JP7122078B2 - 人工弁 - Google Patents
人工弁 Download PDFInfo
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- JP7122078B2 JP7122078B2 JP2020133436A JP2020133436A JP7122078B2 JP 7122078 B2 JP7122078 B2 JP 7122078B2 JP 2020133436 A JP2020133436 A JP 2020133436A JP 2020133436 A JP2020133436 A JP 2020133436A JP 7122078 B2 JP7122078 B2 JP 7122078B2
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/2436—Deployment by retracting a sheath
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- A—HUMAN NECESSITIES
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- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0061—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0058—X-shaped
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0073—Quadric-shaped
- A61F2230/0078—Quadric-shaped hyperboloidal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0069—Sealing means
Description
以下の開示は、本開示の第1の一般的実施形態に関するもので、この第1の一般的実施形態は、進歩性のある人工弁と、損傷し若しくは病変のある弁を置換する方法とに関する。
以下の説明は、本開示の第2の一般的実施形態に関するもので、この第1の一般的実施形態は、進歩性のある人工弁と、損傷し若しくは病変のある弁を置換する方法と、人工弁を送達するシステムと、キットと、人工弁を送達する方法とに関する。
例示的な送達および移植処置は、人工弁を送達する本開示のシステムと、本開示に係る人工弁とを使って次のように行われる。
本発明に係る人工弁は、in situで、いくつかの異なる力を弁輪とその周囲の組織に及ぼす。そのような力は、移植部位で係止されて適切に配置された状態で保たれる当該人工弁独自の能力に寄与する。例えば、前記上方および下方フランジは、それぞれへ向かって反り曲がり、フランジと前記中間領域との間に介在する組織は、そのフランジと中間領域との間に把持される。また、前記ステントも弁輪壁に対して径方向外向きの力を及ぼす。そのような力を個別に測定することは難しいが、移植された人工弁を抜去する上で必要な力は、前記ステントが及ぼす各力の総計の一部を表す。
Claims (25)
- 人工僧帽弁であって、
拡張状態と未拡張状態とを有するステントであって、
長軸と、
第1の端部と第2の端部とを備えるとともに、外面および内面を画定するワイヤーフレームワークを有する中間領域と、
前記中間領域の前記第1の端部に形成され、不規則に離間されたアレイを形成してなる複数のフランジ要素を有する下方フランジ部であって、前記フランジ要素の各々は、前記中間領域に取着された第1の端部と、当該第1の端部から離間され且つ当該第1の端部と対向する位置にある第2の端部とを有するものである、前記下方フランジ部と、
前記中間領域の前記第2の端部に形成され、複数のフランジ要素を有する上方フランジ部であって、前記フランジ要素の各々は、前記中間領域に取着された第1の端部と、当該第1の端部から離間され且つ当該第1の端部と対向する位置にある第2の端部とを有するものである、前記上方フランジ部と
を有するものである、前記ステントと、
前記ステントの前記中間領域の内面に取り付けられた弁と
を有し、
前記上方フランジ部および前記下方フランジ部は、前記ステントが前記未拡張状態にあるとき、前記ステントの長軸に実質的に沿った位置に配置されており、
前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記ステントの長軸に対する前記下方フランジ部の位置が変化して、前記下方フランジ部は前記ステントの長軸に実質的に沿った位置ではない位置に配置されるものであり、
前記下方フランジ部は、前記ステントが前記拡張状態にあるとき、前記ステントの長軸に対して所定の鋭角を成しているものであり、
前記下方フランジ部は、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、僧帽弁輪の心室側において組織を当該下方フランジ部と前記中間領域の外面によって包み込むようにして挟持することで前記ステントを前記僧帽弁輪内に係止するように構成されているものであり、
前記上方フランジ部は、組織を当該上方フランジ部と前記中間領域の外面によって挟持することで前記ステントを前記僧帽弁輪内に係止するように構成されているものである、
人工僧帽弁。 - 請求項1記載の人工僧帽弁において、前記下方フランジ部は、当該下方フランジ部と前記中間領域の外面によって前記僧帽弁輪の心室側の弁下組織を挟持することにより、前記ステントを前記僧帽弁輪内に係止するように構成されているものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記下方フランジ部は、天然僧帽弁の弁尖を当該下方フランジ部と前記中間領域の外面によって包み込むようにして挟持することにより、前記ステントを前記僧帽弁輪内に係止するように構成されているものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記下方フランジ部は、当該下方フランジ部と前記中間領域の外面によって前記僧帽弁輪の心室側の腱索を挟持することにより、前記ステントを前記僧帽弁輪内に係止するように構成されているものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記下方フランジ部は、左心室壁を当該下方フランジ部と前記中間領域の外面によって挟持することにより、前記ステントを前記僧帽弁輪内に係止するように構成されているものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記上方フランジ部は、左心房の組織を当該上方フランジ部と前記中間