JP6954890B2 - ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 - Google Patents
ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 Download PDFInfo
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- JP6954890B2 JP6954890B2 JP2018501179A JP2018501179A JP6954890B2 JP 6954890 B2 JP6954890 B2 JP 6954890B2 JP 2018501179 A JP2018501179 A JP 2018501179A JP 2018501179 A JP2018501179 A JP 2018501179A JP 6954890 B2 JP6954890 B2 JP 6954890B2
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
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- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
- A61K2239/29—Multispecific CARs
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C12N2510/00—Genetically modified cells
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020209010A JP7348160B2 (ja) | 2015-07-13 | 2020-12-17 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562191918P | 2015-07-13 | 2015-07-13 | |
| US62/191,918 | 2015-07-13 | ||
| US201562247469P | 2015-10-28 | 2015-10-28 | |
| US62/247,469 | 2015-10-28 | ||
| US201662315438P | 2016-03-30 | 2016-03-30 | |
| US62/315,438 | 2016-03-30 | ||
| PCT/US2016/042024 WO2017011519A1 (en) | 2015-07-13 | 2016-07-13 | Delivery methods and compositions for nuclease-mediated genome engineering |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020209010A Division JP7348160B2 (ja) | 2015-07-13 | 2020-12-17 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018525979A JP2018525979A (ja) | 2018-09-13 |
| JP2018525979A5 JP2018525979A5 (cg-RX-API-DMAC7.html) | 2019-08-22 |
| JP6954890B2 true JP6954890B2 (ja) | 2021-10-27 |
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ID=57758305
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501179A Active JP6954890B2 (ja) | 2015-07-13 | 2016-07-13 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
| JP2020209010A Active JP7348160B2 (ja) | 2015-07-13 | 2020-12-17 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020209010A Active JP7348160B2 (ja) | 2015-07-13 | 2020-12-17 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10450585B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3322297B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6954890B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108024544B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016291778B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2991301A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017011519A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
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| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
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| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| EP3092049A1 (en) | 2014-01-08 | 2016-11-16 | Flodesign Sonics Inc. | Acoustophoresis device with dual acoustophoretic chamber |
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| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2016073990A2 (en) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
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| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
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| US10166255B2 (en) | 2015-07-31 | 2019-01-01 | Regents Of The University Of Minnesota | Intracellular genomic transplant and methods of therapy |
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| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| KR20240027153A (ko) | 2017-06-15 | 2024-02-29 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 표적화된 비-바이러스 dna 삽입 |
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- 2016-07-13 CA CA2991301A patent/CA2991301A1/en active Pending
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| EP3322297C0 (en) | 2024-12-04 |
| US20170016027A1 (en) | 2017-01-19 |
| EP3322297A4 (en) | 2019-04-17 |
| US20200102577A1 (en) | 2020-04-02 |
| JP2018525979A (ja) | 2018-09-13 |
| JP7348160B2 (ja) | 2023-09-20 |
| EP3322297B1 (en) | 2024-12-04 |
| AU2016291778A1 (en) | 2018-01-25 |
| WO2017011519A1 (en) | 2017-01-19 |
| US10450585B2 (en) | 2019-10-22 |
| CA2991301A1 (en) | 2017-01-19 |
| JP2021045166A (ja) | 2021-03-25 |
| CN108024544A (zh) | 2018-05-11 |
| AU2016291778B2 (en) | 2021-05-06 |
| EP3322297A1 (en) | 2018-05-23 |
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