 이량체성 또는 중합체성 염료 |
| WO2017197014A2 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| WO2017196954A1 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| EP3455300A1 (en) | 2016-05-11 | 2019-03-20 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
| JP7068191B2 (ja) | 2016-06-06 | 2022-05-16 | ソニーグループ株式会社 | 蛍光または有色レポーター基を含むイオン性ポリマー |
| US12018159B2 (en) | 2016-07-29 | 2024-06-25 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| AU2018282868B2 (en) | 2017-06-16 | 2023-10-19 | Duke University | Resonator networks for improved label detection, computation, analyte sensing, and tunable random number generation |
| EP3691689A1 (en) | 2017-10-05 | 2020-08-12 | Sony Corporation | Programmable dendritic drugs |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| WO2019140301A1 (en) | 2018-01-12 | 2019-07-18 | Sony Corporation | Polymers with rigid spacing groups comprising biologically active compounds |
| EP4616912A3 (en) | 2018-01-12 | 2025-11-19 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| KR102742386B1 (ko) | 2018-03-19 | 2024-12-16 | 소니그룹주식회사 | 형광 신호 향상을 위한 2가 금속의 사용 |
| WO2019182766A1 (en) | 2018-03-21 | 2019-09-26 | Sony Corporation | Polymeric tandem dyes with linker groups |
| WO2019191482A1 (en) | 2018-03-30 | 2019-10-03 | Becton, Dickinson And Company | Water-soluble polymeric dyes having pendant chromophores |
| KR102854332B1 (ko) | 2018-06-27 | 2025-09-03 | 소니그룹주식회사 | 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료 |
| EP3952916A1 (en) * | 2019-04-11 | 2022-02-16 | Sony Group Corporation | Programmable polymeric drugs |
| KR102486779B1 (ko) | 2019-09-26 | 2023-01-12 | 소니그룹주식회사 | 링커 그룹을 갖는 중합체성 탠덤 염료 |
| EP4256078A1 (en) | 2020-12-07 | 2023-10-11 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| US12180401B2 (en) | 2021-04-07 | 2024-12-31 | Becton, Dickinson And Company | Water-soluble fluorescent polymeric dyes |
| WO2025199201A1 (en) * | 2024-03-19 | 2025-09-25 | Board Of Regents, The University Of Texas System | Ionic polymers for solute capture and methods of making and use thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060063186A1 (en) | 2004-09-14 | 2006-03-23 | Applera Corporation | Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes |
| WO2015027176A1 (en) | 2013-08-22 | 2015-02-26 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
Family Cites Families (170)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450305A (en) | 1982-10-25 | 1984-05-22 | American Cyanamid Company | Poly(ethyleneoxy)-substituted-9,10-bis(phenylethynyl)anthracenes |
| US4476229A (en) | 1982-11-08 | 1984-10-09 | Abbott Laboratories | Substituted carboxyfluoresceins |
| SU1121931A1 (ru) | 1983-01-10 | 1988-04-15 | Институт Биологической Химии Ан Бсср | Конъюгаты тиреоидных гормонов с альбумином дл выработки антител к тиреоидным гормонам у животных |
| EP0355864A3 (en) | 1984-03-15 | 1991-09-18 | Wako Pure Chemical Industries, Ltd. | Method of quantitatively measuring an oxidative substance by using triphenyl methane type leuco compounds as coloring matter |
| JPH0665677B2 (ja) | 1985-03-09 | 1994-08-24 | 三菱化成株式会社 | リン脂質類似構造を有するジオ−ルおよびその製造方法 |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5053054A (en) | 1988-09-12 | 1991-10-01 | Ortho Pharmaceutical Corporation | Methods and reagents for staining intracellular components |
| US5318894A (en) | 1990-01-30 | 1994-06-07 | Miles Inc. | Composition, device and method of assaying for peroxidatively active substances |
| US6365730B1 (en) | 1990-06-19 | 2002-04-02 | Gene Shears Pty. Limited | DNA-Armed ribozymes and minizymes |
