JP6963385B2 - 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 - Google Patents
抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 Download PDFInfo
- Publication number
- JP6963385B2 JP6963385B2 JP2016570201A JP2016570201A JP6963385B2 JP 6963385 B2 JP6963385 B2 JP 6963385B2 JP 2016570201 A JP2016570201 A JP 2016570201A JP 2016570201 A JP2016570201 A JP 2016570201A JP 6963385 B2 JP6963385 B2 JP 6963385B2
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- combination
- antibody
- ctla
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN499DE2014 | 2014-02-21 | ||
| IN499/DEL/2014 | 2014-02-21 | ||
| IN3087DE2014 | 2014-10-29 | ||
| IN3087/DEL/2014 | 2014-10-29 | ||
| PCT/IN2015/000099 WO2015125159A1 (en) | 2014-02-21 | 2015-02-20 | Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an an anti-pd-1 antibody |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019016875A Division JP2019077723A (ja) | 2014-02-21 | 2019-02-01 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506264A JP2017506264A (ja) | 2017-03-02 |
| JP2017506264A5 JP2017506264A5 (enExample) | 2018-01-18 |
| JP6963385B2 true JP6963385B2 (ja) | 2021-11-10 |
Family
ID=53055076
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570201A Active JP6963385B2 (ja) | 2014-02-21 | 2015-02-20 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
| JP2019016875A Withdrawn JP2019077723A (ja) | 2014-02-21 | 2019-02-01 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
| JP2021018007A Withdrawn JP2021073296A (ja) | 2014-02-21 | 2021-02-08 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019016875A Withdrawn JP2019077723A (ja) | 2014-02-21 | 2019-02-01 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
| JP2021018007A Withdrawn JP2021073296A (ja) | 2014-02-21 | 2021-02-08 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10010587B2 (enExample) |
| EP (2) | EP3134123B1 (enExample) |
| JP (3) | JP6963385B2 (enExample) |
| KR (1) | KR102410090B1 (enExample) |
| CN (1) | CN106132438B (enExample) |
| AU (3) | AU2015220408B2 (enExample) |
| CA (1) | CA2937660A1 (enExample) |
| CY (1) | CY1124226T1 (enExample) |
| DK (1) | DK3134123T3 (enExample) |
| ES (1) | ES2872848T3 (enExample) |
| HR (1) | HRP20210377T1 (enExample) |
| HU (1) | HUE053982T2 (enExample) |
| IL (1) | IL247320B (enExample) |
| LT (1) | LT3134123T (enExample) |
| MX (2) | MX385194B (enExample) |
| PL (1) | PL3134123T3 (enExample) |
| PT (1) | PT3134123T (enExample) |
| RS (1) | RS61661B1 (enExample) |
| SI (1) | SI3134123T1 (enExample) |
| SM (1) | SMT202100191T1 (enExample) |
| WO (1) | WO2015125159A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3211001B1 (en) | 2010-12-22 | 2020-10-07 | The Board of Trustees of the Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| FI3077041T3 (fi) | 2013-12-05 | 2024-10-16 | Rfemb Holdings Llc | Syövän immunoterapia radiotaajuisella sähköisellä solukalvon hajotuksella (rf-emb) |
| SI3081576T1 (sl) | 2013-12-12 | 2019-12-31 | Shanghai Hengrui Pharmaceutical Co., Ltd., | Protitelo PD-1, njegov antigen-vezavni fragment in njegova medicinska uporaba |
| PL3134123T3 (pl) * | 2014-02-21 | 2021-07-12 | Nektar Therapeutics (India) Pvt. Ltd. | Agoniści selektywni względem IL-2Rbeta w kombinacji z przeciwciałem anty-CTLA-4 lub z przeciwciałem anty-PD-1 |
| CA2946398A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| US11141216B2 (en) | 2015-01-30 | 2021-10-12 | Immunsys, Inc. | Radio-frequency electrical membrane breakdown for the treatment of high risk and recurrent prostate cancer, unresectable pancreatic cancer, tumors of the breast, melanoma or other skin malignancies, sarcoma, soft tissue tumors, ductal carcinoma, neoplasia, and intra and extra luminal abnormal tissue |
