JP2018527288A5 - - Google Patents

Download PDF

Info

Publication number
JP2018527288A5
JP2018527288A5 JP2017562721A JP2017562721A JP2018527288A5 JP 2018527288 A5 JP2018527288 A5 JP 2018527288A5 JP 2017562721 A JP2017562721 A JP 2017562721A JP 2017562721 A JP2017562721 A JP 2017562721A JP 2018527288 A5 JP2018527288 A5 JP 2018527288A5
Authority
JP
Japan
Prior art keywords
human insulin
desb30 human
insulin
desb30
extended
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017562721A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018527288A (ja
JP6983075B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2016/062514 external-priority patent/WO2016193380A1/en
Publication of JP2018527288A publication Critical patent/JP2018527288A/ja
Publication of JP2018527288A5 publication Critical patent/JP2018527288A5/ja
Priority to JP2021070977A priority Critical patent/JP2021119156A/ja
Application granted granted Critical
Publication of JP6983075B2 publication Critical patent/JP6983075B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017562721A 2015-06-02 2016-06-02 極性の組換え延長部を有するインスリン Expired - Fee Related JP6983075B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021070977A JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15170337 2015-06-02
EP15170337.8 2015-06-02
EP15176207.7 2015-07-10
EP15176207 2015-07-10
PCT/EP2016/062514 WO2016193380A1 (en) 2015-06-02 2016-06-02 Insulins with polar recombinant extensions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021070977A Division JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

Publications (3)

Publication Number Publication Date
JP2018527288A JP2018527288A (ja) 2018-09-20
JP2018527288A5 true JP2018527288A5 (https=) 2019-05-09
JP6983075B2 JP6983075B2 (ja) 2021-12-17

Family

ID=56098249

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017562721A Expired - Fee Related JP6983075B2 (ja) 2015-06-02 2016-06-02 極性の組換え延長部を有するインスリン
JP2021070977A Withdrawn JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021070977A Withdrawn JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

Country Status (6)

Country Link
US (1) US11208452B2 (https=)
EP (1) EP3303380B1 (https=)
JP (2) JP6983075B2 (https=)
CN (1) CN107743494B (https=)
ES (1) ES2784603T3 (https=)
WO (1) WO2016193380A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6983075B2 (ja) 2015-06-02 2021-12-17 ノヴォ ノルディスク アー/エス 極性の組換え延長部を有するインスリン
CN108136043B (zh) 2015-10-01 2022-09-06 诺和诺德股份有限公司 蛋白质缀合物
EP3939605A1 (en) 2016-12-09 2022-01-19 Akston Biosciences Corporation Insulin-fc fusions and methods of use
CN110505885A (zh) * 2017-04-05 2019-11-26 诺和诺德股份有限公司 寡聚体延伸的胰岛素-Fc缀合物
JP7589049B2 (ja) * 2018-06-21 2024-11-25 ノヴォ ノルディスク アー/エス 肥満を治療するための新規化合物
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
KR20210029210A (ko) 2018-06-29 2021-03-15 악스톤 바이오사이언시스 코퍼레이션 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법
CN112839681A (zh) 2018-10-10 2021-05-25 诺和诺德股份有限公司 寡聚体延伸的胰岛素-Fc缀合物及其医学用途
FI4073098T3 (fi) 2019-12-19 2023-11-15 Akston Biosciences Corp Ultrapitkävaikutteiset insuliini-Fc-fuusioproteiinit ja niiden käyttömenetelmät
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
CN115260313B (zh) * 2019-12-31 2023-07-18 北京质肽生物医药科技有限公司 Glp-1和gdf15的融合蛋白以及其缀合物
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
CN116096733A (zh) 2020-04-10 2023-05-09 阿卡斯通生物科学公司 Covid-19融合蛋白的抗原特异性免疫疗法和使用方法
DE102020110543A1 (de) 2020-04-17 2021-10-21 Bayerische Motoren Werke Aktiengesellschaft Energiespeichereinrichtung, Kraftfahrzeug und Kühlplattenanordnung
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
EP3915571A1 (en) * 2020-05-29 2021-12-01 Adocia Pharmaceutical composition in the form of an injectable aqueous solution including at least a rapid acting insulin analog and a glucagon suppressor with prandial action
CN114729060B (zh) * 2020-09-30 2022-11-25 北京质肽生物医药科技有限公司 多肽缀合物和使用方法
US11667689B2 (en) 2021-07-23 2023-06-06 Akston Biosciences Corporation Insulin-Fc fusion proteins and methods of use to treat cancer
EP4323413A4 (en) 2022-03-30 2025-10-15 Beijing Ql Biopharmaceutical Co Ltd LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF
CN115716877B (zh) * 2022-07-04 2023-09-01 北京惠之衡生物科技有限公司 一种表达glp-1和胰岛素缀合物多肽的重组工程菌
CN115947822B (zh) * 2022-07-04 2023-08-18 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其药物组合物和应用
WO2024051787A1 (zh) * 2022-09-09 2024-03-14 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其应用

