JP7134870B2 - 心臓血管疾患及び事象のための診断及び予後方法 - Google Patents

心臓血管疾患及び事象のための診断及び予後方法 Download PDF

Info

Publication number
JP7134870B2
JP7134870B2 JP2018559674A JP2018559674A JP7134870B2 JP 7134870 B2 JP7134870 B2 JP 7134870B2 JP 2018559674 A JP2018559674 A JP 2018559674A JP 2018559674 A JP2018559674 A JP 2018559674A JP 7134870 B2 JP7134870 B2 JP 7134870B2
Authority
JP
Japan
Prior art keywords
panel
biomarkers
less
clinical
history
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018559674A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019507354A (ja
JP2019507354A5 (enExample
Inventor
ロンダ フェイ ライネ，
クレイグ アガメムノン マーガレット，
ジョン エドワード ストロベック，
ジェイムズ ルイス ジュニア ジャヌッツィ，
Original Assignee
プレベンシオ， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by プレベンシオ， インコーポレイテッド filed Critical プレベンシオ， インコーポレイテッド
Publication of JP2019507354A publication Critical patent/JP2019507354A/ja
Publication of JP2019507354A5 publication Critical patent/JP2019507354A5/ja
Priority to JP2021097387A priority Critical patent/JP7403498B2/ja
Application granted granted Critical
Publication of JP7134870B2 publication Critical patent/JP7134870B2/ja
Priority to JP2022150335A priority patent/JP2022171936A/ja
Priority to JP2024214563A priority patent/JP2025029196A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4884—Other medical applications inducing physiological or psychological stress, e.g. applications for stress testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/503—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the heart
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Optics & Photonics (AREA)
  • Social Psychology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
JP2018559674A 2016-02-01 2017-02-01 心臓血管疾患及び事象のための診断及び予後方法 Active JP7134870B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021097387A JP7403498B2 (ja) 2016-02-01 2021-06-10 心臓血管疾患及び事象のための診断及び予後方法
JP2022150335A JP2022171936A (ja) 2016-02-01 2022-09-21 心臓血管疾患及び事象のための診断及び予後方法
JP2024214563A JP2025029196A (ja) 2016-02-01 2024-12-09 心臓血管疾患及び事象のための診断及び予後方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662289513P 2016-02-01 2016-02-01
US62/289,513 2016-02-01
US201662378535P 2016-08-23 2016-08-23
US62/378,535 2016-08-23
PCT/US2017/016081 WO2017136464A1 (en) 2016-02-01 2017-02-01 Diagnostic and prognostic methods for cardiovascular diseases and events

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021097387A Division JP7403498B2 (ja) 2016-02-01 2021-06-10 心臓血管疾患及び事象のための診断及び予後方法

Publications (3)

Publication Number Publication Date
JP2019507354A JP2019507354A (ja) 2019-03-14
JP2019507354A5 JP2019507354A5 (enExample) 2020-03-12
JP7134870B2 true JP7134870B2 (ja) 2022-09-12

Family

ID=59500904

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018559674A Active JP7134870B2 (ja) 2016-02-01 2017-02-01 心臓血管疾患及び事象のための診断及び予後方法
JP2021097387A Active JP7403498B2 (ja) 2016-02-01 2021-06-10 心臓血管疾患及び事象のための診断及び予後方法
JP2022150335A Pending JP2022171936A (ja) 2016-02-01 2022-09-21 心臓血管疾患及び事象のための診断及び予後方法
JP2024214563A Pending JP2025029196A (ja) 2016-02-01 2024-12-09 心臓血管疾患及び事象のための診断及び予後方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021097387A Active JP7403498B2 (ja) 2016-02-01 2021-06-10 心臓血管疾患及び事象のための診断及び予後方法
JP2022150335A Pending JP2022171936A (ja) 2016-02-01 2022-09-21 心臓血管疾患及び事象のための診断及び予後方法
JP2024214563A Pending JP2025029196A (ja) 2016-02-01 2024-12-09 心臓血管疾患及び事象のための診断及び予後方法

Country Status (13)

