JP7311966B2 - 細菌細胞培養物中で多糖を生成するための培地および発酵方法 - Google Patents

細菌細胞培養物中で多糖を生成するための培地および発酵方法 Download PDF

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JP7311966B2
JP7311966B2 JP2018525463A JP2018525463A JP7311966B2 JP 7311966 B2 JP7311966 B2 JP 7311966B2 JP 2018525463 A JP2018525463 A JP 2018525463A JP 2018525463 A JP2018525463 A JP 2018525463A JP 7311966 B2 JP7311966 B2 JP 7311966B2
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polysaccharide
vvh
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グルラオ デザイ スニル
アレン ハンソン マイケル
パトリック キンロス ジョナサン
アール．ラスコー ダニエル
エリス ロンバーク スコット
アーノルド ロトヴィン ジェイソン
カウシクバーイ ペーテル－ブラウン スジャータ
サン ウェイキャン
アンソニー トマセロ ピーター
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018525463A 2015-11-17 2016-11-10 細菌細胞培養物中で多糖を生成するための培地および発酵方法 Active JP7311966B2 (ja)

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JP2021182236A JP7814142B2 (ja) 2015-11-17 2021-11-09 細菌細胞培養物中で多糖を生成するための培地および発酵方法
JP2023213432A JP2024037949A (ja) 2015-11-17 2023-12-19 細菌細胞培養物中で多糖を生成するための培地および発酵方法

Applications Claiming Priority (5)

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US201562256347P 2015-11-17 2015-11-17
US62/256,347 2015-11-17
US201662413051P 2016-10-26 2016-10-26
US62/413,051 2016-10-26
PCT/IB2016/056780 WO2017085602A1 (en) 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture

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JP2018533366A JP2018533366A (ja) 2018-11-15
JP2018533366A5 JP2018533366A5 (https=) 2019-12-19
JP7311966B2 true JP7311966B2 (ja) 2023-07-20

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JP2018525463A Active JP7311966B2 (ja) 2015-11-17 2016-11-10 細菌細胞培養物中で多糖を生成するための培地および発酵方法
JP2021182236A Active JP7814142B2 (ja) 2015-11-17 2021-11-09 細菌細胞培養物中で多糖を生成するための培地および発酵方法
JP2023213432A Withdrawn JP2024037949A (ja) 2015-11-17 2023-12-19 細菌細胞培養物中で多糖を生成するための培地および発酵方法

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JP2023213432A Withdrawn JP2024037949A (ja) 2015-11-17 2023-12-19 細菌細胞培養物中で多糖を生成するための培地および発酵方法

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US (3) US10947494B2 (https=)
EP (1) EP3377613A1 (https=)
JP (3) JP7311966B2 (https=)
KR (1) KR102069988B1 (https=)
CN (1) CN108473945A (https=)
AU (1) AU2016357567B2 (https=)
BR (1) BR112018008864A8 (https=)
CA (2) CA3005308C (https=)
HK (1) HK1259103A1 (https=)
IL (2) IL319202A (https=)
MX (2) MX385736B (https=)
RU (2) RU2021135165A (https=)
WO (1) WO2017085602A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI815599B (zh) 2011-04-22 2023-09-11 美商惠氏有限責任公司 與難養芽胞梭菌（Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅ）之突變毒素有關之組成物及彼之方法
PT2837680T (pt) * 2011-07-01 2020-04-17 Amgen Inc Cultura celular de mamífero
BR122016023101B1 (pt) * 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
BR112019003992A2 (pt) 2016-09-02 2019-05-28 Sanofi Pasteur Inc vacina contra neisseria meningitidis
EP4656208A3 (en) 2017-01-31 2026-03-04 Merck Sharp & Dohme LLC Methods for making polysaccharide-protein conjugates
JP7680185B2 (ja) 2017-02-24 2025-05-20 メルク・シャープ・アンド・ドーム・エルエルシー 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強
MX394767B (es) 2017-09-07 2025-03-24 Merck Sharp & Dohme Llc Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora.
MX394768B (es) 2017-09-07 2025-03-21 Merck Sharp & Dohme Llc Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina.
ES3058336T3 (es) 2017-12-06 2026-03-10 Merck Sharp & Dohme Llc Composiciones que comprenden conjugados polisacárido-proteína de Streptococcus pneumoniae y métodos de uso de los mismos
EP3787673A4 (en) 2018-04-30 2022-04-27 Merck Sharp & Dohme Corp. Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates
US12144855B2 (en) 2018-04-30 2024-11-19 Merck Sharp & Dohme Llc Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres
EP3788143B1 (en) 2018-04-30 2023-06-28 Merck Sharp & Dohme LLC Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide
CN113423815A (zh) * 2018-12-06 2021-09-21 创赏有限公司 非动物来源培养基上的细菌生长
CA3122085A1 (en) * 2018-12-11 2020-06-18 Erbi Biosystems, Inc. Methods of manufacturing cell based products using small volume perfusion processes
CR20210333A (es) 2018-12-19 2021-08-18 Merck Sharp & Dohme Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso
CN111254103B (zh) * 2019-11-19 2023-06-02 河南省生物工程技术研究中心 一种非洲猪瘟基因工程疫苗高密度发酵补料培养基及发酵工艺
US20230200424A1 (en) * 2020-04-20 2023-06-29 Evonik Operations Gmbh Compositions comprising cys-peptides
WO2021255690A2 (en) 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
CN114015622A (zh) * 2021-12-14 2022-02-08 塔里木大学 无乳链球菌培养基及其制备方法
WO2023131588A1 (en) * 2022-01-05 2023-07-13 Nordmark Pharma Gmbh Culture medium for cultivating hathewaya histolytica (or clostridium histolyticum) and the production of one or more proteases
CN114181872B (zh) * 2022-01-07 2023-11-24 北京大北农科技集团股份有限公司 一种屎肠球菌高密度发酵培养方法
KR102866798B1 (ko) * 2022-12-27 2025-10-01 (주)진성유니텍 살모넬라균 증균을 위한 최소배지 및 이를 이용한 살모넬라균 증균방법
KR102864280B1 (ko) * 2022-12-27 2025-09-26 (주)진성유니텍 포도상구균 증균을 위한 최소배지 및 이를 이용한 포도상구균 증균방법
CN117821342B (zh) * 2024-02-29 2024-06-04 北京民海生物科技有限公司 一种14型肺炎链球菌的发酵方法
KR102894728B1 (ko) 2024-11-27 2025-12-08 한국콜마주식회사 피지 생성 억제 효능, 모공 개선 효능 및 피부 장벽 강화 효능이 우수한 흑효모 발효물 및 이의 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009501387A (ja) 2005-07-12 2009-01-15 ティブコ ソフトウェア インク 推論による状態機械
JP2009513155A (ja) 2005-11-01 2009-04-02 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル 連鎖球菌のための流加培養法
WO2011151841A1 (en) 2010-05-31 2011-12-08 Panacea Biotec Limited Fermentation process for streptococcus pneumoniae

