JP7286191B2 - 高いバイオアベイラビリティを有する水溶性クルクミン混合物およびその調製方法と応用 - Google Patents
高いバイオアベイラビリティを有する水溶性クルクミン混合物およびその調製方法と応用 Download PDFInfo
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- JP7286191B2 JP7286191B2 JP2021158141A JP2021158141A JP7286191B2 JP 7286191 B2 JP7286191 B2 JP 7286191B2 JP 2021158141 A JP2021158141 A JP 2021158141A JP 2021158141 A JP2021158141 A JP 2021158141A JP 7286191 B2 JP7286191 B2 JP 7286191B2
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Classifications
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- A—HUMAN NECESSITIES
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Description
本発明は、高いバイオアベイラビリティを有する水溶性クルクミン混合物の調製方法を提供する。また、本発明は、食品、健康食品または医薬品への、上記の水溶性クルクミン混合物の応用を提供する。中でも、本発明は、食品の形態に特に制限はなく、前記水溶性クルクミン混合物は、液状食品または固形食品、好ましくは飲料に添加され得る。また、本発明では、前記健康食品の剤型に特に制限はなく、カプセルまたは錠剤であってもよい。
1.本発明は、VC、パルミチン酸アスコルビルおよびクルクミンの共結晶を開示しており、これによりクルクミンを効果的に保護し、クルクミンの酸化的分解を低減することができる。同時に、クルクミン-VC-パルミチン酸アスコルビルの共結晶は、クルクミンの水溶性を改善することができる。
2.本発明は、調製プロセスにおいて合成乳化剤を使用せず無溶媒の調製方法を採用する。得られた製品は、品質の安全性および応用の完全性の問題を有していない。前記調製プロセスはより安全であり、このことは当該製品の工業化生産に有益である。
3.本発明は、真空乳化技術、二段湿式粉砕、超高圧均質化技術の効果的な組み合わせを採用しており、このことによりクルクミンの粒子径を効果的に減少させ、クルクミンの水溶性を向上させることができる。
4.本発明は、リン酸塩を採用して、エマルション調製完了の段階でゼータ電位を調整し、このことによりクルクミンエマルションの安定性がより助長され、クルクミン混合製品の品質の均一性が確保される。
93%クルクミン100gを秤量し、攪拌しながら95%エタノール1000gに溶解し、VC1.0gおよびパルミチン酸アスコルビル1.0gをゆっくりと加え、混合物を35℃~40℃までゆっくりと加熱し、完全に溶解するまでゆっくりと攪拌した。この混合物を、温度が65℃~75℃になるまで加熱し、0.08MPaの真空下でエタノールを蒸発させて、暗黄色の粘性物質を得た。この粘性物質を真空乾燥炉に移し、0.09MPa、75℃~80℃の環境で12時間乾燥させた。溶媒残留物が50ppm以下であることが検出され、VC-パルミチン酸アスコルビル-クルクミン共結晶が得られた。
表1 バイオアベイラビリティ試験結果
93%クルクミン200gを秤量し、撹拌下で95%エタノール3000gに溶解させ、VC3.0gとパルミチン酸アスコルビル3.5gをゆっくりと加え、混合物を35℃~40℃にゆっくりと加熱し、完全に溶解するまでゆっくりと撹拌した。この混合物を65℃~75℃になるまで加熱し、0.08MPaの真空下でエタノールを蒸発させて、濃い黄色の粘性物質を得た。この粘性物質を真空乾燥炉に移し、0.09MPa、75℃~80℃の環境下で15時間乾燥させた。残留溶媒が50ppm未満であることが検出され、VC-パルミチン酸アスコルビル-クルクミン共結晶を得た。