Country Link
US (4) US10983135B2 (enExample)
EP (2) EP4574024A3 (enExample)
JP (4) JP7134870B2 (enExample)
KR (1) KR20180101595A (enExample)
CN (2) CN108700596A (enExample)
AU (1) AU2017214469A1 (enExample)
BR (1) BR112018015698A2 (enExample)
CA (1) CA3012192A1 (enExample)
MA (1) MA43980A (enExample)
MX (1) MX2018009304A (enExample)
RU (1) RU2018130866A (enExample)
SG (1) SG11201805906WA (enExample)
WO (1) WO2017136464A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017136464A1 (en) 2016-02-01 2017-08-10 Prevencio, Inc. Diagnostic and prognostic methods for cardiovascular diseases and events
WO2019055609A1 (en) * 2017-09-14 2019-03-21 University Of Alabama At Birmingham BIOMARKERS AND METHODS OF RISK ASSESSMENT OF MYOCARDIAL INFARCTION AND SEVERE INFECTION IN PATIENTS WITH RHEUMATOID ARTHRITIS
JP7372251B2 (ja) * 2017-11-02 2023-10-31 プリベンシオ，インコーポレイテッド 末梢動脈疾患、大動脈弁狭窄症についての診断および予後の方法、ならびにアウトカム
US11009452B2 (en) 2018-01-26 2021-05-18 Viavi Solutions Inc. Reduced false positive identification for spectroscopic quantification
EP3928098B1 (en) * 2019-02-20 2025-01-08 Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol In vitro method for predicting mortality risk in patients suffering from cardiogenic shock
CN110232975A (zh) * 2019-05-20 2019-09-13 郑州大学第一附属医院 一种对糖尿病肾病患者3年内进入到肾脏替代治疗风险预测的方法
CN110491512A (zh) * 2019-08-08 2019-11-22 郑州大学第一附属医院 一种对肾活检确诊糖尿病肾病患者3年内进入到终末期肾脏病风险预测的方法
CN110596399B (zh) * 2019-08-29 2022-07-22 首都医科大学附属北京安贞医院 检测血管生成素样蛋白8含量的物质的应用
CN110970131B (zh) * 2019-10-24 2024-01-26 中国医科大学附属盛京医院 一种基于免疫球蛋白定量检测的肾小球疾病分类分型模型及其应用
RU2726314C1 (ru) * 2019-11-15 2020-07-14 Федеральное государственное бюджетное образовательное учреждение высшего образования "Тихоокеанский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ раннего прогнозирования риска острого повреждения почек у пациентов с ишемической болезнью сердца после реваскуляризации миокарда методом аортокоронарного шунтирования
RU2760445C1 (ru) * 2020-11-13 2021-11-25 Виталий Юрьевич Мишланов Способ диагностики патологических состояний человека
JP7717152B2 (ja) * 2021-03-23 2025-08-01 テルモ株式会社 情報処理装置、情報処理方法およびプログラム
CN113342963B (zh) * 2021-04-29 2022-03-04 山东大学 一种基于迁移学习的服务推荐方法及系统
RU2770550C1 (ru) * 2021-05-31 2022-04-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ прогнозирования сердечно-сосудистого риска с помощью определения уровня эстрогенов
EP4500552A2 (en) * 2022-03-30 2025-02-05 Inflammatix, Inc. Methods for diagnosing myocardial infarction
CN114974576A (zh) * 2022-07-12 2022-08-30 曜立科技(北京)有限公司 一种基于元数据的心脑血管数疾病诊断管理系统
CN115185936B (zh) 2022-07-12 2023-02-03 曜立科技(北京)有限公司 一种基于大数据的医疗临床数据质量分析系统

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080057590A1 (en) 2006-06-07 2008-03-06 Mickey Urdea Markers associated with arteriovascular events and methods of use thereof
US20080300798A1 (en) 2007-04-16 2008-12-04 Mcdevitt John T Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics
WO2011022628A1 (en) 2009-08-20 2011-02-24 The Board Of Regents Of The University Of Texas System Methods and compositions for diagnosis of acute myocardial infarction (ami)
WO2012145037A1 (en) 2011-04-19 2012-10-26 Scott & White Healthcare Novel apoc-i isoforms and their use as biomarkers and risk factors of atherosclerotic disease
JP2012529655A (ja) 2009-06-08 2012-11-22 シンギュレックス・インコーポレイテッド 高感度バイオマーカーパネル
JP2013513387A (ja) 2009-12-09 2013-04-22 アヴィール インコーポレイテッド 循環器疾患の診断と分類のためのバイオマーカーアッセイ
JP2013178249A (ja) 2006-10-26 2013-09-09 Brahms Gmbh プロバソプレシンまたはその断片および部分ペプチド、特にコペプチンまたはニューロフィジンｉｉを使用する、急性冠動脈症候群についてのリスク層化
WO2015171989A1 (en) 2014-05-08 2015-11-12 University Of Maryland, Baltimore Methods for assessing differential risk for developing heart failure

