JP7161940B2 - がんの治療のための、補体不活性化に耐性のエンベロープウイルス - Google Patents

がんの治療のための、補体不活性化に耐性のエンベロープウイルス Download PDF

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JP7161940B2
JP7161940B2 JP2018564966A JP2018564966A JP7161940B2 JP 7161940 B2 JP7161940 B2 JP 7161940B2 JP 2018564966 A JP2018564966 A JP 2018564966A JP 2018564966 A JP2018564966 A JP 2018564966A JP 7161940 B2 JP7161940 B2 JP 7161940B2
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fusion protein
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ティアンチ ルオ
ルネ モリーナ
ガブリエル カスティーユ
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Wellstat ImmunoTherapeutics LLC
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JP2018564966A 2017-05-10 2018-05-10 がんの治療のための、補体不活性化に耐性のエンベロープウイルス Active JP7161940B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762504120P 2017-05-10 2017-05-10
US62/504,120 2017-05-10
PCT/US2018/032018 WO2018209052A1 (en) 2017-05-10 2018-05-10 Enveloped virus resistant to complement inactivation for the treatment of cancer

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JP2020519230A JP2020519230A (ja) 2020-07-02
JP2020519230A5 JP2020519230A5 (https=) 2021-05-20
JP7161940B2 true JP7161940B2 (ja) 2022-10-27

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US (2) US11274141B2 (https=)
EP (1) EP3621635A4 (https=)
JP (1) JP7161940B2 (https=)
KR (3) KR20250118857A (https=)
CN (3) CN121343934A (https=)
AU (1) AU2018265258B2 (https=)
BR (1) BR112018075281A2 (https=)
CA (1) CA3026892A1 (https=)
IL (1) IL263979B2 (https=)
MX (1) MX2018015599A (https=)
NZ (1) NZ748798A (https=)
WO (1) WO2018209052A1 (https=)
ZA (1) ZA201808040B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3596108A4 (en) 2017-03-15 2020-12-23 Pandion Operations, Inc. TARGETED IMMUNOTOLERANCE
US10676516B2 (en) 2017-05-24 2020-06-09 Pandion Therapeutics, Inc. Targeted immunotolerance
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
CN112759654A (zh) * 2019-11-06 2021-05-07 深圳普菲科生命科技有限公司 一种病毒囊膜蛋白装配系统及其方法和应用
EP4107187A4 (en) 2020-02-21 2024-07-03 Pandion Operations, Inc. TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR
US20240067936A1 (en) * 2021-02-26 2024-02-29 Sillajen, Inc. Oncolytic virus and uses thereof
CN113736810B (zh) * 2021-09-08 2024-05-24 苏州因特药物研发有限公司 构建体、载体、蛋白、细胞、制备方法、产品及应用
KR20240003051A (ko) * 2022-06-29 2024-01-08 신라젠(주) Cd55 및 cd59를 동시 발현하는 항암 바이러스
KR20240035360A (ko) * 2022-09-07 2024-03-15 신라젠(주) 항암 바이러스의 신규 용도

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002509695A (ja) 1997-11-21 2002-04-02 ゲセルシャフト フュア バイオテクノロギッシェフォーシュング エムベーハー（ゲーベーエフ） 一本鎖ｄｎａ又は二本鎖ｄｎａ、コード化融合タンパク質，ウイルス，パッケージング細胞及びこれらの使用ヒト補体システムによる不活化に耐えるウイルスの開発
JP2008507272A (ja) 2004-07-21 2008-03-13 ダナ−ファーバー キャンサー インスティチュート，インコーポレイテッド レンチウイルスベクターおよびその使用
JP2008061539A (ja) 2006-09-05 2008-03-21 Osaka Univ ヒト補体制御因子発現遺伝子およびその利用
WO2016174407A1 (en) 2015-04-27 2016-11-03 Ucl Business Plc Nucleic acid construct for expressing more than one chimeric antigen receptor

