JP7282039B2 - Mk2阻害剤、その合成、およびそれに至るまでの中間体 - Google Patents

Mk2阻害剤、その合成、およびそれに至るまでの中間体 Download PDF

Info

Publication number
JP7282039B2
JP7282039B2 JP2019550605A JP2019550605A JP7282039B2 JP 7282039 B2 JP7282039 B2 JP 7282039B2 JP 2019550605 A JP2019550605 A JP 2019550605A JP 2019550605 A JP2019550605 A JP 2019550605A JP 7282039 B2 JP7282039 B2 JP 7282039B2
Authority
JP
Japan
Prior art keywords
formula
compound
salt
base
reaction conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019550605A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020510063A5 (cg-RX-API-DMAC7.html
JP2020510063A (ja
Inventor
グレッグ・ブライアン・フェイゲルソン
マリル・イー・ジェハーティ
リチャード・マーティン・ハイド・ジュニア
モヒト・コータレ
ホン-ワー・マン
アレクサンダー・エル・ルチェルマン
ジョン・エフ・トラバース
ケルビン・ヒンヨン・ヨン
チェンミン・ジャン
Original Assignee
セルジーン シーエーアール エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by セルジーン シーエーアール エルエルシー filed Critical セルジーン シーエーアール エルエルシー
Publication of JP2020510063A publication Critical patent/JP2020510063A/ja
Publication of JP2020510063A5 publication Critical patent/JP2020510063A5/ja
Application granted granted Critical
Publication of JP7282039B2 publication Critical patent/JP7282039B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
JP2019550605A 2017-03-16 2018-03-15 Mk2阻害剤、その合成、およびそれに至るまでの中間体 Active JP7282039B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762472024P 2017-03-16 2017-03-16
US62/472,024 2017-03-16
PCT/US2018/022547 WO2018170203A1 (en) 2017-03-16 2018-03-15 Mk2 inhibitors, synthesis thereof, and intermediates thereto

Publications (3)

Publication Number Publication Date
JP2020510063A JP2020510063A (ja) 2020-04-02
JP2020510063A5 JP2020510063A5 (cg-RX-API-DMAC7.html) 2021-04-30
JP7282039B2 true JP7282039B2 (ja) 2023-05-26

Family

ID=63523971

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019550605A Active JP7282039B2 (ja) 2017-03-16 2018-03-15 Mk2阻害剤、その合成、およびそれに至るまでの中間体

Country Status (8)

