JP6997627B2 - Ｃｄｋ９阻害剤としての多環式アミド誘導体 - Google Patents

Ｃｄｋ９阻害剤としての多環式アミド誘導体 Download PDF

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Publication number
JP6997627B2
JP6997627B2 JP2017567737A JP2017567737A JP6997627B2 JP 6997627 B2 JP6997627 B2 JP 6997627B2 JP 2017567737 A JP2017567737 A JP 2017567737A JP 2017567737 A JP2017567737 A JP 2017567737A JP 6997627 B2 JP6997627 B2 JP 6997627B2
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pyridine
chloro
cyclohexanecarboxamide
dihydro
acetamide
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Japanese (ja)
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JP2018522869A5 (OSRAM
JP2018522869A (ja
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カート・ゴードン・パイク
ベルナール・クリストフ・バルラーム
ジャネット・ホーキンス
クリストファー・デ・サビ
メリッサ・メアリー・バズビンダー
アレクサンダー・ハード
ミッシェル・ラム
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Detergent Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017567737A 2015-06-29 2016-06-27 Ｃｄｋ９阻害剤としての多環式アミド誘導体 Active JP6997627B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562185852P 2015-06-29 2015-06-29
US62/185,852 2015-06-29
PCT/EP2016/064899 WO2017001354A1 (en) 2015-06-29 2016-06-27 Polycyclic amide derivatives as cdk9 inhibitors

Publications (3)

Publication Number Publication Date
JP2018522869A JP2018522869A (ja) 2018-08-16
JP2018522869A5 JP2018522869A5 (OSRAM) 2019-07-18
JP6997627B2 true JP6997627B2 (ja) 2022-01-17

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US (4) US9845331B2 (OSRAM)
EP (2) EP3313838B1 (OSRAM)
JP (1) JP6997627B2 (OSRAM)
KR (1) KR102663113B1 (OSRAM)
CN (1) CN107873028B (OSRAM)
AR (1) AR105179A1 (OSRAM)
AU (1) AU2016286200B2 (OSRAM)
BR (1) BR122019013677B1 (OSRAM)
CA (1) CA2989499C (OSRAM)
CL (1) CL2017003306A1 (OSRAM)
CO (1) CO2017013713A2 (OSRAM)
CR (2) CR20210297A (OSRAM)
CY (2) CY1122111T1 (OSRAM)
DK (2) DK3313838T3 (OSRAM)
DO (2) DOP2017000295A (OSRAM)
EA (1) EA035383B1 (OSRAM)
ES (2) ES2728356T3 (OSRAM)
HR (2) HRP20190748T1 (OSRAM)
HU (2) HUE043440T2 (OSRAM)
IL (1) IL256393B (OSRAM)
LT (2) LT3313838T (OSRAM)
ME (1) ME03404B (OSRAM)
MX (1) MX371034B (OSRAM)
MY (1) MY201673A (OSRAM)
NI (1) NI201700174A (OSRAM)
PE (1) PE20180530A1 (OSRAM)
PH (1) PH12017502334B1 (OSRAM)
PL (2) PL3313838T3 (OSRAM)
PT (2) PT3539961T (OSRAM)
RS (2) RS62781B1 (OSRAM)
SI (2) SI3313838T1 (OSRAM)
SM (2) SMT201900298T1 (OSRAM)
SV (1) SV2017005598A (OSRAM)
TN (1) TN2017000486A1 (OSRAM)
TR (1) TR201909286T4 (OSRAM)
TW (1) TWI723028B (OSRAM)
WO (1) WO2017001354A1 (OSRAM)
ZA (1) ZA201800563B (OSRAM)

