JP6936224B2 - オクタヒドロピロロ［３，４−ｃ］ピロール誘導体およびその使用 - Google Patents

オクタヒドロピロロ［３，４−ｃ］ピロール誘導体およびその使用 Download PDF

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JP6936224B2
JP6936224B2 JP2018526672A JP2018526672A JP6936224B2 JP 6936224 B2 JP6936224 B2 JP 6936224B2 JP 2018526672 A JP2018526672 A JP 2018526672A JP 2018526672 A JP2018526672 A JP 2018526672A JP 6936224 B2 JP6936224 B2 JP 6936224B2
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disorders
alkyl
mmol
compound according
triazole
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JP2018534338A5 (https=
JP2018534338A (ja
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ジャン・インジュン
ジン・チュアンフェイ
ジャン・ジ
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Sunshine Lake Pharma Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2018526672A 2015-11-23 2016-11-23 オクタヒドロピロロ［３，４−ｃ］ピロール誘導体およびその使用 Active JP6936224B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510823712 2015-11-23
CN201510823712.8 2015-11-23
PCT/CN2016/106937 WO2017088759A1 (en) 2015-11-23 2016-11-23 OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF

Publications (3)

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JP2018534338A JP2018534338A (ja) 2018-11-22
JP2018534338A5 JP2018534338A5 (https=) 2019-10-31
JP6936224B2 true JP6936224B2 (ja) 2021-09-15

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US (1) US10370380B2 (https=)
EP (1) EP3380475A4 (https=)
JP (1) JP6936224B2 (https=)
CN (1) CN106749269B (https=)
AU (1) AU2016360245B2 (https=)
CA (1) CA3005918C (https=)
SG (1) SG11201804223TA (https=)
WO (1) WO2017088759A1 (https=)

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CN109988171A (zh) * 2017-12-29 2019-07-09 广东东阳光药业有限公司 八氢吡咯并[3,4-c]吡咯衍生物及其用途
WO2020158415A1 (ja) * 2019-01-28 2020-08-06 サントリーホールディングス株式会社 オレキシン受容体拮抗阻害用組成物
WO2021104294A1 (en) * 2019-11-29 2021-06-03 Sunshine Lake Pharma Co., Ltd. CRYSTAL FORMS OF OCTAHYDROPYRROLO [3,4-c] PYRROLE DERIVATIVES
CN112876479B (zh) * 2019-11-29 2022-07-26 广东东阳光药业有限公司 八氢吡咯并[3,4-c]吡咯衍生物的晶型
CN112876481B (zh) * 2019-11-29 2022-07-26 广东东阳光药业有限公司 八氢吡咯并[3,4-c]吡咯衍生物的晶型
CN112876480B (zh) * 2019-11-29 2022-07-26 广东东阳光药业有限公司 八氢吡咯并[3,4-c]吡咯衍生物的晶型
CN112876478B (zh) * 2019-11-29 2022-07-26 广东东阳光药业有限公司 八氢吡咯并[3,4-c]吡咯衍生物的晶型
WO2022194122A1 (zh) * 2021-03-16 2022-09-22 上海翰森生物医药科技有限公司 含氮杂环的多环化合物及其制备方法和应用
CN116217593B (zh) * 2021-12-02 2025-05-09 江苏恩华药业股份有限公司 一种八氢吡咯并[3,4-c]吡咯甲基酮衍生物及其应用
KR20250065855A (ko) * 2022-09-14 2025-05-13 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 질소 함유 헤테로고리의 다환식 화합물의 유리 염기 결정형 및 이의 제조 방법
TW202428580A (zh) 2022-10-31 2024-07-16 日商武田藥品工業股份有限公司 雜環化合物
WO2024125395A1 (zh) * 2022-12-12 2024-06-20 江苏恩华药业股份有限公司 一种取代四氢环戊基[c]吡咯衍生物、制备方法、中间体及其应用
CN118580243B (zh) * 2024-08-07 2025-01-03 艾斯拓康生物医药(天津)有限公司 一类含氮并环化合物及其制备方法和应用

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