CN108473945A - 用于在细菌细胞培养物中生产多糖的培养基和发酵方法 - Google Patents

用于在细菌细胞培养物中生产多糖的培养基和发酵方法 Download PDF

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Publication number
CN108473945A
CN108473945A CN201680077135.5A CN201680077135A CN108473945A CN 108473945 A CN108473945 A CN 108473945A CN 201680077135 A CN201680077135 A CN 201680077135A CN 108473945 A CN108473945 A CN 108473945A
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medium
concentration
yeast extract
total
culture
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Chinese (zh)
Inventor
S.G.德赛
M.A.汉森
J.P.金罗斯
D.R.拉斯科
S.E.隆伯克
J.A.洛特文
S.K.帕特尔-布朗
W.孙
P.A.托马塞罗
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Pfizer Inc
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Pfizer Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680077135.5A 2015-11-17 2016-11-10 用于在细菌细胞培养物中生产多糖的培养基和发酵方法 Pending CN108473945A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562256347P 2015-11-17 2015-11-17
US62/256347 2015-11-17
US201662413051P 2016-10-26 2016-10-26
US62/413051 2016-10-26
PCT/IB2016/056780 WO2017085602A1 (en) 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture

Publications (1)

Publication Number Publication Date
CN108473945A true CN108473945A (zh) 2018-08-31

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CN201680077135.5A Pending CN108473945A (zh) 2015-11-17 2016-11-10 用于在细菌细胞培养物中生产多糖的培养基和发酵方法

Country Status (13)

Country Link
US (3) US10947494B2 (https=)
EP (1) EP3377613A1 (https=)
JP (3) JP7311966B2 (https=)
KR (1) KR102069988B1 (https=)
CN (1) CN108473945A (https=)
AU (1) AU2016357567B2 (https=)
BR (1) BR112018008864A8 (https=)
CA (2) CA3138763A1 (https=)
HK (1) HK1259103A1 (https=)
IL (2) IL319202A (https=)
MX (2) MX385736B (https=)
RU (2) RU2761633C2 (https=)
WO (1) WO2017085602A1 (https=)

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CN111254103A (zh) * 2019-11-19 2020-06-09 河南省生物工程技术研究中心 一种非洲猪瘟基因工程疫苗高密度发酵补料培养基及发酵工艺
CN113423815A (zh) * 2018-12-06 2021-09-21 创赏有限公司 非动物来源培养基上的细菌生长
CN114015622A (zh) * 2021-12-14 2022-02-08 塔里木大学 无乳链球菌培养基及其制备方法
CN117821342A (zh) * 2024-02-29 2024-04-05 北京民海生物科技有限公司 一种14型肺炎链球菌的发酵方法

