DK3548492T5 - Cell impermeable coelenterazine analogues - Google Patents
Cell impermeable coelenterazine analogues Download PDFInfo
- Publication number
- DK3548492T5 DK3548492T5 DK17829356.9T DK17829356T DK3548492T5 DK 3548492 T5 DK3548492 T5 DK 3548492T5 DK 17829356 T DK17829356 T DK 17829356T DK 3548492 T5 DK3548492 T5 DK 3548492T5
- Authority
- DK
- Denmark
- Prior art keywords
- cell impermeable
- coelenterazine analogues
- coelenterazine
- analogues
- impermeable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662428997P | 2016-12-01 | 2016-12-01 | |
| US201762477512P | 2017-03-28 | 2017-03-28 | |
| PCT/US2017/064229 WO2018102693A1 (en) | 2016-12-01 | 2017-12-01 | Cell impermeable coelenterazine analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK3548492T3 DK3548492T3 (en) | 2023-08-07 |
| DK3548492T5 true DK3548492T5 (en) | 2024-08-05 |
Family
ID=60972321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17829356.9T DK3548492T5 (en) | 2016-12-01 | 2017-12-01 | Cell impermeable coelenterazine analogues |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10577370B2 (https=) |
| EP (2) | EP3548492B1 (https=) |
| JP (1) | JP7139330B2 (https=) |
| DK (1) | DK3548492T5 (https=) |
| WO (1) | WO2018102693A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3548492B1 (en) * | 2016-12-01 | 2023-07-05 | Promega Corporation | Cell impermeable coelenterazine analogues |
| JP7036343B2 (ja) * | 2017-03-28 | 2022-03-15 | 国立大学法人電気通信大学 | 新規セレンテラジン誘導体 |
| JP7419260B2 (ja) * | 2018-05-01 | 2024-01-22 | プロメガ コーポレイション | NanoLuc自殺基質としてのセレンテラジン化合物 |
| WO2020041579A1 (en) * | 2018-08-23 | 2020-02-27 | Promega Corporation | Coelenterazine analogues |
| CA3114424A1 (en) | 2018-10-03 | 2020-04-09 | Promega Corporation | Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof |
| CN111116594B (zh) * | 2019-12-03 | 2021-05-28 | 山东大学 | 一种C-6位改造NanoLuc类型类似物及其制备方法与应用 |
| KR102940072B1 (ko) * | 2022-01-10 | 2026-03-17 | 주식회사 엘지화학 | 환상 술폰산에스테르 유도체 화합물의 제조방법 |
| CN116082185B (zh) * | 2023-04-06 | 2023-07-21 | 佛山职业技术学院 | 虫酰肼类半抗原、抗原、抗体、检测装置及其制备与应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
| US8883486B2 (en) | 2004-05-04 | 2014-11-11 | Universite De Montreal | Arrestin biosensor |
| WO2008118445A1 (en) | 2007-03-26 | 2008-10-02 | Promega Corporation | Methods to quench light from optical reactions |
| ES2795287T3 (es) | 2009-05-01 | 2020-11-23 | Promega Corp | Luciferasas de Oplophorus sintéticas con mayor emisión de luz |
| SG10202103336SA (en) | 2010-11-02 | 2021-04-29 | Promega Corp | Novel coelenterazine substrates and methods of use |
| CN103180324A (zh) | 2010-11-02 | 2013-06-26 | 普罗美加公司 | 腔肠素衍生物及其使用方法 |
| JP6067019B2 (ja) | 2011-09-02 | 2017-01-25 | プロメガ コーポレイションPromega Corporation | 代謝的に活性な細胞の酸化還元状態を評価するための化合物及び方法、ならびにnad(p)/nad(p)hを測定するための方法 |
| WO2013078244A1 (en) | 2011-11-21 | 2013-05-30 | Promega Corporation | Carboxy x rhodamine analogs |
| CN104395306B (zh) * | 2012-03-02 | 2019-04-23 | 皮尔斯生物科技有限公司 | 作为生物分子的标记染料的吲哚衍生物 |
| EP3099691B1 (en) | 2014-01-29 | 2019-11-20 | Promega Corporation | Pro-substrates for live cell applications |
| US9790537B2 (en) | 2014-01-29 | 2017-10-17 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| WO2016210294A1 (en) | 2015-06-25 | 2016-12-29 | Promega Corporation | Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases |
| JP7092677B2 (ja) | 2016-02-15 | 2022-06-28 | プロメガ コーポレイション | セレンテラジン類似体 |
| CN105968114B (zh) * | 2016-05-27 | 2018-11-09 | 山东大学 | 一种腔肠素类似物及其制备方法与应用 |
| JP7212612B2 (ja) * | 2016-07-28 | 2023-01-25 | プロメガ コーポレイション | セレンテラジン類縁体 |
| JP7200102B2 (ja) * | 2016-11-01 | 2023-01-06 | プロメガ コーポレイション | エネルギー受容体に係留されたセレンテラジン類縁体 |
| EP3548492B1 (en) * | 2016-12-01 | 2023-07-05 | Promega Corporation | Cell impermeable coelenterazine analogues |
-
2017
- 2017-12-01 EP EP17829356.9A patent/EP3548492B1/en active Active
- 2017-12-01 US US15/829,262 patent/US10577370B2/en active Active
- 2017-12-01 DK DK17829356.9T patent/DK3548492T5/da active
- 2017-12-01 EP EP23175129.8A patent/EP4279490A3/en active Pending
- 2017-12-01 JP JP2019529473A patent/JP7139330B2/ja active Active
- 2017-12-01 WO PCT/US2017/064229 patent/WO2018102693A1/en not_active Ceased
-
2019
- 2019-12-23 US US16/725,602 patent/US11192894B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3548492A1 (en) | 2019-10-09 |
| EP3548492B1 (en) | 2023-07-05 |
| US11192894B2 (en) | 2021-12-07 |
| WO2018102693A1 (en) | 2018-06-07 |
| DK3548492T3 (en) | 2023-08-07 |
| JP7139330B2 (ja) | 2022-09-20 |
| US10577370B2 (en) | 2020-03-03 |
| EP4279490A3 (en) | 2024-04-10 |
| US20200239475A1 (en) | 2020-07-30 |
| EP4279490A2 (en) | 2023-11-22 |
| JP2020510617A (ja) | 2020-04-09 |
| US20180155350A1 (en) | 2018-06-07 |
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