ES2872848T3 - Agonistas selectivos de IL-2Rbeta en combinación con un anticuerpo anti-CTLA-4 o un anticuerpo anti-PD-1 - Google Patents
Agonistas selectivos de IL-2Rbeta en combinación con un anticuerpo anti-CTLA-4 o un anticuerpo anti-PD-1 Download PDFInfo
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- ES2872848T3 ES2872848T3 ES15721044T ES15721044T ES2872848T3 ES 2872848 T3 ES2872848 T3 ES 2872848T3 ES 15721044 T ES15721044 T ES 15721044T ES 15721044 T ES15721044 T ES 15721044T ES 2872848 T3 ES2872848 T3 ES 2872848T3
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| FI3077041T3 (fi) | 2013-12-05 | 2024-10-16 | Rfemb Holdings Llc | Syövän immunoterapia radiotaajuisella sähköisellä solukalvon hajotuksella (rf-emb) |
| SI3081576T1 (sl) | 2013-12-12 | 2019-12-31 | Shanghai Hengrui Pharmaceutical Co., Ltd., | Protitelo PD-1, njegov antigen-vezavni fragment in njegova medicinska uporaba |
| PL3134123T3 (pl) * | 2014-02-21 | 2021-07-12 | Nektar Therapeutics (India) Pvt. Ltd. | Agoniści selektywni względem IL-2Rbeta w kombinacji z przeciwciałem anty-CTLA-4 lub z przeciwciałem anty-PD-1 |
| CA2946398A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| US11141216B2 (en) | 2015-01-30 | 2021-10-12 | Immunsys, Inc. | Radio-frequency electrical membrane breakdown for the treatment of high risk and recurrent prostate cancer, unresectable pancreatic cancer, tumors of the breast, melanoma or other skin malignancies, sarcoma, soft tissue tumors, ductal carcinoma, neoplasia, and intra and extra luminal abnormal tissue |
| RU2711380C2 (ru) | 2015-07-16 | 2020-01-16 | Байоксэл Терапьютикс, Инк. | Новый подход к лечению рака с применением иммуномодуляции |
| US11262360B2 (en) | 2015-10-02 | 2022-03-01 | Julius-Maximilians-Universität Würzburg | GDF-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers |
| CA3000211A1 (en) * | 2015-10-08 | 2017-04-13 | Nektar Therapeutics | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
| KR20180113976A (ko) | 2015-11-20 | 2018-10-17 | 센화 바이오사이언시즈 인코포레이티드 | 암을 치료하기 위한 테트라사이클릭 퀴놀론 유사체의 병행 요법 |
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| US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| BR112019003248A2 (pt) * | 2016-08-19 | 2019-10-01 | Brooklyn Immunotherapeutics Llc | usos de inibidores de pd-1/pd-l1 e/ou inibidores de ctla-4 com um biológico contendo múltiplos componentes citocínicos para o tratamento de câncer |
| MA46771A (fr) * | 2016-11-10 | 2021-06-02 | Univ Texas | Méthode de traitement de tumeur immunothérapeutique |
| KR102619747B1 (ko) * | 2017-01-10 | 2023-12-29 | 넥타르 테라퓨틱스 | Tlr 효현제 화합물의 다중-아암 중합체 컨쥬게이트 및 관련 면역 요법적 치료 방법 |
| EP3589303A4 (en) | 2017-03-01 | 2020-11-25 | Nektar Therapeutics | Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| MA48862A (fr) * | 2017-05-02 | 2020-04-01 | Nektar Therapeutics | Méthode de traitement de tumeur immunothérapeutique |
| BR112019024745B1 (pt) * | 2017-05-25 | 2024-01-16 | Institute For Basic Science | Anticorpo anti-hil-2 ou fragmento de ligação a antígeno do mesmo,ácido nucleico, vetor recombinante, célula procariótica transformada, método para a produção de um anticorpo anti-hil-2 ou um fragmento do mesmo e complexo |
| CN111201035A (zh) | 2017-06-19 | 2020-05-26 | 梅迪塞纳医疗股份有限公司 | Il-2超激动剂、激动剂及其融合体的用途和方法 |
| EP3668548A2 (en) * | 2017-08-17 | 2020-06-24 | Nektar Therapeutics | Immunotherapeutic tumor treatment method |
| CN111511762B (zh) | 2017-08-21 | 2025-05-06 | 天演药业公司 | 抗cd137分子及其用途 |
| JP2021502344A (ja) * | 2017-11-06 | 2021-01-28 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 腫瘍を処置する方法 |
| EP3706770A4 (en) * | 2017-11-07 | 2021-10-27 | Nektar Therapeutics | IMMUNOTHERAPEUTIC COMBINATION FOR THE TREATMENT OF CANCER |
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| EP3713592A4 (en) | 2017-11-21 | 2022-01-12 | The Board of Trustees of the Leland Stanford Junior University | INTERLEUKIN-2 PARTIAL AGONISTS |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| WO2019168688A2 (en) | 2018-02-15 | 2019-09-06 | Senhwa Biosciences, Inc. | Quinolone analogs and their salts, compositions, and method for their use |
| EP3768715A1 (en) | 2018-03-23 | 2021-01-27 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
| CA3093722A1 (en) * | 2018-03-28 | 2019-10-03 | Ascendis Pharma Oncology Division A/S | Il-2 conjugates |
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| KR20210020907A (ko) | 2018-05-14 | 2021-02-24 | 웨어울프 세라퓨틱스, 인크. | 활성화가능한 인터루킨 12 폴리펩타이드 및 이의 사용 방법 |
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| WO2020095183A1 (en) | 2018-11-05 | 2020-05-14 | Pfizer Inc. | Combination for treating cancer |
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| DE60006541D1 (de) * | 1999-06-30 | 2003-12-18 | Merck & Co Inc | Src-kinase hemmende verbindungen |
| CN101084012A (zh) * | 2004-05-20 | 2007-12-05 | 津莫吉尼蒂克斯公司 | 使用il－21和单克隆抗体疗法治疗癌症的方法 |
| JP4361545B2 (ja) * | 2005-05-09 | 2009-11-11 | 小野薬品工業株式会社 | ＰｒｏｇｒａｍｍｅｄＤｅａｔｈ１（ＰＤ−１）に対するヒトモノクローナル抗体および抗ＰＤ−１抗体単独または他の免疫療法と併用した癌治療方法 |
| HUE025208T2 (en) | 2005-06-16 | 2016-03-29 | Nektar Therapeutics | Conjugates with degradable binding and polymer reagents useful in the preparation of such conjugates |
| AU2011325989C1 (en) | 2010-11-12 | 2015-04-23 | Endocyte, Inc. | Methods of treating cancer |
| JP2014506116A (ja) * | 2010-11-12 | 2014-03-13 | ウェルズ ファーゴ バンク ナショナル アソシエイション | Ｉｌ−２部分とポリマーとのコンジュゲート |
| CN103476943A (zh) * | 2011-03-10 | 2013-12-25 | 普罗维克图斯药品公司 | 用于增强治疗癌症的局部和全身性免疫调节疗法的组合 |
| PL3134123T3 (pl) * | 2014-02-21 | 2021-07-12 | Nektar Therapeutics (India) Pvt. Ltd. | Agoniści selektywni względem IL-2Rbeta w kombinacji z przeciwciałem anty-CTLA-4 lub z przeciwciałem anty-PD-1 |
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