AU2017249988C1 - Combination therapy with notch and PI3K/mTOR inhibitors for use in treating cancer - Google Patents

Combination therapy with notch and PI3K/mTOR inhibitors for use in treating cancer Download PDF

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Publication number
AU2017249988C1
AU2017249988C1 AU2017249988A AU2017249988A AU2017249988C1 AU 2017249988 C1 AU2017249988 C1 AU 2017249988C1 AU 2017249988 A AU2017249988 A AU 2017249988A AU 2017249988 A AU2017249988 A AU 2017249988A AU 2017249988 C1 AU2017249988 C1 AU 2017249988C1
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cancer
acceptable salt
pharmaceutically acceptable
methyl
oxo
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AU2017249988A1 (en
AU2017249988B2 (en
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Bharvin Kumar Patel
Michele C. Smith
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Eli Lilly and Co
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Eli Lilly and Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2017249988A 2016-04-12 2017-04-05 Combination therapy with notch and PI3K/mTOR inhibitors for use in treating cancer Active AU2017249988C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662321307P 2016-04-12 2016-04-12
US62/321,307 2016-04-12
PCT/US2017/026099 WO2017180385A1 (en) 2016-04-12 2017-04-05 Combination therapy with notch and pi3k/mtor inhibitors for use in treating cancer

Publications (3)

Publication Number Publication Date
AU2017249988A1 AU2017249988A1 (en) 2018-11-01
AU2017249988B2 AU2017249988B2 (en) 2022-10-27
AU2017249988C1 true AU2017249988C1 (en) 2023-02-16

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AU2017249988A Active AU2017249988C1 (en) 2016-04-12 2017-04-05 Combination therapy with notch and PI3K/mTOR inhibitors for use in treating cancer

Country Status (11)

Country Link
US (1) US11564929B2 (enExample)
EP (1) EP3442528B1 (enExample)
JP (2) JP6911048B2 (enExample)
KR (1) KR102418766B1 (enExample)
CN (1) CN109310685B (enExample)
AU (1) AU2017249988C1 (enExample)
CA (1) CA3020918A1 (enExample)
ES (1) ES2898952T3 (enExample)
MX (1) MX380780B (enExample)
RU (1) RU2754452C2 (enExample)
WO (1) WO2017180385A1 (enExample)

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TWI609687B (zh) 2015-04-14 2018-01-01 美國禮來大藥廠 平滑肌肉瘤之標靶性治療
RU2754452C2 (ru) 2016-04-12 2021-09-02 Эли Лилли Энд Компани Комбинированная терапия ингибиторами notch и pi3k/mtor для применения в лечении рака
CA3020875A1 (en) * 2016-04-12 2017-10-19 Eli Lilly And Company Combination therapy with notch and cdk4/6 inhibitors for the treatment of cancer
ES2904880T3 (es) 2016-05-20 2022-04-06 Lilly Co Eli Terapia combinada con inhibidores de Notch y de PD-1 o PD-L1
WO2018071307A1 (en) 2016-10-12 2018-04-19 Eli Lilly And Company Targeted treatment of mature t-cell lymphoma
MX2019009552A (es) 2017-02-17 2019-10-02 Hutchinson Fred Cancer Res Terapias de combinacion para el tratamiento de canceres relacionados con el antigeno de maduracion de celulas b (bcma) y trastornos autoinmunitarios.
PL3703750T3 (pl) 2017-11-01 2025-04-07 Juno Therapeutics, Inc. Chimeryczne receptory antygenowe specyficzne dla antygenu dojrzewania komórek b i kodujące polinukleotydy
CA3080395A1 (en) 2017-11-06 2019-05-09 Juno Therapeutics, Inc. Combination of a cell therapy and a gamma secretase inhibitor

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WO2012097039A1 (en) * 2011-01-14 2012-07-19 Eli Lilly And Company Imidazo [4, 5 -c] quinolin- 2 -one compound and its use as pi3 kinase / mtor dual inhibitor
WO2013016081A1 (en) * 2011-07-27 2013-01-31 Eli Lilly And Company Notch pathway signaling inhibitor compound

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EP1117778A2 (en) 1998-10-02 2001-07-25 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein
KR101888321B1 (ko) 2005-07-01 2018-08-13 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
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KR20140007979A (ko) 2008-01-11 2014-01-20 에프. 호프만-라 로슈 아게 암 치료를 위한 감마-세크레타제 저해제의 용도
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Publication number Publication date
AU2017249988A1 (en) 2018-11-01
US11564929B2 (en) 2023-01-31
JP7278331B2 (ja) 2023-05-19
CA3020918A1 (en) 2017-10-19
CN109310685A (zh) 2019-02-05
JP6911048B2 (ja) 2021-07-28
WO2017180385A1 (en) 2017-10-19
JP2019511529A (ja) 2019-04-25
KR20180129917A (ko) 2018-12-05
US20210177859A1 (en) 2021-06-17
MX2018012456A (es) 2019-03-07
KR102418766B1 (ko) 2022-07-08
CN109310685B (zh) 2021-10-29
MX380780B (es) 2025-03-12
RU2018138626A3 (enExample) 2020-09-21
JP2021169474A (ja) 2021-10-28
EP3442528B1 (en) 2021-05-26
ES2898952T3 (es) 2022-03-09
EP3442528A1 (en) 2019-02-20
RU2018138626A (ru) 2020-05-13
AU2017249988B2 (en) 2022-10-27
RU2754452C2 (ru) 2021-09-02

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