JP7194128B2 - 固形腫瘍の診断用のバイオマーカーの絶対定量の方法および装置 - Google Patents

固形腫瘍の診断用のバイオマーカーの絶対定量の方法および装置 Download PDF

Info

Publication number
JP7194128B2
JP7194128B2 JP2019571981A JP2019571981A JP7194128B2 JP 7194128 B2 JP7194128 B2 JP 7194128B2 JP 2019571981 A JP2019571981 A JP 2019571981A JP 2019571981 A JP2019571981 A JP 2019571981A JP 7194128 B2 JP7194128 B2 JP 7194128B2
Authority
JP
Japan
Prior art keywords
marker
ffpe
analysis
quantitative
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019571981A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020526747A (ja
JP2020526747A5 (enExample
Inventor
ジャンディ チャン
Original Assignee
イェンタイ クワンティシジョン ディアグノスティックス インク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イェンタイ クワンティシジョン ディアグノスティックス インク filed Critical イェンタイ クワンティシジョン ディアグノスティックス インク
Publication of JP2020526747A publication Critical patent/JP2020526747A/ja
Publication of JP2020526747A5 publication Critical patent/JP2020526747A5/ja
Application granted granted Critical
Publication of JP7194128B2 publication Critical patent/JP7194128B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2019571981A 2017-06-29 2018-06-28 固形腫瘍の診断用のバイオマーカーの絶対定量の方法および装置 Active JP7194128B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762526425P 2017-06-29 2017-06-29
US62/526,425 2017-06-29
PCT/US2018/040075 WO2019006156A1 (en) 2017-06-29 2018-06-28 APPARATUS AND METHOD FOR ABSOLUTE QUANTIFICATION OF BIOMARKERS FOR SOLID TUMOR DIAGNOSIS

Publications (3)

Publication Number Publication Date
JP2020526747A JP2020526747A (ja) 2020-08-31
JP2020526747A5 JP2020526747A5 (enExample) 2020-11-12
JP7194128B2 true JP7194128B2 (ja) 2022-12-21

Family

ID=64734814

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019571981A Active JP7194128B2 (ja) 2017-06-29 2018-06-28 固形腫瘍の診断用のバイオマーカーの絶対定量の方法および装置

Country Status (8)

