JP6983075B2 - 極性の組換え延長部を有するインスリン - Google Patents

極性の組換え延長部を有するインスリン Download PDF

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Publication number
JP6983075B2
JP6983075B2 JP2017562721A JP2017562721A JP6983075B2 JP 6983075 B2 JP6983075 B2 JP 6983075B2 JP 2017562721 A JP2017562721 A JP 2017562721A JP 2017562721 A JP2017562721 A JP 2017562721A JP 6983075 B2 JP6983075 B2 JP 6983075B2
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human insulin
insulin
desb30 human
desb30
group
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JP2018527288A (ja
JP2018527288A5 (https=
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トマス・バアウロム・ケルスン
トマス・ホウ−イェンセン
ティネ・ニガール・ヴィンター
フランティセク・フバレク
イングリッド・ペテルソン
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2017562721A 2015-06-02 2016-06-02 極性の組換え延長部を有するインスリン Expired - Fee Related JP6983075B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021070977A JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15170337 2015-06-02
EP15170337.8 2015-06-02
EP15176207.7 2015-07-10
EP15176207 2015-07-10
PCT/EP2016/062514 WO2016193380A1 (en) 2015-06-02 2016-06-02 Insulins with polar recombinant extensions

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JP2021070977A Division JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

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JP2018527288A JP2018527288A (ja) 2018-09-20
JP2018527288A5 JP2018527288A5 (https=) 2019-05-09
JP6983075B2 true JP6983075B2 (ja) 2021-12-17

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JP2017562721A Expired - Fee Related JP6983075B2 (ja) 2015-06-02 2016-06-02 極性の組換え延長部を有するインスリン
JP2021070977A Withdrawn JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

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US (1) US11208452B2 (https=)
EP (1) EP3303380B1 (https=)
JP (2) JP6983075B2 (https=)
CN (1) CN107743494B (https=)
ES (1) ES2784603T3 (https=)
WO (1) WO2016193380A1 (https=)

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JP6983075B2 (ja) 2015-06-02 2021-12-17 ノヴォ ノルディスク アー／エス 極性の組換え延長部を有するインスリン
CN108136043B (zh) 2015-10-01 2022-09-06 诺和诺德股份有限公司 蛋白质缀合物
EP3939605A1 (en) 2016-12-09 2022-01-19 Akston Biosciences Corporation Insulin-fc fusions and methods of use
CN110505885A (zh) * 2017-04-05 2019-11-26 诺和诺德股份有限公司 寡聚体延伸的胰岛素-Fc缀合物
JP7589049B2 (ja) * 2018-06-21 2024-11-25 ノヴォ ノルディスク アー／エス 肥満を治療するための新規化合物
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
KR20210029210A (ko) 2018-06-29 2021-03-15 악스톤 바이오사이언시스 코퍼레이션 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법
CN112839681A (zh) 2018-10-10 2021-05-25 诺和诺德股份有限公司 寡聚体延伸的胰岛素-Fc缀合物及其医学用途
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US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
CN115260313B (zh) * 2019-12-31 2023-07-18 北京质肽生物医药科技有限公司 Glp-1和gdf15的融合蛋白以及其缀合物
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
CN116096733A (zh) 2020-04-10 2023-05-09 阿卡斯通生物科学公司 Covid-19融合蛋白的抗原特异性免疫疗法和使用方法
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CN114729060B (zh) * 2020-09-30 2022-11-25 北京质肽生物医药科技有限公司 多肽缀合物和使用方法
US11667689B2 (en) 2021-07-23 2023-06-06 Akston Biosciences Corporation Insulin-Fc fusion proteins and methods of use to treat cancer
EP4323413A4 (en) 2022-03-30 2025-10-15 Beijing Ql Biopharmaceutical Co Ltd LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF
CN115716877B (zh) * 2022-07-04 2023-09-01 北京惠之衡生物科技有限公司 一种表达glp-1和胰岛素缀合物多肽的重组工程菌
CN115947822B (zh) * 2022-07-04 2023-08-18 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其药物组合物和应用
WO2024051787A1 (zh) * 2022-09-09 2024-03-14 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其应用

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Also Published As

Publication number Publication date
JP2018527288A (ja) 2018-09-20
JP2021119156A (ja) 2021-08-12
US20180291076A1 (en) 2018-10-11
CN107743494B (zh) 2022-04-29
US11208452B2 (en) 2021-12-28
EP3303380B1 (en) 2020-01-15
ES2784603T3 (es) 2020-09-29
CN107743494A (zh) 2018-02-27
EP3303380A1 (en) 2018-04-11
WO2016193380A1 (en) 2016-12-08

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