JP6887708B1 - ハイブリッド光学システム - Google Patents

ハイブリッド光学システム Download PDF

Info

Publication number
JP6887708B1
JP6887708B1 JP2020563803A JP2020563803A JP6887708B1 JP 6887708 B1 JP6887708 B1 JP 6887708B1 JP 2020563803 A JP2020563803 A JP 2020563803A JP 2020563803 A JP2020563803 A JP 2020563803A JP 6887708 B1 JP6887708 B1 JP 6887708B1
Authority
JP
Japan
Prior art keywords
light
wavelength region
cars
target
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020563803A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021519437A (ja
Inventor
ルーカス ブルックナー
ルーカス ブルックナー
デイヴィッド アンダーソン
デイヴィッド アンダーソン
プラカッシ スリダラ ムルティ
プラカッシ スリダラ ムルティ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atonarp Inc
Original Assignee
Atonarp Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atonarp Inc filed Critical Atonarp Inc
Priority to JP2021080786A priority Critical patent/JP7477882B2/ja
Application granted granted Critical
Publication of JP6887708B1 publication Critical patent/JP6887708B1/ja
Publication of JP2021519437A publication Critical patent/JP2021519437A/ja
Priority to JP2024063652A priority patent/JP2024079850A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Emergency Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2020563803A 2019-04-29 2020-04-23 ハイブリッド光学システム Active JP6887708B1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021080786A JP7477882B2 (ja) 2019-04-29 2021-05-12 ハイブリッド光学システム
JP2024063652A JP2024079850A (ja) 2019-04-29 2024-04-10 Ｃａｒｓ光学システム

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962840001P 2019-04-29 2019-04-29
US62/840,001 2019-04-29
PCT/JP2020/017447 WO2020222300A1 (en) 2019-04-29 2020-04-23 Hybrid optical system

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021080786A Division JP7477882B2 (ja) 2019-04-29 2021-05-12 ハイブリッド光学システム

Publications (2)

Publication Number Publication Date
JP6887708B1 true JP6887708B1 (ja) 2021-06-16
JP2021519437A JP2021519437A (ja) 2021-08-10

Family

ID=73028975

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020563803A Active JP6887708B1 (ja) 2019-04-29 2020-04-23 ハイブリッド光学システム
JP2021080786A Active JP7477882B2 (ja) 2019-04-29 2021-05-12 ハイブリッド光学システム
JP2024063652A Pending JP2024079850A (ja) 2019-04-29 2024-04-10 Ｃａｒｓ光学システム

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021080786A Active JP7477882B2 (ja) 2019-04-29 2021-05-12 ハイブリッド光学システム
JP2024063652A Pending JP2024079850A (ja) 2019-04-29 2024-04-10 Ｃａｒｓ光学システム

Country Status (6)

Country Link
US (2) US11944407B2 (enExample)
JP (3) JP6887708B1 (enExample)
KR (1) KR20220005449A (enExample)
CN (1) CN113631897B (enExample)
TW (1) TW202107067A (enExample)
WO (1) WO2020222300A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021113831A (ja) * 2019-04-29 2021-08-05 アトナープ株式会社 ハイブリッド光学システム

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7565554B2 (ja) * 2020-05-22 2024-10-11 国立大学法人山梨大学 分光計、分析システム及び分析方法
US20240167958A1 (en) * 2021-04-22 2024-05-23 Atonarp Inc. Method and system for acquiring cars spectrum
JP7577388B2 (ja) * 2021-08-20 2024-11-05 アトナープ株式会社 Ｃａｒｓスペクトルを取得するための方法およびシステム
CN117881957A (zh) * 2021-08-31 2024-04-12 株式会社岛津制作所 拉曼分光装置
WO2023058710A1 (en) * 2021-10-06 2023-04-13 Atonarp Inc. Method and system for acquiring cars spectrum
WO2023063415A1 (en) * 2021-10-14 2023-04-20 Atonarp Inc. System including a laser module
CN114795120B (zh) * 2021-11-22 2025-10-31 北京航空航天大学 一种多模态成像装置
KR102753085B1 (ko) * 2021-12-27 2025-01-10 고려대학교 산학협력단 광대역 비표지 분자 이미징 시스템
KR20240169663A (ko) * 2022-03-31 2024-12-03 온투 이노베이션 아이엔씨. 다중 파장 레이저 음향을 사용하여 샘플의 특성화를 수행하기 위한 시스템 및 방법
GB202212043D0 (en) * 2022-08-18 2022-10-05 Univ Of Lancaster Glucose concentration measuring device