| JPH04282391A (ja) | 1991-03-08 | 1992-10-07 | Fujisawa Pharmaceut Co Ltd | エタノールアミン誘導体およびその製造法 |
| US5698391A (en) | 1991-08-23 | 1997-12-16 | Isis Pharmaceuticals, Inc. | Methods for synthetic unrandomization of oligomer fragments |
| ATE152831T1 (de) * | 1991-09-16 | 1997-05-15 | Molecular Probes Inc | Dimere unsymmetrische cyaninfarbstoffe |
| US5565322A (en) | 1991-11-07 | 1996-10-15 | Nanogen, Inc. | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfer system |
| DK0693065T3 (da) | 1993-04-13 | 2002-03-04 | Naxcor | Ikke-nucleosidiske cumarinderivater som reagenser til tværbinding af polynucleotider |
| EP0708837B1 (en) | 1993-07-13 | 2006-03-08 | Abbott Laboratories | Fluorescent polymer labeled conjugates and intermediates |
| WO1995006731A2 (en) | 1993-09-02 | 1995-03-09 | Ribozyme Pharmaceuticals, Inc. | Non-nucleotide containing enzymatic nucleic acid |
| US5886177A (en) | 1994-01-11 | 1999-03-23 | Isis Pharmaceuticals, Inc. | Phosphate linked oligomers |
| US6171859B1 (en) | 1994-03-30 | 2001-01-09 | Mitokor | Method of targeting conjugate molecules to mitochondria |
| US5994143A (en) | 1996-02-01 | 1999-11-30 | Abbott Laboratories | Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment |
| US6218108B1 (en) | 1997-05-16 | 2001-04-17 | Research Corporation Technologies, Inc. | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor |
| DE19633268A1 (de) | 1996-08-19 | 1998-02-26 | Hoechst Ag | Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung |
| JP2001511128A (ja) | 1997-01-28 | 2001-08-07 | ファルマシア・アンド・アップジョン・カンパニー | 水不溶性ポルフィリンの脂質錯体の凍結乾燥物 |
| US6893868B2 (en) | 1997-02-20 | 2005-05-17 | Onco Immunin, Inc. | Homo-doubly labeled compositions for the detection of enzyme activity in biological samples |
| US5986030A (en) | 1997-04-15 | 1999-11-16 | Nalco Chemical Company | Fluorescent water soluble polymers |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| JP3078793B2 (ja) | 1998-04-30 | 2000-08-21 | 株式会社分子バイオホトニクス研究所 | ロタキサン構造を有する色素、ラベル化剤、およびラベル化方法 |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6627400B1 (en) | 1999-04-30 | 2003-09-30 | Aclara Biosciences, Inc. | Multiplexed measurement of membrane protein populations |
| US6514700B1 (en) | 1999-04-30 | 2003-02-04 | Aclara Biosciences, Inc. | Nucleic acid detection using degradation of a tagged sequence |
| US7037654B2 (en) | 1999-04-30 | 2006-05-02 | Aclara Biosciences, Inc. | Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents |
| US20020142329A1 (en) | 1999-04-30 | 2002-10-03 | Aclara Biosciences, Inc. | Compositions and methods employing cleavable electrophoretic tag reagents |
| WO2001007430A1 (en) | 1999-07-22 | 2001-02-01 | Nalco Chemical Compant | Fluorescent water-soluble polymers |
| US6479650B1 (en) | 1999-12-14 | 2002-11-12 | Research Corporation Technologies, Inc. | Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same |
| AU2001245643A1 (en) | 2000-03-14 | 2001-09-24 | Genigma Corporation | Biomarkers for the labeling, visual detection and quantification of biomolecules |
| CA2402955C (en) | 2000-03-28 | 2010-03-09 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US20040067498A1 (en) | 2000-04-28 | 2004-04-08 | Ahmed Chenna | Detection of nucleic acid sequences by cleavage and separation of tag-containing structures |
| KR20030040208A (ko) | 2000-05-08 | 2003-05-22 | 큐티엘 바이오시스템즈 엘엘씨 | 개선된 형광 폴리머-qtl 바이오센싱 방법 |
| AU2001265252A1 (en) | 2000-05-31 | 2001-12-11 | The Johns-Hopkins University | Biologically useful polyphosphates |
| US20020099013A1 (en) | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
