ES2877763T3 - Antagonistas del trpv4 - Google Patents

Antagonistas del trpv4 Download PDF

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Publication number
ES2877763T3
ES2877763T3 ES17784401T ES17784401T ES2877763T3 ES 2877763 T3 ES2877763 T3 ES 2877763T3 ES 17784401 T ES17784401 T ES 17784401T ES 17784401 T ES17784401 T ES 17784401T ES 2877763 T3 ES2877763 T3 ES 2877763T3
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Prior art keywords
sulfonyl
hydroxy
pyrrolidin
hydroxymethyl
alkyl
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ES17784401T
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English (en)
Spanish (es)
Inventor
Edward J Brnardic
Carl A Brooks
Brian Griffin Lawhorn
Peng Li
Jay M Matthews
John Jeffrey Mcatee
Matthew Robert Sender
Lamont Roscoe Terrell
Joseph E Pero
David J Behm
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GlaxoSmithKline Intellectual Property No 2 Ltd
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GlaxoSmithKline Intellectual Property No 2 Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Reproductive Health (AREA)
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ES17784401T 2016-09-20 2017-09-20 Antagonistas del trpv4 Active ES2877763T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662397008P 2016-09-20 2016-09-20
US201762482300P 2017-04-06 2017-04-06
PCT/IB2017/055702 WO2018055526A1 (en) 2016-09-20 2017-09-20 Trpv4 antagonists

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