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BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
KR102906912B1 (ko) 2016-09-02 2026-01-05 사노피 파스퇴르 인크 네이세리아 메닌기티디스 백신
CN110225764A (zh) 2017-01-31 2019-09-10 默沙东公司 制备多糖-蛋白缀合物的方法
CA3050120A1 (en) 2017-02-24 2018-08-30 Merck Sharp & Dohme Corp. Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates
CN111065387B (zh) 2017-09-07 2023-08-25 默沙东有限责任公司 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途
WO2019050813A1 (en) 2017-09-07 2019-03-14 Merck Sharp & Dohme Corp. ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER
TWI725359B (zh) 2017-12-06 2021-04-21 美商默沙東藥廠 包含肺炎鏈球菌多醣-蛋白結合物之組合物及其使用方法
EP3787673A4 (en) 2018-04-30 2022-04-27 Merck Sharp & Dohme Corp. Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates
JP7397000B2 (ja) 2018-04-30 2023-12-12 メルク・シャープ・アンド・ドーム・エルエルシー 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法
US12144855B2 (en) 2018-04-30 2024-11-19 Merck Sharp & Dohme Llc Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres
WO2020123524A1 (en) * 2018-12-11 2020-06-18 Erbi Biosystems, Inc. Methods of manufacturing cell based products using small volume perfusion processes
GEAP202415690A (en) 2018-12-19 2024-01-10 Merck Sharp & Dohme Llc Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
AU2021259110B2 (en) * 2020-04-20 2026-04-02 Evonik Operations Gmbh Compositions comprising Cys-peptides
EP4168032A2 (en) 2020-06-19 2023-04-26 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
WO2023131588A1 (en) * 2022-01-05 2023-07-13 Nordmark Pharma Gmbh Culture medium for cultivating hathewaya histolytica (or clostridium histolyticum) and the production of one or more proteases
CN114181872B (zh) * 2022-01-07 2023-11-24 北京大北农科技集团股份有限公司 一种屎肠球菌高密度发酵培养方法
KR102864280B1 (ko) * 2022-12-27 2025-09-26 (주)진성유니텍 포도상구균 증균을 위한 최소배지 및 이를 이용한 포도상구균 증균방법
KR102866798B1 (ko) * 2022-12-27 2025-10-01 (주)진성유니텍 살모넬라균 증균을 위한 최소배지 및 이를 이용한 살모넬라균 증균방법
KR102894728B1 (ko) 2024-11-27 2025-12-08 한국콜마주식회사 피지 생성 억제 효능, 모공 개선 효능 및 피부 장벽 강화 효능이 우수한 흑효모 발효물 및 이의 제조방법

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113423815A (zh) * 2018-12-06 2021-09-21 创赏有限公司 非动物来源培养基上的细菌生长
CN111254103A (zh) * 2019-11-19 2020-06-09 河南省生物工程技术研究中心 一种非洲猪瘟基因工程疫苗高密度发酵补料培养基及发酵工艺
CN111254103B (zh) * 2019-11-19 2023-06-02 河南省生物工程技术研究中心 一种非洲猪瘟基因工程疫苗高密度发酵补料培养基及发酵工艺
CN114015622A (zh) * 2021-12-14 2022-02-08 塔里木大学 无乳链球菌培养基及其制备方法
CN117821342A (zh) * 2024-02-29 2024-04-05 北京民海生物科技有限公司 一种14型肺炎链球菌的发酵方法
CN117821342B (zh) * 2024-02-29 2024-06-04 北京民海生物科技有限公司 一种14型肺炎链球菌的发酵方法

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Publication number Publication date
IL319202A (en) 2025-04-01
US20190292513A1 (en) 2019-09-26
KR20180073699A (ko) 2018-07-02
MX2021010518A (es) 2021-10-01
JP7311966B2 (ja) 2023-07-20
RU2018118035A (ru) 2019-12-18
HK1259103A1 (zh) 2019-11-22
US10947494B2 (en) 2021-03-16
IL259404B2 (en) 2025-08-01
KR102069988B1 (ko) 2020-01-23
AU2016357567B2 (en) 2020-05-07
CA3005308A1 (en) 2017-05-26
IL259404A (en) 2018-07-31
EP3377613A1 (en) 2018-09-26
US20210180008A1 (en) 2021-06-17
AU2016357567A1 (en) 2018-05-17
US20260008994A1 (en) 2026-01-08
JP2022017529A (ja) 2022-01-25
JP7814142B2 (ja) 2026-02-16
JP2018533366A (ja) 2018-11-15
WO2017085602A1 (en) 2017-05-26
BR112018008864A2 (pt) 2018-11-06
MX2018006063A (es) 2018-09-17
BR112018008864A8 (pt) 2019-02-26
IL259404B1 (en) 2025-04-01
RU2018118035A3 (https=) 2019-12-18
MX385736B (es) 2025-03-18
RU2761633C2 (ru) 2021-12-13
RU2021135165A (ru) 2021-12-29
CA3138763A1 (en) 2017-05-26
CA3005308C (en) 2022-01-04
JP2024037949A (ja) 2024-03-19

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