| AU8911101A (en) | 2000-09-11 | 2002-03-26 | Univ Columbia | Combinatorial fluorescence energy transfer tags and uses thereof |
| WO2002024815A1 (en) | 2000-09-19 | 2002-03-28 | Li-Cor, Inc. | Cyanine dyes |
| US6448407B1 (en) | 2000-11-01 | 2002-09-10 | Pe Corporation (Ny) | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| GB2372256A (en) | 2001-02-14 | 2002-08-21 | Kalibrant Ltd | Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection |
| US6743905B2 (en) | 2001-04-16 | 2004-06-01 | Applera Corporation | Mobility-modified nucleobase polymers and methods of using same |
| US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| JP3813890B2 (ja) | 2002-03-22 | 2006-08-23 | 富士写真フイルム株式会社 | 3層レジストプロセス用中間層材料組成物及びそれを用いたパターン形成方法 |
| US20040086914A1 (en) | 2002-07-12 | 2004-05-06 | Affymetrix, Inc. | Nucleic acid labeling methods |
| AU2003262833A1 (en) | 2002-08-23 | 2004-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent glycosides and methods for their use |
| WO2004092324A2 (en) | 2002-08-26 | 2004-10-28 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| US20040138467A1 (en) | 2002-11-26 | 2004-07-15 | French Roger Harquail | Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties |
| US7759459B2 (en) | 2003-01-10 | 2010-07-20 | Albert Einstein College Of Medicine Of Yeshiva University | Fluorescent assays for protein kinases |
| US7238792B2 (en) | 2003-03-18 | 2007-07-03 | Washington State University Research Foundation | Foldable polymers as probes |
| US7172907B2 (en) | 2003-03-21 | 2007-02-06 | Ge Healthcare Bio-Sciences Corp. | Cyanine dye labelling reagents with meso-substitution |
| EP1653989B1 (fr) | 2003-08-14 | 2009-07-15 | Diatos | Composition anti-bacterienne plus particulierement contre les bacteries gram negatif comprenent un peptide et un agent anti-bacterien avantageusement hydrophobe |
| US7667024B2 (en) | 2003-11-19 | 2010-02-23 | Allelogic Biosciences Corp. | Oligonucleotides labeled with a plurality of fluorophores |
| AU2003296419A1 (en) | 2003-12-09 | 2005-07-21 | Molecular Probes, Inc. | Pyrenyloxysulfonic acid fluorescent agents |
| WO2006078278A2 (en) | 2004-04-27 | 2006-07-27 | Alnylam Pharmaceuticals, Inc. | Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety |
| US20060035302A1 (en) | 2004-06-21 | 2006-02-16 | Applera Corporation | Kinase substrates with multiple phosphorylation sites |
| ES2461858T3 (es) | 2004-08-13 | 2014-05-21 | Epoch Biosciences, Inc. | Colorantes fluorescentes de fosfonato y conjugados |
| US8153706B2 (en) | 2004-10-25 | 2012-04-10 | Hewlett-Packard Development Company, L.P. | Polymeric colorants having pigment and dye components and corresponding ink compositions |
| EP1655317B1 (en) | 2004-11-09 | 2007-06-13 | Ipagsa Industrial, SL. | Thermally reactive infrared absorption polymers and their use in a heat sensitive lithographic printing plate |
| EP2502946B1 (en) | 2005-01-10 | 2017-10-04 | The Regents of The University of California | Cationic conjugated polymers suitable for strand-specific polynucleiotide detection in homogeneous and solid state assays |
| AU2006223384B2 (en) | 2005-03-09 | 2012-08-02 | Cepheid | Polar dyes |
| US8227621B2 (en) | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
| WO2007038659A1 (en) | 2005-09-26 | 2007-04-05 | Invitrogen Corporation | Violet laser excitable dyes and their method of use |
| WO2007061793A2 (en) | 2005-11-18 | 2007-05-31 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SCIENCES, CENTERS FOR DISEASE CONTROL AND PREVENTION | Modified cardiolipin and uses therefor |
