JP7106528B2 - Trpv4拮抗薬 - Google Patents
Trpv4拮抗薬 Download PDFInfo
- Publication number
- JP7106528B2 JP7106528B2 JP2019515428A JP2019515428A JP7106528B2 JP 7106528 B2 JP7106528 B2 JP 7106528B2 JP 2019515428 A JP2019515428 A JP 2019515428A JP 2019515428 A JP2019515428 A JP 2019515428A JP 7106528 B2 JP7106528 B2 JP 7106528B2
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- JP
- Japan
- Prior art keywords
- sulfonyl
- hydroxymethyl
- pyrrolidin
- hydroxy
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- C07D498/10—Spiro-condensed systems
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662397008P | 2016-09-20 | 2016-09-20 | |
| US62/397,008 | 2016-09-20 | ||
| US201762482300P | 2017-04-06 | 2017-04-06 | |
| US62/482,300 | 2017-04-06 | ||
| PCT/IB2017/055702 WO2018055526A1 (en) | 2016-09-20 | 2017-09-20 | Trpv4 antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532052A JP2019532052A (ja) | 2019-11-07 |
| JP2019532052A5 JP2019532052A5 (enExample) | 2021-02-12 |
| JP7106528B2 true JP7106528B2 (ja) | 2022-07-26 |
Family
ID=60084021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515428A Active JP7106528B2 (ja) | 2016-09-20 | 2017-09-20 | Trpv4拮抗薬 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11260049B2 (enExample) |
| EP (1) | EP3515888B1 (enExample) |
| JP (1) | JP7106528B2 (enExample) |
| KR (1) | KR20190049865A (enExample) |
| CN (1) | CN109790116B (enExample) |
| AU (1) | AU2017330620A1 (enExample) |
| CA (1) | CA3036933A1 (enExample) |
| ES (1) | ES2877763T3 (enExample) |
| RU (1) | RU2019110821A (enExample) |
| WO (1) | WO2018055526A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| TWI878266B (zh) | 2019-02-15 | 2025-04-01 | 愛爾蘭商博士倫愛爾蘭有限公司 | 治療眼表痛之方法 |
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| CA3180132A1 (en) | 2020-04-30 | 2021-10-30 | Raqualia Pharma Inc. | Pyrimidin-4(3h)-one derivatives as trpv4 antagonists |
| CN115776890A (zh) | 2020-07-16 | 2023-03-10 | 拉夸里亚创药株式会社 | 作为眼病治疗剂的trpv4抑制剂 |
| CN112500419A (zh) * | 2020-11-23 | 2021-03-16 | 浙大城市学院 | 一种环氧稠合的2-亚甲基吡咯烷类化合物及其制备方法 |
| CN114058694A (zh) * | 2021-11-29 | 2022-02-18 | 上海市普陀区中心医院 | Trpv1在筛选或制备预防、缓解和/或治疗肝脏疾病的药物中的应用 |
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- 2017-09-20 RU RU2019110821A patent/RU2019110821A/ru not_active Application Discontinuation
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- 2017-09-20 JP JP2019515428A patent/JP7106528B2/ja active Active
- 2017-09-20 WO PCT/IB2017/055702 patent/WO2018055526A1/en not_active Ceased
- 2017-09-20 KR KR1020197010953A patent/KR20190049865A/ko not_active Withdrawn
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Also Published As
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|---|---|
| ES2877763T3 (es) | 2021-11-17 |
| RU2019110821A (ru) | 2020-10-22 |
| US11260049B2 (en) | 2022-03-01 |
| EP3515888B1 (en) | 2021-03-31 |
| CA3036933A1 (en) | 2018-03-29 |
| KR20190049865A (ko) | 2019-05-09 |
| AU2017330620A1 (en) | 2019-03-28 |
| WO2018055526A1 (en) | 2018-03-29 |
| US20210299113A1 (en) | 2021-09-30 |
| EP3515888A1 (en) | 2019-07-31 |
| BR112019005416A2 (pt) | 2019-06-18 |
| CN109790116A (zh) | 2019-05-21 |
| JP2019532052A (ja) | 2019-11-07 |
| CN109790116B (zh) | 2022-10-28 |
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