JP6896711B2 - ビヘテロアリール置換１，４−ベンゾジアゼピン及び癌の治療のためのその使用 - Google Patents

ビヘテロアリール置換１，４−ベンゾジアゼピン及び癌の治療のためのその使用 Download PDF

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JP6896711B2
JP6896711B2 JP2018514863A JP2018514863A JP6896711B2 JP 6896711 B2 JP6896711 B2 JP 6896711B2 JP 2018514863 A JP2018514863 A JP 2018514863A JP 2018514863 A JP2018514863 A JP 2018514863A JP 6896711 B2 JP6896711 B2 JP 6896711B2
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compound
cancer
formula
compounds
acid
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JP2018527390A (ja
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アンギボー，パトリック，ルネ
ブロッジーニ，ディエゴ，フェルナンド，ドメニコ
クィッケンス，フィリップ，アルベルト．セー．
ホスティン，スティーヴン，アンナ
ジョンズ，ラッセル，マーク
ケロル，オリヴィエ，アレクシス，ジョルジュ
ヴェルムレン，ウィム
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ヤンセン ファーマシューティカ エヌ．ベー．
ヤンセン ファーマシューティカ エヌ．ベー．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2018514863A 2015-09-23 2016-09-22 ビヘテロアリール置換１，４−ベンゾジアゼピン及び癌の治療のためのその使用 Active JP6896711B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15186478.2 2015-09-23
EP15186478 2015-09-23
PCT/EP2016/072501 WO2017050865A1 (en) 2015-09-23 2016-09-22 Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer

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JP2018527390A JP2018527390A (ja) 2018-09-20
JP6896711B2 true JP6896711B2 (ja) 2021-06-30

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US (2) US11542247B2 (enExample)
EP (1) EP3353164B1 (enExample)
JP (1) JP6896711B2 (enExample)
KR (1) KR102691777B1 (enExample)
CN (1) CN108137546B (enExample)
AU (1) AU2016328693B2 (enExample)
BR (1) BR112018005625B1 (enExample)
CA (1) CA2996989C (enExample)
DK (1) DK3353164T3 (enExample)
ES (1) ES2904513T3 (enExample)
HR (1) HRP20220012T1 (enExample)
HU (1) HUE057090T2 (enExample)
LT (1) LT3353164T (enExample)
MX (1) MX378230B (enExample)
RU (1) RU2747644C2 (enExample)
SI (1) SI3353164T1 (enExample)
WO (1) WO2017050865A1 (enExample)

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AU2016328692B2 (en) * 2015-09-23 2021-03-11 Janssen Pharmaceutica Nv New compounds
JP2023520916A (ja) * 2020-04-08 2023-05-22 リミックス セラピューティクス インコーポレイテッド スプライシングを調整するための化合物及び方法

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