| EP2573833B1 (en) | 2005-12-12 | 2014-04-02 | Basf Se | Organic semiconductors, their manufacture and semiconductor devices comprising them |
| US20070148094A1 (en) | 2005-12-22 | 2007-06-28 | Uzgiris Egidijus E | Polymeric imaging agents and medical imaging methods |
| JP5493117B2 (ja) | 2006-02-15 | 2014-05-14 | 国立大学法人岐阜大学 | オリゴヌクレオチド誘導体及びその利用 |
| WO2007122388A2 (en) | 2006-04-13 | 2007-11-01 | Midatech Limited | Nanoparticles containing three various ligands for providing immune responses against infectious agents |
| WO2008021208A2 (en) | 2006-08-12 | 2008-02-21 | Stx Aprilis, Inc. | Sensitizer dyes for photoacid generating systems using short visible wavelengths |
| US8217389B2 (en) | 2006-10-12 | 2012-07-10 | Idemitsu Kosan, Co., Ltd. | Organic thin film transistor device and organic thin film light-emitting transistor |
| EP2064290B1 (en) | 2006-10-27 | 2013-10-09 | Life Technologies Corporation | Fluorogenic ph sensitive dyes and their method of use |
| US8053588B2 (en) | 2007-03-07 | 2011-11-08 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Organosilane compound and organosilica obtained therefrom |
| ES2516827T3 (es) | 2007-04-23 | 2014-10-31 | Deliversir Ltd | Un sistema para entregar agentes terapéuticos a células vivas y núcleos de células |
| US9556210B2 (en) | 2007-04-23 | 2017-01-31 | Sabag-Rfa Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
| US9156865B2 (en) | 2007-04-23 | 2015-10-13 | Deliversir Ltd | System for delivering therapeutic agents into living cells and cells nuclei |
| WO2008138726A2 (en) | 2007-05-11 | 2008-11-20 | Basf Se | Polymeric dyes |
| EP2014698A1 (en) | 2007-07-12 | 2009-01-14 | Crystax Pharmaceuticals S.L. | Polymers and their use as fluorescent labels |
| TWI409280B (zh) | 2007-07-31 | 2013-09-21 | American Dye Source Inc | 聚合物染料、塗覆層組合物及熱微影印刷板 |
| GB2456298A (en) | 2008-01-07 | 2009-07-15 | Anthony Ian Newman | Electroluminescent materials comprising oxidation resistant fluorenes |
| EP2272897B1 (en) | 2008-03-10 | 2016-12-28 | The University of Tokyo | Copolymer including uncharged hydrophilic block and cationic polyamino acid block having lateral chain to which hydrophobic radical is partially introduced, and use of copolymer |
| ES2613844T3 (es) | 2008-04-21 | 2017-05-26 | Lawrence Livermore National Security, Llc | Ligandos polidentados de alta afinidad selectivos y métodos para producirlos |
| KR101041446B1 (ko) | 2008-07-21 | 2011-06-14 | 부산대학교 산학협력단 | 공액고분자 2단계 fret 시스템 및 바이오센서 |
| JPWO2010026957A1 (ja) | 2008-09-03 | 2012-02-02 | 国立大学法人富山大学 | 水溶性ロタキサン型蛍光色素および蛍光性有機分子 |
| WO2010055789A1 (ja) | 2008-11-14 | 2010-05-20 | 独立行政法人科学技術振興機構 | オリゴヌクレオチド誘導体、ラベル化剤及びその利用 |
| JP5798487B2 (ja) | 2008-11-20 | 2015-10-21 | ネーデルランドセ・オルガニサティ・フォール・トゥーヘパスト−ナトゥールウェテンスハッペライク・オンデルズーク・テーエヌオー | Fretに基づく病原体の迅速診断 |
| CA2745307A1 (en) | 2008-12-12 | 2010-06-17 | University Of Massachusetts | Polyesters with grafted zwitterions |
| US10191060B2 (en) | 2009-11-09 | 2019-01-29 | University Of Washington | Functionalized chromophoric polymer dots and bioconjugates thereof |
| US9400273B1 (en) | 2009-12-09 | 2016-07-26 | Life Technologies Corporation | 7-hydroxycoumarin-based cell-tracking reagents |
| WO2011088193A2 (en) | 2010-01-13 | 2011-07-21 | University Of Medicine And Dentistry Of New Jersey | Fluorophore chelated lanthanide luminiscent probes with improved quantum efficiency |
| EP2545373B1 (en) | 2010-03-11 | 2022-08-24 | Medtronic Minimed, Inc. | Measuring analyte concentration incorporating temperature and ph correction |
