JP7109424B2 - 体液に基づくセルフリーＤＮＡ（ｃｆＤＮＡ）アッセイを通して臓器損傷状態を査定するための新規のイムノプローブに基づく方法 - Google Patents

体液に基づくセルフリーＤＮＡ（ｃｆＤＮＡ）アッセイを通して臓器損傷状態を査定するための新規のイムノプローブに基づく方法 Download PDF

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JP7109424B2
JP7109424B2 JP2019508929A JP2019508929A JP7109424B2 JP 7109424 B2 JP7109424 B2 JP 7109424B2 JP 2019508929 A JP2019508929 A JP 2019508929A JP 2019508929 A JP2019508929 A JP 2019508929A JP 7109424 B2 JP7109424 B2 JP 7109424B2
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cfdna
score
renal
urine sample
nucleic acid
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JP2019528063A (ja
JP2019528063A5 (enExample
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ミニー エム． サーワル
タラ ケイ． シグデル
ジョシュア ワイ． ヤン
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University of California San Diego UCSD
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JP2019508929A 2016-08-17 2017-08-17 体液に基づくセルフリーＤＮＡ（ｃｆＤＮＡ）アッセイを通して臓器損傷状態を査定するための新規のイムノプローブに基づく方法 Active JP7109424B2 (ja)

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US201662376299P 2016-08-17 2016-08-17
US62/376,299 2016-08-17
PCT/US2017/047372 WO2018035340A1 (en) 2016-08-17 2017-08-17 A novel immunoprobe-based method to assess organ injury status through a biofluid-based cell-free dna (cfdna) assay

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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
EP2946345B1 (en) 2013-01-17 2024-04-03 Personalis, Inc. Methods and systems for genetic analysis
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
US11506655B2 (en) 2016-07-29 2022-11-22 Streck, Inc. Suspension composition for hematology analysis control
JP7109424B2 (ja) 2016-08-17 2022-07-29 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体液に基づくセルフリーＤＮＡ（ｃｆＤＮＡ）アッセイを通して臓器損傷状態を査定するための新規のイムノプローブに基づく方法
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
ES2991437T3 (es) 2017-10-19 2024-12-03 Streck Llc Composiciones para la regulación de la hemólisis y la coagulación y la estabilización de vesículas extracelulares
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US12234509B2 (en) * 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3905881A1 (en) * 2019-01-04 2021-11-10 QIAGEN GmbH Urine stabilization
EP4632078A2 (en) * 2019-01-24 2025-10-15 Illumina, Inc. Methods and systems for monitoring organ health and disease
EP4055610A4 (en) 2019-11-05 2023-11-29 Personalis, Inc. ESTIMATION OF TUMOR PURITY FROM SINGLE SAMPLES
US11980636B2 (en) 2020-11-18 2024-05-14 Jazz Pharmaceuticals Ireland Limited Treatment of hematological disorders
EP4263383A4 (en) 2020-12-17 2024-10-23 Nephrosant, Inc. KITS FOR STABILIZATION OF URINE SAMPLES
CA3226436A1 (en) * 2021-07-23 2023-01-26 Megan E. Mcnamara Use of circulating cell-free methylated dna to detect tissue damage
EP4413580A4 (en) 2021-10-05 2025-08-13 Personalis Inc PERSONALIZED TESTS FOR PERSONALIZED CANCER MONITORING
WO2024057280A1 (en) 2022-09-16 2024-03-21 Illumina Cambridge Limited Nanoparticle with polynucleotide binding site and method of making thereof
WO2025076525A1 (en) * 2023-10-06 2025-04-10 Neutrolis, Inc. Biomarker and precision therapy for inflammatory disease

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021041A1 (en) 1994-12-29 1996-07-11 Eiken Kagaku Kabushiki Kaisha Method of cell detection
JP2010017178A (ja) 2008-06-11 2010-01-28 Sumitomo Chemical Co Ltd Ｄｎａを定量又は検出する方法
WO2011057184A1 (en) 2009-11-09 2011-05-12 Streck, Inc. Stabilization of rna in and extracting from intact cells within a blood sample
JP2016512698A (ja) 2013-03-15 2016-05-09 イムコア ジーティーアイ ダイアグノスティクス インコーポレイテッド 尿中セルフリーｄｎａを用いて腎状態を評価するための方法および組成物
JP2016520293A (ja) 2013-03-18 2016-07-14 キアゲン ゲーエムベーハー 細胞外核酸の安定化および単離