含有量93%のクルクミン250gを秤量し、攪拌しながら95%エタノール3500gに溶解し、VC2.5gおよびパルミチン酸アスコルビル3.5gをゆっくりと加え、35℃~40℃までゆっくりと加熱し、完全に溶解するまでゆっくりと攪拌した。この混合物を、温度が65℃~75℃になるまで加熱し、0.08MPaの真空下でエタノールを蒸発させて、暗黄色の粘性物質を得た。この粘性物質を真空乾燥炉に移し、0.09MPa、75℃~80℃の環境下で16時間乾燥させた。溶媒残留物が50ppm未満であることが検出され、VC-パルミチン酸アスコルビル-クルクミン共結晶が得られた。
クルクミン原料
クルクミン原料を水に分散させ、その結果を図2に示す。図2は、水へのクルクミン原料の溶解性を示す写真である。図2から、クルクミンが水に溶けないことがわかる。
実施例3のプロセスによれば、93%のクルクミンが調製試験の原料として直接使用された。そのプロセスおよび結果は以下の通りである。
クルクミンエマルションDのゼータ電位調整を行わなかった以外は、実施例1のプロセスに従って、試験を行った。そのプロセスおよび結果は、以下の通りである。
クルクミンエマルションCを80MPaの圧力で均質化したこと以外は、実施例1のプロセスプランに従って、試験を行った。そのプロセスおよび結果は以下の通りである。
Claims (4)
- 高いバイオアベイラビリティを有する水溶性クルクミン混合物を調製する方法であって、
A)クルクミン、ビタミンCおよびパルミチン酸アスコルビルを水性エタノール溶液に溶解し、減圧下でエタノールを蒸発させ、真空乾燥して、クルクミン-ビタミンC-パルミチン酸アスコルビル共結晶を得るステップ、
B)前記クルクミン-ビタミンC-パルミチン酸アスコルビル共結晶と壁材コロイド溶液とを真空下で高速乳化し、2段階の湿式粉砕、均質化、および電位調整を順次行い、乳化体を得るステップ、および
C)前記乳化体を壁材で二次マイクロカプセル化し、乾燥させて前記水溶性クルクミン混合物を得るステップ
を含む、方法。 - クルクミン、ビタミンC、およびパルミチン酸アスコルビルの質量比が、100:(0.001~30):(0.001~30)であり、ステップA)において、クルクミン、ビタミンCおよびパルミチン酸アスコルビルを水性エタノール溶液に0~60℃で溶解し、エタノールを0.05MPa以上大気圧未満の圧力下で、25℃~100℃で蒸発させる、請求項1に記載の方法。
- 前記壁材コロイド溶液が、オクテニルコハク酸デンプンナトリウム、ヒドロキシプロピルデンプン、酢酸デンプン、カルボキシメチルデンプン、リン酸デンプン、アラビアガム、ガティガム、キサンタンガム、プルラン、フコイダン、トレハロース、およびラクトースからなる群から選択されるうちの1つ以上を含み、
前記壁材コロイド溶液が、充填剤をさらに含み、前記充填剤が、マルトデキストリン、微結晶セルロース、ラクチトール、エリスリトール、マルチトール、ソルビトール、α-シクロデキストリン、β-シクロデキストリン、γ-シクロデキストリン、またはそれらの組み合わせであり、そして
前記壁材コロイド溶液が、5重量%~65重量%の壁材コロイド濃度、および5重量%~65重量%の充填剤濃度を有する、請求項1に記載の方法。 - 前記2段階の湿式粉砕が、第1粉砕および第2粉砕を含み、前記第1粉砕が、直径0.3mm~0.4mmのジルコニアビーズを使用し、500rpm~3500rpmの速度で1~10時間行われ、前記第2粉砕が、直径0.1mm~0.2mmのジルコニアビーズを使用し、500rpm~3500rpmの速度で1~10時間行われ、
前記高速乳化が、0.05MPa以上大気圧未満の圧力下で、10℃~90℃で行われ、前記均質化が、100MPa~200MPaで行われ、前記電位調整が、ヘキサメタリン酸ナトリウム、ポリリン酸ナトリウム、ピロリン酸ナトリウム、トリポリリン酸ナトリウムからなる群から選択されるゼータ電位調整剤を使用し、コロイド乳化体の電位が、-10mv~-60mvに調整され、
前記壁材が、デンプン、マルトデキストリン、またはそれらの混合物であり、マルトデキストリンのDE値が、5~20であり、前記マイクロカプセル化が、160℃~200℃の乾燥入口空気温度、70℃~100℃の出口空気温度、70℃~90℃の底部空気温度で行われ、そして
前記水溶性クルクミン混合物が、0.01重量%~70重量%、好ましくは5重量%~40重量%のクルクミン-ビタミンC-パルミチン酸アスコルビル共結晶濃度を有する、請求項1に記載の方法。
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