| WO2011120053A1 (en) | 2010-03-26 | 2011-09-29 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| US9995679B2 (en) | 2010-05-25 | 2018-06-12 | Carnegie Mellon University | Targeted probes of cellular physiology |
| CN102971283A (zh) | 2010-07-08 | 2013-03-13 | 旭硝子株式会社 | 含氟芳香族化合物、有机半导体材料和有机薄膜器件 |
| WO2012039855A1 (en) | 2010-09-22 | 2012-03-29 | The Board Of Regents Of The University Of Texas System | Ph-sensitive compositions for delivery of beta lapachone and methods of use |
| WO2012080836A2 (en) | 2010-12-13 | 2012-06-21 | Marek Kwiatkowski | Functionalized polymers |
| WO2012086857A1 (ko) | 2010-12-21 | 2012-06-28 | (주)파낙스이엠 | 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 |
| CN102174078A (zh) | 2011-01-10 | 2011-09-07 | 中国药科大学 | 肿瘤细胞选择性穿膜肽的应用 |
| WO2013012687A2 (en) | 2011-07-15 | 2013-01-24 | Glumetrics, Inc. | Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors |
| BR112014004544A2 (pt) | 2011-08-31 | 2017-04-04 | Mallinckrodt Llc | modificação com peg de nanopartículas com h-fosfonatos |
| US20130059343A1 (en) | 2011-09-06 | 2013-03-07 | Li-Cor, Inc. | Nucleotide derivatives |
| US9085761B1 (en) | 2012-06-14 | 2015-07-21 | Affymetrix, Inc. | Methods and compositions for amplification of nucleic acids |
| CA2880290C (en) | 2012-09-12 | 2020-10-27 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules targeting p53 and methods of use thereof |
| US20150258217A1 (en) | 2012-10-04 | 2015-09-17 | The General Hospital Corporation | Methods of Synthesizing and Using Peg-Like Fluorochromes |
| EP2908864B1 (en) | 2012-10-22 | 2019-12-11 | Sabag-Rfa Ltd. | Phosphate compounds for delivering therapeutic agents into living cells and cells nuclei |
| WO2014102803A1 (en) | 2012-12-31 | 2014-07-03 | Yeda Research And Development Co. Ltd. | Molecular sensor and methods of use thereof |
| US9545447B2 (en) | 2013-01-04 | 2017-01-17 | The Texas A&M University System | Polymer-drug systems |
| WO2014175974A2 (en) | 2013-03-13 | 2014-10-30 | Elitech Holding B.V. | Artificial nucleic acids |
| WO2014159392A1 (en) | 2013-03-14 | 2014-10-02 | Dana-Farber Cancer Institute, Inc. | Bromodomain binding reagents and uses thereof |
| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| WO2014147642A1 (en) | 2013-03-19 | 2014-09-25 | Council Of Scientific & Industrial Research | Substituted fluoranthene-7-carbonitriles as fluorescent dyes for cell imaging applications |
| CN103319378B (zh) | 2013-06-27 | 2015-06-10 | 中国科学院宁波材料技术与工程研究所 | 两性离子有机小分子太阳能电池阴极界面材料及其制法和用途 |
| KR101572901B1 (ko) | 2013-07-12 | 2015-12-15 | 부산대학교 산학협력단 | 2-단계 fret를 이용한 공액고분자 전해질 및 압타머 프로브 기반 표적 물질의 검출 방법 및 형광 센서 |
| US10406246B2 (en) | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| WO2015068697A1 (ja) | 2013-11-11 | 2015-05-14 | オリンパスメディカルシステムズ株式会社 | 処置システム |
| US9150782B2 (en) | 2013-12-06 | 2015-10-06 | Monosol, Llc | Fluorescent tracer for water-soluble films, related methods, and related articles |
| JP6461973B2 (ja) | 2013-12-20 | 2019-01-30 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 2以上の疎水性ドメインおよびpeg部分を含む親水性ドメインを含む化合物の、細胞の安定化のための使用 |
| KR101829159B1 (ko) | 2014-01-16 | 2018-02-13 | 소니 주식회사 | 수용성 형광 또는 유색 염료 |
| JP6374172B2 (ja) | 2014-01-31 | 2018-08-15 | 富士フイルム株式会社 | 着色組成物、およびこれを用いた硬化膜、カラーフィルタ、パターン形成方法、カラーフィルタの製造方法、固体撮像素子、画像表示装置ならびに染料多量体 |
| CN104072727A (zh) | 2014-06-23 | 2014-10-01 | 华南理工大学 | 一种含磷脂酰胆碱基的2,7-芴的共轭聚合物及其制备方法与应用 |
| US10617670B2 (en) | 2014-10-10 | 2020-04-14 | Pfizer Inc. | Synergistic auristatin combinations |
| US10709791B2 (en) | 2014-11-12 | 2020-07-14 | University Of Washington | Stabilized polymeric carriers for therapeutic agent delivery |