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801054A (en) * 1996-09-19 1998-09-01 The United States Of America As Represented By The Secretary Of The Air Force Cell culture vessel with self-maintained atmosphere
DE69838383T2 (de) 1997-05-28 2008-06-05 Novartis Vaccines And Diagnostics S.R.L. Kulturmedium mit sojabohnenextrakt als aminosäuren-quelle und ohne proteinkomplexe tierischen ursprungs
US7115385B2 (en) * 2001-08-02 2006-10-03 North Carolina State University Media and methods for cultivation of microorganisms
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
US7491517B2 (en) 2006-07-19 2009-02-17 Jeeri R Reddy Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135
SI2078071T1 (sl) * 2006-11-08 2015-05-29 Wyeth Llc Racionalno zasnovana gojišča za celično kulturo
GB0818453D0 (en) * 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
CN103052717B (zh) * 2011-05-17 2015-01-14 中国食品发酵工业研究院 一种工业化生产玉米降压活性肽的方法
CN104080904B (zh) * 2011-12-15 2017-06-30 血清研究所印度私人有限公司 培养细菌以提高荚膜多糖产率的新方法
EP2647715A1 (en) * 2012-04-03 2013-10-09 Nomad Bioscience GmbH Agrobacterium for transient transfection of whole plants
GB201211256D0 (en) 2012-06-25 2012-08-08 Glaxosmithkline Biolog Sa Fermentation process
WO2014080423A2 (en) * 2012-11-21 2014-05-30 Serum Institute Of India Ltd. Production of high yields of bacterial polysaccharides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009501387A (ja) 2005-07-12 2009-01-15 ティブコ ソフトウェア インク 推論による状態機械
JP2009513155A (ja) 2005-11-01 2009-04-02 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル 連鎖球菌のための流加培養法
WO2011151841A1 (en) 2010-05-31 2011-12-08 Panacea Biotec Limited Fermentation process for streptococcus pneumoniae

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
日本食品工業学会誌，１９８１年，Ｖｏｌ．２８，Ｎｏ．１０，ｐ．５３４－５４１
鈴木智雄監修，「微生物工学技術ハンドブック」，株式会社朝倉書店，１９９０年５月２０日，ｐ．９－１７

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Publication number Publication date
JP7814142B2 (ja) 2026-02-16
KR102069988B1 (ko) 2020-01-23
IL259404B1 (en) 2025-04-01
CA3005308C (en) 2022-01-04
IL259404B2 (en) 2025-08-01
MX385736B (es) 2025-03-18
BR112018008864A2 (pt) 2018-11-06
JP2022017529A (ja) 2022-01-25
HK1259103A1 (zh) 2019-11-22
US20190292513A1 (en) 2019-09-26
MX2018006063A (es) 2018-09-17
US10947494B2 (en) 2021-03-16
RU2018118035A3 (https=) 2019-12-18
RU2018118035A (ru) 2019-12-18
CN108473945A (zh) 2018-08-31
AU2016357567A1 (en) 2018-05-17
IL259404A (en) 2018-07-31
JP2018533366A (ja) 2018-11-15
RU2761633C2 (ru) 2021-12-13
JP2024037949A (ja) 2024-03-19
US20210180008A1 (en) 2021-06-17
KR20180073699A (ko) 2018-07-02
RU2021135165A (ru) 2021-12-29
MX2021010518A (es) 2021-10-01
CA3138763A1 (en) 2017-05-26
AU2016357567B2 (en) 2020-05-07
IL319202A (en) 2025-04-01
EP3377613A1 (en) 2018-09-26
WO2017085602A1 (en) 2017-05-26
CA3005308A1 (en) 2017-05-26
BR112018008864A8 (pt) 2019-02-26
US20260008994A1 (en) 2026-01-08

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