JP6889101B2 - グルタミナーゼ阻害剤の結晶形態 - Google Patents

グルタミナーゼ阻害剤の結晶形態 Download PDF

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Publication number
JP6889101B2
JP6889101B2 JP2017506401A JP2017506401A JP6889101B2 JP 6889101 B2 JP6889101 B2 JP 6889101B2 JP 2017506401 A JP2017506401 A JP 2017506401A JP 2017506401 A JP2017506401 A JP 2017506401A JP 6889101 B2 JP6889101 B2 JP 6889101B2
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cancer
compound
tumor
crystal
lymphoma
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JP2017523991A (ja
JP2017523991A5 (https=
Inventor
ティモシー エフ． スタントン，
ティモシー エフ． スタントン，
ジェイムズ ジェイ． スプリンガー，
ジェイムズ ジェイ． スプリンガー，
ジャクリーン エヌ． ウィリアムズ，
ジャクリーン エヌ． ウィリアムズ，
Original Assignee
キャリセラ バイオサイエンシーズ， インコーポレイテッド
キャリセラ バイオサイエンシーズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2017506401A 2014-08-07 2015-08-07 グルタミナーゼ阻害剤の結晶形態 Expired - Fee Related JP6889101B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462034547P 2014-08-07 2014-08-07
US62/034,547 2014-08-07
PCT/US2015/044301 WO2016022969A1 (en) 2014-08-07 2015-08-07 Crystal forms of glutaminase inhibitors

Related Child Applications (1)

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JP2019208032A Division JP2020037588A (ja) 2014-08-07 2019-11-18 グルタミナーゼ阻害剤の結晶形態

Publications (3)

Publication Number Publication Date
JP2017523991A JP2017523991A (ja) 2017-08-24
JP2017523991A5 JP2017523991A5 (https=) 2018-08-30
JP6889101B2 true JP6889101B2 (ja) 2021-06-18

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JP2017506401A Expired - Fee Related JP6889101B2 (ja) 2014-08-07 2015-08-07 グルタミナーゼ阻害剤の結晶形態
JP2019208032A Pending JP2020037588A (ja) 2014-08-07 2019-11-18 グルタミナーゼ阻害剤の結晶形態
JP2021108805A Withdrawn JP2021165286A (ja) 2014-08-07 2021-06-30 グルタミナーゼ阻害剤の結晶形態

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JP2019208032A Pending JP2020037588A (ja) 2014-08-07 2019-11-18 グルタミナーゼ阻害剤の結晶形態
JP2021108805A Withdrawn JP2021165286A (ja) 2014-08-07 2021-06-30 グルタミナーゼ阻害剤の結晶形態

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US (2) US10316030B2 (https=)
EP (1) EP3193876B1 (https=)
JP (3) JP6889101B2 (https=)
KR (1) KR20170082494A (https=)
CN (1) CN106999490A (https=)
AU (2) AU2015300825B2 (https=)
BR (1) BR112017002403A2 (https=)
CA (1) CA2957225A1 (https=)
EA (1) EA037738B1 (https=)
IL (1) IL250391B (https=)
MX (1) MX2017001620A (https=)
SG (1) SG11201700816YA (https=)
WO (1) WO2016022969A1 (https=)

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Also Published As

Publication number Publication date
EA037738B1 (ru) 2021-05-17
JP2020037588A (ja) 2020-03-12
JP2021165286A (ja) 2021-10-14
MX2017001620A (es) 2017-05-10
WO2016022969A1 (en) 2016-02-11
KR20170082494A (ko) 2017-07-14
CA2957225A1 (en) 2016-02-11
SG11201700816YA (en) 2017-02-27
US10316030B2 (en) 2019-06-11
JP2017523991A (ja) 2017-08-24
AU2019284149A1 (en) 2020-01-30
US20190359607A1 (en) 2019-11-28
US10676472B2 (en) 2020-06-09
EA201790337A1 (ru) 2017-09-29
AU2015300825A1 (en) 2017-03-09
BR112017002403A2 (pt) 2017-12-05
CN106999490A (zh) 2017-08-01
US20170226101A1 (en) 2017-08-10
EP3193876A4 (en) 2017-12-27
IL250391A0 (en) 2017-03-30
IL250391B (en) 2021-10-31
EP3193876B1 (en) 2022-01-12
EP3193876A1 (en) 2017-07-26
AU2015300825B2 (en) 2019-10-10

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