JP6901421B2 - 半フッ化アルカンを基礎にした局所薬学的組成物 - Google Patents
半フッ化アルカンを基礎にした局所薬学的組成物 Download PDFInfo
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- JP6901421B2 JP6901421B2 JP2018040265A JP2018040265A JP6901421B2 JP 6901421 B2 JP6901421 B2 JP 6901421B2 JP 2018040265 A JP2018040265 A JP 2018040265A JP 2018040265 A JP2018040265 A JP 2018040265A JP 6901421 B2 JP6901421 B2 JP 6901421B2
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- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Description
− 10μm厚の1枚の薄片(角質層に対応する)
− 各々20μmの4枚の薄片(生きている表皮に対応する)
− 各々40μmの5×5枚の薄片(真皮の5つの層に対応する)。
Claims (8)
- 角質層の下の皮膚の層に影響を及ぼす疾患または症状の防止または処置に用いるための皮膚投与用薬学的組成物であり、有効量の活性成分、および次式:
RFRH
(式中、RFは、4〜12個の炭素原子を有する線状過フッ化炭化水素セグメントであり、そしてRHは、4〜8個の炭素原子を有する線状アルキル基である)
で表わされる半フッ化アルカンを含み、前記活性成分が角質層を通って浸透し、角質層の下の皮膚の層に送達され、
前記疾患または症状が、皮膚の生きている表皮、真皮および/または皮下組織に影響を及ぼすものであり、また
前記活性成分が、皮膚の生きている表皮、真皮および/または皮下組織に送達されるものであり、
単一の相からなり、溶液の形態である、組成物。 - 前記半フッ化アルカンが、F4H5、F4H6、F4H8、F6H4、F6H6、およびF6H8(ここで、Fは過フッ化炭化水素セグメントを意味し、Hは非フッ化セグメントを意味し、そして数字はそれぞれのセグメントの炭素原子の数である)から選択される、請求項1に記載の組成物。
- 液体または半固体溶液の形態である、請求項1または2のいずれかに記載の組成物。
- エタノール、アセトン、酢酸エチル、イソプロピルアルコール、グリセロール、プロピレングリコール、ペンチレングリコール、ポリエチレングリコール、液体パラフィン、トリグリセリド油、HFA134aおよび/またはHFA227から選択されるヒドロフルオロカーボン、および液体モノまたはジグリセリドから選択される生理学的に許容可能な共溶媒を含む請求項1〜3のいずれかに記載の組成物。
- (i)活性成分の局所投与量の少なくとも5%を30分以内に生きている表皮に送達するか、
(ii)活性成分の局所投与量の少なくとも5%を30分以内に真皮に送達するか、
(iii)活性成分の局所投与量の少なくとも10%を30分以内に真皮に送達するか、
(iv)活性成分の局所投与量の少なくとも5%を30分以内に皮下組織に送達するか、または
(v)活性成分の局所投与量の少なくとも10%を30分以内に皮下組織に送達する
ものである、請求項1〜4のいずれかに記載の組成物。 - 活性成分の局所投与量の少なくとも15%を30分以内に10μmの深さに送達するものである、請求項1〜5のいずれかに記載の組成物。
- 活性成分の局所投与量の少なくとも20%を30分以内に10μmの深さに送達するものである、請求項1〜6のいずれかに記載の組成物。
- 活性成分の局所投与量の少なくとも10%、または15%、または20%を30分以内に100μmの深さに送達するものである、請求項1〜7のいずれかに記載の組成物。
Applications Claiming Priority (5)
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EP11167552.6 | 2011-05-25 | ||
EP11167552 | 2011-05-25 | ||
EP11167732.4 | 2011-05-26 | ||
EP11167732 | 2011-05-26 | ||
JP2016215748A JP6306126B2 (ja) | 2011-05-25 | 2016-11-03 | 半フッ化アルカンを基礎にした局所薬学的組成物 |
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JP2018123138A JP2018123138A (ja) | 2018-08-09 |
JP6901421B2 true JP6901421B2 (ja) | 2021-07-14 |
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JP2014511893A Active JP6039145B2 (ja) | 2011-05-25 | 2012-05-24 | 半フッ化アルカンを基礎にした局所薬学的組成物 |
JP2016215748A Active JP6306126B2 (ja) | 2011-05-25 | 2016-11-03 | 半フッ化アルカンを基礎にした局所薬学的組成物 |
JP2018040265A Active JP6901421B2 (ja) | 2011-05-25 | 2018-03-07 | 半フッ化アルカンを基礎にした局所薬学的組成物 |
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JP2016215748A Active JP6306126B2 (ja) | 2011-05-25 | 2016-11-03 | 半フッ化アルカンを基礎にした局所薬学的組成物 |
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US (4) | US10130707B2 (ja) |
EP (3) | EP3311802B1 (ja) |
JP (3) | JP6039145B2 (ja) |
KR (2) | KR101790388B1 (ja) |
CN (4) | CN108283623A (ja) |
AU (3) | AU2012260787B2 (ja) |
CA (1) | CA2834855C (ja) |
DK (2) | DK2714010T3 (ja) |
ES (3) | ES2808051T3 (ja) |
HK (1) | HK1247116A1 (ja) |
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