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE257197C (https=)
DE286509C (https=)
US3914252A (en) 1971-03-15 1975-10-21 Continental Oil Co Preparation of N-iodocompounds
DD257197A1 (de) 1987-01-28 1988-06-08 Univ Dresden Tech Verfahren zur herstellung von immobilisierten, in ihrer biologischen aktivitaet stabilisierten und in ihren pharmakologischen eigenschaften modifizierten insulinpraeparationen
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DD286509A5 (de) 1989-06-30 1991-01-31 Veb Berlin-Chemie,De Verfahren zur herstellung von aktivitaetsstabilisierten, wirkungsverlaengerten rektal applizierbaren insulinpraeparationen
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
CA2230492C (en) 1995-09-21 2009-05-26 Genentech, Inc. Human growth hormone variants
WO1998022577A1 (en) 1996-11-15 1998-05-28 Maria Grazia Masucci Fusion proteins having increased half-lives
EP0946735B1 (en) 1996-12-20 2006-02-08 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
ATE375363T1 (de) 1997-07-14 2007-10-15 Bolder Biotechnology Inc Derivate des wachstumshormons und verwandte proteine
ATE407697T1 (de) 1999-07-13 2008-09-15 Bolder Biotechnology Inc Erythropoietin immunglobulin fusionsproteine
US20050287153A1 (en) 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
EP2180054A1 (en) 1999-12-24 2010-04-28 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
EP1352062A2 (en) 2001-01-11 2003-10-15 Maxygen Aps Improved growth hormone molecules
US20060183197A1 (en) 2001-01-11 2006-08-17 Andersen Kim V Variant growth hormone molecules conjugated with macromolecules compounds
PE20020908A1 (es) 2001-03-21 2002-10-26 Cell Therapeutics Inc Produccion recombinante de polimeros polianionicos y uso de de los mismos
US20050233417A1 (en) 2001-11-12 2005-10-20 Cooper David N Growth hormone variations in humans and their uses
GB2389115B (en) 2001-12-14 2005-03-16 Asterion Ltd Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone
WO2004029207A2 (en) 2002-09-27 2004-04-08 Xencor Inc. Optimized fc variants and methods for their generation
US20040180054A1 (en) 2003-03-13 2004-09-16 Hanmi Pharm. Co., Ltd. Physiologically active polypeptide conjugate having prolonged in vivo half-life
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
ATE555133T1 (de) 2003-11-13 2012-05-15 Hanmi Holdings Co Ltd Igg fc fragment für einen arzneimittelträger und verfahren zu dessen herstellung
KR100594607B1 (ko) 2004-11-03 2006-06-30 재단법인서울대학교산학협력재단 신규한 경구투여용 재조합 인간 성장호르몬 분비미생물제제 및 그 제조방법
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
WO2006081249A2 (en) * 2005-01-25 2006-08-03 Cell Therapeutics, Inc. Conjugates of biologically active proteins having a modified in vivo half-life
ZA200707006B (en) * 2005-01-25 2008-11-26 Cell Therapeutics Inc Conjugates of biologically active proteins having a modified in vivo half-life
EP1843790A2 (en) 2005-01-27 2007-10-17 Novo Nordisk A/S Insulin derivatives conjugated with structurally well defined branched polymers
BRPI0607775A2 (en) 2005-02-16 2018-06-26 Novo Nordisk A/S conjugate, pharmaceutical composition, use of a compound, and method for treating or preventing disease
KR100754667B1 (ko) 2005-04-08 2007-09-03 한미약품 주식회사 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물
WO2006116260A2 (en) 2005-04-26 2006-11-02 Medimmune, Inc. Modulation of antibody effector function by hinge domain engineering
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
AU2006324488B2 (en) 2005-12-12 2013-03-21 Abcam Limited Production of conjugates
CN101384272B (zh) 2005-12-20 2013-05-01 杜克大学 用于递送具有增强的药理性质的活性剂的方法和组合物
