JP7042547B2 - Ｍａｇｌ阻害剤 - Google Patents

Ｍａｇｌ阻害剤 Download PDF

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Publication number
JP7042547B2
JP7042547B2 JP2019523587A JP2019523587A JP7042547B2 JP 7042547 B2 JP7042547 B2 JP 7042547B2 JP 2019523587 A JP2019523587 A JP 2019523587A JP 2019523587 A JP2019523587 A JP 2019523587A JP 7042547 B2 JP7042547 B2 JP 7042547B2
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Prior art keywords
pharmaceutically acceptable
solvate
compound
formula
acceptable salt
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Expired - Fee Related
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JP2019523587A
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Japanese (ja)
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JP2020504707A5 (https=
JP2020504707A (ja
Inventor
エー． グライス，シェリル
ジェイ． バザード，ダニエル
ビー． シャガフィ，マイケル
Original Assignee
ルンドベック ラ ホーヤ リサーチ センター，インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019523587A 2016-11-16 2017-11-15 Ｍａｇｌ阻害剤 Expired - Fee Related JP7042547B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662423099P 2016-11-16 2016-11-16
US62/423,099 2016-11-16
PCT/US2017/061868 WO2018093947A1 (en) 2016-11-16 2017-11-15 Magl inhibitors

Publications (3)

Publication Number Publication Date
JP2020504707A JP2020504707A (ja) 2020-02-13
JP2020504707A5 JP2020504707A5 (https=) 2021-02-04
JP7042547B2 true JP7042547B2 (ja) 2022-03-28

Family

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Family Applications (1)

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JP2019523587A Expired - Fee Related JP7042547B2 (ja) 2016-11-16 2017-11-15 Ｍａｇｌ阻害剤

Country Status (29)

Country Link
US (1) US10093635B2 (https=)
EP (1) EP3541821A4 (https=)
JP (1) JP7042547B2 (https=)
KR (1) KR20190077544A (https=)
CN (1) CN110267963B (https=)
AR (1) AR110089A1 (https=)
AU (1) AU2017361251B2 (https=)
BR (1) BR112019009994A2 (https=)
CA (1) CA3043615A1 (https=)
CL (1) CL2019001339A1 (https=)
CO (1) CO2019005059A2 (https=)
CR (1) CR20190241A (https=)
DO (1) DOP2019000122A (https=)
EA (1) EA038090B1 (https=)
EC (1) ECSP19035077A (https=)
GE (2) GEP20237470B (https=)
IL (1) IL266523B (https=)
JO (1) JOP20190106A1 (https=)
MA (1) MA46857A (https=)
MX (1) MX391117B (https=)
NI (1) NI201900051A (https=)
PE (1) PE20191144A1 (https=)
PH (1) PH12019501097A1 (https=)
RU (1) RU2754536C1 (https=)
TN (1) TN2019000153A1 (https=)
TW (1) TWI756299B (https=)
UA (1) UA124542C2 (https=)
WO (1) WO2018093947A1 (https=)
ZA (1) ZA201903100B (https=)

Cited By (1)

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JP2021523200A (ja) * 2018-05-15 2021-09-02 ルンドベック ラ ホーヤ リサーチ センター，インク． Ｍａｇｌ阻害剤

