JP7139330B2 - 細胞不透過性セレンテラジンアナログ - Google Patents

細胞不透過性セレンテラジンアナログ Download PDF

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JP7139330B2
JP7139330B2 JP2019529473A JP2019529473A JP7139330B2 JP 7139330 B2 JP7139330 B2 JP 7139330B2 JP 2019529473 A JP2019529473 A JP 2019529473A JP 2019529473 A JP2019529473 A JP 2019529473A JP 7139330 B2 JP7139330 B2 JP 7139330B2
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benzyl
pyrazin
oxo
methyl
optionally substituted
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JP2020510617A (ja
JP2020510617A5 (https=
Inventor
メアリー ホール
トーマス カークランド
ポンチョ マイセンハイマー
ラチェル フリードマン オハナ
アントン シャクミン
ジョエル アール ウォーカー
ウェンフイ ジョウ
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Promega Corp
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Promega Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019529473A 2016-12-01 2017-12-01 細胞不透過性セレンテラジンアナログ Active JP7139330B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662428997P 2016-12-01 2016-12-01
US62/428,997 2016-12-01
US201762477512P 2017-03-28 2017-03-28
US62/477,512 2017-03-28
PCT/US2017/064229 WO2018102693A1 (en) 2016-12-01 2017-12-01 Cell impermeable coelenterazine analogues

Publications (3)

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JP2020510617A JP2020510617A (ja) 2020-04-09
JP2020510617A5 JP2020510617A5 (https=) 2021-01-21
JP7139330B2 true JP7139330B2 (ja) 2022-09-20

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JP2019529473A Active JP7139330B2 (ja) 2016-12-01 2017-12-01 細胞不透過性セレンテラジンアナログ

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US (2) US10577370B2 (https=)
EP (2) EP3548492B1 (https=)
JP (1) JP7139330B2 (https=)
DK (1) DK3548492T5 (https=)
WO (1) WO2018102693A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021523111A (ja) * 2018-05-01 2021-09-02 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10577370B2 (en) * 2016-12-01 2020-03-03 Promega Corporation Cell impermeable coelenterazine analogues
JP7036343B2 (ja) * 2017-03-28 2022-03-15 国立大学法人電気通信大学 新規セレンテラジン誘導体
JP7653351B2 (ja) * 2018-08-23 2025-03-28 プロメガ コーポレイション セレンテラジン類似体
CN112996923B (zh) 2018-10-03 2025-02-18 普洛麦格公司 用于稳定腔肠素及其类似物和衍生物的组合物和方法
CN111116594B (zh) * 2019-12-03 2021-05-28 山东大学 一种C-6位改造NanoLuc类型类似物及其制备方法与应用
KR102940072B1 (ko) * 2022-01-10 2026-03-17 주식회사 엘지화학 환상 술폰산에스테르 유도체 화합물의 제조방법
CN116082185B (zh) * 2023-04-06 2023-07-21 佛山职业技术学院 虫酰肼类半抗原、抗原、抗体、检测装置及其制备与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013544242A (ja) 2010-11-02 2013-12-12 プロメガ コーポレイション セレンテラジン誘導体およびその使用方法
JP2014503485A (ja) 2010-11-02 2014-02-13 プロメガ コーポレイション 新規セレンテラジン基質及び使用法

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US7268229B2 (en) 2001-11-02 2007-09-11 Promega Corporation Compounds to co-localize luminophores with luminescent proteins
US8883486B2 (en) 2004-05-04 2014-11-11 Universite De Montreal Arrestin biosensor
US20080248511A1 (en) 2007-03-26 2008-10-09 Promega Corporation Methods to quench light from optical reactions
LT3409764T (lt) 2009-05-01 2020-06-10 Promega Corporation Sintetinės oplophorus liuciferazės su sustiprinta šviesos išeiga
JP6067019B2 (ja) 2011-09-02 2017-01-25 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 代謝的に活性な細胞の酸化還元状態を評価するための化合物及び方法、ならびにｎａｄ（ｐ）／ｎａｄ（ｐ）ｈを測定するための方法
EP2782916B1 (en) 2011-11-21 2018-02-28 Promega Corporation Carboxy x rhodamine analogs
WO2013130761A1 (en) * 2012-03-02 2013-09-06 Pierce Biotechnology, Inc. Indole derivatives as labeling dye for biomolecule
US9927430B2 (en) 2014-01-29 2018-03-27 Promega Corporation Pro-substrates for live cell applications
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
CN107922428B (zh) 2015-06-25 2021-02-05 普洛麦格公司 噻吩并吡咯化合物及其作为刺虾源性荧光素酶的抑制剂的用途
EP3416968B1 (en) 2016-02-15 2022-07-27 Promega Corporation Coelenterazine analogues
CN105968114B (zh) * 2016-05-27 2018-11-09 山东大学 一种腔肠素类似物及其制备方法与应用
JP7212612B2 (ja) * 2016-07-28 2023-01-25 プロメガ コーポレイション セレンテラジン類縁体
EP3535270B3 (en) * 2016-11-01 2024-05-29 Promega Corporation Coelenterazine analogues tethered to energy acceptors
US10577370B2 (en) * 2016-12-01 2020-03-03 Promega Corporation Cell impermeable coelenterazine analogues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013544242A (ja) 2010-11-02 2013-12-12 プロメガ コーポレイション セレンテラジン誘導体およびその使用方法
JP2014503485A (ja) 2010-11-02 2014-02-13 プロメガ コーポレイション 新規セレンテラジン基質及び使用法

Non-Patent Citations (3)

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Title
Chem. Eur. J. ，2016年，22，10369-10375
Chemical Science，2013年，4，4395-4400
Tetrahedron ，2003年，59，8129-8142

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021523111A (ja) * 2018-05-01 2021-09-02 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物
JP7419260B2 (ja) 2018-05-01 2024-01-22 プロメガ コーポレイション ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物

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Publication number Publication date
JP2020510617A (ja) 2020-04-09
DK3548492T3 (en) 2023-08-07
US11192894B2 (en) 2021-12-07
US20200239475A1 (en) 2020-07-30
WO2018102693A1 (en) 2018-06-07
EP4279490A3 (en) 2024-04-10
DK3548492T5 (en) 2024-08-05
EP3548492A1 (en) 2019-10-09
EP3548492B1 (en) 2023-07-05
EP4279490A2 (en) 2023-11-22
US20180155350A1 (en) 2018-06-07
US10577370B2 (en) 2020-03-03

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