Country Link
US (2) US10894796B2 (cg-RX-API-DMAC7.html)
EP (1) EP3596086A4 (cg-RX-API-DMAC7.html)
JP (1) JP7282039B2 (cg-RX-API-DMAC7.html)
CN (1) CN110678471B (cg-RX-API-DMAC7.html)
AU (1) AU2018236290B2 (cg-RX-API-DMAC7.html)
CA (1) CA3054826A1 (cg-RX-API-DMAC7.html)
MX (1) MX387359B (cg-RX-API-DMAC7.html)
WO (1) WO2018170203A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023051962A (ja) * 2017-03-16 2023-04-11 セルジーン シーエーアール エルエルシー 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS62017B1 (sr) 2014-09-17 2021-07-30 Celgene Car Llc Mk2 inhibitori i njihova upotreba
EP3596086A4 (en) 2017-03-16 2020-12-16 Celgene CAR LLC MK2 INHIBITORS, THEIR SYNTHESIS AND THEIR INTERMEDIARIES
JP2020511468A (ja) 2017-03-16 2020-04-16 セルジーン シーエーアール エルエルシー Mk2阻害剤の重水素化アナログおよびその使用
US11124525B2 (en) 2017-03-16 2021-09-21 Celgene Car Llc Heteroaryl compounds useful as MK2 inhibitors
AU2018236286B2 (en) 2017-03-16 2022-02-17 Bristol-Myers Squibb Company Forms and compositions of a MK2 inhibitor
WO2020236636A1 (en) * 2019-05-17 2020-11-26 Celgene Car Llc Methods of treating a mk2-mediated disorder
EP4284805A1 (en) * 2021-02-01 2023-12-06 Celgene Corporation Mk2 inhibitors, the synthesis thereof, and intermediates thereto
WO2023025298A1 (zh) * 2021-08-27 2023-03-02 瑞石生物医药有限公司 喹啉并呋喃衍生物及其用途
EP4464694A4 (en) 2022-01-14 2026-04-01 Shanghai Hansoh Biomedical Co Ltd POLYCYCLIC DERIVATIVE CONTAINING PYRIDINE, ITS PREPARATION PROCESS AND ITS USE
CN116643046B (zh) * 2023-05-30 2025-09-12 南昌市高新区人民医院(南昌大学第一附属医院高新医院) Mk2在癌症恶病质肌肉萎缩中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013533885A (ja) 2010-07-02 2013-08-29 ギリアード サイエンシーズ, インコーポレイテッド Hiv抗ウイルス化合物としての2−キノリニル−酢酸誘導体
WO2016044463A2 (en) 2014-09-17 2016-03-24 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
JP2016518316A (ja) 2013-03-15 2016-06-23 セルジーン アビロミクス リサーチ, インコーポレイテッド Mk2阻害剤およびそれらの使用
WO2017040449A1 (en) 2015-09-03 2017-03-09 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0317430A (pt) 2002-12-20 2005-10-25 Pharmacia Corp Compostos inibidores de quinase-2 de proteìna ativada por quinase de proteìna ativada por mitógeno
US20060106020A1 (en) 2004-04-28 2006-05-18 Rodgers James D Tetracyclic inhibitors of Janus kinases
EP2223925A1 (en) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2010533674A (ja) 2007-07-16 2010-10-28 ノバルティス アーゲー Mk2阻害剤として有用なヘテロ環式化合物
JP5369173B2 (ja) 2008-04-22 2013-12-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キノリン若しくはイソキノリン置換p2x7アンタゴニスト
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
CN103189377B (zh) * 2010-10-29 2015-02-25 辉瑞大药厂 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂
BR112013010564B1 (pt) * 2010-11-01 2021-09-21 Celgene Car Llc Compostos heterocíclicos e composições compreendendo os mesmos
DK2648516T3 (da) * 2010-12-06 2019-01-02 Aclaris Therapeutics Inc Substituerede pyridinon-pyridinylforbindelser
BR112015000399A2 (pt) 2012-07-10 2017-06-27 Ares Trading Sa derivados de pirazolil pirimidina
EP2872144A4 (en) * 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
CN104177340A (zh) * 2013-05-22 2014-12-03 中国中化股份有限公司 一种新型的喹唑啉(硫)酮类化合物及其用途
EP3110874B1 (en) 2014-02-27 2018-03-21 Council of Scientific and Industrial Research Poly-benzimidazole with pyrene and anthracene flourophore
WO2016025561A1 (en) * 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Forms and compositions of an erk inhibitor
EP3596084A4 (en) 2017-03-16 2020-12-23 Celgene CAR LLC 9,10,11,12-TETRAHYDRO-8H- [1,4] DIAZEPINO [5 ', 6': 4,5] THIÉNO [3,2-F] QUINOLIN-8-ONE COMPOUNDS AND THEIR USES
JP2020511468A (ja) 2017-03-16 2020-04-16 セルジーン シーエーアール エルエルシー Mk2阻害剤の重水素化アナログおよびその使用
US11124525B2 (en) 2017-03-16 2021-09-21 Celgene Car Llc Heteroaryl compounds useful as MK2 inhibitors
EP3596086A4 (en) 2017-03-16 2020-12-16 Celgene CAR LLC MK2 INHIBITORS, THEIR SYNTHESIS AND THEIR INTERMEDIARIES
AU2018236286B2 (en) 2017-03-16 2022-02-17 Bristol-Myers Squibb Company Forms and compositions of a MK2 inhibitor
WO2020236636A1 (en) 2019-05-17 2020-11-26 Celgene Car Llc Methods of treating a mk2-mediated disorder
WO2022020562A1 (en) 2020-07-24 2022-01-27 Bristol-Myers Squibb Company Methods of treating acute respiratory disorders
EP4284805A1 (en) 2021-02-01 2023-12-06 Celgene Corporation Mk2 inhibitors, the synthesis thereof, and intermediates thereto

