CN110461839B - 含有4元杂环酰胺的jak抑制剂 - Google Patents

含有4元杂环酰胺的jak抑制剂 Download PDF

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Publication number
CN110461839B
CN110461839B CN201880017046.0A CN201880017046A CN110461839B CN 110461839 B CN110461839 B CN 110461839B CN 201880017046 A CN201880017046 A CN 201880017046A CN 110461839 B CN110461839 B CN 110461839B
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compound
pharmaceutically acceptable
lung
ethyl
compounds
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CN110461839A (zh
Inventor
保罗·R·法特里
G·E·L·勃兰特
卡梅伦·史密斯
史蒂文·D·E·沙利文
洛里·琼·范奥登
M·A·克莱因舍尔克
G·D·克拉泰尔
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Theravance Biopharma R&D IP LLC
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Theravance Biopharma R&D IP LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
CN201880017046.0A 2017-03-09 2018-03-08 含有4元杂环酰胺的jak抑制剂 Active CN110461839B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762469073P 2017-03-09 2017-03-09
US62/469,073 2017-03-09
PCT/US2018/021489 WO2018165392A1 (en) 2017-03-09 2018-03-08 Jak inhibitors containing a 4-membered heterocyclic amide

Publications (2)

Publication Number Publication Date
CN110461839A CN110461839A (zh) 2019-11-15
CN110461839B true CN110461839B (zh) 2022-08-23

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CN201880017046.0A Active CN110461839B (zh) 2017-03-09 2018-03-08 含有4元杂环酰胺的jak抑制剂
CN201880016693.XA Expired - Fee Related CN110382498B (zh) 2017-03-09 2018-03-08 稠合咪唑-哌啶jak抑制剂

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CN201880016693.XA Expired - Fee Related CN110382498B (zh) 2017-03-09 2018-03-08 稠合咪唑-哌啶jak抑制剂

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US (10) US10208040B2 (enExample)
EP (2) EP3592743A1 (enExample)
JP (2) JP6974487B2 (enExample)
KR (2) KR102526764B1 (enExample)
CN (2) CN110461839B (enExample)
AR (2) AR111241A1 (enExample)
AU (2) AU2018231032B2 (enExample)
BR (2) BR112019018648A2 (enExample)
CA (1) CA2997772A1 (enExample)
DK (1) DK3592742T3 (enExample)
EA (2) EA037261B1 (enExample)
ES (1) ES2882186T3 (enExample)
IL (2) IL268689B2 (enExample)
MX (2) MX388750B (enExample)
PH (2) PH12019501941A1 (enExample)
PT (1) PT3592742T (enExample)
SG (2) SG11201907840RA (enExample)
TW (2) TWI754019B (enExample)
WO (2) WO2018165395A1 (enExample)
ZA (2) ZA201905585B (enExample)

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BR112021004087A2 (pt) 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc processo para preparar inibidores de jak e seus intermediários
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JP7580136B2 (ja) * 2019-12-30 2024-11-11 路良 Ｊａｋ阻害剤化合物及びその使用
KR20220149585A (ko) 2020-03-02 2022-11-08 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제 화합물의 결정성 수화물
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WO2022178215A1 (en) * 2021-02-19 2022-08-25 Theravance Biopharma R&D Ip, Llc Amino amide tetrahydro imidazo pyridines as jak inhibitors
TW202317550A (zh) * 2021-06-25 2023-05-01 美商施萬生物製藥研發 Ip有限責任公司 作為jak抑制劑之咪唑吲唑化合物
CN118401508A (zh) * 2021-12-17 2024-07-26 株式会社大熊制药 (2R,3S)-2-(3-(4,5-二氯-1H-苯并[d]咪唑-1-基)丙基)哌啶-3-醇的新酸加成盐及晶形
CN117658852B (zh) * 2023-11-15 2026-03-24 西北工业大学 取代苯氧乙酰肼类化合物及其制备方法和作为stat3的抗炎抑制剂的应用
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TWI754019B (zh) * 2017-03-09 2022-02-01 美商施萬生物製藥研發 Ip有限責任公司 含有4員雜環醯胺之jak抑制劑
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BR112021004063A2 (pt) 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc amidas heterocíclicas com 5 a 7 membros como inibidores de jak
BR112021004087A2 (pt) 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc processo para preparar inibidores de jak e seus intermediários

