JP6890419B2 - ラクトバチルス・クリスパタスおよびその応用 - Google Patents

ラクトバチルス・クリスパタスおよびその応用 Download PDF

Info

Publication number
JP6890419B2
JP6890419B2 JP2016550923A JP2016550923A JP6890419B2 JP 6890419 B2 JP6890419 B2 JP 6890419B2 JP 2016550923 A JP2016550923 A JP 2016550923A JP 2016550923 A JP2016550923 A JP 2016550923A JP 6890419 B2 JP6890419 B2 JP 6890419B2
Authority
JP
Japan
Prior art keywords
lactobacillus
vaginal
crispatas
crispatus
vaginitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016550923A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017501741A5 (https=
JP2017501741A (ja
Inventor
リウ、ヤン
Original Assignee
スーヂョウ オーセル バイオ−ファーム カンパニー、リミテッド
スーヂョウ オーセル バイオ−ファーム カンパニー、リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201310551630.3A external-priority patent/CN104630083B/zh
Priority claimed from CN201310731833.0A external-priority patent/CN104178437B/zh
Application filed by スーヂョウ オーセル バイオ−ファーム カンパニー、リミテッド, スーヂョウ オーセル バイオ−ファーム カンパニー、リミテッド filed Critical スーヂョウ オーセル バイオ−ファーム カンパニー、リミテッド
Publication of JP2017501741A publication Critical patent/JP2017501741A/ja
Publication of JP2017501741A5 publication Critical patent/JP2017501741A5/ja
Application granted granted Critical
Publication of JP6890419B2 publication Critical patent/JP6890419B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016550923A 2013-11-08 2014-10-30 ラクトバチルス・クリスパタスおよびその応用 Active JP6890419B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201310551661.9 2013-11-08
CN201310551630.3 2013-11-08
CN201310551661 2013-11-08
CN201310551630.3A CN104630083B (zh) 2013-11-08 2013-11-08 一种卷曲乳杆菌及其在妇女保健产品中的应用
CN201310731833.0 2013-12-26
CN201310731833.0A CN104178437B (zh) 2013-11-08 2013-12-26 一种卷曲乳杆菌及其在妇科疾病中的应用
PCT/CN2014/089882 WO2015067141A1 (zh) 2013-11-08 2014-10-30 一种卷曲乳杆菌及其应用

Publications (3)

Publication Number Publication Date
JP2017501741A JP2017501741A (ja) 2017-01-19
JP2017501741A5 JP2017501741A5 (https=) 2017-10-26
JP6890419B2 true JP6890419B2 (ja) 2021-06-18

Family

ID=53040891

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016550923A Active JP6890419B2 (ja) 2013-11-08 2014-10-30 ラクトバチルス・クリスパタスおよびその応用

Country Status (9)

