JP7254818B2 - 新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート - Google Patents

新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート Download PDF

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JP7254818B2
JP7254818B2 JP2020541321A JP2020541321A JP7254818B2 JP 7254818 B2 JP7254818 B2 JP 7254818B2 JP 2020541321 A JP2020541321 A JP 2020541321A JP 2020541321 A JP2020541321 A JP 2020541321A JP 7254818 B2 JP7254818 B2 JP 7254818B2
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antibody
drug conjugate
group
cancer
antibody drug
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JPWO2020050406A1 (ja
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敏史 津田
俊樹 田渕
秀昭 渡邉
宏行 小林
雅之 石崎
香生子 原
悌司 和田
雅巳 荒井
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
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JP2020541321A 2018-09-06 2019-09-06 新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート Active JP7254818B2 (ja)

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JP2023050936A JP7483975B2 (ja) 2018-09-06 2023-03-28 新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート
JP2024073463A JP2024099041A (ja) 2018-09-06 2024-04-30 新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート

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JP2018167369 2018-09-06
JP2018167369 2018-09-06
PCT/JP2019/035198 WO2020050406A1 (ja) 2018-09-06 2019-09-06 新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート

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JP2023050936A Active JP7483975B2 (ja) 2018-09-06 2023-03-28 新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート
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JP2024073463A Pending JP2024099041A (ja) 2018-09-06 2024-04-30 新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート

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Publication number Priority date Publication date Assignee Title
PT3848054T (pt) 2018-09-06 2025-04-03 Daiichi Sankyo Co Ltd Conjugados anticorpo-fármaco de derivados de dinucleótidos cíclicos
US20230141284A1 (en) 2020-04-10 2023-05-11 Ono Pharmaceutical Co., Ltd. Cancer therapeutic method
TW202227479A (zh) * 2020-09-02 2022-07-16 日商第一三共股份有限公司 新穎內－β－Ｎ－乙醯葡萄糖胺苷酶
CN116867795A (zh) * 2021-02-01 2023-10-10 第一三共株式会社 抗体－免疫刺激剂偶联物的新型制造方法
TW202241454A (zh) 2021-02-01 2022-11-01 日商第一三共股份有限公司 抗體－免疫賦活化劑共軛物之新穎製造方法
CA3212691A1 (en) 2021-03-12 2022-09-15 Daiichi Sankyo Company, Limited Glycan, and method for producing medicine containing glycan
EP4326314A4 (en) * 2021-04-23 2025-12-17 Univ Maryland FC-GLYCAN REMODELING FOR SITE-SPECIFIC ANTIBODIES CONJUGATION AND APPLICATIONS THEREOF
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
CN115703845A (zh) * 2021-08-05 2023-02-17 中国科学院上海药物研究所 寡糖连接子与侧链亲水性片段组合的糖链定点抗体-药物偶联物，其制法及用途
EP4420682A1 (en) * 2021-10-12 2024-08-28 Chengdu Scimount Pharmatech Co., Ltd. Highly-stable targeted linker-drug conjugate
WO2023074843A1 (ja) 2021-10-29 2023-05-04 第一三共株式会社 新規なオリゴ糖、該オリゴ糖の製造中間体、及びそれらの製造方法
KR20240113514A (ko) 2021-11-30 2024-07-22 다이이찌 산쿄 가부시키가이샤 프로테아제 분해성 마스크 항체
JPWO2023153442A1 (enExample) 2022-02-09 2023-08-17
EP4488378A1 (en) 2022-03-02 2025-01-08 Daiichi Sankyo Company, Limited Method for producing fc-containing molecule
JP2025166269A (ja) * 2022-07-29 2025-11-06 第一三共株式会社 抗腫瘍効果を有する抗体薬物複合体の新規製造方法
CN119744182A (zh) 2022-08-29 2025-04-01 第一三共株式会社 包含突变Fc区的抗体药物偶联物
TW202419107A (zh) 2022-09-09 2024-05-16 日商第一三共股份有限公司 新穎寡醣、該寡醣之製造中間體、及彼等之製造方法
WO2024107827A1 (en) * 2022-11-16 2024-05-23 The Broad Institute, Inc. Therapeutic exploitation of sting channel activity
WO2024118785A2 (en) 2022-11-30 2024-06-06 Regeneron Pharmaceuticals, Inc. Tlr7 agonists and antibody-drug-conjugates thereof
WO2025164597A1 (ja) * 2024-01-29 2025-08-07 第一三共株式会社 抗ｈｅｒ２抗体－薬物コンジュゲートと他剤との組み合わせ
WO2025183064A1 (ja) * 2024-02-28 2025-09-04 第一三共株式会社 抗ｃｄｈ６抗体－薬物コンジュゲートと他剤との組み合わせ