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US20080202927A1 (en) 2000-11-03 2008-08-28 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20030134433A1 (en) 2002-01-16 2003-07-17 Nanomix, Inc. Electronic sensing of chemical and biological agents using functionalized nanostructures
US20060228723A1 (en) 2002-01-16 2006-10-12 Keith Bradley System and method for electronic sensing of biomolecules
US9234867B2 (en) 2003-05-16 2016-01-12 Nanomix, Inc. Electrochemical nanosensors for biomolecule detection
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
WO2006089226A1 (en) * 2005-02-17 2006-08-24 University Of Florida Research Foundation, Inc. β-BLOCKER PHARMACOGENETICS IN HEART FAILURE
CN101495862A (zh) * 2005-06-24 2009-07-29 利兰·斯坦福青年大学托管委员会 诊断和监测动脉粥样硬化性心血管疾病的方法和组合物
US8093017B2 (en) * 2005-12-07 2012-01-10 Siemens Heathcare Diagnostics Inc. Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics
US20100331200A1 (en) * 2006-03-31 2010-12-30 Gordon Neal F Post translational modification pattern analysis
WO2008045799A2 (en) 2006-10-06 2008-04-17 Nanomix, Inc. Electrochemical nanosensors for biomolecule detection
US20100119600A1 (en) 2007-06-01 2010-05-13 Joar Opheim Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof
GB0717637D0 (en) 2007-09-10 2007-10-17 Univ Leiden Future cardiac event biomarkers
US20100267062A1 (en) * 2007-09-26 2010-10-21 Norbert Frey Osteopontin as Novel Prognostic Biomarker for Heart Failure
US8241861B1 (en) 2008-07-08 2012-08-14 Insilicos, Llc Methods and compositions for diagnosis or prognosis of cardiovascular disease
WO2010140117A1 (en) 2009-06-04 2010-12-09 Koninklijke Philips Electronics, N.V. Method and system for providing behavioural therapy for insomnia
KR101256928B1 (ko) * 2010-01-20 2013-04-19 주식회사디엔에이링크 비만 또는 당뇨에 관련된 단일염기다형성 및 그의 용도
WO2012072595A1 (en) * 2010-11-30 2012-06-07 Universiteit Gent Platelet factor 4 variant for the prognosis of cardiovascular outcome in patients having heart disease
ES2767123T3 (es) 2011-03-09 2020-06-16 Abionic Sa Cuantificación rápida de biomoléculas en un biosensor nanofluídico selectivamente funcionalizado y método de la misma
US20140011811A1 (en) * 2011-10-06 2014-01-09 The United States Government As Represented By The Department Of Veterans Affairs Myosin binding protein-c for use in methods relating to diastolic heart failure
US11450431B2 (en) * 2012-11-16 2022-09-20 Siemens Healthcare Gmbh Method to identify optimum coronary artery disease treatment
WO2015006713A1 (en) 2013-07-12 2015-01-15 Emory University Diagnostic assay to predict cardiovascular risk
TR201819992T4 (tr) 2013-07-17 2019-02-21 Abionic Sa Bi̇yoassay i̇çi̇n yöntem ve ci̇haz
US20150160229A1 (en) * 2013-12-06 2015-06-11 Thomas D. Schaal Methods for detection of heart failure
US10434508B2 (en) 2014-07-03 2019-10-08 Abionic Sa Capsule for rapid molecular quantification of a fluid sample such as whole blood
WO2017136464A1 (en) 2016-02-01 2017-08-10 Prevencio, Inc. Diagnostic and prognostic methods for cardiovascular diseases and events
JP7310591B2 (ja) 2019-12-19 2023-07-19 株式会社オートネットワーク技術研究所 駆動装置

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080057590A1 (en) 2006-06-07 2008-03-06 Mickey Urdea Markers associated with arteriovascular events and methods of use thereof
JP2013178249A (ja) 2006-10-26 2013-09-09 Brahms Gmbh プロバソプレシンまたはその断片および部分ペプチド、特にコペプチンまたはニューロフィジンｉｉを使用する、急性冠動脈症候群についてのリスク層化
US20080300798A1 (en) 2007-04-16 2008-12-04 Mcdevitt John T Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics
JP2012529655A (ja) 2009-06-08 2012-11-22 シンギュレックス・インコーポレイテッド 高感度バイオマーカーパネル
WO2011022628A1 (en) 2009-08-20 2011-02-24 The Board Of Regents Of The University Of Texas System Methods and compositions for diagnosis of acute myocardial infarction (ami)
JP2013513387A (ja) 2009-12-09 2013-04-22 アヴィール インコーポレイテッド 循環器疾患の診断と分類のためのバイオマーカーアッセイ
WO2012145037A1 (en) 2011-04-19 2012-10-26 Scott & White Healthcare Novel apoc-i isoforms and their use as biomarkers and risk factors of atherosclerotic disease
WO2015171989A1 (en) 2014-05-08 2015-11-12 University Of Maryland, Baltimore Methods for assessing differential risk for developing heart failure