EP1996937A4 (en) 2006-03-06 2009-04-08 Amunix Inc GENETIC PACKS AND USES THEREOF
JP5256199B2 (ja) 2006-08-07 2013-08-07 テヴァ バイオファーマシューティカルズ ユーエスエー,インコーポレーティッド アルブミン−インスリン融合タンパク質
PT2094728E (pt) 2006-10-26 2013-05-27 Janssen Biotech Inc Métodos de adaptação de anticorpos monoclonais ao ser humano
WO2008049711A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
WO2008147456A2 (en) 2006-11-20 2008-12-04 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
WO2008092117A2 (en) 2007-01-25 2008-07-31 Xencor, Inc. Immunoglobulins with modifications in the fcr binding region
KR20080095141A (ko) 2007-04-23 2008-10-28 포항공과대학교 산학협력단 인간 알부민 링커를 통하여 면역글로불린의 Fc에 결합된생리학적 활성 폴리펩티드의 융합 폴리펩티드, 및 이의제조방법
CN105131127B (zh) 2007-05-30 2018-09-07 浦项工科大学校产学协力团 免疫球蛋白融合蛋白
AU2008255352B2 (en) 2007-05-31 2014-05-22 Genmab A/S Stable IgG4 antibodies
WO2009015345A1 (en) 2007-07-25 2009-01-29 Amgen Inc. Pharmaceutical compositions comprising fc fusion proteins
US8933197B2 (en) * 2007-08-15 2015-01-13 Amunix Operating Inc. Compositions comprising modified biologically active polypeptides
JP5314033B2 (ja) 2007-10-22 2013-10-16 メルク セローノ ソシエテ アノニム 突然変異IgGFcフラグメントと融合した単一IFN−ベータ
KR101784231B1 (ko) 2008-06-20 2017-11-08 노파르티스 아게 응집이 감소된 면역글로불린
US20110119848A1 (en) 2008-07-02 2011-05-26 Koninklijke Philips Electronics N.V. V-spring configuration and end attachment assemblies therefor for use in a personal care appliance
UA101670C2 (ru) 2008-07-23 2013-04-25 Ханми Сайенс Ко., Лтд. Полипептидный комплекс, содержащий непептидильный полимер, который имеет три функциональных конца
CA2748314C (en) * 2009-02-03 2018-10-02 Amunix Operating Inc. Extended recombinant polypeptides and compositions comprising same
GB0914110D0 (en) 2009-08-12 2009-09-16 Medical Res Council Peptide libraries
MX2012003939A (es) 2009-09-30 2012-07-30 Glaxo Group Ltd Fusiones y conjugados de farmaco.
US20120276092A1 (en) 2009-10-29 2012-11-01 Jinquan Luo Antibody Glycosylation Variants
US8637637B2 (en) 2010-01-12 2014-01-28 Bill Nai-Chau Sun Fc fusion proteins of human growth hormone
AR081066A1 (es) 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
WO2011144756A1 (en) 2010-05-21 2011-11-24 Xl-Protein Gmbh Biosynthetic proline/alanine random coil polypeptides and their uses
KR101337797B1 (ko) 2010-07-14 2013-12-06 한미사이언스 주식회사 지속형 인간 성장 호르몬 결합체 액상 제제
US9783571B2 (en) 2011-04-05 2017-10-10 Warham Lance Martin Isolation of cysteine containing peptides
UA117901C2 (uk) 2011-07-06 2018-10-25 Ґенмаб Б.В. Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
CN117462693A (zh) 2012-02-27 2024-01-30 阿穆尼克斯运营公司 Xten缀合组合物和制造其的方法
CA2873112A1 (en) 2012-05-11 2013-11-14 Alexander Krantz Site-specific labeling and targeted delivery of proteins for the treatment of cancer
JP2016521701A (ja) 2013-06-07 2016-07-25 ノヴォ ノルディスク アー/エス 成熟インスリンポリペプチドを作製するための方法
CN105792851B (zh) 2013-09-13 2023-10-10 斯克利普斯研究所 修饰的治疗剂及其组合物
JP6620094B2 (ja) 2013-11-26 2019-12-11 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. 免疫応答を調節するための組成物および方法
TW201619188A (zh) 2014-03-05 2016-06-01 優稀美生物醫藥公司 多聚體Fc蛋白質
CN106687482B (zh) 2014-09-17 2022-01-25 诺和诺德股份有限公司 能够结合组织因子途径抑制剂(1-161)上的两个表位的抗体
US10894089B2 (en) 2015-02-17 2021-01-19 Hanmi Pharm. Co., Ltd. Long-acting insulin or insulin analogue conjugate
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
JP6983075B2 (ja) 2015-06-02 2021-12-17 ノヴォ ノルディスク アー/エス 極性の組換え延長部を有するインスリン
CA2994853C (en) 2015-08-14 2023-06-27 Rc Biotechnologies, Inc. Covalent linkers in antibody-drug conjugates and methods of making and using the same
CN108136043B (zh) 2015-10-01 2022-09-06 诺和诺德股份有限公司 蛋白质缀合物
CN110505885A (zh) 2017-04-05 2019-11-26 诺和诺德股份有限公司 寡聚体延伸的胰岛素-Fc缀合物

Similar Documents

Publication Publication Date Title
JP2018527288A5 (https=)
NZ592510A (en) HLA-A*1101-restricted WTI peptide and pharmaceutical composition comprising the same
JP2017532343A5 (https=)
SI2864350T1 (en) GLUCAGON ANALOGUE ANALOGUE WITH ACTIVITY OF GIP RECEPTOR
ES2661860T3 (es) Péptido antibiótico y método de su preparación, y aplicación del mismo
AR105816A2 (es) Derivados de exendina-4 funcionalizada
WO2009033770A3 (en) Calcitonin c-terminal flanking peptide for use as a therapeutic agent
JP2014129355A5 (https=)
HRP20181026T1 (hr) Dugodjelujuće formulacije inzulina
JP2005537234A5 (https=)
WO2009033718A3 (en) Use of anti -inflammatory peptide 1 as a therapeutic agent
CN106232616A (zh) 两亲性合成抗菌肽、其药物组合物及其用途
WO2009043466A3 (en) Therapeutic use of the peptide gluten exorphin a5
WO2009033711A3 (en) Use of glp-1 as a therapeutic agent
JP2012511506A5 (https=)
WO2009043451A3 (en) Use of chorionic gonadotropin-beta (109-145) as a therapeutic agent
WO2009046822A3 (en) Use of the peptide ymdgtmsqv as a therapeutic agent
RU2018107727A (ru) Новые производные инсулина и их медицинские применения
WO2009046858A3 (en) Therapeutic uses of kisspeptin 13 and compositions thereof
JP2019513752A5 (https=)
WO2016105545A3 (en) Insulin analogues with enhanced stabilized and reduced mitogenicity
JP2017505772A5 (https=)
JP2020508074A5 (https=)
MY200047A (en) Rapid-acting insulin analogues of enhanced stability
WO2009033722A3 (en) Use of a octreotide as a therapeutic agent