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US20200289506A1 (en) 2017-09-25 2020-09-17 Astrazeneca Ab Combination of a btk inhibitor and an inhibitor or cdk9 to treat cancer
WO2019074748A1 (en) * 2017-10-09 2019-04-18 Merck Sharp & Dohme Corp. NOVEL SUBSTITUTED PHENYL-OXETANE AND PHENYLTETRAHYDROFURAN COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO)
CN108129288B (zh) * 2017-12-27 2021-01-22 上海毕得医药科技股份有限公司 一种反式-3-羟基环丁基甲酸的合成方法
TW202344250A (zh) 2018-11-14 2023-11-16 瑞典商阿斯特捷利康公司 治療癌症之方法
CN114008046B (zh) * 2019-06-27 2023-08-18 南京明德新药研发有限公司 作为cdk9抑制剂的氮杂吲哚连吡唑类化合物
AU2020345950A1 (en) * 2019-09-11 2022-03-31 Prelude Therapeutics Incorporated CDK inhibitors and their use as pharmaceuticals
WO2021115335A1 (zh) * 2019-12-09 2021-06-17 石药集团中奇制药技术（石家庄）有限公司 作为周期蛋白依赖性激酶9抑制剂的化合物及其应用
WO2021227906A1 (zh) * 2020-05-12 2021-11-18 苏州阿尔脉生物科技有限公司 一种作为cdk抑制剂的吡啶乙酰胺类衍生物、其制备方法及用途
JP7406008B2 (ja) * 2020-05-12 2023-12-26 蘇州阿尓脈生物科技有限公司 Ｃｄｋ９阻害剤としての多環式アミド系誘導体、その調製方法及び用途
TW202216207A (zh) * 2020-06-24 2022-05-01 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物及cdk9抑制劑之組合
US20230271942A1 (en) 2020-08-07 2023-08-31 Pharmablock Sciences (Nanjing), Inc. Cdk9 inhibitor and use thereof
TWI809330B (zh) * 2020-11-20 2023-07-21 大陸商勁方醫藥科技(上海)有限公司 Cdk9抑制劑的多晶型物及其製法和用途
CN115381824B (zh) * 2021-05-24 2024-11-05 石药集团中奇制药技术（石家庄）有限公司 周期蛋白依赖性激酶9抑制剂的用途
CN115381823B (zh) * 2021-05-24 2024-11-05 石药集团中奇制药技术（石家庄）有限公司 一种周期蛋白依赖性激酶9抑制剂的用途
CN117813289A (zh) * 2021-07-14 2024-04-02 上海海雁医药科技有限公司 吡唑衍生物及其中间体和制备方法
CN115703738B (zh) * 2021-08-16 2024-06-21 中国科学院上海药物研究所 含2-芳杂环取代的脲类化合物、其制备方法和用途
CN118613257A (zh) * 2021-12-23 2024-09-06 鲁汶大学 用于抑制yap/taz-tead的四氢吡唑并嘧啶及相关类似物
AU2023326499A1 (en) 2022-08-17 2025-03-27 Korea Research Institute Of Bioscience And Biotechnology Compounds for inhibiting or decomposing cdk2 and/or cdk9, and medicinal uses thereof
AU2024258350A1 (en) * 2023-04-19 2025-10-30 Alcon Inc. N-substituted c6 cyclyl carboxamide compounds and uses thereof
WO2025076115A1 (en) * 2023-10-02 2025-04-10 Prelude Therapeutics Incorporated Cdk inhibitors and their use as pharmaceuticals

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WO2008133192A1 (ja) 2007-04-19 2008-11-06 Takeda Pharmaceutical Company Limited 縮合イミダゾール化合物およびその用途
WO2011101640A1 (en) 2010-02-19 2011-08-25 Medical Research Council Technology Fused heterocyclic compounds for use in the treatment of malaria
WO2011124539A1 (de) 2010-04-07 2011-10-13 Bayer Cropscience Ag Bicyclische pyridinylpyrazole
WO2012101063A1 (en) 2011-01-28 2012-08-02 Novartis Ag N-acyl pyridine biaryl compounds and their uses
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AU2008309517B2 (en) 2007-10-12 2013-03-14 Astrazeneca Ab Inhibitors of protein kinases
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WO2012101064A1 (en) 2011-01-28 2012-08-02 Novartis Ag N-acyl pyrimidine biaryl compounds as protein kinase inhibitors
BR112015023013A2 (pt) 2013-03-13 2017-07-18 Abbvie Inc inibidores de quinase cdk9
UY35419A (es) 2013-03-14 2014-10-31 Abbvie Inc Inhibidores de cdk9 quinasa de pirrolo (2,3- b) piridina
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WO2008133192A1 (ja) 2007-04-19 2008-11-06 Takeda Pharmaceutical Company Limited 縮合イミダゾール化合物およびその用途
WO2011101640A1 (en) 2010-02-19 2011-08-25 Medical Research Council Technology Fused heterocyclic compounds for use in the treatment of malaria
WO2011124539A1 (de) 2010-04-07 2011-10-13 Bayer Cropscience Ag Bicyclische pyridinylpyrazole
WO2012101063A1 (en) 2011-01-28 2012-08-02 Novartis Ag N-acyl pyridine biaryl compounds and their uses
WO2013050434A1 (en) 2011-10-06 2013-04-11 Bayer Intellectual Property Gmbh Heterocyclylpyri(mi)dinylpyrazole
WO2014160017A1 (en) 2013-03-13 2014-10-02 Abbvie Inc. Pyridine cdk9 kinase inhibitors

