AU2018231032B2 - JAK inhibitors containing a 4-membered heterocyclic amide - Google Patents

JAK inhibitors containing a 4-membered heterocyclic amide Download PDF

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Publication number
AU2018231032B2
AU2018231032B2 AU2018231032A AU2018231032A AU2018231032B2 AU 2018231032 B2 AU2018231032 B2 AU 2018231032B2 AU 2018231032 A AU2018231032 A AU 2018231032A AU 2018231032 A AU2018231032 A AU 2018231032A AU 2018231032 B2 AU2018231032 B2 AU 2018231032B2
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AU
Australia
Prior art keywords
compound
lung
pharmaceutically
disease
ethyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2018231032A
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English (en)
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AU2018231032A1 (en
AU2018231032A8 (en
Inventor
Gary E.L. BRANDT
Glenn D. CRATER
Paul R. Fatheree
Melanie A. Kleinschek
Cameron Smith
Steven D.E. Sullivan
Lori Jean Van Orden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theravance Biopharma R&D IP LLC
Original Assignee
Theravance Biopharma R&D IP LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of AU2018231032A1 publication Critical patent/AU2018231032A1/en
Publication of AU2018231032A8 publication Critical patent/AU2018231032A8/en
Application granted granted Critical
Publication of AU2018231032B2 publication Critical patent/AU2018231032B2/en
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
AU2018231032A 2017-03-09 2018-03-08 JAK inhibitors containing a 4-membered heterocyclic amide Ceased AU2018231032B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762469073P 2017-03-09 2017-03-09
US62/469,073 2017-03-09
PCT/US2018/021489 WO2018165392A1 (en) 2017-03-09 2018-03-08 Jak inhibitors containing a 4-membered heterocyclic amide

Publications (3)

Publication Number Publication Date
AU2018231032A1 AU2018231032A1 (en) 2019-09-05
AU2018231032A8 AU2018231032A8 (en) 2019-10-17
AU2018231032B2 true AU2018231032B2 (en) 2021-08-19

Family

ID=61683956

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018231032A Ceased AU2018231032B2 (en) 2017-03-09 2018-03-08 JAK inhibitors containing a 4-membered heterocyclic amide
AU2018231035A Ceased AU2018231035B2 (en) 2017-03-09 2018-03-08 Fused imidazo-piperidine JAK inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2018231035A Ceased AU2018231035B2 (en) 2017-03-09 2018-03-08 Fused imidazo-piperidine JAK inhibitors

Country Status (20)

Country Link
US (10) US10208040B2 (enExample)
EP (2) EP3592743A1 (enExample)
JP (2) JP6974487B2 (enExample)
KR (2) KR102526764B1 (enExample)
CN (2) CN110461839B (enExample)
AR (2) AR111241A1 (enExample)
AU (2) AU2018231032B2 (enExample)
BR (2) BR112019018648A2 (enExample)
CA (1) CA2997772A1 (enExample)
DK (1) DK3592742T3 (enExample)
EA (2) EA037261B1 (enExample)
ES (1) ES2882186T3 (enExample)
IL (2) IL268689B2 (enExample)
MX (2) MX388750B (enExample)
PH (2) PH12019501941A1 (enExample)
PT (1) PT3592742T (enExample)
SG (2) SG11201907840RA (enExample)
TW (2) TWI754019B (enExample)
WO (2) WO2018165395A1 (enExample)
ZA (2) ZA201905585B (enExample)

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UA130579C2 (uk) 2019-03-05 2026-03-25 Інсайт Корпорейшн Інгібітори шляхів jak1 для лікування хронічної дисфункції алотрансплантата легень
CN114901659A (zh) * 2019-11-26 2022-08-12 施万生物制药研发Ip有限责任公司 作为jak抑制剂的稠合嘧啶吡啶酮化合物
JP7580136B2 (ja) * 2019-12-30 2024-11-11 路良 Ｊａｋ阻害剤化合物及びその使用
KR20220149585A (ko) 2020-03-02 2022-11-08 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제 화합물의 결정성 수화물
EP3944859A1 (en) * 2020-07-30 2022-02-02 Assistance Publique Hôpitaux de Paris Method for treating immune toxicities induced by immune checkpoint inhibitors
WO2022178215A1 (en) * 2021-02-19 2022-08-25 Theravance Biopharma R&D Ip, Llc Amino amide tetrahydro imidazo pyridines as jak inhibitors
TW202317550A (zh) * 2021-06-25 2023-05-01 美商施萬生物製藥研發 Ip有限責任公司 作為jak抑制劑之咪唑吲唑化合物
CN118401508A (zh) * 2021-12-17 2024-07-26 株式会社大熊制药 (2R,3S)-2-(3-(4,5-二氯-1H-苯并[d]咪唑-1-基)丙基)哌啶-3-醇的新酸加成盐及晶形
CN117658852B (zh) * 2023-11-15 2026-03-24 西北工业大学 取代苯氧乙酰肼类化合物及其制备方法和作为stat3的抗炎抑制剂的应用
WO2025157904A1 (en) * 2024-01-24 2025-07-31 Kiox Pharmaceuticals Aps Inhalable formulations of ruxolitinib, methods of manufacture and uses thereof
CN118903009B (zh) * 2024-10-11 2025-01-21 江苏长泰药业股份有限公司 一种调节呼吸道微生态的丙酮酸钠气雾剂及其制备方法和应用