Country Link
US (2) US10788484B2 (enExample)
EP (1) EP3646328A4 (enExample)
JP (1) JP7194128B2 (enExample)
KR (1) KR102502745B1 (enExample)
CN (1) CN110753845B (enExample)
CA (1) CA3101968A1 (enExample)
SG (1) SG11201908865WA (enExample)
WO (1) WO2019006156A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX357763B (es) 2013-10-18 2018-07-23 Univ Health Network Tratamiento para cancer pancreatico.
SG11201808629UA (en) * 2016-04-21 2018-11-29 Immatics Biotechnologies Gmbh Immunotherapy against melanoma and other cancers
DE102016209871A1 (de) 2016-06-06 2017-12-07 Robert Bosch Gmbh Stanzvorrichtung und Verfahren zum Stanzen eines Lumens und Implantieren einer Implantateinrichtung
DE102018201030B4 (de) * 2018-01-24 2025-10-16 Kardion Gmbh Magnetkuppelelement mit magnetischer Lagerungsfunktion
DE102018206750A1 (de) 2018-05-02 2019-11-07 Kardion Gmbh Vorrichtung zur induktiven Energieübertragung in einen menschlichen Körper und deren Verwendung
DE102018206754A1 (de) 2018-05-02 2019-11-07 Kardion Gmbh Verfahren und Vorrichtung zur Bestimmung der Temperatur an einer Oberfläche sowie Verwendung des Verfahrens
DE102018206725A1 (de) 2018-05-02 2019-11-07 Kardion Gmbh Empfangseinheit, Sendeeinheit, Energieübertragungssystem und Verfahren zur drahtlosen Energieübertragung
DE102018206727A1 (de) 2018-05-02 2019-11-07 Kardion Gmbh Energieübertragungssystem und Empfangseinheit zur drahtlosen transkutanen Energieübertragung
DE102018206724A1 (de) 2018-05-02 2019-11-07 Kardion Gmbh Energieübertragungssystem und Verfahren zur drahtlosen Energieübertragung
DE102018206731A1 (de) 2018-05-02 2019-11-07 Kardion Gmbh Vorrichtung zur induktiven Energieübertragung in einen menschlichen Körper und Verwendung der Vorrichtung
DE102018207611A1 (de) 2018-05-16 2019-11-21 Kardion Gmbh Rotorlagerungssystem
DE102018207575A1 (de) 2018-05-16 2019-11-21 Kardion Gmbh Magnetische Stirndreh-Kupplung zur Übertragung von Drehmomenten
DE102018208539A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Motorgehäusemodul zum Abdichten eines Motorraums eines Motors eines Herzunterstützungssystems und Herzunterstützungssystem und Verfahren zum Montieren eines Herzunterstützungssystems
DE102018208538A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Intravasale Blutpumpe und Verfahren zur Herstellung von elektrischen Leiterbahnen
DE102018208541A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Axialpumpe für ein Herzunterstützungssystem und Verfahren zum Herstellen einer Axialpumpe für ein Herzunterstützungssystem
DE102018208549A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Elektronikmodul für ein Herzunterstützungssystem und Verfahren zum Herstellen eines Elektronikmoduls für ein Herzunterstützungssystem
DE102018208550A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Leitungsvorrichtung zum Leiten eines Blutstroms für ein Herzunterstützungssystem, Herzunterstützungssystem und Verfahren zum Herstellen einer Leitungsvorrichtung
DE102018208555A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Vorrichtung zum Verankern eines Herzunterstützungssystems in einem Blutgefäß, Verfahren zum Betreiben und Herstellverfahren zum Herstellen einer Vorrichtung und Herzunterstützungssystem
DE102018210076A1 (de) 2018-06-21 2019-12-24 Kardion Gmbh Verfahren und Vorrichtung zum Erkennen eines Verschleißzustands eines Herzunterstützungssystems, Verfahren und Vorrichtung zum Betreiben eines Herzunterstützungssystems und Herzunterstützungssystem
DE102018210058A1 (de) 2018-06-21 2019-12-24 Kardion Gmbh Statorschaufelvorrichtung zur Strömungsführung eines aus einer Austrittsöffnung eines Herzunterstützungssystems ausströmenden Fluids, Herzunterstützungssystem mit Statorschaufelvorrichtung, Verfahren zum Betreiben einer Statorschaufelvorrichtung und Herstellverfahren
EP3818496A4 (en) * 2018-07-02 2022-04-20 Tempus Labs, Inc. 3D RADIOMICS PLATFORM FOR IMAGING BIOMARKER DEVELOPMENT
DE102018211297A1 (de) 2018-07-09 2020-01-09 Kardion Gmbh Herzunterstützungssystem und Verfahren zur Überwachung der Integrität einer Haltestruktur eines Herzunterstützungssystems
DE102018211327A1 (de) 2018-07-10 2020-01-16 Kardion Gmbh Laufrad für ein implantierbares, vaskuläres Unterstützungssystem
DE102018211328A1 (de) 2018-07-10 2020-01-16 Kardion Gmbh Laufradgehäuse für ein implantierbares, vaskuläres Unterstützungssystem
DE102018212153A1 (de) 2018-07-20 2020-01-23 Kardion Gmbh Zulaufleitung für eine Pumpeneinheit eines Herzunterstützungssystems, Herzunterstützungssystem und Verfahren zum Herstellen einer Zulaufleitung für eine Pumpeneinheit eines Herzunterstützungssystems
AU2019320533B2 (en) 2018-08-07 2024-11-21 Kardion Gmbh Bearing device for a cardiac support system, and method for flushing an intermediate space in a bearing device for a cardiac support system
CN114631027A (zh) * 2019-11-01 2022-06-14 烟台康体诊医疗科技有限公司 基于定量生物标志物的癌症诊断方法及其数据库
AU2021207312A1 (en) * 2020-01-17 2022-06-30 Universität Zürich Single cell pathology analysis of tumour samples
DE102020102474A1 (de) 2020-01-31 2021-08-05 Kardion Gmbh Pumpe zum Fördern eines Fluids und Verfahren zum Herstellen einer Pumpe
US11699551B2 (en) 2020-11-05 2023-07-11 Kardion Gmbh Device for inductive energy transmission in a human body and use of the device

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011948A1 (ja) 2002-07-25 2004-02-05 Ajinomoto Co., Inc. タンパク質の分析方法
JP2008541115A (ja) 2005-05-19 2008-11-20 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング ホルマリン固定組織からのタンパク質の定量的測定
JP2009538436A (ja) 2006-05-26 2009-11-05 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム 逆相プロテインアレイ、タンパク質活性化及び発現のサイン並びに関連する方法
JP2009540319A (ja) 2006-06-13 2009-11-19 アストラゼネカ ユーケー リミテッド 質量分析バイオマーカーアッセイ
JP2013099253A (ja) 2010-03-11 2013-05-23 Intec Systems Institute Inc 肺癌または子宮頸癌の診断マーカー
JP2014025946A (ja) 2006-12-21 2014-02-06 Ajinomoto Co Inc 癌の評価方法、ならびに癌評価装置、癌評価方法、癌評価システム、癌評価プログラムおよび記録媒体
JP2015500487A (ja) 2012-01-06 2015-01-05 チャン ジャンディJIANDI, Zhang タンパク質含有量の測定方法
WO2016188132A1 (en) 2015-05-26 2016-12-01 Yantai Zestern Biotechnique Co., Ltd Multi-unit plate for immunoblot analysis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60200248T2 (de) * 2002-08-01 2005-01-27 Mtm Laboratories Ag Verfahren für Lösung-basierte Diagnose
US8771962B2 (en) * 2008-10-02 2014-07-08 Sarka O. Southern Health test for a broad spectrum of health problems
EP2239675A1 (en) 2009-04-07 2010-10-13 BIOCRATES Life Sciences AG Method for in vitro diagnosing a complex disease
PT2714926E (pt) * 2011-05-25 2015-11-03 Novartis Ag Biomarcadores para o cancro do pulmão
WO2016172216A1 (en) * 2015-04-20 2016-10-27 The Methodist Hospital Use of soluble crkl compositions as breast cancer biomarkers and predictors of cancer metastasis
IL294138A (en) * 2015-05-29 2022-08-01 Genentech Inc Therapeutic and diagnostic methods for cancer
EP3465200A4 (en) * 2016-06-05 2020-07-08 Berg LLC PATIENT STRATIFICATION SYSTEMS AND METHODS AND IDENTIFICATION OF POTENTIAL BIOMARKERS

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011948A1 (ja) 2002-07-25 2004-02-05 Ajinomoto Co., Inc. タンパク質の分析方法
JP2008541115A (ja) 2005-05-19 2008-11-20 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング ホルマリン固定組織からのタンパク質の定量的測定
JP2009538436A (ja) 2006-05-26 2009-11-05 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム 逆相プロテインアレイ、タンパク質活性化及び発現のサイン並びに関連する方法
JP2009540319A (ja) 2006-06-13 2009-11-19 アストラゼネカ ユーケー リミテッド 質量分析バイオマーカーアッセイ
JP2014025946A (ja) 2006-12-21 2014-02-06 Ajinomoto Co Inc 癌の評価方法、ならびに癌評価装置、癌評価方法、癌評価システム、癌評価プログラムおよび記録媒体
JP2013099253A (ja) 2010-03-11 2013-05-23 Intec Systems Institute Inc 肺癌または子宮頸癌の診断マーカー
JP2015500487A (ja) 2012-01-06 2015-01-05 チャン ジャンディJIANDI, Zhang タンパク質含有量の測定方法
WO2016188132A1 (en) 2015-05-26 2016-12-01 Yantai Zestern Biotechnique Co., Ltd Multi-unit plate for immunoblot analysis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
PUTRA, S. E. D. et al.，Dealing with large sample sizes: comparison of a new one spot dot blot method to western blot，Clinical Laboratory，2014年，vol.60，pp.1871-1877
TIAN, G. et al.，Quantitative dot blot analysis (QDB), a versatile high throughput immunoblot method，Oncotarget，2017年，Vol.8, No.35，pp.58553-58526
TORRES, J. M. et al.，Immunoglobulin G in 1・6 Million-year-old Fossil Bones from Venta Micena (Granada, Spain)，Journal of Archaeological Science，2002年02月，Vol.29, No.2，pp.167-175
WULFKUHLE, J. D. et al.，Molecular Analysis of HER2 Signaling in Human Breast Cancer by Functional Protein Pathway Activation Mapping，Clinical Cancer Research，2012年10月08日，Vol.18, No.23，pp.6426-6435

