CA2937660A1 - Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an anti-pd-1 antibody - Google Patents
Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an anti-pd-1 antibody Download PDFInfo
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- CA2937660A1 CA2937660A1 CA2937660A CA2937660A CA2937660A1 CA 2937660 A1 CA2937660 A1 CA 2937660A1 CA 2937660 A CA2937660 A CA 2937660A CA 2937660 A CA2937660 A CA 2937660A CA 2937660 A1 CA2937660 A1 CA 2937660A1
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| CA2932765A1 (en) | 2013-12-05 | 2015-06-11 | Rfemb Holdings, Llc | Cancer immunotherapy by radiofrequency electrical membrane breakdown (rf-emb) |
| LT3081576T (lt) | 2013-12-12 | 2019-10-25 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antikūnas, antigeną surišantis jo fragmentas ir jų medicininis pritaikomumas |
| SMT202100191T1 (it) | 2014-02-21 | 2021-05-07 | Nektar Therapeutics | Agonisti selettivi per il-2rbeta in combinazione con un anticorpo anti.ctla-4 o un anticorpo anti-pd-1 |
| CN106659757B (zh) | 2014-04-24 | 2022-01-28 | 利兰斯坦福初级大学董事会 | 白介素2的超级激动剂、部分激动剂和拮抗剂 |
| KR102128856B1 (ko) | 2015-01-30 | 2020-07-02 | 알에프이엠비 홀딩스, 엘엘씨 | 고주파 전기적 막 파괴를 이용하여 생명체의 바람직하지 않은 연조직을 절제하는 시스템 |
| MA42459A (fr) | 2015-07-16 | 2018-05-23 | Bioxcel Therapeutics Inc | Nouvelle approche pour le traitement du cancer par immunomodulation |
| EP3356827B1 (en) | 2015-10-02 | 2023-12-06 | Julius-Maximilians-Universität Würzburg | Gdf-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers |
| MX2018004296A (es) | 2015-10-08 | 2018-08-01 | Nektar Therapeutics | Combinacion de un agonista selectivo de il-2rbeta y un agonista il-15 de accion prolongada. |
| KR20180113976A (ko) | 2015-11-20 | 2018-10-17 | 센화 바이오사이언시즈 인코포레이티드 | 암을 치료하기 위한 테트라사이클릭 퀴놀론 유사체의 병행 요법 |
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| EP3433275A1 (en) | 2016-03-24 | 2019-01-30 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| AU2017312121A1 (en) * | 2016-08-19 | 2019-03-21 | Brooklyn Immunotherapeutics Llc | Uses of PD-1/PD-L1 inhibitors and/or CTLA-4 inhibitors with a biologic containing multiple cytokine components to treat cancer |
| WO2018089669A2 (en) * | 2016-11-10 | 2018-05-17 | Nektar Therapeutics | Immunotherapeutic tumor treatment method |
| CN110167598A (zh) | 2017-01-10 | 2019-08-23 | 尼克塔治疗公司 | Tlr激动剂化合物的多臂聚合物缀合物以及相关的免疫治疗方法 |
| WO2018160877A1 (en) * | 2017-03-01 | 2018-09-07 | Nektar Therapeutics | Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| MA48862A (fr) * | 2017-05-02 | 2020-04-01 | Nektar Therapeutics | Méthode de traitement de tumeur immunothérapeutique |
| AU2018271751B2 (en) * | 2017-05-25 | 2021-04-01 | Institute For Basic Science | Anti-human interleukin-2 antibodies and uses thereof |
| WO2018234862A1 (en) | 2017-06-19 | 2018-12-27 | Medicenna Therapeutics Inc. | Uses and methods for il-2 superagonists, agonists, and fusions thereof |
| US12030940B2 (en) | 2017-08-17 | 2024-07-09 | Nektar Therapeutics | Immunotherapeutic tumor treatment method |
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| WO2019090330A1 (en) | 2017-11-06 | 2019-05-09 | Bristol-Myers Squibb Company | Methods of treating a tumor |
| US20210154277A1 (en) * | 2017-11-07 | 2021-05-27 | Nektar Therapeutics | Immunotherapeutic combination for treating cancer |
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| RU2020130050A (ru) | 2018-02-15 | 2022-03-15 | Сэньхва Байосайенсиз, Инк. | Аналоги хинолонов и их соли, композиции и способ их применения |
| AU2019236865A1 (en) | 2018-03-23 | 2020-10-01 | Bristol-Myers Squibb Company | Antibodies against MICA and/or MICB and uses thereof |
| IL277572B2 (en) * | 2018-03-28 | 2024-05-01 | Ascendis Pharma Oncology Div A/S | Il-2 conjugates |
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| MX2020012248A (es) | 2018-05-14 | 2021-04-28 | Werewolf Therapeutics Inc | Polipeptidos de citocina activables y metodos de uso de los mismos. |
| JP2022509917A (ja) | 2018-11-05 | 2022-01-25 | ファイザー・インク | がんを処置するための組合せ |
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| CN113316590B (zh) | 2018-11-16 | 2025-02-28 | 百时美施贵宝公司 | 抗nkg2a抗体及其用途 |
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| MX2023007650A (es) | 2020-12-28 | 2023-09-11 | Bristol Myers Squibb Co | Metodos de tratamiento de tumores. |
| DK4267105T3 (da) | 2020-12-28 | 2025-05-19 | Bristol Myers Squibb Co | Antistofsammensætninger og fremgangsmåder til anvendelse deraf |
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| WO2022212876A1 (en) | 2021-04-02 | 2022-10-06 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| WO2022256538A1 (en) * | 2021-06-03 | 2022-12-08 | Synthorx, Inc. | Head and neck cancer combination therapy comprising an il-2 conjugate and cetuximab |
| JP2024524534A (ja) | 2021-07-09 | 2024-07-05 | ブライト ピーク セラピューティクス エージー | 炎症性疾患及び自己免疫疾患の治療のための修飾ｉｌ－２ポリペプチド |
| CA3258064A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | ANTIBODY COMPOSITIONS AND THEIR METHODS OF USE |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
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| DE60006541D1 (de) * | 1999-06-30 | 2003-12-18 | Merck & Co Inc | Src-kinase hemmende verbindungen |
| CN101084012A (zh) * | 2004-05-20 | 2007-12-05 | 津莫吉尼蒂克斯公司 | 使用il－21和单克隆抗体疗法治疗癌症的方法 |
| CA2970873C (en) | 2005-05-09 | 2022-05-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| CN101242858B (zh) | 2005-06-16 | 2012-12-19 | 尼克塔治疗公司 | 具有可降解键的轭合物以及用于制备这种轭合物的聚合物试剂 |
| BR112013011659A2 (pt) | 2010-11-12 | 2016-08-02 | Endocyte Inc | métodos de tratamento do câncer |
| CN110812488A (zh) * | 2010-11-12 | 2020-02-21 | 尼克塔治疗公司 | Il-2部分与聚合物的缀合物 |
| JP6322413B2 (ja) * | 2011-03-10 | 2018-05-09 | プロヴェクタス ファーマテック，インク． | 改善されたがん治療のための局所および全身性免疫修飾療法の組み合わせ |
| SMT202100191T1 (it) | 2014-02-21 | 2021-05-07 | Nektar Therapeutics | Agonisti selettivi per il-2rbeta in combinazione con un anticorpo anti.ctla-4 o un anticorpo anti-pd-1 |
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