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
CA2161671A1 (en) 1993-04-30 1994-11-10 Robert M. Lorence Methods of treating and detecting cancer using viruses
JPH10313865A (ja) * 1997-05-15 1998-12-02 Deinabetsuku Kenkyusho:Kk ヒト補体制御因子が呈示されたベクター
JP4544497B2 (ja) 1997-12-22 2010-09-15 ユニバーシティ オブ テネシー リサーチ ファウンデーション 異種融合タンパク質を有する組変えラブドウイルス
NZ507063A (en) * 1998-04-02 2003-11-28 Rigel Pharmaceuticals Inc Self-dimerising peptides causing the formation of compact structures
IL145899A0 (en) 1999-04-15 2002-07-25 Pro Virus Inc Treatment of neoplasms with viruses
AU2003298650B2 (en) * 2002-11-15 2010-03-11 Musc Foundation For Research Development Complement receptor 2 targeted complement modulators
WO2008118258A2 (en) * 2007-02-06 2008-10-02 Genizon Biosciences Inc. Genemap of the human genes associated with adhd
JP5332064B2 (ja) * 2007-03-01 2013-11-06 ウェルスタット イムノセラピューティクス， エルエルシー 炎症により特徴付けられる疾患の治療
US8877896B2 (en) 2008-02-15 2014-11-04 Tufts University Compositions, methods and kits for modeling, diagnosing, and treating complement disorders
US20140206850A1 (en) 2011-04-29 2014-07-24 Keygene N.V. Glyphosate resistance enhancement
EP2704744B1 (en) 2011-05-05 2019-04-24 Wellstat ImmunoTherapeutics, LLC Complement factor b analogs and their uses
ES2651521T3 (es) * 2011-12-01 2018-01-26 Innovent Biologics, Inc. Inhibidores proteicos de las rutas del complemento y de VEGF y métodos de uso de los mismos
AU2015244039B2 (en) * 2014-04-07 2021-10-21 Novartis Ag Treatment of cancer using anti-CD19 chimeric antigen receptor
DK3143134T3 (da) * 2014-05-15 2021-01-04 Nat Univ Singapore Modificerede, naturlige dræberceller og anvendelser deraf
RS61907B1 (sr) 2015-04-06 2021-06-30 Subdomain Llc Polipeptidi koji sadrže de novo vezujući domen i njihova primena
AU2016274989A1 (en) 2015-06-12 2017-11-02 Immunomedics, Inc. Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
WO2017197525A1 (en) 2016-05-19 2017-11-23 Evgin Laura Pseudotyped oncolytic rhabdoviruses and their use in combination therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002509695A (ja) 1997-11-21 2002-04-02 ゲセルシャフト フュア バイオテクノロギッシェフォーシュング エムベーハー（ゲーベーエフ） 一本鎖ｄｎａ又は二本鎖ｄｎａ、コード化融合タンパク質，ウイルス，パッケージング細胞及びこれらの使用ヒト補体システムによる不活化に耐えるウイルスの開発
JP2008507272A (ja) 2004-07-21 2008-03-13 ダナ−ファーバー キャンサー インスティチュート，インコーポレイテッド レンチウイルスベクターおよびその使用
JP2008061539A (ja) 2006-09-05 2008-03-21 Osaka Univ ヒト補体制御因子発現遺伝子およびその利用
WO2016174407A1 (en) 2015-04-27 2016-11-03 Ucl Business Plc Nucleic acid construct for expressing more than one chimeric antigen receptor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Molecular therapy，2005年，11(4)，645-651

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IL263979A (en) 2019-02-28
EP3621635A4 (en) 2021-02-24
CA3026892A1 (en) 2018-11-15
CN121343935A (zh) 2026-01-16
IL263979B2 (en) 2023-09-01
JP2020519230A (ja) 2020-07-02
EP3621635A1 (en) 2020-03-18
KR20250118857A (ko) 2025-08-06
CN121343934A (zh) 2026-01-16
RU2018146446A3 (https=) 2021-09-10
NZ748798A (en) 2026-03-27
ZA201808040B (en) 2019-09-25
KR20240073085A (ko) 2024-05-24
CN109414483B (zh) 2025-10-24
US20190194292A1 (en) 2019-06-27
MX2018015599A (es) 2019-05-16
IL263979B1 (en) 2023-05-01
CN109414483A (zh) 2019-03-01
US11274141B2 (en) 2022-03-15
KR102839445B1 (ko) 2025-07-28
BR112018075281A2 (pt) 2020-02-11
WO2018209052A1 (en) 2018-11-15
KR20200005721A (ko) 2020-01-16
RU2018146446A (ru) 2021-06-10
KR102662049B1 (ko) 2024-05-23
AU2018265258A1 (en) 2019-01-17
US20220169701A1 (en) 2022-06-02
AU2018265258B2 (en) 2023-01-05

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