JP7207877B2 - ナットウキナーゼを含む食品 - Google Patents
ナットウキナーゼを含む食品 Download PDFInfo
- Publication number
- JP7207877B2 JP7207877B2 JP2018122371A JP2018122371A JP7207877B2 JP 7207877 B2 JP7207877 B2 JP 7207877B2 JP 2018122371 A JP2018122371 A JP 2018122371A JP 2018122371 A JP2018122371 A JP 2018122371A JP 7207877 B2 JP7207877 B2 JP 7207877B2
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- gelatin
- nattokinase
- food
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000013305 food Nutrition 0.000 title claims description 71
- 229940086319 nattokinase Drugs 0.000 title claims description 48
- 108010073682 nattokinase Proteins 0.000 title claims description 48
- 108010010803 Gelatin Proteins 0.000 claims description 80
- 239000008273 gelatin Substances 0.000 claims description 80
- 229920000159 gelatin Polymers 0.000 claims description 80
- 235000019322 gelatine Nutrition 0.000 claims description 80
- 235000011852 gelatine desserts Nutrition 0.000 claims description 80
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 38
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 25
- 238000000354 decomposition reaction Methods 0.000 claims description 24
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims description 21
- 239000011715 vitamin B12 Substances 0.000 claims description 21
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 claims description 20
- 239000002775 capsule Substances 0.000 claims description 17
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 16
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 16
- 229930003268 Vitamin C Natural products 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
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- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 15
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- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 8
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- GUMSHIGGVOJLBP-SLRPQMTOSA-N methyl hesperidin Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 GUMSHIGGVOJLBP-SLRPQMTOSA-N 0.000 claims description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 5
- 229960000304 folic acid Drugs 0.000 claims description 5
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- 235000019157 thiamine Nutrition 0.000 claims description 5
- 239000011721 thiamine Substances 0.000 claims description 5
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- 229960002104 cyanocobalamin Drugs 0.000 claims description 4
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 4
- 239000011666 cyanocobalamin Substances 0.000 claims description 4
- 235000010374 vitamin B1 Nutrition 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 239000011719 vitamin A Substances 0.000 claims description 2