| RU2711380C2 (ru) | 2015-07-16 | 2020-01-16 | Байоксэл Терапьютикс, Инк. | Новый подход к лечению рака с применением иммуномодуляции |
| US11262360B2 (en) | 2015-10-02 | 2022-03-01 | Julius-Maximilians-Universität Würzburg | GDF-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers |
| CA3000211A1 (en) * | 2015-10-08 | 2017-04-13 | Nektar Therapeutics | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
| KR20180113976A (ko) | 2015-11-20 | 2018-10-17 | 센화 바이오사이언시즈 인코포레이티드 | 암을 치료하기 위한 테트라사이클릭 퀴놀론 유사체의 병행 요법 |
| US11612426B2 (en) | 2016-01-15 | 2023-03-28 | Immunsys, Inc. | Immunologic treatment of cancer |
| WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
| US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| BR112019003248A2 (pt) * | 2016-08-19 | 2019-10-01 | Brooklyn Immunotherapeutics Llc | usos de inibidores de pd-1/pd-l1 e/ou inibidores de ctla-4 com um biológico contendo múltiplos componentes citocínicos para o tratamento de câncer |
| MA46771A (fr) * | 2016-11-10 | 2021-06-02 | Univ Texas | Méthode de traitement de tumeur immunothérapeutique |
| KR102619747B1 (ko) * | 2017-01-10 | 2023-12-29 | 넥타르 테라퓨틱스 | Tlr 효현제 화합물의 다중-아암 중합체 컨쥬게이트 및 관련 면역 요법적 치료 방법 |
| EP3589303A4 (en) | 2017-03-01 | 2020-11-25 | Nektar Therapeutics | Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| MA48862A (fr) * | 2017-05-02 | 2020-04-01 | Nektar Therapeutics | Méthode de traitement de tumeur immunothérapeutique |
| BR112019024745B1 (pt) * | 2017-05-25 | 2024-01-16 | Institute For Basic Science | Anticorpo anti-hil-2 ou fragmento de ligação a antígeno do mesmo,ácido nucleico, vetor recombinante, célula procariótica transformada, método para a produção de um anticorpo anti-hil-2 ou um fragmento do mesmo e complexo |
| CN111201035A (zh) | 2017-06-19 | 2020-05-26 | 梅迪塞纳医疗股份有限公司 | Il-2超激动剂、激动剂及其融合体的用途和方法 |
| EP3668548A2 (en) * | 2017-08-17 | 2020-06-24 | Nektar Therapeutics | Immunotherapeutic tumor treatment method |
| CN111511762B (zh) | 2017-08-21 | 2025-05-06 | 天演药业公司 | 抗cd137分子及其用途 |
| JP2021502344A (ja) * | 2017-11-06 | 2021-01-28 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 腫瘍を処置する方法 |
| EP3706770A4 (en) * | 2017-11-07 | 2021-10-27 | Nektar Therapeutics | IMMUNOTHERAPEUTIC COMBINATION FOR THE TREATMENT OF CANCER |
| US20200317784A1 (en) * | 2017-11-13 | 2020-10-08 | Bioxcel Therapeutics, Inc. | Methods and compositions for treating cancer by modifying multiple arms of the immune system |
| EP3713592A4 (en) | 2017-11-21 | 2022-01-12 | The Board of Trustees of the Leland Stanford Junior University | INTERLEUKIN-2 PARTIAL AGONISTS |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| WO2019168688A2 (en) | 2018-02-15 | 2019-09-06 | Senhwa Biosciences, Inc. | Quinolone analogs and their salts, compositions, and method for their use |
| EP3768715A1 (en) | 2018-03-23 | 2021-01-27 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
| CA3093722A1 (en) * | 2018-03-28 | 2019-10-03 | Ascendis Pharma Oncology Division A/S | Il-2 conjugates |
| MX2020012251A (es) | 2018-05-14 | 2021-04-28 | Werewolf Therapeutics Inc | Polipeptidos de interleucina-2 activables y metodos de uso de los mismos. |
| KR20210020907A (ko) | 2018-05-14 | 2021-02-24 | 웨어울프 세라퓨틱스, 인크. | 활성화가능한 인터루킨 12 폴리펩타이드 및 이의 사용 방법 |
| US20210355223A1 (en) | 2018-11-05 | 2021-11-18 | Pfizer Inc. | Combinations for Treating Cancer |
| WO2020095183A1 (en) | 2018-11-05 | 2020-05-14 | Pfizer Inc. | Combination for treating cancer |
| KR20210092769A (ko) | 2018-11-16 | 2021-07-26 | 브리스톨-마이어스 스큅 컴퍼니 | 항-nkg2a 항체 및 그의 용도 |
| SG11202112541RA (en) | 2019-05-14 | 2021-12-30 | Werewolf Therapeutics Inc | Separation moieties and methods and use thereof |
| AU2020384375A1 (en) | 2019-11-14 | 2022-05-26 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| CA3162406A1 (en) | 2020-01-10 | 2021-07-15 | Vijaya Raghavan PATTABIRAMAN | Modified il-2 polypeptides and uses thereof |
| US11491205B2 (en) | 2020-01-14 | 2022-11-08 | Synthekine, Inc. | Biased IL2 muteins methods and compositions |
| CA3168738A1 (en) * | 2020-05-26 | 2021-12-02 | Matthew G. Fury | Methods of treating cervical cancer by administering a pd-1 inhibitor |
| US12428461B2 (en) | 2020-06-03 | 2025-09-30 | Ascendis Pharma Oncology Division A/S | Treating cancer with a conjugate comprising an IL-2 moiety |
| WO2022098954A1 (en) | 2020-11-06 | 2022-05-12 | Nektar Therapeutics | Tlr agonist compounds and related cancer immunotherapy methods |
| CA3196999A1 (en) | 2020-12-28 | 2022-07-07 | Masano HUANG | Methods of treating tumors |
| SI4267105T1 (sl) | 2020-12-28 | 2025-07-31 | Bristol-Myers Squibb Company | Sestave protiteles in načini njihove uporabe |
| EP4313154A4 (en) * | 2021-03-29 | 2025-05-07 | AJ Sciences (Yixing) Co., Ltd | Protein-macromolecule conjugates and methods of use thereof |
| JP2024514530A (ja) | 2021-04-02 | 2024-04-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 切断型cdcp1に対する抗体およびその使用 |
| WO2022256534A1 (en) * | 2021-06-03 | 2022-12-08 | Synthorx, Inc. | Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab |
| EP4366779A1 (en) | 2021-07-09 | 2024-05-15 | Bright Peak Therapeutics AG | Modified tnf-antibodies and uses thereof |
| CA3258064A1 (en) | 2022-06-02 | 2023-12-07 | Bristol Myers Squibb Co | ANTIBODY COMPOSITIONS AND THEIR METHODS OF USE |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60006541D1 (de) * | 1999-06-30 | 2003-12-18 | Merck & Co Inc | Src-kinase hemmende verbindungen |
| CN101084012A (zh) * | 2004-05-20 | 2007-12-05 | 津莫吉尼蒂克斯公司 | 使用il-21和单克隆抗体疗法治疗癌症的方法 |
| JP4361545B2 (ja) * | 2005-05-09 | 2009-11-11 | 小野薬品工業株式会社 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| HUE025208T2 (en) | 2005-06-16 | 2016-03-29 | Nektar Therapeutics | Conjugates with degradable binding and polymer reagents useful in the preparation of such conjugates |
| AU2011325989C1 (en) | 2010-11-12 | 2015-04-23 | Endocyte, Inc. | Methods of treating cancer |
| JP2014506116A (ja) * | 2010-11-12 | 2014-03-13 | ウェルズ ファーゴ バンク ナショナル アソシエイション | Il−2部分とポリマーとのコンジュゲート |
| CN103476943A (zh) * | 2011-03-10 | 2013-12-25 | 普罗维克图斯药品公司 | 用于增强治疗癌症的局部和全身性免疫调节疗法的组合 |
| PL3134123T3 (pl) * | 2014-02-21 | 2021-07-12 | Nektar Therapeutics (India) Pvt. Ltd. | Agoniści selektywni względem IL-2Rbeta w kombinacji z przeciwciałem anty-CTLA-4 lub z przeciwciałem anty-PD-1 |
-
2015
- 2015-02-20 PL PL15721044T patent/PL3134123T3/pl unknown
- 2015-02-20 HU HUE15721044A patent/HUE053982T2/hu unknown
- 2015-02-20 US US15/120,214 patent/US10010587B2/en active Active
- 2015-02-20 CA CA2937660A patent/CA2937660A1/en active Pending
- 2015-02-20 PT PT157210444T patent/PT3134123T/pt unknown
- 2015-02-20 JP JP2016570201A patent/JP6963385B2/ja active Active
- 2015-02-20 RS RS20210363A patent/RS61661B1/sr unknown
- 2015-02-20 DK DK15721044.4T patent/DK3134123T3/da active
- 2015-02-20 CN CN201580009152.0A patent/CN106132438B/zh active Active
- 2015-02-20 WO PCT/IN2015/000099 patent/WO2015125159A1/en not_active Ceased
- 2015-02-20 ES ES15721044T patent/ES2872848T3/es active Active
- 2015-02-20 LT LTEP15721044.4T patent/LT3134123T/lt unknown
- 2015-02-20 AU AU2015220408A patent/AU2015220408B2/en active Active
- 2015-02-20 SM SM20210191T patent/SMT202100191T1/it unknown
- 2015-02-20 HR HRP20210377TT patent/HRP20210377T1/hr unknown
- 2015-02-20 KR KR1020167023162A patent/KR102410090B1/ko active Active
- 2015-02-20 EP EP15721044.4A patent/EP3134123B1/en not_active Revoked
- 2015-02-20 MX MX2016010870A patent/MX385194B/es unknown
- 2015-02-20 SI SI201531552T patent/SI3134123T1/sl unknown
- 2015-02-20 IL IL247320A patent/IL247320B/en unknown
- 2015-02-20 EP EP20217706.9A patent/EP3834838A1/en not_active Withdrawn
-
2016
- 2016-08-19 MX MX2021009926A patent/MX2021009926A/es unknown
-
2018
- 2018-06-04 US US15/997,487 patent/US10786552B2/en active Active
-
2019
- 2019-02-01 JP JP2019016875A patent/JP2019077723A/ja not_active Withdrawn
-
2020
- 2020-08-04 AU AU2020213296A patent/AU2020213296A1/en not_active Abandoned
- 2020-08-12 US US16/991,936 patent/US20200368321A1/en not_active Abandoned
-
2021
- 2021-02-08 JP JP2021018007A patent/JP2021073296A/ja not_active Withdrawn
- 2021-04-07 CY CY20211100297T patent/CY1124226T1/el unknown
-
2022
- 2022-05-25 AU AU2022203550A patent/AU2022203550A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6963385B2 (ja) | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 | |
| EP3242678B1 (en) | Combined preparations for the treatment of cancer or infection | |
| US20200317784A1 (en) | Methods and compositions for treating cancer by modifying multiple arms of the immune system | |
| WO2020176797A1 (en) | Immunotherapeutic combination for treating cancer | |
| JP2021020921A (ja) | 腫瘍微小環境に影響する抗癌剤と組み合わせたβ−グルカン | |
| EP3589303A1 (en) | Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy | |
| JP2022526408A (ja) | 細胞免疫療法を増強するための方法 | |
| JP2023099731A (ja) | IL-2Rβ選択的作動薬と長時間作用型IL-15作動薬との併用 | |
| KR20210090203A (ko) | 또 다른 약리학적 활성제와 조합된 지속 작용성 인터류킨-15 수용체 효현제 | |
| KR20220015375A (ko) | Sephb4-hsa 융합 단백질을 이용한 암의 치료 | |
| HK40056474A (en) | Il-2rbeta-selective agonists in combination with an anti-pd-1 antibody | |
| JP7412576B2 (ja) | 腎がんの相乗的治療におけるペグインターフェロンおよびプロトオンコジーン産物標的阻害剤の適用 | |
| CN112472803A (zh) | 抗pd-1抗体和抗ctla-4抗体的组合在制备治疗肾癌药物中的应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171204 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20171204 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180903 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20181130 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190201 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190509 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190808 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20191008 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191111 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20191111 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20200302 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200702 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20200702 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20200702 |
|
| C11 | Written invitation by the commissioner to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C11 Effective date: 20200730 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20200903 |
|
| C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20200904 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20201023 |
|
| C211 | Notice of termination of reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C211 Effective date: 20201027 |
|
| C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20210412 |
|
| C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20210706 |
|
| C23 | Notice of termination of proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C23 Effective date: 20210823 |
|
| C03 | Trial/appeal decision taken |
Free format text: JAPANESE INTERMEDIATE CODE: C03 Effective date: 20210916 |
|
| C30A | Notification sent |
Free format text: JAPANESE INTERMEDIATE CODE: C3012 Effective date: 20210916 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20211015 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6963385 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |