JP7134990B2 - 縮合イミダゾ-ピペリジンjak阻害剤 - Google Patents

縮合イミダゾ-ピペリジンjak阻害剤 Download PDF

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JP7134990B2
JP7134990B2 JP2019548369A JP2019548369A JP7134990B2 JP 7134990 B2 JP7134990 B2 JP 7134990B2 JP 2019548369 A JP2019548369 A JP 2019548369A JP 2019548369 A JP2019548369 A JP 2019548369A JP 7134990 B2 JP7134990 B2 JP 7134990B2
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disease
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JP2020510010A (ja
JP2020510010A5 (enExample
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ポール アール. ファザリー,
ゲイリー イー.エル. ブラント,
キャメロン スミス,
スティーブン ディー.イー. サリバン,
オーデン, ロリ ジーン バン
メラニー エー. クラインシェック,
グレン ディー. クレーター,
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セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
JP2019548369A 2017-03-09 2018-03-08 縮合イミダゾ-ピペリジンjak阻害剤 Active JP7134990B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762469073P 2017-03-09 2017-03-09
US62/469,073 2017-03-09
PCT/US2018/021492 WO2018165395A1 (en) 2017-03-09 2018-03-08 Fused imidazo-piperidine jak inhibitors

Publications (3)

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JP2020510010A JP2020510010A (ja) 2020-04-02
JP2020510010A5 JP2020510010A5 (enExample) 2021-04-01
JP7134990B2 true JP7134990B2 (ja) 2022-09-12

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JP2019548369A Active JP7134990B2 (ja) 2017-03-09 2018-03-08 縮合イミダゾ-ピペリジンjak阻害剤
JP2019548449A Active JP6974487B2 (ja) 2017-03-09 2018-03-08 4員ヘテロ環式アミドを含むjak阻害剤

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JP2019548449A Active JP6974487B2 (ja) 2017-03-09 2018-03-08 4員ヘテロ環式アミドを含むjak阻害剤

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US (10) US10196393B2 (enExample)
EP (2) EP3592742B1 (enExample)
JP (2) JP7134990B2 (enExample)
KR (2) KR102533646B1 (enExample)
CN (2) CN110461839B (enExample)
AR (2) AR111241A1 (enExample)
AU (2) AU2018231035B2 (enExample)
BR (2) BR112019018649A2 (enExample)
CA (1) CA2997772A1 (enExample)
DK (1) DK3592742T3 (enExample)
EA (2) EA037748B1 (enExample)
ES (1) ES2882186T3 (enExample)
IL (2) IL268679B (enExample)
MX (2) MX388749B (enExample)
PH (2) PH12019501941A1 (enExample)
PT (1) PT3592742T (enExample)
SG (2) SG11201907544VA (enExample)
TW (2) TWI754019B (enExample)
WO (2) WO2018165392A1 (enExample)
ZA (2) ZA201905585B (enExample)

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US10100049B2 (en) 2015-11-03 2018-10-16 Theravance Biopharma R&D Ip, Llc JAK kinase inhibitor compounds for treatment of respiratory disease
CN110461839B (zh) 2017-03-09 2022-08-23 施万生物制药研发Ip有限责任公司 含有4元杂环酰胺的jak抑制剂
CA3059785A1 (en) 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Methods of treatment using a jak inhibitor compound
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
PL3837258T3 (pl) * 2018-09-04 2024-09-16 Theravance Biopharma R&D Ip, Llc Amidy dimetyloaminoazetydyny jako inhibitory jak
EA202190686A1 (ru) 2018-09-04 2021-07-23 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи 5-7-членные гетероциклические амиды в качестве ингибиторов jak
MX2021002273A (es) 2018-09-04 2021-05-27 Theravance Biopharma R&D Ip Llc Proceso para preparar inhibidores de las jak y productos intermedios de estos.
AU2019373059A1 (en) 2018-10-29 2021-05-06 Theravance Biopharma R&D Ip, Llc 2-azabicyclo hexane compound as JAK inhibitor
HRP20240994T1 (hr) 2019-02-25 2024-10-25 Henan Medinno Pharmaceutical Technology Co., Ltd. Spoj inhibitora jak i njegova uporaba
KR20210137087A (ko) 2019-03-05 2021-11-17 인사이트 코포레이션 만성 폐 동종이식 기능장애의 치료를 위한 jak1 경로 억제제
WO2021108803A1 (en) * 2019-11-26 2021-06-03 Theravance Biopharma R&D Ip, Llc Fused pyrimidine pyridinone compounds as jak inhibitors
WO2021136345A1 (zh) * 2019-12-30 2021-07-08 路良 Jak抑制剂化合物及其用途
TW202144343A (zh) * 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
EP3944859A1 (en) 2020-07-30 2022-02-02 Assistance Publique Hôpitaux de Paris Method for treating immune toxicities induced by immune checkpoint inhibitors
WO2022178215A1 (en) * 2021-02-19 2022-08-25 Theravance Biopharma R&D Ip, Llc Amino amide tetrahydro imidazo pyridines as jak inhibitors
CA3223194A1 (en) * 2021-06-25 2022-12-29 Theravance Biopharma R&D Ip, Llc Imidazolo indazole compounds as jak inhibitors
TWI876245B (zh) * 2021-12-17 2025-03-11 南韓商大熊製藥股份有限公司 (2R, 3S)-2-(3-(4,5-二氯-1H-苯并[d]咪唑-1-基)丙基)哌啶-3-醇的新穎酸加成鹽及晶形
CN117658852A (zh) * 2023-11-15 2024-03-08 西北工业大学 取代苯氧乙酰肼类化合物及其制备方法和作为stat3的抗炎抑制剂的应用
WO2025157904A1 (en) * 2024-01-24 2025-07-31 Kiox Pharmaceuticals Aps Inhalable formulations of ruxolitinib, methods of manufacture and uses thereof
CN118903009B (zh) * 2024-10-11 2025-01-21 江苏长泰药业股份有限公司 一种调节呼吸道微生态的丙酮酸钠气雾剂及其制备方法和应用

