JP6911048B2 - がんの処置において使用するための、Notch阻害剤およびPI3K/mTOR阻害剤を用いた併用療法 - Google Patents

がんの処置において使用するための、Notch阻害剤およびPI3K/mTOR阻害剤を用いた併用療法 Download PDF

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JP6911048B2
JP6911048B2 JP2018553368A JP2018553368A JP6911048B2 JP 6911048 B2 JP6911048 B2 JP 6911048B2 JP 2018553368 A JP2018553368 A JP 2018553368A JP 2018553368 A JP2018553368 A JP 2018553368A JP 6911048 B2 JP6911048 B2 JP 6911048B2
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oxo
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cancer
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JP2019511529A (ja
JP2019511529A5 (enExample
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クマール パテル,バーヴィン
クマール パテル,バーヴィン
シー. スミス,ミシェル
シー. スミス,ミシェル
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イーライ リリー アンド カンパニー
イーライ リリー アンド カンパニー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018553368A 2016-04-12 2017-04-05 がんの処置において使用するための、Notch阻害剤およびPI3K/mTOR阻害剤を用いた併用療法 Active JP6911048B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021112585A JP7278331B2 (ja) 2016-04-12 2021-07-07 がんの処置において使用するための、Notch阻害剤およびPI3K/mTOR阻害剤を用いた併用療法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662321307P 2016-04-12 2016-04-12
US62/321,307 2016-04-12
PCT/US2017/026099 WO2017180385A1 (en) 2016-04-12 2017-04-05 Combination therapy with notch and pi3k/mtor inhibitors for use in treating cancer

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JP2021112585A Division JP7278331B2 (ja) 2016-04-12 2021-07-07 がんの処置において使用するための、Notch阻害剤およびPI3K/mTOR阻害剤を用いた併用療法

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JP2019511529A JP2019511529A (ja) 2019-04-25
JP2019511529A5 JP2019511529A5 (enExample) 2020-05-14
JP6911048B2 true JP6911048B2 (ja) 2021-07-28

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JP2018553368A Active JP6911048B2 (ja) 2016-04-12 2017-04-05 がんの処置において使用するための、Notch阻害剤およびPI3K/mTOR阻害剤を用いた併用療法
JP2021112585A Active JP7278331B2 (ja) 2016-04-12 2021-07-07 がんの処置において使用するための、Notch阻害剤およびPI3K/mTOR阻害剤を用いた併用療法

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US (1) US11564929B2 (enExample)
EP (1) EP3442528B1 (enExample)
JP (2) JP6911048B2 (enExample)
KR (1) KR102418766B1 (enExample)
CN (1) CN109310685B (enExample)
AU (1) AU2017249988C1 (enExample)
CA (1) CA3020918A1 (enExample)
ES (1) ES2898952T3 (enExample)
MX (1) MX380780B (enExample)
RU (1) RU2754452C2 (enExample)
WO (1) WO2017180385A1 (enExample)

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WO2017180385A1 (en) 2016-04-12 2017-10-19 Eli Lilly And Company Combination therapy with notch and pi3k/mtor inhibitors for use in treating cancer
MX380779B (es) 2016-04-12 2025-03-12 Lilly Co Eli Terapia combinatoria con inhibidores notch y cdk4/6
JP7194022B2 (ja) 2016-05-20 2022-12-21 イーライ リリー アンド カンパニー Notch阻害剤とPD-1またはPD-L1阻害剤との併用療法
EP3525796A1 (en) 2016-10-12 2019-08-21 Eli Lilly and Company Targeted treatment of mature t-cell lymphoma
AU2018222749B2 (en) 2017-02-17 2024-04-18 Fred Hutchinson Cancer Center Combination therapies for treatment of BCMA-related cancers and autoimmune disorders
EP3703750B1 (en) 2017-11-01 2024-12-04 Juno Therapeutics, Inc. Chimeric antigen receptors specific for b-cell maturation antigen and encoding polynucleotides
MA50564A (fr) 2017-11-06 2020-09-16 Hutchinson Fred Cancer Res Association d'une thérapie cellulaire et d'un inhibiteur de gamma secrétase

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Publication number Publication date
CN109310685B (zh) 2021-10-29
EP3442528B1 (en) 2021-05-26
AU2017249988B2 (en) 2022-10-27
MX380780B (es) 2025-03-12
JP2019511529A (ja) 2019-04-25
JP7278331B2 (ja) 2023-05-19
MX2018012456A (es) 2019-03-07
RU2754452C2 (ru) 2021-09-02
CN109310685A (zh) 2019-02-05
AU2017249988C1 (en) 2023-02-16
JP2021169474A (ja) 2021-10-28
KR102418766B1 (ko) 2022-07-08
AU2017249988A1 (en) 2018-11-01
WO2017180385A1 (en) 2017-10-19
RU2018138626A3 (enExample) 2020-09-21
RU2018138626A (ru) 2020-05-13
KR20180129917A (ko) 2018-12-05
US20210177859A1 (en) 2021-06-17
US11564929B2 (en) 2023-01-31
EP3442528A1 (en) 2019-02-20
ES2898952T3 (es) 2022-03-09
CA3020918A1 (en) 2017-10-19

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