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1754033B1 (en) * 2004-05-27 2011-06-22 Yeda Research And Development Co., Ltd. Coherently controlled nonlinear raman spectroscopy
JP5100461B2 (ja) 2008-03-14 2012-12-19 英明 加納 非線形分光計測システム用の光源装置、非線形分光計測システム及び方法
JP2009258071A (ja) * 2008-03-28 2009-11-05 Fujifilm Corp 粒子分析装置および粒子分析方法
JP2010002256A (ja) 2008-06-19 2010-01-07 Fujifilm Corp 非線形ラマン散乱光測定装置
US9285575B2 (en) * 2009-01-26 2016-03-15 President And Fellows Of Harvard College Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping
GB0904739D0 (en) 2009-03-19 2009-05-06 Univ Cardiff Coherent anti-stokes raman spectroscopy
JP5444457B2 (ja) * 2009-05-11 2014-03-19 コリア リサーチ インスティテュート オブ スタンダーズ アンド サイエンス 非線形光学顕微鏡を用いた血管内脂質の非破壊的病理的変化診断プログラム
US8553219B2 (en) * 2011-01-24 2013-10-08 Vanderbilt University Common detector for combined raman spectroscopy-optical coherence tomography
WO2013047698A1 (ja) * 2011-09-30 2013-04-04 学校法人東京理科大学 光干渉計、情報取得装置、及び情報取得方法
US9594023B2 (en) * 2011-12-05 2017-03-14 Sony Corporation Measurement apparatus and measurement method
JP5996665B2 (ja) 2012-10-19 2016-09-21 株式会社日立製作所 Ｃａｒｓ顕微鏡
WO2014180986A1 (en) * 2013-05-10 2014-11-13 Ludwig-Maximilians-Universität München A system and method for stimulated raman spectroscopy
EP2806263A1 (en) 2013-05-24 2014-11-26 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Method and detector for detecting an analyte
WO2014205413A2 (en) * 2013-06-21 2014-12-24 Invenio Imaging Inc. Multi-photon systems and methods
WO2015025389A1 (ja) * 2013-08-22 2015-02-26 株式会社日立製作所 Cars顕微鏡
US20160007840A1 (en) * 2014-07-10 2016-01-14 The Board Of Trustees Of The University Of Illinois Handheld Device for Identification of Microbiological Constituents in the Middle Ear
US20170023482A1 (en) * 2015-07-20 2017-01-26 United States Of America, As Represented By The Secretary Of Commerce Simultaneous plural color broadband coherent anti-stokes raman scattering microscope and imaging
EP3474001B1 (en) * 2016-06-17 2021-11-17 Saitama Medical University Test object visualizing device
JP6765648B2 (ja) 2016-07-13 2020-10-07 国立大学法人東京農工大学 光検出装置、光検出方法および光検出プログラム
WO2018089865A1 (en) * 2016-11-12 2018-05-17 The Trustees Of Columbia University In The City Of New York Microscopy devices, methods and systems
WO2018231724A1 (en) * 2017-06-12 2018-12-20 Trustees Of Boston University Systems and methods for oblique laser scanning
KR20220005449A (ko) * 2019-04-29 2022-01-13 아토나프 가부시키가이샤 하이브리드 광학 시스템

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021113831A (ja) * 2019-04-29 2021-08-05 アトナープ株式会社 ハイブリッド光学システム
JP7477882B2 (ja) 2019-04-29 2024-05-02 アトナープ株式会社 ハイブリッド光学システム

Also Published As

Publication number Publication date
JP2021519437A (ja) 2021-08-10
US20220087530A1 (en) 2022-03-24
WO2020222300A1 (en) 2020-11-05
US11944407B2 (en) 2024-04-02
KR20220005449A (ko) 2022-01-13
JP2024079850A (ja) 2024-06-11
US12343113B2 (en) 2025-07-01
CN113631897B (zh) 2024-07-16
TW202107067A (zh) 2021-02-16
JP2021113831A (ja) 2021-08-05
CN113631897A (zh) 2021-11-09
JP7477882B2 (ja) 2024-05-02
US20240197182A1 (en) 2024-06-20

Similar Documents

Publication Publication Date Title
JP6887708B1 (ja) ハイブリッド光学システム
JP5329449B2 (ja) 顕微鏡イメージングを実行する方法
JP6008299B2 (ja) 光干渉計、情報取得装置、及び情報取得方法
EP1754033B1 (en) Coherently controlled nonlinear raman spectroscopy
US9494522B2 (en) Device and method for stimulated Raman detection
JP6340474B2 (ja) 光計測装置及び光計測方法
US20120050733A1 (en) Laser microscope
US20190094133A1 (en) Observation apparatus and observation method
EP1975602A1 (en) Optical analyzer
JPWO2006104237A1 (ja) 空間情報検出装置
JP2015197513A (ja) 光源装置およびそれを用いた情報取得装置
WO2017217534A1 (ja) 被験対象可視化装置
WO2017090075A1 (ja) 光計測装置及び光計測方法
JP7475707B2 (ja) Ｃａｒｓ光学系を含むシステム
JP7577388B2 (ja) Ｃａｒｓスペクトルを取得するための方法およびシステム
JP2014126491A (ja) 情報取得システム、情報取得装置、および情報取得方法
JP2009058578A (ja) 標本観察条件演算装置およびこれを備える顕微鏡システム
JPH075107A (ja) 分光ファイバースコープ

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201127

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20201127

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20201127

TRDD Decision of grant or rejection written
A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20210408

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210414

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210512

R150 Certificate of patent or registration of utility model

Ref document number: 6887708

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250