| US20170326233A1 (en) | 2014-11-14 | 2017-11-16 | Angiochem Inc. | Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin |
| KR102676814B1 (ko) | 2015-02-26 | 2024-06-21 | 소니그룹주식회사 | 접합 그룹을 포함하는 수용성 형광 또는 착색 염료 |
| WO2016138457A1 (en) | 2015-02-26 | 2016-09-01 | Sony Corporation | Phenylethynylnaphthalene dyes and methods for their use |
| ES2925694T3 (es) | 2015-03-12 | 2022-10-19 | Becton Dickinson Co | Colorantes poliméricos de BODIPY y métodos de uso de los mismos |
| JP6849599B2 (ja) | 2015-05-11 | 2021-03-24 | ソニー株式会社 | 超明色ダイマーまたはポリマー染料 |
| US9670318B2 (en) | 2015-05-28 | 2017-06-06 | Miltenyi Biotec Gmbh | Bright fluorochromes based on multimerization of fluorescent dyes |
| US11512160B2 (en) | 2015-06-02 | 2022-11-29 | University Of Washington | Free-standing non-fouling polymers, their compositions, and related monomers |
| JP6817288B2 (ja) | 2015-08-10 | 2021-01-20 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 新規な連結体及び生体分子と薬物との特異的共役におけるその使用 |
| EP3359194A4 (en) | 2015-10-06 | 2019-04-24 | Merck Sharp & Dohme Corp. | ANTIBODY-ACTIVE CONJUGATE FOR ANTI-INFLAMMATORY APPLICATIONS |
| RS65660B1 (sr) | 2015-11-25 | 2024-07-31 | Ligachem Biosciences Inc | Konјugati koji sadrže samozapaljive grupe i postupci povezani sa njima |
| AU2016364431B2 (en) | 2015-12-04 | 2020-08-27 | Zenyaku Kogyo Co., Ltd. | Anti-IL-17 aptamer having improved retention in blood |
| US9913992B2 (en) | 2015-12-22 | 2018-03-13 | Colgate-Palmolive Company | Oral treatment device |
| JP2017124994A (ja) | 2016-01-15 | 2017-07-20 | 靖彦 中村 | 癌治療及び癌再発防止のための装置並びにポルフィリン類含有製剤 |
| KR102530707B1 (ko) | 2016-04-01 | 2023-05-11 | 소니그룹주식회사 | 초휘도 이량체성 또는 중합체성 염료 |
| US11434377B2 (en) | 2016-04-01 | 2022-09-06 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| KR20180133890A (ko) | 2016-04-06 | 2018-12-17 | 소니 주식회사 | 스페이싱 링커 그룹을 포함하는 초고명도 이량체성 또는 중합체성 염료 |
| WO2017197014A2 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| WO2017196954A1 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| EP3455300A1 (en) | 2016-05-11 | 2019-03-20 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
| JP7068191B2 (ja) | 2016-06-06 | 2022-05-16 | ソニーグループ株式会社 | 蛍光または有色レポーター基を含むイオン性ポリマー |
| US12018159B2 (en) | 2016-07-29 | 2024-06-25 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| US20180092993A1 (en) | 2016-09-01 | 2018-04-05 | Life Technologies Corporation | Compositions and methods for enhanced fluorescence |
| GB2554666B (en) | 2016-09-30 | 2019-12-18 | Sumitomo Chemical Co | Composite Particle |
| CN106589005B (zh) | 2016-11-01 | 2019-08-06 | 北京擎科生物科技有限公司 | 一种荧光信号放大探针中间体、荧光探针及其制备方法 |
| AU2018223809B2 (en) | 2017-02-27 | 2022-12-15 | Ivanti, Inc. | Systems and methods for role-based computer security configurations |
| US12398104B2 (en) | 2017-04-27 | 2025-08-26 | The Procter & Gamble Company | Odorless thiols for permanent waving, straightening and depilatory applications |
| JP7234151B2 (ja) | 2017-07-07 | 2023-03-07 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 脂肪酸誘導体およびこれらの使用 |
| EP3691689A1 (en) | 2017-10-05 | 2020-08-12 | Sony Corporation | Programmable dendritic drugs |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| WO2019118714A1 (en) | 2017-12-13 | 2019-06-20 | Sony Corporation | Ionic polymers comprising biologically active compounds |
