JP2018533366A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018533366A5 JP2018533366A5 JP2018525463A JP2018525463A JP2018533366A5 JP 2018533366 A5 JP2018533366 A5 JP 2018533366A5 JP 2018525463 A JP2018525463 A JP 2018525463A JP 2018525463 A JP2018525463 A JP 2018525463A JP 2018533366 A5 JP2018533366 A5 JP 2018533366A5
- Authority
- JP
- Japan
- Prior art keywords
- medium
- cell culture
- total concentration
- medium according
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002609 medium Substances 0.000 claims 40
- 238000004113 cell culture Methods 0.000 claims 19
- 238000000034 method Methods 0.000 claims 14
- 241000894006 Bacteria Species 0.000 claims 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- 229940041514 candida albicans extract Drugs 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 239000012138 yeast extract Substances 0.000 claims 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 6
- 150000004676 glycans Chemical class 0.000 claims 6
- 229920001282 polysaccharide Polymers 0.000 claims 6
- 239000005017 polysaccharide Substances 0.000 claims 6
- 239000004471 Glycine Substances 0.000 claims 5
- 230000010412 perfusion Effects 0.000 claims 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 241000193985 Streptococcus agalactiae Species 0.000 claims 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 238000000855 fermentation Methods 0.000 claims 2
- 230000004151 fermentation Effects 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 235000015097 nutrients Nutrition 0.000 claims 2
- 239000001103 potassium chloride Substances 0.000 claims 2
- 235000011164 potassium chloride Nutrition 0.000 claims 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims 1
- 229910052939 potassium sulfate Inorganic materials 0.000 claims 1
- 235000011151 potassium sulphates Nutrition 0.000 claims 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021182236A JP7814142B2 (ja) | 2015-11-17 | 2021-11-09 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
| JP2023213432A JP2024037949A (ja) | 2015-11-17 | 2023-12-19 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562256347P | 2015-11-17 | 2015-11-17 | |
| US62/256,347 | 2015-11-17 | ||
| US201662413051P | 2016-10-26 | 2016-10-26 | |
| US62/413,051 | 2016-10-26 | ||
| PCT/IB2016/056780 WO2017085602A1 (en) | 2015-11-17 | 2016-11-10 | Media and fermentation methods for producing polysaccharides in bacterial cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021182236A Division JP7814142B2 (ja) | 2015-11-17 | 2021-11-09 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533366A JP2018533366A (ja) | 2018-11-15 |
| JP2018533366A5 true JP2018533366A5 (https=) | 2019-12-19 |
| JP7311966B2 JP7311966B2 (ja) | 2023-07-20 |
Family
ID=57394621
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525463A Active JP7311966B2 (ja) | 2015-11-17 | 2016-11-10 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
| JP2021182236A Active JP7814142B2 (ja) | 2015-11-17 | 2021-11-09 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
| JP2023213432A Withdrawn JP2024037949A (ja) | 2015-11-17 | 2023-12-19 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021182236A Active JP7814142B2 (ja) | 2015-11-17 | 2021-11-09 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
| JP2023213432A Withdrawn JP2024037949A (ja) | 2015-11-17 | 2023-12-19 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10947494B2 (https=) |
| EP (1) | EP3377613A1 (https=) |
| JP (3) | JP7311966B2 (https=) |
| KR (1) | KR102069988B1 (https=) |
| CN (1) | CN108473945A (https=) |
| AU (1) | AU2016357567B2 (https=) |
| BR (1) | BR112018008864A8 (https=) |
| CA (2) | CA3005308C (https=) |
| HK (1) | HK1259103A1 (https=) |
| IL (2) | IL319202A (https=) |
| MX (2) | MX385736B (https=) |
| RU (2) | RU2021135165A (https=) |
| WO (1) | WO2017085602A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI815599B (zh) | 2011-04-22 | 2023-09-11 | 美商惠氏有限責任公司 | 與難養芽胞梭菌（Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅ）之突變毒素有關之組成物及彼之方法 |
| PT2837680T (pt) * | 2011-07-01 | 2020-04-17 | Amgen Inc | Cultura celular de mamífero |
| BR122016023101B1 (pt) * | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| BR112019003992A2 (pt) | 2016-09-02 | 2019-05-28 | Sanofi Pasteur Inc | vacina contra neisseria meningitidis |
| EP4656208A3 (en) | 2017-01-31 | 2026-03-04 | Merck Sharp & Dohme LLC | Methods for making polysaccharide-protein conjugates |
| JP7680185B2 (ja) | 2017-02-24 | 2025-05-20 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| MX394767B (es) | 2017-09-07 | 2025-03-24 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora. |
| MX394768B (es) | 2017-09-07 | 2025-03-21 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina. |
| ES3058336T3 (es) | 2017-12-06 | 2026-03-10 | Merck Sharp & Dohme Llc | Composiciones que comprenden conjugados polisacárido-proteína de Streptococcus pneumoniae y métodos de uso de los mismos |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| EP3788143B1 (en) | 2018-04-30 | 2023-06-28 | Merck Sharp & Dohme LLC | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| CN113423815A (zh) * | 2018-12-06 | 2021-09-21 | 创赏有限公司 | 非动物来源培养基上的细菌生长 |
| CA3122085A1 (en) * | 2018-12-11 | 2020-06-18 | Erbi Biosystems, Inc. | Methods of manufacturing cell based products using small volume perfusion processes |
| CR20210333A (es) | 2018-12-19 | 2021-08-18 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso |
| CN111254103B (zh) * | 2019-11-19 | 2023-06-02 | 河南省生物工程技术研究中心 | 一种非洲猪瘟基因工程疫苗高密度发酵补料培养基及发酵工艺 |
| US20230200424A1 (en) * | 2020-04-20 | 2023-06-29 | Evonik Operations Gmbh | Compositions comprising cys-peptides |
| WO2021255690A2 (en) | 2020-06-19 | 2021-12-23 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| CN114015622A (zh) * | 2021-12-14 | 2022-02-08 | 塔里木大学 | 无乳链球菌培养基及其制备方法 |
| WO2023131588A1 (en) * | 2022-01-05 | 2023-07-13 | Nordmark Pharma Gmbh | Culture medium for cultivating hathewaya histolytica (or clostridium histolyticum) and the production of one or more proteases |
| CN114181872B (zh) * | 2022-01-07 | 2023-11-24 | 北京大北农科技集团股份有限公司 | 一种屎肠球菌高密度发酵培养方法 |
| KR102866798B1 (ko) * | 2022-12-27 | 2025-10-01 | (주)진성유니텍 | 살모넬라균 증균을 위한 최소배지 및 이를 이용한 살모넬라균 증균방법 |
| KR102864280B1 (ko) * | 2022-12-27 | 2025-09-26 | (주)진성유니텍 | 포도상구균 증균을 위한 최소배지 및 이를 이용한 포도상구균 증균방법 |
| CN117821342B (zh) * | 2024-02-29 | 2024-06-04 | 北京民海生物科技有限公司 | 一种14型肺炎链球菌的发酵方法 |
| KR102894728B1 (ko) | 2024-11-27 | 2025-12-08 | 한국콜마주식회사 | 피지 생성 억제 효능, 모공 개선 효능 및 피부 장벽 강화 효능이 우수한 흑효모 발효물 및 이의 제조방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801054A (en) * | 1996-09-19 | 1998-09-01 | The United States Of America As Represented By The Secretary Of The Air Force | Cell culture vessel with self-maintained atmosphere |
| DE69838383T2 (de) | 1997-05-28 | 2008-06-05 | Novartis Vaccines And Diagnostics S.R.L. | Kulturmedium mit sojabohnenextrakt als aminosäuren-quelle und ohne proteinkomplexe tierischen ursprungs |
| US7115385B2 (en) * | 2001-08-02 | 2006-10-03 | North Carolina State University | Media and methods for cultivation of microorganisms |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US7472101B2 (en) | 2005-07-12 | 2008-12-30 | Tibco Software Inc. | Inferential state machines |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| US7491517B2 (en) | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
| SI2078071T1 (sl) * | 2006-11-08 | 2015-05-29 | Wyeth Llc | Racionalno zasnovana gojišča za celično kulturo |
| GB0818453D0 (en) * | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| WO2011151841A1 (en) * | 2010-05-31 | 2011-12-08 | Panacea Biotec Limited | Fermentation process for streptococcus pneumoniae |
| CN103052717B (zh) * | 2011-05-17 | 2015-01-14 | 中国食品发酵工业研究院 | 一种工业化生产玉米降压活性肽的方法 |
| CN104080904B (zh) * | 2011-12-15 | 2017-06-30 | 血清研究所印度私人有限公司 | 培养细菌以提高荚膜多糖产率的新方法 |
| EP2647715A1 (en) * | 2012-04-03 | 2013-10-09 | Nomad Bioscience GmbH | Agrobacterium for transient transfection of whole plants |
| GB201211256D0 (en) | 2012-06-25 | 2012-08-08 | Glaxosmithkline Biolog Sa | Fermentation process |
| WO2014080423A2 (en) * | 2012-11-21 | 2014-05-30 | Serum Institute Of India Ltd. | Production of high yields of bacterial polysaccharides |
-
2016
- 2016-11-10 EP EP16801312.6A patent/EP3377613A1/en active Pending
- 2016-11-10 CA CA3005308A patent/CA3005308C/en active Active
- 2016-11-10 RU RU2021135165A patent/RU2021135165A/ru unknown
- 2016-11-10 JP JP2018525463A patent/JP7311966B2/ja active Active
- 2016-11-10 CA CA3138763A patent/CA3138763A1/en active Pending
- 2016-11-10 WO PCT/IB2016/056780 patent/WO2017085602A1/en not_active Ceased
- 2016-11-10 BR BR112018008864A patent/BR112018008864A8/pt active Search and Examination
- 2016-11-10 AU AU2016357567A patent/AU2016357567B2/en active Active
- 2016-11-10 CN CN201680077135.5A patent/CN108473945A/zh active Pending
- 2016-11-10 RU RU2018118035A patent/RU2761633C2/ru active
- 2016-11-10 IL IL319202A patent/IL319202A/en unknown
- 2016-11-10 HK HK19101603.6A patent/HK1259103A1/zh unknown
- 2016-11-10 US US15/775,172 patent/US10947494B2/en active Active
- 2016-11-10 MX MX2018006063A patent/MX385736B/es unknown
- 2016-11-10 IL IL259404A patent/IL259404B2/en unknown
- 2016-11-10 KR KR1020187016942A patent/KR102069988B1/ko not_active Expired - Fee Related
-
2018
- 2018-05-16 MX MX2021010518A patent/MX2021010518A/es unknown
-
2021
- 2021-02-08 US US17/170,036 patent/US20210180008A1/en not_active Abandoned
- 2021-11-09 JP JP2021182236A patent/JP7814142B2/ja active Active
-
2023
- 2023-12-19 JP JP2023213432A patent/JP2024037949A/ja not_active Withdrawn
-
2025
- 2025-09-16 US US19/330,622 patent/US20260008994A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018533366A5 (https=) | ||
| RU2018118035A (ru) | Среды и способы ферментации для производства полисахаридов в бактериальной клеточной культуре | |
| JP2016528906A (ja) | 液体培養におけるアーバスキュラ菌根菌類の連続的増殖および大量生産のためのシステムおよび方法 | |
| HRP20160783T1 (hr) | Medij za kultiviranje stanica za ekspresiju adamts proteina | |
| CN104774784B (zh) | 一种解磷菌及其获取方法 | |
| RU2010101310A (ru) | Золотистые водоросли и способ производства | |
| ES2681993T3 (es) | Método para producir antígenos de Haemophilus influenzae de tipo b | |
| Bhattacharya et al. | Isolation and characterization of Rhizobium sp. form root of legume plant (Pisum sativum) and its antibacterial activity against different bacterial strains | |
| JP2017512477A5 (https=) | ||
| CN116622560A (zh) | 一株含细菌叶绿素且产胞外多糖的赤杆菌scsio17413及其在岛礁结皮中的应用 | |
| CN103215212B (zh) | 一种经济高效的钝顶螺旋藻的混养方法 | |
| US3936355A (en) | Microorganism growth media and the stabilization thereof | |
| IL299373A (en) | Microbial culture medium | |
| CN119391584A (zh) | 一株节杆菌gd-20及其在固碳和溶磷中的应用 | |
| CN102586383B (zh) | 胞磷胆碱的制备方法 | |
| AU770840B2 (en) | Culture of mycobacteria | |
| CN111019859B (zh) | L-精氨酸在作为蜡样芽孢杆菌趋化物质及群游物质中的应用 | |
| KR20180110781A (ko) | 배가스 내 이산화탄소를 이용하여 제조된 중탄산 버퍼, 및 무기 인산염 버퍼를 활용한 광합성 미생물의 배양방법 | |
| CN108913635B (zh) | 一种生产甘油葡萄糖苷过程中恢复蛋白质含量的方法 | |
| CN104388323A (zh) | 一种快速筛选叶酸高产菌的方法 | |
| CN104046582A (zh) | 一种富集耳炎假单胞菌的培养基 | |
| RU2849181C1 (ru) | Способ повышения сроков сохранения жизнеспособности грамотрицательных бактерий | |
| CN104031948A (zh) | 利用海洋真菌生产免疫抑制化合物的方法及其培养基 | |
| KR102069058B1 (ko) | 질산환원효소 유전자가 녹아웃된 미세조류의 성장을 증진시키기 위한 최적 배지 조성물 및 이의 용도 | |
| CN107460153A (zh) | 一种用天然海水加味精发酵母液生产螺旋藻生物质的方法 |