JP7149076B2 - ブルトン型チロシンキナーゼ阻害剤の薬学的製剤 - Google Patents

ブルトン型チロシンキナーゼ阻害剤の薬学的製剤 Download PDF

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JP7149076B2
JP7149076B2 JP2017541753A JP2017541753A JP7149076B2 JP 7149076 B2 JP7149076 B2 JP 7149076B2 JP 2017541753 A JP2017541753 A JP 2017541753A JP 2017541753 A JP2017541753 A JP 2017541753A JP 7149076 B2 JP7149076 B2 JP 7149076B2
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ibrutinib
tablet formulation
solid tablet
microcrystalline cellulose
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JP2018507200A5 (https=
JP2018507200A (ja
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アトラリ，ハリシャ
チョン，チン，ワー
キュール，ロバート
タン，ヘオウ
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ファーマサイクリックス エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017541753A 2015-03-03 2016-03-02 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤 Active JP7149076B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022106400A JP2022141701A (ja) 2015-03-03 2022-06-30 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤
JP2024129576A JP2024170405A (ja) 2015-03-03 2024-08-05 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562127717P 2015-03-03 2015-03-03
US62/127,717 2015-03-03
US201562193518P 2015-07-16 2015-07-16
US62/193,518 2015-07-16
PCT/US2016/020467 WO2016141068A1 (en) 2015-03-03 2016-03-02 Pharmaceutical formulations of bruton's tyrosine kinase inhibtor

Related Child Applications (1)

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JP2022106400A Division JP2022141701A (ja) 2015-03-03 2022-06-30 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

Publications (3)

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JP2018507200A JP2018507200A (ja) 2018-03-15
JP2018507200A5 JP2018507200A5 (https=) 2019-04-25
JP7149076B2 true JP7149076B2 (ja) 2022-10-06

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JP2017541753A Active JP7149076B2 (ja) 2015-03-03 2016-03-02 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤
JP2022106400A Pending JP2022141701A (ja) 2015-03-03 2022-06-30 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤
JP2024129576A Pending JP2024170405A (ja) 2015-03-03 2024-08-05 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

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JP2024129576A Pending JP2024170405A (ja) 2015-03-03 2024-08-05 ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

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US (9) US9655857B2 (https=)
EP (2) EP4338738A3 (https=)
JP (3) JP7149076B2 (https=)
KR (2) KR20250016514A (https=)
CN (4) CN121754493A (https=)
AU (4) AU2016226279B2 (https=)
BR (2) BR112017018931A2 (https=)
CA (3) CA2976695C (https=)
DK (1) DK3265084T3 (https=)
ES (1) ES2971597T3 (https=)
FI (1) FI3265084T3 (https=)
HR (1) HRP20240231T1 (https=)
HU (1) HUE065703T2 (https=)
IL (3) IL315294A (https=)
LT (1) LT3265084T (https=)
MD (1) MD3265084T2 (https=)
MX (5) MX394784B (https=)
NZ (1) NZ734446A (https=)
PL (1) PL3265084T3 (https=)
PT (1) PT3265084T (https=)
RS (1) RS65234B1 (https=)
RU (1) RU2017133990A (https=)
SG (2) SG11201707122QA (https=)
SI (1) SI3265084T1 (https=)
SM (1) SMT202400074T1 (https=)
TW (6) TWI632912B (https=)
WO (1) WO2016141068A1 (https=)
ZA (1) ZA201907661B (https=)

Cited By (1)

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JP2022141701A (ja) * 2015-03-03 2022-09-29 ファーマサイクリックス エルエルシー ブルトン型チロシンキナーゼ阻害剤の薬学的製剤

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JO3754B1 (ar) 2012-06-04 2021-01-31 Pharmacyclics Llc أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون
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US9795604B2 (en) 2013-10-25 2017-10-24 Pharmacyclics Llc Methods of treating and preventing graft versus host disease
TW202402295A (zh) * 2013-12-02 2024-01-16 美商製藥公司 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法
SG11201700849XA (en) * 2014-08-07 2017-03-30 Pharmacyclics Llc Novel formulations of a bruton's tyrosine kinase inhibitor
HK1249014A1 (zh) 2015-03-20 2018-10-26 The Trustees Of The University Of Pennsylvania 具有作为佐剂的cd40配体的疫苗
RS64653B1 (sr) * 2015-04-06 2023-10-31 Janssen Pharmaceutica Nv Kompozicije koje sadrže ibrutinib
WO2017125423A1 (en) * 2016-01-19 2017-07-27 Janssen Pharmaceutica Nv Formulations/compositions comprising a btk inhibitor
EP3523280B1 (en) 2016-10-06 2026-03-11 Janssen Pharmaceutica NV Processes and intermediates for preparing a btk inhibitor
KR102674902B1 (ko) * 2016-12-01 2024-06-14 아비나스 오퍼레이션스, 인코포레이티드 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 및 테트라히드로이소퀴놀린 유도체
CN108653231A (zh) * 2017-04-01 2018-10-16 北京赛林泰医药技术有限公司 含有布鲁顿酪氨酸激酶抑制剂的组合物及其制备方法
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JP2022523371A (ja) * 2019-02-22 2022-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 医薬製剤
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KR20250016514A (ko) 2025-02-03
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