Country Link
US (1) US9937214B2 (https=)
EP (1) EP3040413B1 (https=)
JP (1) JP6890419B2 (https=)
KR (1) KR101808972B1 (https=)
ES (1) ES2670536T3 (https=)
MY (1) MY172685A (https=)
SG (1) SG11201603346VA (https=)
TW (1) TWI652343B (https=)
WO (1) WO2015067141A1 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018013583A2 (en) 2016-07-11 2018-01-18 The Brigham And Women's Hospital, Inc. Medicinal vaginal lactobacillus cocktail
EP3498819A4 (en) * 2016-08-12 2020-04-08 BGI Shenzhen FAECALIBACTERIUM BUTYRICIGENERANS AND METHOD FOR BREEDING THEM AND APPLICATION THEREOF
WO2019010282A1 (en) 2017-07-07 2019-01-10 Osel, Inc. STABILIZED FORMULATIONS WITH HIGH POWER OF LACTOBACILLUS VAGINAL
EP3648779A4 (en) * 2017-07-07 2021-03-17 Osel, Inc. USING VAGINAL LACTOBACILLI TO IMPROVE THE SUCCESS RATE OF IN VITRO FERTILIZATION
EP3427745A1 (en) 2017-07-12 2019-01-16 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO New probiotic composition for prevention of bacterial vaginosis
JP7424636B2 (ja) * 2017-10-06 2024-01-30 ジェディア バイオテック エービー 微生物感染症の治療および／または予防用グルコン酸誘導体
AU2019274350B2 (en) * 2018-05-23 2022-04-07 Kobiolabs, Inc. Lactobacillus crispatus KBL693 strain and use thereof
GB201816425D0 (en) * 2018-10-09 2018-11-28 Tervisetehnoloogiate Arenduskeskus As Probiotics
CN109394796A (zh) * 2018-12-06 2019-03-01 青岛东海药业有限公司 卷曲乳杆菌制剂及其应用
CN112458007A (zh) * 2020-11-10 2021-03-09 深圳华大生命科学研究院 用于预防和/或治疗生殖道菌群紊乱相关疾病的卷曲乳杆菌
FR3117340B1 (fr) * 2020-12-15 2024-01-05 Basf Beauty Care Solutions France Sas Utilisation cosmétique, nutraceutique ou dermatologique d’une souche deLactobacillus crispatus et / ou d’une composition la comprenant
CN112708578A (zh) * 2020-12-31 2021-04-27 四川厌氧生物科技有限责任公司 一种卷曲乳杆菌及其应用
JP2024503366A (ja) * 2021-01-05 2024-01-25 ラクトバイオ アー／エス 菌株、組成物および使用方法
CN112899182B (zh) * 2021-01-08 2023-03-24 安徽省肿瘤医院 一种能够预防和/或治疗子宫颈鳞癌的卷曲乳杆菌
CN113512509B (zh) * 2021-05-07 2022-02-22 南方医科大学珠江医院 卷曲乳杆菌及其用途
KR102618322B1 (ko) * 2021-10-08 2023-12-27 순천향대학교 산학협력단 신규한 락토 바실러스 균주, 및 이를 포함하는 결핵 예방, 치료, 또는 개선용 조성물
CN114214256B (zh) * 2022-01-12 2022-06-28 哈尔滨美华生物技术股份有限公司 一株用于防治泌尿生殖感染的格氏乳杆菌及其应用
CN114657093B (zh) * 2022-03-07 2023-07-07 北京市农林科学院 一株鸽源卷曲乳杆菌bl4014及其应用
CN116814474B (zh) * 2022-05-19 2025-07-04 广东君薇生物科技有限公司 一株卷曲乳杆菌及其应用
CN115404185A (zh) * 2022-08-31 2022-11-29 江苏新申奥生物科技有限公司 一种拮抗白色念珠菌的卷曲乳杆菌lcp051及其应用
CN116024129B (zh) * 2022-11-29 2024-09-24 光明乳业股份有限公司 一株能够与幽门螺杆菌共聚集的卷曲乳杆菌及其应用
CN116694498B (zh) * 2023-01-31 2026-02-24 江南大学 一种缓解多种阴道炎的阴道益生菌组合物
CN116286484B (zh) * 2023-02-08 2025-01-24 善恩康生物科技（苏州）有限公司 卷曲乳杆菌及其用途
JPWO2024262189A1 (https=) * 2023-06-20 2024-12-26
CN116769676B (zh) * 2023-08-09 2023-12-05 杭州微致生物科技有限公司 一种卷曲乳杆菌及其应用
CN120330074A (zh) * 2024-01-17 2025-07-18 杭州远大生物制药有限公司 卷曲乳杆菌及其用途
WO2025207473A1 (en) * 2024-03-26 2025-10-02 Medstar Health, Inc. Methods and compositions for diagnosing and selectively treating or preventing urinary tract infection and urobiome dysbiosis
CN118256405B (zh) * 2024-05-31 2024-08-13 哈尔滨医科大学 卷曲乳杆菌fy121及其胞外囊泡在防治hpv感染及宫颈癌的应用
CN121160511A (zh) * 2024-06-17 2025-12-19 上海赛增医疗科技有限公司 新型乳杆菌菌株及其组合物和应用
CN119506125A (zh) * 2024-10-24 2025-02-25 北京科拓恒通生物技术股份有限公司 一种可促进女性生殖道健康和延缓生殖道免疫衰老的卷曲乳杆菌
CN119326803B (zh) * 2024-12-19 2025-06-27 江西益百润生物科技有限公司 一种后生元组合物的制备方法及其产品和应用
CN120648589A (zh) * 2025-05-23 2025-09-16 乾生(宁波)科技有限公司 一种改善细菌性阴道炎的益生菌及其组合物和应用
CN120775750A (zh) * 2025-09-09 2025-10-14 成都大学 一种卷曲乳杆菌及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093394A (en) 1997-04-11 2000-07-25 Gynelogix, Inc. Vaginal lactobacillus medicant
US8329447B2 (en) * 2008-12-12 2012-12-11 Osel, Inc. Strain of Lactobacillus crispatus
FR2992973B1 (fr) * 2012-07-09 2015-12-18 S P M D Nouvelle souche de lactobacillus crispatus
CN103074270A (zh) * 2012-11-15 2013-05-01 上海交大昂立股份有限公司 一种卷曲乳杆菌及其应用
CN104178437B (zh) * 2013-11-08 2016-08-24 苏州欧赛微科生物医药科技有限公司 一种卷曲乳杆菌及其在妇科疾病中的应用
CN104630083B (zh) * 2013-11-08 2018-07-06 苏州欧赛微科生物医药科技有限公司 一种卷曲乳杆菌及其在妇女保健产品中的应用