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- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 description 5
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- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 4
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Landscapes
- General Preparation And Processing Of Foods (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
項1. (A)ナットウキナーゼ、(B)ゼラチン、並びに(C)ビタミンB1類、ビタミンB9類、ビタミンB12類、ビタミンP類、及びビタミンC類よりなる群から選択される少なくとも1種を含む、食品。
項2. 前記(C)成分が、チアミン、葉酸、シアノコバラミン、メチルヘスペリジン、及びこれらの塩よりなる群から選択される少なくとも1種である、項1に記載の食品。
項3. 前記(B)成分で形成されたカプセル皮膜を含むカプセル剤である、項1又は2に記載の食品。
項4. ナットウキナーゼ及びゼラチンを含む食品においてゼラチンの分解を抑制する方法であって、
食品に、(A)ナットウキナーゼ及び(B)ゼラチンと共に、(C)ビタミンB1類、ビタミンB9類、ビタミンB12類、ビタミンP類、及びビタミンC類よりなる群から選択される少なくとも1種を配合する、ゼラチンの分解抑制方法。
本発明の食品は、(A)ナットウキナーゼ、(B)ゼラチン、並びに(C)ビタミンB1類、ビタミンB9類、ビタミンB12類、ビタミンP類、及びビタミンC類よりなる群から選択される少なくとも1種を含むことを特徴とする。以下、本発明の食品について詳述する。
本発明の食品は、ナットウキナーゼ((A)成分と表記することもある)を含む。ナットウキナーゼとは、納豆菌が産生するフィブリン分解作用を有する酵素である。
本発明の食品は、ゼラチン((B)成分と表記することもある)を含む。ゼラチンとは、動物の皮、骨、腱等の主成分であるコラーゲンに熱を加え、抽出したものである。
本発明において、ゼラチンは、公知の製造方法で得られたものを使用でき、例えば、牛、豚、鶏、魚等の皮、骨、腱等を原料とし、酸又はアルカリで処理して得られる粗コラーゲンを加熱抽出して製造されたものを使用することができる。また、本発明で使用されるゼラチンは、加水分解物、酸素分解物、ゼラチン誘導体(例えば、アシル化ゼラチン等)等であってもよい。
本発明の食品は、ビタミンB1類、ビタミンB9類、ビタミンB12類、ビタミンP類、及びビタミンC類よりなる群から選択される少なくとも1種((C)成分と表記することもある)を含む。このように特定のビタミンを含むことにより、ナットウキナーゼによるゼラチンの分解を抑制することが可能になる。
(C)成分がビタミンB 1 類である場合:ビタミンB1類が、好ましくは0.2~50重量%、更に好ましくは1~30重量%、特に好ましくは5~20重量%。
(C)成分がビタミンB 9 類である場合:ビタミンB9類が、好ましくは5~50重量%、更に好ましくは10~30重量%、特に好ましくは15~25重量%。
(C)成分がビタミンB 12 類である場合:ビタミンB12類が、好ましくは0.001~50重量%、更に好ましくは0.005~30重量%、特に好ましくは0.01~20重量%。
(C)成分がビタミンP類である場合:ビタミンP類が、好ましくは3.5~50重量%、更に好ましくは7~20重量%、特に好ましくは10~15重量%。
(C)成分がビタミンC類である場合:ビタミンC類が、好ましくは
0.2~50重量%、更に好ましくは1~30重量%、特に好ましくは5~20重量%。
(C)成分がビタミンB 1 類である場合:(A)成分1000FUに対して、ビタミンB1類が好ましくは2.5~625mg、更に好ましくは12.5~375mg、特に好ましくは62.5~250mg。
(C)成分がビタミンB 9 類である場合:(A)成分1000FUに対して、ビタミンB9類が好ましくは62.5~625mg、更に好ましくは125~375mg、特に好ましくは187.5~312.5mg。
(C)成分がビタミンB 12 類である場合:(A)成分1000FUに対して、ビタミンB12類が好ましくは0.01~625mg、更に好ましくは0.06~250mg、特に好ましくは0.125~250mg。
(C)成分がビタミンP類である場合:(A)成分1000FUに対して、ビタミンP類が好ましくは43.8~625mg、更に好ましくは87.5~250mg、特に好ましくは125~187.5mg。
(C)成分がビタミンC類である場合:(A)成分1000FUに対して、ビタミンC類が好ましくは2.5~625mg、更に好ましくは12.5~375mg、特に好ましくは62.5~250mg。
本発明の食品は、前述する成分の他に、必要に応じて、他の栄養成分や機能性成分を含有していてもよい。このような栄養成分や機能性成分としては、食品に使用可能なものであることを限度として特に制限されないが、例えば、ビタミンB2類、ビタミンB6類、ビタミンA類、ビタミンD類、ビタミンE類、ビタミンK類、ナイアシン、パントテン酸、ビオチン、リコペン等のビタミン類;カテキン、テアフラビン、ロイコアントシアニジン、ペラルゴニジン、シアニジン、ペツニジン、ペオニジン、ペチュニジン、デルフィニジン、マルビジン、フラボン、アピゲニン、ルテオニン、アピゲニニジン、ルテリオニジン、バイカレイン、ケルセチン、ケンフェロール、ミリセチン、ナリジン、ヘスペリジン、リキリチゲニン、アルピノン、タキシフォリン、ゲニステイン、ダイゼイン、ダイジン、グリシテイン、エクオール、ビオカニンA、クメストロール、プエラリン、ホルモノネチン、カルタミン、プロレチン、没食子酸、フェノール酸、クロロゲン酸、エラグ酸、リグナン、セサミン、ピノレジノール、ラリシレジノール、セコイソラリシレジノール、マタイレジノール、クルクミン、クマリン、レスベラトロール、加水分解型タンニン等のポリフェノール;塩酸ベタイン、塩化カルニチン、塩化ベタネコール等の健胃剤;カルシウム、イオウ、マグネシウム、亜鉛、セレン、鉄等のミネラル類;大豆タンパク、卵白粉末、乳清タンパク、サーデンペプチド等のタンパク質・ペプチド;グリシン、アラニン、アルギニン、アスパラギン酸、シスチン、フェニルアラニン、タウリン、トリプトファン等のアミノ酸;リノール酸、γ-リノレン酸、α-リノレン酸等の脂肪酸類;カラメル色素、クチナシ色素、アントシアニン色素、アナトー色素、パプリカ色素、紅花色素、紅麹色素、フラボノイド色素、コチニール色素、アマランス、エリスロシン、アルラレッドAC、ニューコクシン、フロキシン、ローズベンガル、アシッドレッド、タートラジン、サンセットイエローFCF、ファストグリーンFCF、ブリリアントブルーFCF、インジゴカルミン等の色素;各種フルーツのフレーバーやエッセンス等の香料;クエン酸及びその塩、リンゴ酸及びその塩、酒石酸及びその塩、酢酸及びその塩、乳酸及びその塩、食塩、グルタミン酸及びその塩、みりん、食酢、天然果汁、植物抽出エキス、果実・海産物等の裁断物又は粉末化物等の調味剤;アガリクス、シイタケエキス、レイシ、ヤマブシタケ等のキノコ類又はそのエキス;食物繊維、ローヤルゼリー、プロポリス、ハチミツ、コンドロイチン硫酸、グルコサミン、セラミド、ヒアルロン酸等のその他機能性素材等が挙げられる。これらの成分は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。また、これらの成分の含有量については、使用する成分の種類や食品の形態等に応じて適宜設定される。
本発明の食品は、固体状、半固体状、又は液体状のいずれであってもよい。
本発明の分解抑制方法は、ナットウキナーゼ及びゼラチンを含む食品においてゼラチンの分解を抑制する方法であって、食品に、(A)ナットウキナーゼ及び(B)ゼラチンと共に、(C)ビタミンB1類、ビタミンB9類、ビタミンB12類、ビタミンP類、及びビタミンC類よりなる群から選択される少なくとも1種を配合することを特徴とする。
ナットウキナーゼ粉末:商品名「納豆菌培養エキス NSK-SD40」、株式会社日本生物.科学研究所製
チアミン塩酸塩:商品名「チアミン塩酸塩」、DSMニュートリションジャパン株式会社製
ビタミンB 9 :商品名「葉酸」、DSMニュートリションジャパン株式会社製
ビタミンB 12 :商品名「ビタミンB12 1000倍散」、BASFジャパン株式会社製
メチルヘスペリジン:商品名「αGヘスペリジンPA-T」、東洋製糖株式会社製
アルギニン:商品名「L-アルギニン」、協和発酵バイオ株式会社製
リジン:商品名「食品添加物 L-リジン塩酸塩」、味の素株式会社製
シトルリン:商品名「発酵シトルリン協和」、協和発酵バイオ株式会社製
難消化性デキストリン:商品名「ファイバーソル2AG」、松谷化学工業株式会社製
ルチン:商品名「αGルチンP」、東洋製糖株式会社製
ゼラチンプレートを作成し、各種成分存在下で、当該ゼラチンプレートに対するナットウキナーゼの分解作用について評価した。具体的な試験方法及び結果は、以下の通りである。
1-1.ゼラチンプレートの作成
先ず、精製水を50℃に加温し、ゼラチンを20重量%、メチルパラベン(防腐剤)を0.2重量%となるように添加して混合し、ゼラチン溶液を調製した。得られたゼラチン溶液10gをシャーレ(内径9cm)に広げ、シャーレ内のゼラチンの厚みを均一にした後に、4℃で1時間以上冷却し、ゼラチンをゲル化させ、シャーレ内にゼラチンプレート形成させた。
表1及び2に示す組成の試験液を調製し、各試験液0.5mlをシャーレ内のゼラチンプレートに滴下し、シャーレに蓋をした状態で室温で一晩静置した。その後、ゼラチンプレートの外観を目視にて確認し、以下の判定基準に従って、ゼラチンの分解耐性を評価した。
<ゼラチンの分解耐性の判定基準>
0:ゼラチンプレートが全く溶解していない。
1:ゼラチンプレートが僅かに溶解している。
2:ゼラチンプレートが少し溶解しており滴下していない部分との差が明らか。
3:ゼラチンプレートの厚さ半分程度が溶解している。
4:ゼラチンプレートの大部分が溶解しており一部シャーレの底が露出する。
5:ゼラチンプレートが完全に溶解しシャーレの底が完全に露出している。
得られた結果を表1及び2に示す。ナットウキナーゼのみを含む試験液を使用した場合には、ゼラチンプレートは完全に分解されていた(比較例1)。また、ナットウキナーゼと共に、アルギニン、リジン、シトルリン、難消化性デキストリン、又はルチンを含む試験液を使用した場合でも、ゼラチンプレートの分解は全く抑制できていなかった(比較例2~6)。これに対して、ナットウキナーゼと共に、チアミン塩酸塩、ビタミンB9、ビタミンB12、又はビタミンPを含む試験液を使用した場合には、ゼラチンプレートの分解を十分に抑制できていた(実施例1~7)。とりわけ、ビタミンB12は、極めて低濃度であっても、ナットウキナーゼによるゼラチンプレートの分解を十分に抑制できており、ゼラチンの分解に対する抑制効果が顕著に奏されていた(実施例5及び6)。
表3に示す組成の内容液、及び表4に示す組成の剤皮(カプセル皮膜)を用いて、ソフトカプセル剤(1剤当り、内容液300mg、剤皮150mg含有)を製造した。
表5に示す組成の錠剤(1錠当たり700mg)を製造した。
表6に示す組成の顆粒剤を製造した。
Claims (4)
- (A)ナットウキナーゼ、(B)ゼラチン、並びに(C)ビタミンB1類、ビタミンB9類、ビタミンB12類、ビタミンP類、及びビタミンC類よりなる群から選択される少なくとも1種を含む、食品(但し、納豆自体を含む場合;乳酸菌末、紅麹末及びビフィズス菌末を含む場合;並びにイチョウ葉エキス、DHA、及びEPAを含む場合を除く)。
- 前記(C)成分が、チアミン、葉酸、シアノコバラミン、メチルヘスペリジン、及びこれらの塩よりなる群から選択される少なくとも1種である、請求項1に記載の食品。
- 前記(B)成分で形成されたカプセル皮膜を含むカプセル剤である、請求項1又は2に記載の食品。
- ナットウキナーゼ及びゼラチンを含む食品においてゼラチンの分解を抑制する方法であって、
食品(但し、乳酸菌末、紅麹末及びビフィズス菌末を含む場合;並びにイチョウ葉エキス、DHA、及びEPAを含む場合を除く)に、(A)ナットウキナーゼ及び(B)ゼラチンと共に、(C)ビタミンB1類、ビタミンB9類、ビタミンB12類、ビタミンP類、及びビタミンC類よりなる群から選択される少なくとも1種を配合する、ゼラチンの分解抑制方法。
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