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JP2014522865A (ja) 2011-07-27 2014-09-08 ファイザー・リミテッド インダゾール
WO2017077288A1 (en) 2015-11-03 2017-05-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
JP2018531982A (ja) 2015-11-03 2018-11-01 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー 呼吸器疾患の処置のためのjakキナーゼ阻害剤化合物
JP2020510015A (ja) 2017-03-09 2020-04-02 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー 4員ヘテロ環式アミドを含むjak阻害剤

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AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
KR102032418B1 (ko) 2017-06-15 2019-10-16 한국화학연구원 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물
EA202190686A1 (ru) 2018-09-04 2021-07-23 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи 5-7-членные гетероциклические амиды в качестве ингибиторов jak
PL3837258T3 (pl) 2018-09-04 2024-09-16 Theravance Biopharma R&D Ip, Llc Amidy dimetyloaminoazetydyny jako inhibitory jak
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JP2014522865A (ja) 2011-07-27 2014-09-08 ファイザー・リミテッド インダゾール
WO2017077288A1 (en) 2015-11-03 2017-05-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
JP2018531982A (ja) 2015-11-03 2018-11-01 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー 呼吸器疾患の処置のためのjakキナーゼ阻害剤化合物
JP2020510015A (ja) 2017-03-09 2020-04-02 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー 4員ヘテロ環式アミドを含むjak阻害剤

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AR111242A1 (es) 2019-06-19
CA2997772A1 (en) 2018-09-09
JP6974487B2 (ja) 2021-12-01
US11667637B2 (en) 2023-06-06
CN110461839A (zh) 2019-11-15
EP3592743A1 (en) 2020-01-15
PH12019501941A1 (en) 2020-07-06
US20190337945A1 (en) 2019-11-07
TW201840560A (zh) 2018-11-16
ZA201905585B (en) 2020-05-27
MX2019010541A (es) 2019-10-21
WO2018165392A1 (en) 2018-09-13
AR111241A1 (es) 2019-06-19
US20220289737A1 (en) 2022-09-15
IL268679B (en) 2021-10-31
IL268689B (en) 2022-10-01
EA201992126A1 (ru) 2020-02-05
AU2018231032A1 (en) 2019-09-05
IL268679A (en) 2019-10-31
MX388749B (es) 2025-03-11
US20200181141A1 (en) 2020-06-11
EP3592742B1 (en) 2021-05-19
US20180258087A1 (en) 2018-09-13
US20180258088A1 (en) 2018-09-13
MX388750B (es) 2025-03-20
PH12019501985A1 (en) 2020-10-05
US11878977B2 (en) 2024-01-23
EA037261B1 (ru) 2021-03-01
BR112019018648A2 (pt) 2020-06-16
TW201837037A (zh) 2018-10-16
US20190119275A1 (en) 2019-04-25
PT3592742T (pt) 2021-07-30
US11254669B2 (en) 2022-02-22
JP2020510015A (ja) 2020-04-02
AU2018231035A1 (en) 2019-09-05
MX2019010539A (es) 2019-10-21
KR102533646B1 (ko) 2023-05-17
BR112019018649A2 (pt) 2020-04-07
KR102526764B1 (ko) 2023-04-27
JP2020510010A (ja) 2020-04-02
US20190127371A1 (en) 2019-05-02
AU2018231035B2 (en) 2021-09-09
TWI779016B (zh) 2022-10-01
ZA201905618B (en) 2021-05-26
KR20190127798A (ko) 2019-11-13
KR20190127796A (ko) 2019-11-13
US10208040B2 (en) 2019-02-19
TWI754019B (zh) 2022-02-01
SG11201907840RA (en) 2019-09-27
US20200216447A1 (en) 2020-07-09
CN110461839B (zh) 2022-08-23
AU2018231032A8 (en) 2019-10-17
US20230063643A1 (en) 2023-03-02
EP3592742A1 (en) 2020-01-15
US10392386B2 (en) 2019-08-27
US10519153B2 (en) 2019-12-31
EA037748B1 (ru) 2021-05-18
ES2882186T3 (es) 2021-12-01
IL268689B2 (en) 2023-02-01
SG11201907544VA (en) 2019-09-27
CN110382498A (zh) 2019-10-25
US20210269436A1 (en) 2021-09-02
US11453668B2 (en) 2022-09-27
IL268689A (en) 2019-10-31
NZ756823A (en) 2021-04-30
DK3592742T3 (da) 2021-08-09
US10550118B2 (en) 2020-02-04
US10954237B2 (en) 2021-03-23
CN110382498B (zh) 2022-07-12
EA201992128A1 (ru) 2020-01-29
AU2018231032B2 (en) 2021-08-19
US10196393B2 (en) 2019-02-05
WO2018165395A1 (en) 2018-09-13

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