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0821041B2 (ja) 1988-06-01 1996-03-04 横河電機株式会社 プリント基板ｃａｄの部品シンボル作成方法
US5849517A (en) 1991-05-08 1998-12-15 Streck Laboratories, Inc. Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same
JPH0821041A (ja) 1994-07-07 1996-01-23 Ig Tech Res Inc 瓦棒葺屋根の改修構造
JPH1021041A (ja) * 1996-06-28 1998-01-23 Matsushita Electric Ind Co Ltd 操作パネル
US7537889B2 (en) * 2003-09-30 2009-05-26 Life Genetics Lab, Llc. Assay for quantitation of human DNA using Alu elements
US20090280479A1 (en) * 2005-05-27 2009-11-12 John Wayne Cancer Institute Use of free circulating dna for diagnosis, prognosis, and treatment of cancer funding
US20110300608A1 (en) 2007-09-21 2011-12-08 Streck, Inc. Nucleic acid isolation in preserved whole blood
EP3290530B1 (en) 2009-02-18 2020-09-02 Streck Inc. Preservation of cell-free nucleic acids
US8404444B2 (en) 2009-02-25 2013-03-26 Diacarta Llc Method for predicting the level of damage to cells by measuring free circulating Alu nucleic acid
US20110027771A1 (en) 2009-07-31 2011-02-03 Artemis Health, Inc. Methods and compositions for cell stabilization
JP5763098B2 (ja) 2009-12-20 2015-08-12 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
WO2012108538A1 (ja) * 2011-02-10 2012-08-16 国立大学法人 長崎大学 急性肺損傷診断方法
JP5214042B2 (ja) 2012-02-03 2013-06-19 アンリツ株式会社 光素子パッケージの製造方法
US10472679B2 (en) * 2012-05-15 2019-11-12 Cornell University Non-invasive method of diagnosing renal fibrosis
US10233508B2 (en) * 2012-08-21 2019-03-19 Qiagen Gmbh Virus particle stabilisation and method for isolating viral nucleic acids
US20150225712A1 (en) * 2012-08-21 2015-08-13 Qiagen Gmbh Method for isolating nucleic acids from a formaldehyde releaser stabilized sample
WO2014074501A1 (en) * 2012-11-06 2014-05-15 Quest Diagnostics Investments Incorporated Molecular markers for diagnosis of acute cellular rejection and acute tubular necrosis
US20160376652A1 (en) * 2013-09-06 2016-12-29 Immucor Gti Diagnostics, Inc. Compositions and methods for diagnosis and prediction of solid organ graft rejection
WO2015159293A2 (en) * 2014-04-14 2015-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
ES2692393T3 (es) 2014-04-24 2018-12-03 Euroclone Spa Método de diagnóstico in vitro para cáncer por medio de ADN circulante libre de células
CA2954576C (en) 2014-07-09 2020-08-11 Daniel ENDERLE Methods for isolating microvesicles and extracting nucleic acids from biological samples
EP3497232A1 (en) 2016-08-12 2019-06-19 Streck, Inc. Molecular reference controls
JP7109424B2 (ja) 2016-08-17 2022-07-29 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体液に基づくセルフリーＤＮＡ（ｃｆＤＮＡ）アッセイを通して臓器損傷状態を査定するための新規のイムノプローブに基づく方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021041A1 (en) 1994-12-29 1996-07-11 Eiken Kagaku Kabushiki Kaisha Method of cell detection
JP2010017178A (ja) 2008-06-11 2010-01-28 Sumitomo Chemical Co Ltd Ｄｎａを定量又は検出する方法
WO2011057184A1 (en) 2009-11-09 2011-05-12 Streck, Inc. Stabilization of rna in and extracting from intact cells within a blood sample
JP2016512698A (ja) 2013-03-15 2016-05-09 イムコア ジーティーアイ ダイアグノスティクス インコーポレイテッド 尿中セルフリーｄｎａを用いて腎状態を評価するための方法および組成物
JP2016520293A (ja) 2013-03-18 2016-07-14 キアゲン ゲーエムベーハー 細胞外核酸の安定化および単離

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Angela Cannas, et al.，Implications of Storing Urinary DNA from Different Populations for Molecular Analyses，Plos one，2009年，Volume 4, Issue 9，p.1-8
Fahim Mohamed, et al.，Kidney damage biomarkers detect acute kidney injury but only functional markers predict mortality after paraquat ingestion，Toxicology Letters，Vol 237，2015年06月09日，p.140-150
Iwijn De Vlaminck, et al.，Noninvasive monitoring of infection and rejection after lung transplantation.，PNAS，2015年，Vol.112, No.43，p.13336-13341
T.K.Mehta, et al.，Quantitative Detection of Promoter Hypermethylation as a Biomarker of Acute Kideney Injury During Transplantation，Transplantation Proceedings，2006年，Volume 38, Issue 10，p.3420-3426
Vaness Garcia Moreira, et al.，Cell-Free DNA as a Noninvasive Acute Rejection Marker in Renal Transplantation，Clinical Chemistry，2009年，55:11，p.1958-1966
Vishal S. Vaidya, et al.，Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Humans.，CTSJOURNAL，Volume 1, Issue 3，p.200-208

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