JP2018533366A5 - - Google Patents
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- JP2018533366A5 JP2018533366A5 JP2018525463A JP2018525463A JP2018533366A5 JP 2018533366 A5 JP2018533366 A5 JP 2018533366A5 JP 2018525463 A JP2018525463 A JP 2018525463A JP 2018525463 A JP2018525463 A JP 2018525463A JP 2018533366 A5 JP2018533366 A5 JP 2018533366A5
- Authority
- JP
- Japan
- Prior art keywords
- medium
- cell culture
- total concentration
- medium according
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002609 medium Substances 0.000 claims 40
- 238000004113 cell culture Methods 0.000 claims 19
- 238000000034 method Methods 0.000 claims 14
- 241000894006 Bacteria Species 0.000 claims 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- 229940041514 candida albicans extract Drugs 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 239000012138 yeast extract Substances 0.000 claims 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 6
- 150000004676 glycans Chemical class 0.000 claims 6
- 229920001282 polysaccharide Polymers 0.000 claims 6
- 239000005017 polysaccharide Substances 0.000 claims 6
- 239000004471 Glycine Substances 0.000 claims 5
- 230000010412 perfusion Effects 0.000 claims 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 241000193985 Streptococcus agalactiae Species 0.000 claims 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 238000000855 fermentation Methods 0.000 claims 2
- 230000004151 fermentation Effects 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 235000015097 nutrients Nutrition 0.000 claims 2
- 239000001103 potassium chloride Substances 0.000 claims 2
- 235000011164 potassium chloride Nutrition 0.000 claims 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims 1
- 229910052939 potassium sulfate Inorganic materials 0.000 claims 1
- 235000011151 potassium sulphates Nutrition 0.000 claims 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021182236A JP7814142B2 (ja) | 2015-11-17 | 2021-11-09 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
| JP2023213432A JP2024037949A (ja) | 2015-11-17 | 2023-12-19 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562256347P | 2015-11-17 | 2015-11-17 | |
| US62/256,347 | 2015-11-17 | ||
| US201662413051P | 2016-10-26 | 2016-10-26 | |
| US62/413,051 | 2016-10-26 | ||
| PCT/IB2016/056780 WO2017085602A1 (en) | 2015-11-17 | 2016-11-10 | Media and fermentation methods for producing polysaccharides in bacterial cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021182236A Division JP7814142B2 (ja) | 2015-11-17 | 2021-11-09 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533366A JP2018533366A (ja) | 2018-11-15 |
| JP2018533366A5 true JP2018533366A5 (https=) | 2019-12-19 |
| JP7311966B2 JP7311966B2 (ja) | 2023-07-20 |
Family
ID=57394621
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525463A Active JP7311966B2 (ja) | 2015-11-17 | 2016-11-10 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
| JP2021182236A Active JP7814142B2 (ja) | 2015-11-17 | 2021-11-09 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
| JP2023213432A Withdrawn JP2024037949A (ja) | 2015-11-17 | 2023-12-19 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021182236A Active JP7814142B2 (ja) | 2015-11-17 | 2021-11-09 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
| JP2023213432A Withdrawn JP2024037949A (ja) | 2015-11-17 | 2023-12-19 | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10947494B2 (https=) |
| EP (1) | EP3377613A1 (https=) |
| JP (3) | JP7311966B2 (https=) |
| KR (1) | KR102069988B1 (https=) |
| CN (1) | CN108473945A (https=) |
| AU (1) | AU2016357567B2 (https=) |
| BR (1) | BR112018008864A8 (https=) |
| CA (2) | CA3138763A1 (https=) |
| HK (1) | HK1259103A1 (https=) |
| IL (2) | IL319202A (https=) |
| MX (2) | MX385736B (https=) |
| RU (2) | RU2761633C2 (https=) |
| WO (1) | WO2017085602A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AR086199A1 (es) | 2011-04-22 | 2013-11-27 | Wyeth Llc | Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos |
| DK2726600T3 (en) * | 2011-07-01 | 2017-05-15 | Amgen Inc | Mammalian Cell Culture |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| KR102906912B1 (ko) | 2016-09-02 | 2026-01-05 | 사노피 파스퇴르 인크 | 네이세리아 메닌기티디스 백신 |
| CN110225764A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 制备多糖-蛋白缀合物的方法 |
| CA3050120A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
| CN111065387B (zh) | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| WO2019050813A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| TWI725359B (zh) | 2017-12-06 | 2021-04-21 | 美商默沙東藥廠 | 包含肺炎鏈球菌多醣-蛋白結合物之組合物及其使用方法 |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| JP7397000B2 (ja) | 2018-04-30 | 2023-12-12 | メルク・シャープ・アンド・ドーム・エルエルシー | 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法 |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| KR102609289B1 (ko) * | 2018-12-06 | 2023-12-01 | 인벤트프라이즈 인크. | 비-동물성 배지에서의 박테리아 증식 |