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Akansha Gupta，Clinical Assessment of Cardiovascular Disorders by Cardiac Biomarkers，Int. J. Pharm. Sci. Rev. Res.，2014年，29(1)，p.87-94
D’Vesharronne Moore，Isoforms of apolipoprotein C-I associated with individuals with coronary artery disease，Biochemical and Biophysical Research Communications，2011年，404，p.1034-1038，http://dx.doi.org/10.1016/j.bbrc.2010.12.105
Johan Bjorkegren，Accumulation of Apolipoprotein C-IRich and Cholesterol-Rich VLDL Remnants During Exaggerated Postprandial Triglyceridemia in Normolipidemic Patients With Coronary Artery Disease，Circulation，2000年01月25日，101(3)，p.227-230，doi: 10.1161/01.cir.101.3.227
Roland R.J. van Kimmenade，Emerging Biomarkers in Heart Failure，Clinical Chemistry，2012年，58(1)，p.127-138，DOI: 10.1373/clinchem.2011.165720
Willibald Hochholzer，Novel biomarkers in cardiovascular disease: Update 2010，American Heart Journal，2010年10月01日，160(4)，p.583-594，DOI: 10.1016/j.ahj.2010.06.010

Also Published As

Publication number Publication date
CA3012192A1 (en) 2017-08-10
JP2021128177A (ja) 2021-09-02
US20230341418A1 (en) 2023-10-26
WO2017136464A1 (en) 2017-08-10
EP4574024A3 (en) 2025-10-08
BR112018015698A2 (pt) 2018-12-26
RU2018130866A (ru) 2020-03-04
CN108700596A (zh) 2018-10-23
JP2025029196A (ja) 2025-03-05
EP4574024A2 (en) 2025-06-25
EP3411720A4 (en) 2019-08-14
US20250060374A1 (en) 2025-02-20
MX2018009304A (es) 2019-01-10
US10983135B2 (en) 2021-04-20
US11977083B2 (en) 2024-05-07
US20190369120A1 (en) 2019-12-05
JP2022171936A (ja) 2022-11-11
US12146888B2 (en) 2024-11-19
US20210072260A1 (en) 2021-03-11
EP3411720B1 (en) 2025-04-16
SG11201805906WA (en) 2018-08-30
EP3411720A1 (en) 2018-12-12
KR20180101595A (ko) 2018-09-12
EP3411720C0 (en) 2025-04-16
JP7403498B2 (ja) 2023-12-22
CN114441773A (zh) 2022-05-06
JP2019507354A (ja) 2019-03-14
MA43980A (fr) 2018-12-12
AU2017214469A1 (en) 2018-07-26

Similar Documents

Publication Publication Date Title
JP7403498B2 (ja) 心臓血管疾患及び事象のための診断及び予後方法
CN103403549B (zh) 败血症的预后的预测方法
MX2014002146A (es) Métodos y composiciones para diagnóstico y pronóstico de lesión renal e insuficiencia renal.
EP1436615A1 (en) Diagnostic assay
JP2021502573A (ja) 末梢動脈疾患、大動脈弁狭窄症についての診断および予後の方法、ならびにアウトカム
US20150293131A1 (en) Methods and compositions for diagnosis and prognosis of sepsis
JP2021518903A (ja) 患者の評価方法
EP2875347A1 (en) Methods and compositions for diagnosis and prognosis of sepsis
JPWO2005080982A1 (ja) Ａ型及びｂ型急性大動脈解離と急性心筋梗塞の鑑別方法及び鑑別用キット
WO2020092909A1 (en) Prognostic and diagnostic methods for risk of acute kidney injury
HK40074056A (en) Diagnostic and prognostic methods for cardiovascular diseases and events
CN111065922A (zh) 肾上腺髓质素原作为危重病患者的肾脏替代治疗的指标
US20240192231A1 (en) Markers for the diagnosis of large vessel occlusion
WO2024037387A1 (en) Blood biomarkers and methods for diagnosis of acute kawasaki disease
HK1261993A1 (en) Diagnostic and prognostic methods for cardiovascular diseases and events
HK1261993B (en) Diagnostic and prognostic methods for cardiovascular diseases and events
US20220276264A1 (en) DARPin REAGENTS THAT DISTINGUISH ALZHEIMER'S DISEASE AND PARKINSON'S DISEASE SAMPLES
HK40029189A (en) Proadrenomedullin as indicator for renal replacement therapy in critically ill patients

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200131

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200131

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20201117

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201210

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210303

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210610

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211008

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20211228

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220408

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220721

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220822

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220831

R150 Certificate of patent or registration of utility model

Ref document number: 7134870

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250