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MX2019010539A (es) 2019-10-21
NZ756823A (en) 2021-04-30
US10392386B2 (en) 2019-08-27
PH12019501985A1 (en) 2020-10-05
US10954237B2 (en) 2021-03-23
CN110461839A (zh) 2019-11-15
SG11201907840RA (en) 2019-09-27
US11667637B2 (en) 2023-06-06
US20180258087A1 (en) 2018-09-13
EA201992128A1 (ru) 2020-01-29
EA037261B1 (ru) 2021-03-01
TWI754019B (zh) 2022-02-01
WO2018165395A1 (en) 2018-09-13
IL268689B (en) 2022-10-01
AU2018231032B2 (en) 2021-08-19
JP2020510010A (ja) 2020-04-02
US20230063643A1 (en) 2023-03-02
AR111241A1 (es) 2019-06-19
DK3592742T3 (da) 2021-08-09
KR102526764B1 (ko) 2023-04-27
US20180258088A1 (en) 2018-09-13
US20210269436A1 (en) 2021-09-02
US10519153B2 (en) 2019-12-31
MX388749B (es) 2025-03-11
EA201992126A1 (ru) 2020-02-05
IL268689A (en) 2019-10-31
US11878977B2 (en) 2024-01-23
US10196393B2 (en) 2019-02-05
SG11201907544VA (en) 2019-09-27
BR112019018648A2 (pt) 2020-06-16
CN110382498B (zh) 2022-07-12
TW201840560A (zh) 2018-11-16
US20200216447A1 (en) 2020-07-09
TW201837037A (zh) 2018-10-16
AU2018231032A1 (en) 2019-09-05
IL268689B2 (en) 2023-02-01
US20190119275A1 (en) 2019-04-25
US20200181141A1 (en) 2020-06-11
ES2882186T3 (es) 2021-12-01
BR112019018649A2 (pt) 2020-04-07
PH12019501941A1 (en) 2020-07-06
US20190337945A1 (en) 2019-11-07
US20220289737A1 (en) 2022-09-15
ZA201905585B (en) 2020-05-27
MX2019010541A (es) 2019-10-21
WO2018165392A1 (en) 2018-09-13
AU2018231035B2 (en) 2021-09-09
US20190127371A1 (en) 2019-05-02
JP2020510015A (ja) 2020-04-02
AU2018231035A1 (en) 2019-09-05
AR111242A1 (es) 2019-06-19
IL268679A (en) 2019-10-31
AU2018231032A8 (en) 2019-10-17
KR20190127798A (ko) 2019-11-13
US10208040B2 (en) 2019-02-19
JP6974487B2 (ja) 2021-12-01
EP3592742B1 (en) 2021-05-19
JP7134990B2 (ja) 2022-09-12
EA037748B1 (ru) 2021-05-18
EP3592743A1 (en) 2020-01-15
TWI779016B (zh) 2022-10-01
US11453668B2 (en) 2022-09-27
IL268679B (en) 2021-10-31
US10550118B2 (en) 2020-02-04
US11254669B2 (en) 2022-02-22
MX388750B (es) 2025-03-20
CN110382498A (zh) 2019-10-25
KR102533646B1 (ko) 2023-05-17
ZA201905618B (en) 2021-05-26
PT3592742T (pt) 2021-07-30
CA2997772A1 (en) 2018-09-09
EP3592742A1 (en) 2020-01-15
KR20190127796A (ko) 2019-11-13

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