JP7199739B2 - Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 - Google Patents

Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 Download PDF

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JP7199739B2
JP7199739B2 JP2020517339A JP2020517339A JP7199739B2 JP 7199739 B2 JP7199739 B2 JP 7199739B2 JP 2020517339 A JP2020517339 A JP 2020517339A JP 2020517339 A JP2020517339 A JP 2020517339A JP 7199739 B2 JP7199739 B2 JP 7199739B2
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compound
salt
xrpd
exhibits
peaks
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JP2021504297A (ja
Inventor
オリバー，ネルソン，ビー．
レディー，キラン
ボテラ，ガブリエル，マルティネス
ロン，マグナス
ラスカー，ポール，エイ．
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Praxis Precision Medicines Inc
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Praxis Precision Medicines Inc
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Priority to JP2024174009A priority patent/JP2025020120A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
JP2020517339A 2018-08-31 2019-08-30 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 Active JP7199739B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022199092A JP2023036708A (ja) 2018-08-31 2022-12-14 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態
JP2024174009A JP2025020120A (ja) 2018-08-31 2024-10-03 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862725805P 2018-08-31 2018-08-31
US62/725,805 2018-08-31
US16/517,369 US10562930B1 (en) 2018-08-31 2019-07-19 Salts and crystal forms of GABAA positive allosteric modulator
US16/517,369 2019-07-19
PCT/US2019/049103 WO2020047434A1 (en) 2018-08-31 2019-08-30 Salts and crystal forms of gabaa positive allosteric modulator

Related Child Applications (1)

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JP2022199092A Division JP2023036708A (ja) 2018-08-31 2022-12-14 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態

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JP2021504297A JP2021504297A (ja) 2021-02-15
JP7199739B2 true JP7199739B2 (ja) 2023-01-06

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JP2020517339A Active JP7199739B2 (ja) 2018-08-31 2019-08-30 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態
JP2022199092A Pending JP2023036708A (ja) 2018-08-31 2022-12-14 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態
JP2024174009A Pending JP2025020120A (ja) 2018-08-31 2024-10-03 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態

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JP2022199092A Pending JP2023036708A (ja) 2018-08-31 2022-12-14 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態
JP2024174009A Pending JP2025020120A (ja) 2018-08-31 2024-10-03 Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態

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US (4) US10562930B1 (enExample)
EP (2) EP4458357B1 (enExample)
JP (3) JP7199739B2 (enExample)
KR (1) KR102845326B1 (enExample)
CN (2) CN113473991B (enExample)
AU (1) AU2019333310B8 (enExample)
BR (1) BR112021003727A2 (enExample)
CA (1) CA3111193A1 (enExample)
IL (1) IL281143B2 (enExample)
MA (1) MA50921A (enExample)
MX (1) MX2021002382A (enExample)
TW (2) TWI823999B (enExample)
WO (1) WO2020047434A1 (enExample)

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CN115551514A (zh) 2020-03-25 2022-12-30 萨奇治疗股份有限公司 用于治疗呼吸系统病症的药物的用途
WO2022006541A1 (en) * 2020-07-02 2022-01-06 Praxis Precision Medicines, Inc. Methods for the treatment of adjustment disorder
WO2022177718A1 (en) 2021-02-18 2022-08-25 Sage Therapeutics, Inc. Use of neuroactive steroid for treatment of sexual dysfunction
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US20240207366A1 (en) 2021-04-27 2024-06-27 Kyungpook National University Industry-Academic Cooperation Foundation Food composition and pharmaceutical composition for preventing or alleviating sarcopenia, containing low-molecular-weight collagen as active ingredient
WO2023159035A1 (en) 2022-02-16 2023-08-24 Sage Therapeutics, Inc. Neuroactive steroids for treatment of cns-related disorders
US20250170148A1 (en) * 2022-02-28 2025-05-29 Sage Therapeutics, Inc. Neuroactive steroids for treatment of gastrointestinal diseases or conditions
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CN113473991B (zh) 2025-12-26
EP4458357A2 (en) 2024-11-06
IL281143B1 (en) 2024-12-01
TWI850138B (zh) 2024-07-21
AU2019333310B8 (en) 2025-04-17
JP2025020120A (ja) 2025-02-12
JP2021504297A (ja) 2021-02-15
US10562930B1 (en) 2020-02-18
CA3111193A1 (en) 2020-03-05
CN113473991A (zh) 2021-10-01
AU2019333310B2 (en) 2024-11-21
AU2019333310A1 (en) 2021-04-08
US20220024967A1 (en) 2022-01-27
US20200255471A1 (en) 2020-08-13
EP4458357B1 (en) 2026-08-19
EP3710465A4 (en) 2020-09-23
US12404297B2 (en) 2025-09-02
KR102845326B1 (ko) 2025-08-12
US10927141B2 (en) 2021-02-23
EP3710465B1 (en) 2024-08-14
CN122103232A (zh) 2026-05-29
KR20210054546A (ko) 2021-05-13
TW202408461A (zh) 2024-03-01
US20240140985A1 (en) 2024-05-02
TWI823999B (zh) 2023-12-01
EP3710465A1 (en) 2020-09-23
MX2021002382A (es) 2021-08-11
WO2020047434A1 (en) 2020-03-05
TW202024108A (zh) 2020-07-01
US20200071350A1 (en) 2020-03-05
AU2019333310A8 (en) 2025-04-17
IL281143A (en) 2021-04-29
IL281143B2 (en) 2025-04-01
BR112021003727A2 (pt) 2021-05-25
MA50921A (fr) 2020-09-23
JP2023036708A (ja) 2023-03-14
EP4458357A3 (en) 2024-12-18

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