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PE20141702A1 (es) 2012-01-06 2014-11-19 Abide Therapeutics Inc Compuestos de carbamato y preparacion y uso de los mismos
CN113413387A (zh) 2015-05-11 2021-09-21 H.隆德贝克有限公司 治疗炎症或神经性疼痛的方法
US10899737B2 (en) 2016-09-19 2021-01-26 Lundbeck La Jolla Research Center, Inc. Piperazine carbamates and methods of making and using same
UA124884C2 (uk) 2016-11-16 2021-12-08 Лундбек Ла Джолла Ресеарч Центер, Інк. Фармацевтичні склади
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
MA46866B1 (fr) 2016-11-16 2021-11-30 H Lundbeck As Une forme cristalline d'un inhibiteur de magl
DK3630744T3 (da) 2017-05-23 2023-03-06 H Lundbeck As Pyrazol-magl-inhibitorer
JP7257387B2 (ja) 2017-08-29 2023-04-13 ハー・ルンドベック・アクチエゼルスカベット スピロ環化合物並びにその作製及び使用方法
CA3125636A1 (en) * 2019-01-25 2020-07-30 H. Lundbeck A/S Methods of treating disease with magl inhibitors
KR20220101095A (ko) * 2019-11-15 2022-07-19 하. 룬드벡 아크티에셀스카브 Magl 억제제의 결정형
IT202000007150A1 (it) * 2020-04-03 2021-10-03 Univ Pisa Inibitori di monoacilglicerolo lipasi (magl)
WO2021214550A1 (en) 2020-04-21 2021-10-28 H. Lundbeck A/S Synthesis of a monoacylglycerol lipase inhibitor
CA3242372A1 (en) 2021-12-29 2023-07-06 Psy Therapeutics, Inc. Inhibiting monoacylglycerol lipase (magl)
KR20250005229A (ko) 2022-05-04 2025-01-09 하. 룬드벡 아크티에셀스카브 모노아실글리세롤 리파제 억제제로서 1,1,1,3,3,3-헥사플루오로프로판-2-일 (s)-1-(피리다진-3-일카르바모일)-6 아자스피로[2.5]옥탄-6-카르복실레이트의 결정질 형태

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JP2009514935A (ja) 2005-11-05 2009-04-09 アストラゼネカ・アクチエボラーグ 新規化合物
JP2012524803A (ja) 2009-04-22 2012-10-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ モノアシルグリセロールリパーゼ阻害剤としてのアゼチジニルジアミド
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JP2014005245A (ja) 2012-06-26 2014-01-16 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体を含有する医薬組成物
JP2019531279A (ja) 2016-09-19 2019-10-31 アビデ セラピューティクス，インク． ピペラジンカルバメート、及びその製造と使用の方法
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JP2021523200A (ja) * 2018-05-15 2021-09-02 ルンドベック ラ ホーヤ リサーチ センター，インク． Ｍａｇｌ阻害剤

Also Published As

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BR112019009994A2 (pt) 2019-08-27
IL266523B (en) 2022-09-01
NI201900051A (es) 2019-10-30
CL2019001339A1 (es) 2019-10-04
KR20190077544A (ko) 2019-07-03
AU2017361251B2 (en) 2021-08-19
CN110267963B (zh) 2022-04-01
GEAP202215088A (en) 2022-08-25
PE20191144A1 (es) 2019-09-02
MX2019005776A (es) 2019-12-05
MX391117B (es) 2025-03-21
US20180134674A1 (en) 2018-05-17
TW201823216A (zh) 2018-07-01
ZA201903100B (en) 2020-11-25
ECSP19035077A (es) 2019-05-31
AU2017361251A1 (en) 2019-05-30
AR110089A1 (es) 2019-02-20
US10093635B2 (en) 2018-10-09
CR20190241A (es) 2019-09-02
TN2019000153A1 (en) 2020-10-05
GEP20237470B (en) 2023-02-10
CN110267963A (zh) 2019-09-20
PH12019501097A1 (en) 2019-08-19
DOP2019000122A (es) 2019-09-30
MA46857A (fr) 2019-09-25
CO2019005059A2 (es) 2019-05-31
EA038090B1 (ru) 2021-07-05
RU2754536C1 (ru) 2021-09-03
EP3541821A1 (en) 2019-09-25
TWI756299B (zh) 2022-03-01
CA3043615A1 (en) 2018-05-24
JOP20190106A1 (ar) 2019-05-09
RU2019116512A (ru) 2020-12-17
UA124542C2 (uk) 2021-10-05
EP3541821A4 (en) 2020-04-22
WO2018093947A1 (en) 2018-05-24
IL266523A (en) 2019-07-31
NZ753264A (en) 2020-12-18
EA201991073A1 (ru) 2019-12-30
JP2020504707A (ja) 2020-02-13

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