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KR102032418B1 (ko) 2017-06-15 2019-10-16 한국화학연구원 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물
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Also Published As

Publication number Publication date
MX2019010539A (es) 2019-10-21
NZ756823A (en) 2021-04-30
US10392386B2 (en) 2019-08-27
PH12019501985A1 (en) 2020-10-05
US10954237B2 (en) 2021-03-23
CN110461839A (zh) 2019-11-15
SG11201907840RA (en) 2019-09-27
US11667637B2 (en) 2023-06-06
US20180258087A1 (en) 2018-09-13
EA201992128A1 (ru) 2020-01-29
EA037261B1 (ru) 2021-03-01
TWI754019B (zh) 2022-02-01
WO2018165395A1 (en) 2018-09-13
IL268689B (en) 2022-10-01
JP2020510010A (ja) 2020-04-02
US20230063643A1 (en) 2023-03-02
AR111241A1 (es) 2019-06-19
DK3592742T3 (da) 2021-08-09
KR102526764B1 (ko) 2023-04-27
US20180258088A1 (en) 2018-09-13
US20210269436A1 (en) 2021-09-02
US10519153B2 (en) 2019-12-31
MX388749B (es) 2025-03-11
EA201992126A1 (ru) 2020-02-05
IL268689A (en) 2019-10-31
US11878977B2 (en) 2024-01-23
US10196393B2 (en) 2019-02-05
SG11201907544VA (en) 2019-09-27
BR112019018648A2 (pt) 2020-06-16
CN110382498B (zh) 2022-07-12
TW201840560A (zh) 2018-11-16
US20200216447A1 (en) 2020-07-09
TW201837037A (zh) 2018-10-16
AU2018231032A1 (en) 2019-09-05
IL268689B2 (en) 2023-02-01
US20190119275A1 (en) 2019-04-25
US20200181141A1 (en) 2020-06-11
ES2882186T3 (es) 2021-12-01
BR112019018649A2 (pt) 2020-04-07
PH12019501941A1 (en) 2020-07-06
US20190337945A1 (en) 2019-11-07
US20220289737A1 (en) 2022-09-15
ZA201905585B (en) 2020-05-27
MX2019010541A (es) 2019-10-21
WO2018165392A1 (en) 2018-09-13
AU2018231035B2 (en) 2021-09-09
US20190127371A1 (en) 2019-05-02
JP2020510015A (ja) 2020-04-02
AU2018231035A1 (en) 2019-09-05
AR111242A1 (es) 2019-06-19
IL268679A (en) 2019-10-31
AU2018231032A8 (en) 2019-10-17
KR20190127798A (ko) 2019-11-13
US10208040B2 (en) 2019-02-19
JP6974487B2 (ja) 2021-12-01
EP3592742B1 (en) 2021-05-19
JP7134990B2 (ja) 2022-09-12
EA037748B1 (ru) 2021-05-18
EP3592743A1 (en) 2020-01-15
TWI779016B (zh) 2022-10-01
US11453668B2 (en) 2022-09-27
IL268679B (en) 2021-10-31
US10550118B2 (en) 2020-02-04
US11254669B2 (en) 2022-02-22
MX388750B (es) 2025-03-20
CN110382498A (zh) 2019-10-25
KR102533646B1 (ko) 2023-05-17
ZA201905618B (en) 2021-05-26
PT3592742T (pt) 2021-07-30
CA2997772A1 (en) 2018-09-09
EP3592742A1 (en) 2020-01-15
CN110461839B (zh) 2022-08-23
KR20190127796A (ko) 2019-11-13

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