領域の外面によって挟持することにより、前記ステントを前記僧帽弁輪内に係止するように構成されているものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記下方フランジ部は、前記ステントが前記未拡張状態にあるとき、前記ステントの長軸に対して実質的に平行である人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記ステントは自己拡張するものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記ステントはワイヤー織りから成るものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記上方フランジ部は、前記ステントが前記拡張状態にあるとき、前記ステントの長軸に対して所定の鋭角を成しているものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記上方フランジ部は、前記ステントが前記未拡張状態にあるとき、前記ステントの長軸に対して実質的に平行である人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記ステントの長軸に対する前記上方フランジ部の位置が変化して、前記上方フランジ部は前記ステントの長軸に実質的に沿った位置ではない位置に配置されるものである人工僧帽弁。
- 請求項12記載の人工僧帽弁において、前記上方フランジ部は、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記僧帽弁輪の心房側において組織を当該上方フランジ部と前記中間領域の外面によって包み込むようにして挟持するように構成されているものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記下方フランジ部における前記フランジ要素の前記第2の端部は、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記ステントの中間領域に向かって移動するものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記上方フランジ部における前記フランジ要素の前記第2の端部は、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記ステントの中間領域に向かって移動するものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記下方フランジ部における前記フランジ要素の前記第2の端部は、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記ステントの長軸から離れる方向に移動するものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記上方フランジ部における前記フランジ要素の前記第2の端部は、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記ステントの長軸から離れる方向に移動するものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記下方フランジ部および前記上方フランジ部のうちの1つ若しくは双方における少なくとも1つのフランジ要素に対してウェビングが設けられており、前記ウェビングは、液体を吸収することによって膨張する吸収材料を有するものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記下方フランジ部の少なくとも1つのフランジ要素に対してウェビングが設けられているものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記下方フランジ部および前記上方フランジ部のうちの1つ若しくは双方における少なくとも1つのフランジ要素に対してウェビングが設けられているものである人工僧帽弁。
- 請求項1記載の人工僧帽弁において、前記上方フランジ部の前記複数のフランジ要素は、不規則に離間されたアレイを形成するものである人工僧帽弁。
- 人工僧帽弁であって、
拡張状態と未拡張状態とを有するステントであって、
長軸と、
第1の端部と第2の端部とを備えるとともに、外面および内面を画定するワイヤーフレームワークを有する中間領域と、
前記中間領域の前記第1の端部に形成され、不規則に離間されたアレイを形成してなる複数のフランジ要素を有する下方フランジ部であって、前記フランジ要素の各々は、前記中間領域に取着された第1の端部と、当該第1の端部から離間され且つ当該第1の端部と対向する位置にある第2の端部とを有するものである、前記下方フランジ部と、
前記中間領域の前記第2の端部に形成された上方フランジ部と、
を有するものである、前記ステントと、
前記ステントの前記中間領域の内面に取り付けられた弁と
を有し、
前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記ステントの長軸に対する前記下方フランジ部の位置が変化して、前記下方フランジ部は前記ステントの長軸に実質的に沿った位置ではない位置に配置されるものであり、
前記下方フランジ部は、前記ステントが前記拡張状態にあるとき、前記ステントの長軸に対して所定の鋭角を成しているものであり、
前記下方フランジ部は、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、僧帽弁輪の心室側において組織を当該下方フランジ部と前記中間領域の外面によって包み込むようにして挟持することで前記ステントを前記僧帽弁輪内に係止するように構成されているものであり、
前記上方フランジ部は、前記中間領域の端部または縁部を構成するものである、
人工僧帽弁。 - 請求項22記載の人工僧帽弁において、前記下方フランジ部は、前記ステントが前記未拡張状態にあるとき、前記ステントの長軸に対して実質的に平行である人工僧帽弁。
- 請求項22記載の人工僧帽弁において、前記下方フランジ部における前記フランジ要素の前記第2の端部は、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記ステントの中間領域に向かって移動するものである人工僧帽弁。
- 請求項22記載の人工僧帽弁において、前記下方フランジ部における前記フランジ要素の前記第2の端部は、前記ステントが前記未拡張状態から前記拡張状態に移行するとき、前記ステントの長軸から離れる方向に移動するものである人工僧帽弁。
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