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US20220340592A1 (en) 2022-10-27
ME03404B (me) 2020-01-20
SMT201900298T1 (it) 2019-07-11
US9845331B2 (en) 2017-12-19
MY201673A (en) 2024-03-12
PE20180530A1 (es) 2018-03-19
CR20210297A (es) 2021-09-29
PL3313838T3 (pl) 2019-08-30
EA201890094A1 (ru) 2018-07-31
KR102663113B1 (ko) 2024-05-02
SI3539961T1 (sl) 2022-02-28
PL3539961T3 (pl) 2022-02-14
DOP2017000295A (es) 2017-12-31
IL256393A (en) 2018-02-28
US20210171541A1 (en) 2021-06-10
DOP2018000207A (es) 2018-10-15
PT3539961T (pt) 2021-12-20
BR112017027394A2 (pt) 2018-11-06
DK3539961T3 (da) 2022-01-03
EP3539961A1 (en) 2019-09-18
AR105179A1 (es) 2017-09-13
MX2017016244A (es) 2018-04-20
PH12017502334B1 (en) 2023-05-26
SV2017005598A (es) 2018-02-23
ZA201800563B (en) 2022-08-31
HRP20190748T1 (hr) 2019-06-14
AU2016286200A1 (en) 2018-02-08
PH12017502334A1 (en) 2018-06-25
HRP20211970T1 (hr) 2022-03-18
CY1125066T1 (el) 2023-03-24
KR20180021830A (ko) 2018-03-05
PT3313838T (pt) 2019-06-24
EP3539961B1 (en) 2021-10-06
HUE043440T2 (hu) 2019-08-28
RS58712B1 (sr) 2019-06-28
CN107873028B (zh) 2021-02-02
AU2016286200B2 (en) 2018-10-04
CN107873028A (zh) 2018-04-03
CA2989499C (en) 2023-10-31
SI3313838T1 (sl) 2019-06-28
DK3313838T3 (da) 2019-06-11
CY1122111T1 (el) 2020-11-25
ES2728356T3 (es) 2019-10-23
ES2902148T3 (es) 2022-03-25
US20180093998A1 (en) 2018-04-05
CO2017013713A2 (es) 2018-03-28
TN2017000486A1 (en) 2019-04-12
BR122019013677B1 (pt) 2024-01-02
LT3313838T (lt) 2019-06-10
TW201718573A (zh) 2017-06-01
EP3313838B1 (en) 2019-04-03
WO2017001354A1 (en) 2017-01-05
LT3539961T (lt) 2021-12-27
NI201700174A (es) 2018-10-19
HUE057343T2 (hu) 2022-05-28
EA035383B1 (ru) 2020-06-04
EP3313838A1 (en) 2018-05-02
IL256393B (en) 2021-12-01
CL2017003306A1 (es) 2018-06-29
RS62781B1 (sr) 2022-01-31
MX371034B (es) 2020-01-13
US11352369B2 (en) 2022-06-07
SMT202200005T1 (it) 2022-03-21
TR201909286T4 (tr) 2019-07-22
US10717746B2 (en) 2020-07-21
CR20170596A (es) 2018-07-04
JP2018522869A (ja) 2018-08-16
CA2989499A1 (en) 2017-01-05
US20160376287A1 (en) 2016-12-29
TWI723028B (zh) 2021-04-01

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