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017161349A1 (en) 2016-03-18 2017-09-21 Immune Sensor, Llc Cyclic di-nucleotide compounds and methods of use
JP2018090562A (ja) 2016-12-01 2018-06-14 武田薬品工業株式会社 環状ジヌクレオチド
JP2018522914A (ja) 2015-08-13 2018-08-16 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド化合物

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
EP0714409A1 (en) 1993-06-16 1996-06-05 Celltech Therapeutics Limited Antibodies
RU2313368C2 (ru) 2001-11-01 2007-12-27 Ю Эй Би Рисерч Фаундейшн Комбинации антител, обладающих селективностью по отношению к рецептору лиганда, индуцирующему апоптоз, ассоциированный с фактором некроза опухоли, и других терапевтических средств
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
EP2263691B1 (en) 2002-07-15 2012-08-29 F.Hoffmann-La Roche Ag Treatment of cancer with the recombinant humanized monoclonal anti-erbb2 antibody 2C4 (rhuMAb 2C4)
ATE472338T1 (de) 2003-02-20 2010-07-15 Seattle Genetics Inc Anti-cd70 antikörper-arzneimittelkonjugate und ihre verwendung zur behandlung von krebs
CA2647632C (en) 2006-03-27 2017-06-27 University Of Maryland Biotechnology Institute Glycoprotein synthesis and remodeling by enzymatic transglycosylation
WO2009028639A1 (ja) 2007-08-30 2009-03-05 Daiichi Sankyo Company, Limited 抗ｅｐｈａ２抗体
JP5566226B2 (ja) 2009-09-03 2014-08-06 旭化成株式会社 １１糖シアリルオリゴ糖ペプチドの製造方法
US9175326B2 (en) 2011-03-03 2015-11-03 University Of Maryland, Baltimore Transglycosylation activity of glycosynthase mutants of an endo-beta-N-acetylglucosaminidase (endo-D) from streptococcus pneumoniae
US10851174B2 (en) 2011-03-03 2020-12-01 University Of Maryland, Baltimore Core fucosylated glycopeptides and glycoproteins: chemoenzymatic synthesis and uses thereof
CA2862925C (en) 2012-02-10 2020-01-21 University Of Maryland, Baltimore Chemoenzymatic glycoengineering of antibodies and fc fragments thereof
IL302494B2 (en) 2012-10-11 2024-11-01 Daiichi Sankyo Co Ltd Antibody-drug conjugates and methods for their preparation
AU2013358892B2 (en) 2012-12-13 2018-06-21 Aduro Biotech, Inc. Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
AU2013363087B2 (en) 2012-12-19 2018-07-19 Board Of Regents, The University Of Texas System Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway
CA2908154C (en) 2013-04-29 2023-11-28 Memorial Sloan Kettering Cancer Center Compositions and methods for altering second messenger signaling
DK2996473T3 (da) 2013-05-18 2019-11-04 Aduro Biotech Inc Sammensætninger og fremgangsmåder til aktivering af "stimulator af interferon-gen"-afhængig signalering
JP6400082B2 (ja) 2013-05-18 2018-10-03 アデュロ バイオテック，インコーポレイテッド 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を抑制するための組成物および方法
US9549944B2 (en) 2013-05-18 2017-01-24 Aduro Biotech, Inc. Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
EP3058083B1 (en) 2013-10-14 2018-04-11 SynAffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
JP2016538877A (ja) 2013-10-14 2016-12-15 シンアフィックス ビー．ブイ． 修飾糖タンパク質、タンパク質コンジュゲート及びそれらの調製方法
WO2015057065A1 (en) 2013-10-14 2015-04-23 Synaffix B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
JP2016538878A (ja) 2013-10-14 2016-12-15 シンアフィックス ビー．ブイ． 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法
EP3071229A4 (en) 2013-11-22 2017-05-10 Brock University Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants
CA2950033A1 (en) 2014-06-04 2015-12-10 Glaxosmithkline Intellectual Property Development Limited Cyclic di-nucleotides as modulators of sting
DE102014214408A1 (de) 2014-07-23 2016-01-28 Wacker Chemie Ag Härtbare Organopolysiloxanzusammensetzungen
PL3608403T3 (pl) 2014-12-15 2025-06-23 Henkel Ag & Co. Kgaa Kompozycja detergentowa zawierająca warianty subtylazy
US11559581B2 (en) 2015-01-09 2023-01-24 Oxford University Innovation Limited Antibody conjugates and methods of making the antibody conjugates
PE20171448A1 (es) 2015-03-10 2017-10-02 Aduro Biotech Inc Composiciones y metodos para activar la senalizacion dependiente del estimulador del gen de interferon