Also Published As

Publication number Publication date
EP3040413A1 (en) 2016-07-06
EP3040413B1 (en) 2018-03-21
KR101808972B1 (ko) 2017-12-13
MY172685A (en) 2019-12-10
TWI652343B (zh) 2019-03-01
ES2670536T3 (es) 2018-05-30
KR20160067893A (ko) 2016-06-14
US20170020934A1 (en) 2017-01-26
WO2015067141A1 (zh) 2015-05-14
SG11201603346VA (en) 2016-05-30
US9937214B2 (en) 2018-04-10
EP3040413A4 (en) 2016-07-06
JP2017501741A (ja) 2017-01-19
TW201531560A (zh) 2015-08-16

Similar Documents

Publication Publication Date Title
JP6890419B2 (ja) ラクトバチルス・クリスパタスおよびその応用
CN104630083B (zh) 一种卷曲乳杆菌及其在妇女保健产品中的应用
US12397024B2 (en) Multi-Lactobacillus composition and application thereof to vaginal health of females
CN104178437B (zh) 一种卷曲乳杆菌及其在妇科疾病中的应用
CN107299065B (zh) 一种植物乳杆菌及其用于制备阴道抑菌药物的应用
CN108004187B (zh) 一种格氏乳杆菌及其用于制备阴道抑菌药物的应用
CN107267415B (zh) 一种罗伊氏乳杆菌及其用于制备阴道抑菌药物的应用
CN110540945B (zh) 一种詹氏乳杆菌及其用于制备阴道抑菌药物的应用
CN108004188B (zh) 一种鼠李糖乳杆菌及其用于制备阴道抑菌药物的应用
CN109880772B (zh) 一种幽门螺杆菌菌株分离培养的方法
CN110777087A (zh) 一种约氏乳杆菌及其应用
CN117535208B (zh) 一种卷曲乳杆菌及其在女性生殖道健康中的应用
CN112708578A (zh) 一种卷曲乳杆菌及其应用
CN110982726A (zh) 一种卷曲乳杆菌及其应用
CN111471623A (zh) 三种乳杆菌的组合物及其用途
CN117535207A (zh) 一种格氏乳杆菌及其应用
CN110538201A (zh) 一种乳杆菌组合物及其用途
CN117511826B (zh) 尿路粘液乳杆菌及其应用
CN117535206B (zh) 一种尿路粘液乳杆菌及其应用
CN117535209B (zh) 左旋短乳杆菌及其在女性生殖道健康中的应用
CN121648167A (zh) 一种改善人体阴道微生态的菌株及其应用
CN121891412A (zh) 一种改善人体阴道微生态的菌株及其应用
CN118542885A (zh) 一种乳酸菌二联活菌制剂、其制备方法及应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160324

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170915

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170915

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180731

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180807

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20181102

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190105

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190207

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190611

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20191105

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20200118

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20201020

C13 Notice of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: C13

Effective date: 20210216

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210326

C23 Notice of termination of proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C23

Effective date: 20210413

C03 Trial/appeal decision taken

Free format text: JAPANESE INTERMEDIATE CODE: C03

Effective date: 20210518

C30A Notification sent

Free format text: JAPANESE INTERMEDIATE CODE: C3012

Effective date: 20210518

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210525

R150 Certificate of patent or registration of utility model

Ref document number: 6890419

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250