| EP3727463A1 (en) | 2017-12-21 | 2020-10-28 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| EP4616912A3 (en) | 2018-01-12 | 2025-11-19 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| US20200360526A1 (en) | 2018-01-12 | 2020-11-19 | Sony Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| WO2019140301A1 (en) | 2018-01-12 | 2019-07-18 | Sony Corporation | Polymers with rigid spacing groups comprising biologically active compounds |
| KR102742386B1 (ko) | 2018-03-19 | 2024-12-16 | 소니그룹주식회사 | 형광 신호 향상을 위한 2가 금속의 사용 |
| WO2019182766A1 (en) | 2018-03-21 | 2019-09-26 | Sony Corporation | Polymeric tandem dyes with linker groups |
| KR102854332B1 (ko) | 2018-06-27 | 2025-09-03 | 소니그룹주식회사 | 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료 |
| WO2020014634A1 (en) | 2018-07-13 | 2020-01-16 | Sony Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| EP3952916A1 (en) | 2019-04-11 | 2022-02-16 | Sony Group Corporation | Programmable polymeric drugs |
| EP3952917A1 (en) | 2019-04-11 | 2022-02-16 | Sony Group Corporation | Programmable polymeric drugs |
| KR20210152522A (ko) | 2019-04-11 | 2021-12-15 | 소니그룹주식회사 | 프로그램 가능한 중합체성 약물 |
| JP7650819B2 (ja) | 2019-04-24 | 2025-03-25 | ブイオーアール バイオファーマ インコーポレーテッド | 抗-cd45抗体薬物コンジュゲート及びその使用 |
| KR102486779B1 (ko) | 2019-09-26 | 2023-01-12 | 소니그룹주식회사 | 링커 그룹을 갖는 중합체성 탠덤 염료 |
| WO2021067483A1 (en) | 2019-09-30 | 2021-04-08 | Sony Corporation | Nucleotide probes |
-
2017
- 2017-07-27 US US16/321,764 patent/US12018159B2/en active Active
- 2017-07-27 JP JP2019526198A patent/JP7312929B2/ja active Active
- 2017-07-27 EP EP17757922.4A patent/EP3491071A1/en active Pending
- 2017-07-27 WO PCT/US2017/044233 patent/WO2018022925A1/en not_active Ceased
-
2020
- 2020-07-21 US US16/934,912 patent/US20210095130A1/en not_active Abandoned
-
2023
- 2023-02-20 JP JP2023024246A patent/JP2023101477A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060063186A1 (en) | 2004-09-14 | 2006-03-23 | Applera Corporation | Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes |
| WO2015027176A1 (en) | 2013-08-22 | 2015-02-26 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
Also Published As
| Publication number | Publication date |
|---|---|
| US20210095130A1 (en) | 2021-04-01 |
| JP2019527289A (ja) | 2019-09-26 |
| WO2018022925A1 (en) | 2018-02-01 |
| US12018159B2 (en) | 2024-06-25 |
| EP3491071A1 (en) | 2019-06-05 |
| JP2023101477A (ja) | 2023-07-21 |
| US20190177549A1 (en) | 2019-06-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7312929B2 (ja) | 超明色二量体またはポリマー色素およびその調製のための方法 | |
| US20240287314A1 (en) | Ultra bright dimeric or polymeric dyes | |
| JP7515786B2 (ja) | リンカー基を有するポリマータンデム色素 | |
| JP7239904B2 (ja) | リンカー基を有するポリマータンデム色素 | |
| JP7145079B2 (ja) | 剛性のスペーシング基を有する超明色ダイマーまたはポリマー染料 | |
| JP7580689B2 (ja) | デオキシリボースを含むリンカー基を有するポリマー色素 | |
| US11685835B2 (en) | Ultra bright dimeric or polymeric dyes | |
| JP6190534B2 (ja) | 水溶性蛍光染料又は有色染料及びその使用方法 | |
| JP2019523787A (ja) | 蛍光または有色レポーター基を含むイオン性ポリマー |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200727 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200727 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210908 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211206 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220427 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220726 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220829 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20221221 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20230120 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20230220 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230220 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7312929 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |