CY1124226T1 - Εκλεκτικοι αγωνιστες il-2rbhta σε συνδυασμο με αντισωμα anti-ctla-4 ή αντισωμα anti-pd-1 - Google Patents
Εκλεκτικοι αγωνιστες il-2rbhta σε συνδυασμο με αντισωμα anti-ctla-4 ή αντισωμα anti-pd-1Info
- Publication number
- CY1124226T1 CY1124226T1 CY20211100297T CY211100297T CY1124226T1 CY 1124226 T1 CY1124226 T1 CY 1124226T1 CY 20211100297 T CY20211100297 T CY 20211100297T CY 211100297 T CY211100297 T CY 211100297T CY 1124226 T1 CY1124226 T1 CY 1124226T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibody
- ctla
- selective
- 2rbhta
- agents
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Η εφεύρεση αφορά (μεταξύ άλλων) σε μέθοδο χορήγησης σε έναν ασθενή που πάσχει από καρκίνο, η οποία μέθοδος περιλαμβάνει τα εξής στάδια: (α) μια ποσότητα ενεργοποίησης IL-2Rβ ενός μακράς δράσης εκλεκτικού αγωνιστή IL-2Rβ• και (β) μια ποσότητα αναστολής της οδού CTLA-4 ενός αντισώματος αντι -CTLA-4 ή μια ποσότητα αναστολής της οδού PD-1 ενός αντισώματος αντι-PD-1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN499DE2014 | 2014-02-21 | ||
IN3087DE2014 | 2014-10-29 | ||
EP15721044.4A EP3134123B1 (en) | 2014-02-21 | 2015-02-20 | Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an an anti-pd-1 antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124226T1 true CY1124226T1 (el) | 2022-05-27 |
Family
ID=53055076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100297T CY1124226T1 (el) | 2014-02-21 | 2021-04-07 | Εκλεκτικοι αγωνιστες il-2rbhta σε συνδυασμο με αντισωμα anti-ctla-4 ή αντισωμα anti-pd-1 |
Country Status (20)
Country | Link |
---|---|
US (3) | US10010587B2 (el) |
EP (2) | EP3134123B1 (el) |
JP (3) | JP6963385B2 (el) |
KR (1) | KR102410090B1 (el) |
CN (1) | CN106132438B (el) |
AU (3) | AU2015220408B2 (el) |
CA (1) | CA2937660A1 (el) |
CY (1) | CY1124226T1 (el) |
DK (1) | DK3134123T3 (el) |
ES (1) | ES2872848T3 (el) |
HR (1) | HRP20210377T1 (el) |
HU (1) | HUE053982T2 (el) |
IL (1) | IL247320B (el) |
LT (1) | LT3134123T (el) |
MX (2) | MX2016010870A (el) |
PL (1) | PL3134123T3 (el) |
PT (1) | PT3134123T (el) |
RS (1) | RS61661B1 (el) |
SI (1) | SI3134123T1 (el) |
WO (1) | WO2015125159A1 (el) |
Families Citing this family (42)
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WO2015085162A1 (en) | 2013-12-05 | 2015-06-11 | Rfemb Holdings, Llc | Cancer immunotherapy by radiofrequency electrical membrane breakdown (rf-emb) |
SG10201804945WA (en) | 2013-12-12 | 2018-07-30 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
US10010587B2 (en) * | 2014-02-21 | 2018-07-03 | Nektar Therapeutics | IL-2Rβ-selective agonists in combination with an anti-CTLA-4 antibody or an anti-PD-1 antibody |
KR102128856B1 (ko) | 2015-01-30 | 2020-07-02 | 알에프이엠비 홀딩스, 엘엘씨 | 고주파 전기적 막 파괴를 이용하여 생명체의 바람직하지 않은 연조직을 절제하는 시스템 |
CN116059218A (zh) | 2015-07-16 | 2023-05-05 | 比奥克斯塞尔医疗股份有限公司 | 一种使用免疫调节治疗癌症的新颖方法 |
AU2016335860B2 (en) * | 2015-10-08 | 2023-08-10 | Nektar Therapeutics | Combination of an IL-2Rbeta-selective agonist and a long-acting IL-15 agonist |
AU2016355268B2 (en) | 2015-11-20 | 2021-08-19 | Senhwa Biosciences, Inc. | Combination therapy of tetracyclic quinolone analogs for treating cancer |
KR20180108655A (ko) | 2016-01-15 | 2018-10-04 | 알에프이엠비 홀딩스, 엘엘씨 | 암의 면역학적 치료 |
EP3433275A1 (en) | 2016-03-24 | 2019-01-30 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
EP3538130A4 (en) * | 2016-11-10 | 2020-06-03 | Nektar Therapeutics | IMMUNOTHERAPEUTIC TUMOR TREATMENT PROCEDURE |
US11744898B2 (en) | 2017-01-10 | 2023-09-05 | Nektar Therapeutics | Multi-arm polymer conjugates of TLR agonist compounds and related immunotherapeutic treatment methods |
CN110366421A (zh) * | 2017-03-01 | 2019-10-22 | 尼克塔治疗公司 | 使用白介素-2受体α,β选择性激动剂与过继性细胞转移疗法的组合的免疫治疗肿瘤治疗方法 |
TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
WO2018204528A1 (en) * | 2017-05-02 | 2018-11-08 | Nektar Therapeutics | Immunotherapeutic tumor treatment method |
US11117958B2 (en) | 2017-05-25 | 2021-09-14 | Institute For Basic Science | Anti-human interleukin-2 antibodies and uses thereof |
WO2018234862A1 (en) * | 2017-06-19 | 2018-12-27 | Medicenna Therapeutics Inc. | USES AND METHODS FOR IL-2 SUPERAGONISTS AND AGONISTS AND FUSIONS THEREOF |
WO2019036031A2 (en) | 2017-08-17 | 2019-02-21 | Nektar Therapeutics | IMMUNOTHERAPEUTIC METHOD FOR TUMOR TREATMENT |
CN111511762A (zh) | 2017-08-21 | 2020-08-07 | 天演药业公司 | 抗cd137分子及其用途 |
CA3081748A1 (en) * | 2017-11-06 | 2019-05-09 | Bristol-Myers Squibb Company | Methods of treating a tumor |
EP3706770A4 (en) * | 2017-11-07 | 2021-10-27 | Nektar Therapeutics | IMMUNOTHERAPEUTIC COMBINATION FOR THE TREATMENT OF CANCER |
US20200317784A1 (en) * | 2017-11-13 | 2020-10-08 | Bioxcel Therapeutics, Inc. | Methods and compositions for treating cancer by modifying multiple arms of the immune system |
WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
JP7445597B2 (ja) | 2018-02-15 | 2024-03-07 | センワ バイオサイエンシズ インコーポレイテッド | キノロン類似体及びそれらの塩、組成物、ならびにそれらの使用方法 |
CA3093407A1 (en) | 2018-03-23 | 2019-09-26 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
BR112020019639A2 (pt) * | 2018-03-28 | 2021-01-05 | Ascendis Pharma Oncology Division A/S | Conjugados de il-2 |
EP3794024B1 (en) | 2018-05-14 | 2023-05-10 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
AU2019271149B2 (en) | 2018-05-14 | 2023-07-13 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides and methods of use thereof |
JP2022509917A (ja) | 2018-11-05 | 2022-01-25 | ファイザー・インク | がんを処置するための組合せ |
WO2020095184A1 (en) | 2018-11-05 | 2020-05-14 | Pfizer Inc. | Combinations for treating cancer |
CA3119838A1 (en) | 2018-11-16 | 2020-05-22 | Bristol-Myers Squibb Company | Anti-nkg2a antibodies and uses thereof |
WO2020232305A1 (en) | 2019-05-14 | 2020-11-19 | Werewolf Therapeutics, Inc. | Separation moieties and methods and use thereof |
JP2023514010A (ja) | 2020-01-10 | 2023-04-05 | ブライト ピーク セラピューティクス エージー | 修飾il-2ポリペプチドおよびその使用 |
MX2022008771A (es) | 2020-01-14 | 2022-10-07 | Synthekine Inc | Metodos y composiciones de muteinas de il2 sesgadas. |
EP4157464A1 (en) * | 2020-05-26 | 2023-04-05 | Regeneron Pharmaceuticals, Inc. | Methods of treating cervical cancer by administering the pd-1 inhibitor antibody cemiplimab |
CN116133676A (zh) | 2020-06-03 | 2023-05-16 | 阿森迪斯药物肿瘤股份有限公司 | Il-2序列及其用途 |
WO2022098954A1 (en) | 2020-11-06 | 2022-05-12 | Nektar Therapeutics | Tlr agonist compounds and related cancer immunotherapy methods |
EP4267105A1 (en) | 2020-12-28 | 2023-11-01 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
JP2024501029A (ja) | 2020-12-28 | 2024-01-10 | ブリストル-マイヤーズ スクイブ カンパニー | Pd1/pd-l1抗体の皮下投与 |
JP2024514530A (ja) | 2021-04-02 | 2024-04-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 切断型cdcp1に対する抗体およびその使用 |
TW202313117A (zh) * | 2021-06-03 | 2023-04-01 | 美商欣爍克斯公司 | 包含il-2接合物及西妥昔單抗(cetuximab)之頭頸癌組合療法 |
WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
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Publication number | Priority date | Publication date | Assignee | Title |
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CA2383546A1 (en) * | 1999-06-30 | 2001-01-04 | William H. Parsons | Src kinase inhibitor compounds |
SI1758610T1 (sl) * | 2004-05-20 | 2012-11-30 | Zymogenetics Inc | Postopek za tretiranje raka z uporabo il in terapije z monoklonalnimi protitelesi |
EP2161336B2 (en) * | 2005-05-09 | 2017-03-29 | ONO Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
BRPI0611872B8 (pt) | 2005-06-16 | 2021-05-25 | Nektar Therapeutics | reagente polimérico, conjugado, método para preparação de um conjugado e composição farmacêutica |
RS61854B1 (sr) * | 2010-11-12 | 2021-06-30 | Nektar Therapeutics | Konjugati il-2 dela i polimera |
EA025069B1 (ru) | 2010-11-12 | 2016-11-30 | Эндосайт, Инк. | Способ и набор для лечения рака |
EP2710137B1 (en) * | 2011-03-10 | 2018-09-19 | Provectus Pharmatech, Inc. | A combination of rose bengal and anti-ctla4 antibody for use in the treatment of cancer |
US10010587B2 (en) | 2014-02-21 | 2018-07-03 | Nektar Therapeutics | IL-2Rβ-selective agonists in combination with an anti-CTLA-4 antibody or an anti-PD-1 antibody |
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2015
- 2015-02-20 US US15/120,214 patent/US10010587B2/en active Active
- 2015-02-20 CA CA2937660A patent/CA2937660A1/en active Pending
- 2015-02-20 CN CN201580009152.0A patent/CN106132438B/zh active Active
- 2015-02-20 EP EP15721044.4A patent/EP3134123B1/en not_active Revoked
- 2015-02-20 EP EP20217706.9A patent/EP3834838A1/en not_active Withdrawn
- 2015-02-20 WO PCT/IN2015/000099 patent/WO2015125159A1/en active Application Filing
- 2015-02-20 IL IL247320A patent/IL247320B/en unknown
- 2015-02-20 SI SI201531552T patent/SI3134123T1/sl unknown
- 2015-02-20 PT PT157210444T patent/PT3134123T/pt unknown
- 2015-02-20 LT LTEP15721044.4T patent/LT3134123T/lt unknown
- 2015-02-20 KR KR1020167023162A patent/KR102410090B1/ko active IP Right Grant
- 2015-02-20 DK DK15721044.4T patent/DK3134123T3/da active
- 2015-02-20 MX MX2016010870A patent/MX2016010870A/es unknown
- 2015-02-20 HU HUE15721044A patent/HUE053982T2/hu unknown
- 2015-02-20 JP JP2016570201A patent/JP6963385B2/ja active Active
- 2015-02-20 RS RS20210363A patent/RS61661B1/sr unknown
- 2015-02-20 PL PL15721044T patent/PL3134123T3/pl unknown
- 2015-02-20 ES ES15721044T patent/ES2872848T3/es active Active
- 2015-02-20 AU AU2015220408A patent/AU2015220408B2/en active Active
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2016
- 2016-08-19 MX MX2021009926A patent/MX2021009926A/es unknown
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2018
- 2018-06-04 US US15/997,487 patent/US10786552B2/en active Active
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2019
- 2019-02-01 JP JP2019016875A patent/JP2019077723A/ja not_active Withdrawn
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2020
- 2020-08-04 AU AU2020213296A patent/AU2020213296A1/en not_active Abandoned
- 2020-08-12 US US16/991,936 patent/US20200368321A1/en not_active Abandoned
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2021
- 2021-02-08 JP JP2021018007A patent/JP2021073296A/ja not_active Withdrawn
- 2021-03-04 HR HRP20210377TT patent/HRP20210377T1/hr unknown
- 2021-04-07 CY CY20211100297T patent/CY1124226T1/el unknown
-
2022
- 2022-05-25 AU AU2022203550A patent/AU2022203550A1/en not_active Abandoned
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