| WO2020123524A1 (en) * | 2018-12-11 | 2020-06-18 | Erbi Biosystems, Inc. | Methods of manufacturing cell based products using small volume perfusion processes |
| GEAP202415690A (en) | 2018-12-19 | 2024-01-10 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| CN111254103B (zh) * | 2019-11-19 | 2023-06-02 | 河南省生物工程技术研究中心 | 一种非洲猪瘟基因工程疫苗高密度发酵补料培养基及发酵工艺 |
| AU2021259110B2 (en) * | 2020-04-20 | 2026-04-02 | Evonik Operations Gmbh | Compositions comprising Cys-peptides |
| EP4168032A2 (en) | 2020-06-19 | 2023-04-26 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| CN114015622A (zh) * | 2021-12-14 | 2022-02-08 | 塔里木大学 | 无乳链球菌培养基及其制备方法 |
| WO2023131588A1 (en) * | 2022-01-05 | 2023-07-13 | Nordmark Pharma Gmbh | Culture medium for cultivating hathewaya histolytica (or clostridium histolyticum) and the production of one or more proteases |
| CN114181872B (zh) * | 2022-01-07 | 2023-11-24 | 北京大北农科技集团股份有限公司 | 一种屎肠球菌高密度发酵培养方法 |
| KR102864280B1 (ko) * | 2022-12-27 | 2025-09-26 | (주)진성유니텍 | 포도상구균 증균을 위한 최소배지 및 이를 이용한 포도상구균 증균방법 |
| KR102866798B1 (ko) * | 2022-12-27 | 2025-10-01 | (주)진성유니텍 | 살모넬라균 증균을 위한 최소배지 및 이를 이용한 살모넬라균 증균방법 |
| CN117821342B (zh) * | 2024-02-29 | 2024-06-04 | 北京民海生物科技有限公司 | 一种14型肺炎链球菌的发酵方法 |
| KR102894728B1 (ko) | 2024-11-27 | 2025-12-08 | 한국콜마주식회사 | 피지 생성 억제 효능, 모공 개선 효능 및 피부 장벽 강화 효능이 우수한 흑효모 발효물 및 이의 제조방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801054A (en) * | 1996-09-19 | 1998-09-01 | The United States Of America As Represented By The Secretary Of The Air Force | Cell culture vessel with self-maintained atmosphere |
| ATE372376T1 (de) * | 1997-05-28 | 2007-09-15 | Novartis Vaccines & Diagnostic | Kulturmedium mit sojabohnenextrakt als aminosäuren-quelle und ohne proteinkomplexe tierischen ursprungs |
| US7115385B2 (en) * | 2001-08-02 | 2006-10-03 | North Carolina State University | Media and methods for cultivation of microorganisms |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US7472101B2 (en) | 2005-07-12 | 2008-12-30 | Tibco Software Inc. | Inferential state machines |
| GB0522303D0 (en) | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| US7491517B2 (en) * | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
| ES2538986T3 (es) * | 2006-11-08 | 2015-06-25 | Wyeth Llc | Medios diseñados racionalmente para un cultivo celular |
| GB0818453D0 (en) * | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| WO2011151841A1 (en) | 2010-05-31 | 2011-12-08 | Panacea Biotec Limited | Fermentation process for streptococcus pneumoniae |
| JP5763203B2 (ja) * | 2011-05-17 | 2015-08-12 | チャイナ ナショナル リサーチ インスティテュート オブ フード アンド ファーメンテーション インダストリーズ | トウモロコシ降圧活性ペプチドを調製するための工業的方法 |
| BR112014014656B1 (pt) * | 2011-12-15 | 2020-03-17 | Serum Institute Of India Ltd. | Método de cultivo de bactérias para produção volumétrica superior de polioses capsulares em comparação com a fermentação em batelada |
| EP2647715A1 (en) * | 2012-04-03 | 2013-10-09 | Nomad Bioscience GmbH | Agrobacterium for transient transfection of whole plants |
| GB201211256D0 (en) * | 2012-06-25 | 2012-08-08 | Glaxosmithkline Biolog Sa | Fermentation process |
| RU2627156C2 (ru) * | 2012-11-21 | 2017-08-03 | Серум Инститьют Оф Индия Прайват Лтд. | Высокоэффективный способ получения бактериального полисахарида, получение конъюгата на его основе и иммуногенная композиция |
-
2016
- 2016-11-10 IL IL319202A patent/IL319202A/en unknown
- 2016-11-10 WO PCT/IB2016/056780 patent/WO2017085602A1/en not_active Ceased
- 2016-11-10 HK HK19101603.6A patent/HK1259103A1/zh unknown
- 2016-11-10 KR KR1020187016942A patent/KR102069988B1/ko not_active Expired - Fee Related
- 2016-11-10 RU RU2018118035A patent/RU2761633C2/ru active
- 2016-11-10 BR BR112018008864A patent/BR112018008864A8/pt active Search and Examination
- 2016-11-10 RU RU2021135165A patent/RU2021135165A/ru unknown
- 2016-11-10 JP JP2018525463A patent/JP7311966B2/ja active Active
- 2016-11-10 CA CA3138763A patent/CA3138763A1/en active Pending
- 2016-11-10 CA CA3005308A patent/CA3005308C/en active Active
- 2016-11-10 CN CN201680077135.5A patent/CN108473945A/zh active Pending
- 2016-11-10 EP EP16801312.6A patent/EP3377613A1/en active Pending
- 2016-11-10 IL IL259404A patent/IL259404B2/en unknown
- 2016-11-10 MX MX2018006063A patent/MX385736B/es unknown
- 2016-11-10 US US15/775,172 patent/US10947494B2/en active Active
- 2016-11-10 AU AU2016357567A patent/AU2016357567B2/en active Active
-
2018
- 2018-05-16 MX MX2021010518A patent/MX2021010518A/es unknown
-
2021
- 2021-02-08 US US17/170,036 patent/US20210180008A1/en not_active Abandoned
- 2021-11-09 JP JP2021182236A patent/JP7814142B2/ja active Active
-
2023
- 2023-12-19 JP JP2023213432A patent/JP2024037949A/ja not_active Withdrawn
-
2025
- 2025-09-16 US US19/330,622 patent/US20260008994A1/en active Pending
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