KR20190049865A - Trpv4 길항제 - Google Patents

Trpv4 길항제 Download PDF

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Publication number
KR20190049865A
KR20190049865A KR1020197010953A KR20197010953A KR20190049865A KR 20190049865 A KR20190049865 A KR 20190049865A KR 1020197010953 A KR1020197010953 A KR 1020197010953A KR 20197010953 A KR20197010953 A KR 20197010953A KR 20190049865 A KR20190049865 A KR 20190049865A
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South Korea
Prior art keywords
sulfonyl
hydroxymethyl
pyrrolidin
hydroxy
benzonitrile
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KR1020197010953A
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English (en)
Korean (ko)
Inventor
에드워드 제이 버나딕
칼 에이. 브룩스
브라이언 그리핀 로혼
펭 리
제이 엠. 매튜스
존 제프리 맥아티
매튜 로버트 센더
라몬트 로스코 테렐
조셉 이. 페로
데이비드 제이. 벰
Original Assignee
글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드
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Publication of KR20190049865A publication Critical patent/KR20190049865A/ko
Withdrawn legal-status Critical Current

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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