WO2016161372A1 (en) 2015-04-01 2016-10-06 President And Fellows Of Harvard College Immunoconjugates for programming or reprogramming of cells
WO2017002776A1 (ja) * 2015-06-29 2017-01-05 第一三共株式会社 抗体－薬物コンジュゲートの選択的製造方法
WO2017010559A1 (ja) 2015-07-16 2017-01-19 第一三共株式会社 新規ＥｎｄｏＳ変異酵素
EP3334742B1 (en) 2015-08-12 2019-05-08 H. Hoffnabb-La Roche Ag Bace1 inhibitors
US11453697B1 (en) 2015-08-13 2022-09-27 Merck Sharp & Dohme Llc Cyclic di-nucleotide compounds as sting agonists
TW201726700A (zh) 2015-10-28 2017-08-01 艾杜諾生物科技公司 用於活化「干擾素基因刺激子」依賴性訊號之組合物及方法
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
NZ738202A (en) 2015-12-03 2019-07-26 Glaxosmithkline Ip Dev Ltd Cyclic purine dinucleotides as modulators of sting
US20170158772A1 (en) 2015-12-07 2017-06-08 Opi Vi - Ip Holdco Llc Compositions of antibody construct - agonist conjugates and methods of use thereof
EP3386536A4 (en) 2015-12-07 2019-07-31 Opi Vi- IP Holdco LLC COMPOSITION OF ANTIBODY CONSTRUCT AGONIST CONJUGATES AND METHOD FOR USE THEREOF
US10723756B2 (en) 2016-01-11 2020-07-28 Innate Tumor Immunity Inc. Cyclic dinucleotides for treating conditions associated with STING activity such as cancer
HRP20251050T1 (hr) 2016-01-11 2025-11-07 Innate Tumor Immunity, Inc. Ciklični dinukleotidi za liječenje stanja povezanih s aktivnošću sting kao što je rak
CN109563081A (zh) 2016-04-07 2019-04-02 葛兰素史克知识产权开发有限公司 可用作蛋白调节剂的杂环酰胺类
AU2017246802B2 (en) 2016-04-07 2021-04-01 Chevron U.S.A. Inc. Smart gel sealants for well systems
US11486223B2 (en) 2016-04-07 2022-11-01 Chevron U.S.A. Inc. Method for sealing a void in a well using smart gels
SI3440076T1 (sl) 2016-04-07 2022-09-30 Glaxosmithkline Intellectual Property Development Limited Heterociklični amidi uporabni kot proteinski modulatorji
WO2018003983A1 (ja) 2016-07-01 2018-01-04 第一三共株式会社 ｈＡＮＰ－Ｆｃ含有分子コンジュゲート
WO2018009466A1 (en) 2016-07-05 2018-01-11 Aduro Biotech, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
MX392605B (es) 2016-07-06 2025-03-11 Invox Pharma Ltd Compuestos, composiciones y metodos para el tratamiento de enfermedades.
US20190345191A1 (en) 2016-08-31 2019-11-14 Innate Tumor Immunity, Inc. Cyclic dinucleotide analogs for treating conditions associated with sting (stimulator of interferon genes) activity
US10537590B2 (en) 2016-09-30 2020-01-21 Boehringer Ingelheim International Gmbh Cyclic dinucleotide compounds
GEP20217285B (en) 2016-10-04 2021-08-10 Merck Sharp & Dohme BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS
KR20190066026A (ko) * 2016-10-07 2019-06-12 다이이찌 산쿄 가부시키가이샤 항 her2 항체-약물 콘주게이트 투여에 의한 내성암의 치료
US11001605B2 (en) 2016-10-07 2021-05-11 Biolog Life Science Institute Gmbh & Co. Kg Cyclic dinucleotides containing benzimidazole, method for the production of same, and use of same to activate stimulator of interferon genes (sting)-dependent signaling pathways
JOP20170192A1 (ar) 2016-12-01 2019-01-30 Takeda Pharmaceuticals Co داي نوكليوتيد حلقي
WO2018118665A1 (en) * 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Cyclic dinucleotide sting agonists for cancer treatment
CA3049791A1 (en) 2017-01-27 2018-08-02 Silverback Therapeutics, Inc. Tumor targeting conjugates and methods of use thereof
TW202532103A (zh) 2017-05-15 2025-08-16 日商第一三共股份有限公司 抗體－藥物結合物及其用途
JP6967739B2 (ja) 2017-11-14 2021-11-17 パナソニックＩｐマネジメント株式会社 給湯機
PT3848054T (pt) * 2018-09-06 2025-04-03 Daiichi Sankyo Co Ltd Conjugados anticorpo-fármaco de derivados de dinucleótidos cíclicos

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018522914A (ja) 2015-08-13 2018-08-16 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド化合物
WO2017161349A1 (en) 2016-03-18 2017-09-21 Immune Sensor, Llc Cyclic di-nucleotide compounds and methods of use
JP2018090562A (ja) 2016-12-01 2018-06-14 武田薬品工業株式会社 環状ジヌクレオチド

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2021177438A1 (enExample) * 2020-03-06 2021-09-10

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