Also Published As

Publication number Publication date
CA3101968A1 (en) 2019-01-03
KR20200020906A (ko) 2020-02-26
US20190004037A1 (en) 2019-01-03
SG11201908865WA (en) 2019-10-30
EP3646328A4 (en) 2021-04-21
EP3646328A1 (en) 2020-05-06
US20210011010A1 (en) 2021-01-14
JP2020526747A (ja) 2020-08-31
CN110753845A (zh) 2020-02-04
WO2019006156A1 (en) 2019-01-03
US10788484B2 (en) 2020-09-29
KR102502745B1 (ko) 2023-02-23
CN110753845B (zh) 2023-08-22

Similar Documents

Publication Publication Date Title
JP7194128B2 (ja) 固形腫瘍の診断用のバイオマーカーの絶対定量の方法および装置
Brennan et al. Antibody-based proteomics: fast-tracking molecular diagnostics in oncology
Caron et al. Cancer immunomics using autoantibody signatures for biomarker discovery
US20180120319A1 (en) Methods for diagnosis and prognosis of epithelial cancers
US20160299145A1 (en) Methods and Kits for Detecting Prostate Cancer Biomarkers
JP2016035475A (ja) 比に基づく生体マーカーおよびそれを使用する方法
US20120295814A1 (en) CA-125 Immune Complexes as Biomarkers of Ovarian Cancer
JP6104796B2 (ja) 方法、アレイ、およびこれらの使用
EP3861348A1 (en) Biomarker combinations for determining aggressive prostate cancer
CN109975549B (zh) 肿瘤来源IgG在胰腺癌诊断或预后中的用途
JP6760666B2 (ja) 前立腺疾患のためのバイオマーカーの組み合わせ
WO2009017475A1 (en) Methods for diagnosis and prognosis of epithelial cancers
Moelans et al. Validation of a fully automated HER2 staining kit in breast cancer
Sarli et al. Relationship study of the verified human epidermal growth factor receptor 2 amplification with other tumor markers and clinicohistopathological characteristics in patients with invasive breast cancer, using chromogenic in situ hybridization
US11791043B2 (en) Methods of prognosing early stage breast lesions
CN114660289A (zh) 肝癌标志物及其应用
JP5130465B2 (ja) 肝細胞癌マーカー及び肝細胞癌の検査方法
CN111208304B (zh) 肿瘤来源IgG在甲状旁腺癌诊断和预后中的用途
Bogen et al. Recent trends and advances in immunodiagnostics of solid tumors
KR102128251B1 (ko) 아르기닌이 메틸화된 drd2에 특이적으로 결합하는 대장암 진단용 바이오마커 조성물
WO2025049926A1 (en) Methods of selecting treatment options for cancer
Pan et al. Translation Research of Novel Biomarker
CN117616280A (zh) 预测癌症复发
WO2023193109A1 (en) Biomarkers for the determination of sample adequacy and lung cancer metastases
Iweala et al. Scientific African

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200918

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200918

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20210527

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20210527

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210831

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210907

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20211206

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220114

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220607

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220829

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20221122

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20221209

R150 Certificate of patent or registration of utility model

Ref document number: 7194128

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250