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013533885A (ja) 2010-07-02 2013-08-29 ギリアード サイエンシーズ, インコーポレイテッド Hiv抗ウイルス化合物としての2−キノリニル−酢酸誘導体
JP2016518316A (ja) 2013-03-15 2016-06-23 セルジーン アビロミクス リサーチ, インコーポレイテッド Mk2阻害剤およびそれらの使用
WO2016044463A2 (en) 2014-09-17 2016-03-24 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
WO2017040449A1 (en) 2015-09-03 2017-03-09 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023051962A (ja) * 2017-03-16 2023-04-11 セルジーン シーエーアール エルエルシー 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用

Also Published As

Publication number Publication date
US20210139501A1 (en) 2021-05-13
US20200102326A1 (en) 2020-04-02
US10894796B2 (en) 2021-01-19
AU2018236290A1 (en) 2019-09-19
US11655257B2 (en) 2023-05-23
AU2018236290B2 (en) 2022-06-02
WO2018170203A1 (en) 2018-09-20
JP2020510063A (ja) 2020-04-02
CN110678471A (zh) 2020-01-10
EP3596086A4 (en) 2020-12-16
MX2019010642A (es) 2019-10-17
CA3054826A1 (en) 2018-09-20
MX387359B (es) 2025-03-18
EP3596086A1 (en) 2020-01-22
CN110678471B (zh) 2022-09-13

Similar Documents

Publication Publication Date Title
US11655257B2 (en) MK2 inhibitors, synthesis thereof, and intermediates thereto
CN113024544B (zh) 一种含氰基并杂环化合物及其用途
EP3893871B1 (en) Benzimidazolone derivatives, and analogues thereof, as il-17 modulators
AU2008210266B2 (en) Thiopyrimidine-based compounds and uses thereof
KR20210100143A (ko) 이미다조[1,2-b]피리다진 il-17a 억제제
AU2021306755B2 (en) Immunomodulator
JP7200120B2 (ja) Mk2阻害剤として有用なヘテロアリール化合物
AU2004215481A1 (en) Pyrazolo(1,5-A)pyrimidine derivatives
AU2012296662A1 (en) Lysophosphatidic acid receptor antagonists
CA2730271A1 (en) Pi3k isoform selective inhibitors
AU2023351608A1 (en) Fused ring compound and pharmaceutical containing same
JP2020511468A (ja) Mk2阻害剤の重水素化アナログおよびその使用
CN110997678B (zh) 作为胆碱激酶抑制剂的吡唑并喹唑啉衍生物
WO2023020209A1 (zh) 含2-芳杂环取代的脲类化合物、其制备方法和用途
CN117222628A (zh) 一种抑制细胞程序性死亡的化合物及其制备方法
US20020193381A1 (en) Thienopyranecarboxamide derivatives
US8299082B2 (en) 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives
TW202321262A (zh) 磺醯亞胺醯胺化合物及其用途
JP5201694B2 (ja) アゼチジン化合物およびその医薬用途
WO2025093058A1 (zh) 2-氧代吲哚啉类衍生物及其制备方法和应用
CN101312974A (zh) 吡唑并异喹啉衍生物
US6387909B1 (en) Thienopyranecarboxamide derivatives
CN115925684A (zh) 一种嘧啶类衍生物及其制备方法和应用
AU2005272298A1 (en) Pyrazolo[1,5-a]pyrimidine derivative
WO2011078226A1 (ja) 三環系化合物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210312

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210312

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220217

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220308

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220606

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220805

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20221115

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230214

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230425

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230516

R150 Certificate of patent or registration of utility model

Ref document number: 7282039

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350