JP7199739B2 - Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 - Google Patents

Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 Download PDF

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JP7199739B2
JP7199739B2 JP2020517339A JP2020517339A JP7199739B2 JP 7199739 B2 JP7199739 B2 JP 7199739B2 JP 2020517339 A JP2020517339 A JP 2020517339A JP 2020517339 A JP2020517339 A JP 2020517339A JP 7199739 B2 JP7199739 B2 JP 7199739B2
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compound
salt
xrpd
exhibits
peaks
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JP2021504297A (ja
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オリバー，ネルソン，ビー．
レディー，キラン
ボテラ，ガブリエル，マルティネス
ロン，マグナス
ラスカー，ポール，エイ．
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Praxis Precision Medicines Inc
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Praxis Precision Medicines Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
JP2020517339A 2018-08-31 2019-08-30 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 Active JP7199739B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022199092A JP2023036708A (ja) 2018-08-31 2022-12-14 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態
JP2024174009A JP2025020120A (ja) 2018-08-31 2024-10-03 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862725805P 2018-08-31 2018-08-31
US62/725,805 2018-08-31
US16/517,369 2019-07-19
US16/517,369 US10562930B1 (en) 2018-08-31 2019-07-19 Salts and crystal forms of GABAA positive allosteric modulator
PCT/US2019/049103 WO2020047434A1 (en) 2018-08-31 2019-08-30 Salts and crystal forms of gabaa positive allosteric modulator

Related Child Applications (1)

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JP2022199092A Division JP2023036708A (ja) 2018-08-31 2022-12-14 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態

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JP2021504297A JP2021504297A (ja) 2021-02-15
JP7199739B2 true JP7199739B2 (ja) 2023-01-06

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JP2020517339A Active JP7199739B2 (ja) 2018-08-31 2019-08-30 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態
JP2022199092A Pending JP2023036708A (ja) 2018-08-31 2022-12-14 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態
JP2024174009A Pending JP2025020120A (ja) 2018-08-31 2024-10-03 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態

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JP2022199092A Pending JP2023036708A (ja) 2018-08-31 2022-12-14 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態
JP2024174009A Pending JP2025020120A (ja) 2018-08-31 2024-10-03 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態

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US (4) US10562930B1 (enExample)
EP (2) EP3710465B1 (enExample)
JP (3) JP7199739B2 (enExample)
KR (1) KR102845326B1 (enExample)
CN (1) CN113473991A (enExample)
AU (1) AU2019333310B8 (enExample)
BR (1) BR112021003727A2 (enExample)
CA (1) CA3111193A1 (enExample)
IL (1) IL281143B2 (enExample)
MA (1) MA50921A (enExample)
MX (1) MX2021002382A (enExample)
TW (2) TWI850138B (enExample)
WO (1) WO2020047434A1 (enExample)

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WO2022231309A1 (ko) 2021-04-27 2022-11-03 경북대학교 산학협력단 저분자 콜라겐을 유효성분으로 포함하는 근감소증의 예방 또는 개선용 식품 조성물 및 약학적 조성물
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US10562930B1 (en) 2020-02-18
AU2019333310A8 (en) 2025-04-17
EP4458357A2 (en) 2024-11-06
IL281143B1 (en) 2024-12-01
WO2020047434A1 (en) 2020-03-05
US20240140985A1 (en) 2024-05-02
US20200071350A1 (en) 2020-03-05
KR102845326B1 (ko) 2025-08-12
MX2021002382A (es) 2021-08-11
EP3710465B1 (en) 2024-08-14
US20200255471A1 (en) 2020-08-13
EP3710465A4 (en) 2020-09-23
JP2025020120A (ja) 2025-02-12
TWI823999B (zh) 2023-12-01
JP2021504297A (ja) 2021-02-15
EP3710465A1 (en) 2020-09-23
AU2019333310B2 (en) 2024-11-21
MA50921A (fr) 2020-09-23
IL281143A (en) 2021-04-29
CN113473991A (zh) 2021-10-01
BR112021003727A2 (pt) 2021-05-25
EP4458357A3 (en) 2024-12-18
US10927141B2 (en) 2021-02-23
IL281143B2 (en) 2025-04-01
KR20210054546A (ko) 2021-05-13
JP2023036708A (ja) 2023-03-14
AU2019333310B8 (en) 2025-04-17
TW202408461A (zh) 2024-03-01
US20220024967A1 (en) 2022-01-27
AU2019333310A1 (en) 2021-04-08
TW202024108A (zh) 2020-07-01
US12404297B2 (en) 2025-09-02
CA3111193A1 (en) 2020-03-05
TWI850138B (zh) 2024-07-21

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